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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105918
UUCD1 version UUC-RaN-00798
Ensembl Protein ID ENSRNOP00000025409.4
UniProt Accession Q498M5; SH3R2_RAT
Genbank Protein ID AAI00156.1
Protein Name Putative E3 ubiquitin-protein ligase SH3RF2; Protein phosphatase 1 regulatory subunit 39; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2
Genbank Nucleotide ID BC100155
Gene Name Sh3rf2; Ppp1r39; Rnf158
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000018780.6 ENSRNOT00000025408.6 ENSRNOP00000025409.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 9.70e-08 32.8 12 53
UBD/SH3 1.30e-30 105.5 385 441
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+e ++   +vlpC+H+f++ Clq++     ++ ke rCP Cr
   Q: 12   CPVCFEKLDVTAKVLPCQHTFCKPCLQRI----FKAHKELRCPECR 53
           ********88899****************....99**********8 PP
   

   UBD/SH3
   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            + + +l+ y+aq  +eL lkkG+ ++v+   ++  gWl+gv+  +g+ G+fP+++v  
   Q: 385  TNMFVALHTYSAQGPEELDLKKGEGIRVL--GKNQDGWLRGVSLVTGRTGIFPSDYVIP 441
           57899************************..556669*******************965 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function (By similarity).
 Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function (By similarity).
Protein Sequence
(Fasta)
MDDLTLLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQRI FKAHKELRCP ECRTLVFCSI 60
EALPANLLLV RLLDGVRSGH NSWRGGSFRR PRILTLQDNR KAKSSPRSLQ ASPFRLGPTV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105918|E3,RING;UBD,SH3|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTTTTTTTC CTCCTTCTTT CAAACAGGCA GGGAGTTCTG ATGCTCCCAA AAGACTGGCT 60
CTACCCCTTC GGTTCGGCTG CCCCTACAAT GTGGATCCTG CTTCTCCAGG TTGGGACTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105918|E3,RING;UBD,SH3|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0650--Protein phosphatase inhibitor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011511--SH3_2
IPR001452--SH3_domain
IPR028511--SH3RF2
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00018--SH3_1
PF07653--SH3_2
PF00097--zf-C3HC4
PRINTS

PR00452--SH3DOMAIN
SMART

SM00184--RING
SM00326--SH3
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0019902--F:phosphatase binding
GO:0008157--F:protein phosphatase 1 binding
GO:0004864--F:protein phosphatase inhibitor activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0010923--P:negative regulation of phosphatase activity
GO:0016567--P:protein ubiquitination
KEGG rno:307472
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001594 Ailuropoda melanoleuca 78.88 0.00e+00 1035.00
IUUC-Apl-003443 Anas platyrhynchos 56.84 2.00e-173 602.00
IUUC-Aca-004632 Anolis carolinensis 53.89 3.00e-170 592.00
IUUC-Bta-013400 Bos taurus 80.17 0.00e+00 977.00
IUUC-Cel-018180 Caenorhabditis elegans 25.36 4.00e-21 97.10
IUUC-Cja-019686 Callithrix jacchus 70.43 0.00e+00 874.00
IUUC-Cfa-020893 Canis familiaris 80.33 0.00e+00 1040.00
IUUC-Cpo-021638 Cavia porcellus 76.16 0.00e+00 967.00
IUUC-Csa-023846 Chlorocebus sabaeus 80.85 0.00e+00 1068.00
IUUC-Cho-024609 Choloepus hoffmanni 80.79 7.00e-162 564.00
IUUC-Dno-028940 Dasypus novemcinctus 78.22 0.00e+00 1020.00
IUUC-Dor-030491 Dipodomys ordii 70.77 9.00e-121 427.00
IUUC-Dse-031414 Dothistroma septosporum 31.82 3.00e-07 50.80
IUUC-Ete-032513 Echinops telfairi 77.02 0.00e+00 998.00
IUUC-Eca-034241 Equus caballus 81.13 0.00e+00 1085.00
IUUC-Eeu-034636 Erinaceus europaeus 72.87 0.00e+00 842.00
IUUC-Fca-035862 Felis catus 77.88 0.00e+00 1030.00
IUUC-Gga-040748 Gallus gallus 52.29 8.00e-146 510.00
IUUC-Ggo-045267 Gorilla gorilla 81.13 0.00e+00 1063.00
IUUC-Hsa-045761 Homo sapiens 80.85 0.00e+00 1056.00
IUUC-Itr-048226 Ictidomys tridecemlineatus 78.10 0.00e+00 1004.00
IUUC-Lch-050498 Latimeria chalumnae 44.46 3.00e-119 422.00
IUUC-Laf-054061 Loxodonta africana 70.76 0.00e+00 743.00
IUUC-Mcc-054746 Macaca mulatta 80.19 0.00e+00 1029.00
IUUC-Meu-056390 Macropus eugenii 55.67 8.00e-81 295.00
IUUC-Mga-059398 Meleagris gallopavo 62.91 2.00e-91 328.00
IUUC-Mmr-061390 Microcebus murinus 76.72 0.00e+00 834.00
IUUC-Mdo-062951 Monodelphis domestica 69.55 0.00e+00 936.00
IUUC-Mmu-063840 Mus musculus 92.29 0.00e+00 1234.00
IUUC-Mpu-065840 Mustela putorius furo 78.68 0.00e+00 1056.00
IUUC-Mlu-067378 Myotis lucifugus 78.43 0.00e+00 991.00
IUUC-Nle-069535 Nomascus leucogenys 78.24 0.00e+00 992.00
IUUC-Opr-070739 Ochotona princeps 76.31 0.00e+00 962.00
IUUC-Oan-073468 Ornithorhynchus anatinus 62.60 0.00e+00 764.00
IUUC-Ocu-074343 Oryctolagus cuniculus 77.46 0.00e+00 947.00
IUUC-Oga-088276 Otolemur garnettii 72.73 0.00e+00 934.00
IUUC-Oar-090315 Ovis aries 79.37 0.00e+00 975.00
IUUC-Ptr-091119 Pan troglodytes 80.72 0.00e+00 1059.00
IUUC-Pan-092158 Papio anubis 82.34 0.00e+00 773.00
IUUC-Psi-092959 Pelodiscus sinensis 58.56 0.00e+00 733.00
IUUC-Pab-097675 Pongo abelii 80.99 0.00e+00 1055.00
IUUC-Pca-101021 Procavia capensis 70.74 0.00e+00 890.00
IUUC-Pva-102619 Pteropus vampyrus 79.72 0.00e+00 995.00
IUUC-Sha-107391 Sarcophilus harrisii 65.54 0.00e+00 850.00
IUUC-Sar-113148 Sorex araneus 74.71 2.00e-175 609.00
IUUC-Ssc-116219 Sus scrofa 72.08 2.00e-115 408.00
IUUC-Tgu-116584 Taeniopygia guttata 63.77 6.00e-73 267.00
IUUC-Tsy-118968 Tarsius syrichta 77.66 1.00e-159 556.00
IUUC-Tbe-128007 Tupaia belangeri 83.69 0.00e+00 763.00
IUUC-Ttr-128499 Tursiops truncatus 77.96 0.00e+00 1033.00
IUUC-Vpa-130075 Vicugna pacos 72.35 1.00e-70 260.00
Created Date 25-Jun-2017

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