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Tag Content
UUCD2 ID IUUC-Bta-012332
UUCD1 version UUC-BoT-00005
Ensembl Protein ID ENSBTAP00000024852.5
UniProt Accession A0JN74; TRI11_BOVIN
Genbank Protein ID AAI26549.1
Protein Name E3 ubiquitin-protein ligase TRIM11; RING-type E3 ubiquitin transferase TRIM11; Tripartite motif-containing protein 11
Genbank Nucleotide ID BC126548
Gene Name TRIM11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000039246.2 ENSBTAT00000024852.5 ENSBTAP00000024852.5
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 8.20e-07 29.1 12 71
E3 activity/RING/RING 3.10e-08 34.1 16 57
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl..asggk..tcPvtrqplteedlvPnltl 61
           ee  C+I l+ ++dPv++ +G+ + r++I+++    +      cP +r+ + +++l Pn  l
   Q: 12   EEATCAICLDYFTDPVMTDCGHNFCRECIRRCWgqPE--GpyACPECRELFPQRNLRPNRPL 71
           7889***************************995333..346*****************866 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           CaiCl+ f d p+ ++CgH f+++C+  +w     +  +   CP Cr
   Q: 16   CAICLDYFTD-PVMTDCGHNFCRECIrRCW----GQPEGPYACPECR 57
           **********.999************99**....66789999****8 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses.
 E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses.
Protein Sequence
(Fasta)
MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP YACPECRELF 60
PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCAAHREPLA AFCGDELRLL CAACERSGEH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012332|E3,U-box;E3,RING|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAACGGGATC CCTAGGCCCT ACCTTCCTGG AGTCGCCGCG TCTCGGAGCC GCACACTCCT 60
CATCCTCGGA ATCGAGAGGC CTCGGACCCC GGAGACCCTG CGCCCAGAAG CTCCCCGAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012332|E3,U-box;E3,RING|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0050768--P:negative regulation of neurogenesis
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0046598--P:positive regulation of viral entry into host cell
KEGG bta:514580
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001800 Ailuropoda melanoleuca 76.94 2.00e-177 615.00
IUUC-Cja-019969 Callithrix jacchus 79.70 0.00e+00 664.00
IUUC-Cfa-020491 Canis familiaris 95.94 0.00e+00 843.00
IUUC-Cpo-021936 Cavia porcellus 87.39 0.00e+00 751.00
IUUC-Csa-024151 Chlorocebus sabaeus 91.67 0.00e+00 743.00
IUUC-Cho-024990 Choloepus hoffmanni 78.32 3.00e-116 410.00
IUUC-Dno-029580 Dasypus novemcinctus 80.08 0.00e+00 647.00
IUUC-Ete-032556 Echinops telfairi 70.52 4.00e-116 410.00
IUUC-Eca-033612 Equus caballus 80.71 4.00e-147 514.00
IUUC-Fca-035821 Felis catus 95.77 1.00e-162 565.00
IUUC-Ggo-044629 Gorilla gorilla 91.88 0.00e+00 746.00
IUUC-Hsa-046332 Homo sapiens 91.88 0.00e+00 746.00
IUUC-Itr-047946 Ictidomys tridecemlineatus 90.38 0.00e+00 761.00
IUUC-Lch-049738 Latimeria chalumnae 37.35 2.00e-69 256.00
IUUC-Laf-054350 Loxodonta africana 74.26 2.00e-143 502.00
IUUC-Mcc-055827 Macaca mulatta 90.38 0.00e+00 725.00
IUUC-Meu-056122 Macropus eugenii 70.88 0.00e+00 652.00
IUUC-Mmr-061700 Microcebus murinus 89.51 0.00e+00 755.00
IUUC-Mdo-062921 Monodelphis domestica 61.75 8.00e-161 560.00
IUUC-Mmu-063762 Mus musculus 86.75 0.00e+00 727.00
IUUC-Mpu-065873 Mustela putorius furo 95.51 0.00e+00 838.00
IUUC-Mlu-067379 Myotis lucifugus 72.67 0.00e+00 630.00
IUUC-Nle-069440 Nomascus leucogenys 91.31 0.00e+00 743.00
IUUC-Opr-070901 Ochotona princeps 80.28 7.00e-176 609.00
IUUC-Ocu-074038 Oryctolagus cuniculus 71.64 4.00e-159 554.00
IUUC-Oga-088948 Otolemur garnettii 85.06 0.00e+00 741.00
IUUC-Oar-090242 Ovis aries 91.84 0.00e+00 800.00
IUUC-Ptr-090615 Pan troglodytes 71.49 3.00e-166 577.00
IUUC-Pan-092626 Papio anubis 91.67 0.00e+00 743.00
IUUC-Pab-097895 Pongo abelii 85.90 0.00e+00 743.00
IUUC-Pca-100435 Procavia capensis 88.65 0.00e+00 747.00
IUUC-Pva-102288 Pteropus vampyrus 85.04 0.00e+00 707.00
IUUC-Pgr-103696 Puccinia graminis 34.78 2.00e-06 45.80
IUUC-Rno-105938 Rattus norvegicus 86.97 0.00e+00 734.00
IUUC-Sha-107354 Sarcophilus harrisii 74.03 0.00e+00 665.00
IUUC-Smo-108838 Selaginella moellendorffii 40.68 1.00e-07 52.80
IUUC-Tbe-127733 Tupaia belangeri 92.04 0.00e+00 765.00
Created Date 25-Jun-2017

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