iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062956

Ensembl Protein ID

ENSMODP00000011923.2

UniProt Accession

F7C424; F7C424_MONDO

Protein Name

Uncharacterized protein

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000009542.3	ENSMODT00000012147.2	ENSMODP00000011923.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-22	78.3	617	655
UBD/Beta-Prp	3.30e-40	138.3	485	655

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 617  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 655
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 485  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 572
           5666788889998885.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 573  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 655
           88888888999*********************************9.********************************997443 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MIRDLSKMYP QTRHPAPHQP AQPFKFTISE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK 60
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCCGGGTG CCTTCTCCTC CTAGTTGCCA TTAAAACAAA TGAACCGAGC TGCTCTACCC 60
AGCGCCGCCA ACTAAATCGG TTTGGATGAT TCGCGATCTG AGCAAGATGT ACCCTCAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005279	Anolis carolinensis	98.45	0.00e+00	1326.00
IUUC-Bta-012646	Bos taurus	98.45	0.00e+00	1360.00
IUUC-Cel-018361	Caenorhabditis elegans	58.71	3.00e-120	425.00
IUUC-Cja-019079	Callithrix jacchus	98.58	0.00e+00	1389.00
IUUC-Cfa-020987	Canis familiaris	98.54	0.00e+00	1336.00
IUUC-Cpo-021606	Cavia porcellus	96.48	0.00e+00	1315.00
IUUC-Csa-023445	Chlorocebus sabaeus	98.97	0.00e+00	1363.00
IUUC-Cho-024590	Choloepus hoffmanni	85.22	0.00e+00	1197.00
IUUC-Dno-028979	Dasypus novemcinctus	98.78	0.00e+00	1315.00
IUUC-Dor-030533	Dipodomys ordii	91.97	0.00e+00	1138.00
IUUC-Ete-032887	Echinops telfairi	87.83	0.00e+00	1205.00
IUUC-Eca-034397	Equus caballus	98.49	0.00e+00	1253.00
IUUC-Fca-036030	Felis catus	98.95	0.00e+00	1363.00
IUUC-Fal-037460	Ficedula albicollis	98.81	0.00e+00	1336.00
IUUC-Gga-040416	Gallus gallus	99.10	0.00e+00	1365.00
IUUC-Ggo-045633	Gorilla gorilla	94.82	0.00e+00	1328.00
IUUC-Hsa-046461	Homo sapiens	94.91	0.00e+00	1361.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	99.10	0.00e+00	1370.00
IUUC-Lch-049943	Latimeria chalumnae	96.29	0.00e+00	1233.00
IUUC-Loc-052835	Lepisosteus oculatus	96.01	0.00e+00	1278.00
IUUC-Laf-053425	Loxodonta africana	99.08	0.00e+00	1359.00
IUUC-Mcc-055766	Macaca mulatta	95.04	0.00e+00	1363.00
IUUC-Mmr-061317	Microcebus murinus	95.51	0.00e+00	1364.00
IUUC-Mmu-063576	Mus musculus	98.71	0.00e+00	1355.00
IUUC-Mpu-066410	Mustela putorius furo	98.88	0.00e+00	1259.00
IUUC-Mlu-067456	Myotis lucifugus	97.04	0.00e+00	1288.00
IUUC-Nle-069495	Nomascus leucogenys	98.95	0.00e+00	1330.00
IUUC-Ont-071419	Oreochromis niloticus	86.62	0.00e+00	1196.00
IUUC-Oan-072842	Ornithorhynchus anatinus	96.10	0.00e+00	1348.00
IUUC-Ocu-074453	Oryctolagus cuniculus	97.55	0.00e+00	1338.00
IUUC-Ola-087090	Oryzias latipes	85.71	0.00e+00	1186.00
IUUC-Oga-087939	Otolemur garnettii	98.97	0.00e+00	1368.00
IUUC-Oar-090347	Ovis aries	98.60	0.00e+00	1240.00
IUUC-Ptr-091048	Pan troglodytes	98.97	0.00e+00	1363.00
IUUC-Pan-091973	Papio anubis	94.32	0.00e+00	1307.00
IUUC-Pma-094452	Petromyzon marinus	78.48	0.00e+00	1113.00
IUUC-Pfo-097518	Poecilia formosa	84.98	0.00e+00	1142.00
IUUC-Pab-097539	Pongo abelii	94.62	0.00e+00	1232.00
IUUC-Pca-101137	Procavia capensis	87.67	0.00e+00	1123.00
IUUC-Pva-103037	Pteropus vampyrus	92.92	0.00e+00	1355.00
IUUC-Rno-105314	Rattus norvegicus	98.65	0.00e+00	1286.00
IUUC-Ssc-116408	Sus scrofa	98.58	0.00e+00	1387.00
IUUC-Tgu-117068	Taeniopygia guttata	98.40	0.00e+00	1340.00
IUUC-Tru-118782	Takifugu rubripes	82.75	0.00e+00	1133.00
IUUC-Tsy-118884	Tarsius syrichta	84.08	0.00e+00	1073.00
IUUC-Tni-120404	Tetraodon nigroviridis	84.47	0.00e+00	1190.00
IUUC-Tbe-128013	Tupaia belangeri	90.74	0.00e+00	1253.00
IUUC-Vpa-130577	Vicugna pacos	90.21	0.00e+00	708.00
IUUC-Xtr-132974	Xenopus tropicalis	96.40	0.00e+00	1286.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence