iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033929

UUCD1 version

UUC-EqC-00978

Ensembl Protein ID

ENSECAP00000017573.1

UniProt Accession

F7CFS8; F7CFS8_HORSE

Protein Name

Uncharacterized protein

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000019670.1	ENSECAT00000021346.1	ENSECAP00000017573.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.30e-203	676.9	415	887

Active Site

Position(s)	Description	Evidence
599	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  q+kl+ +++llvGag++GcEllKn++l+G+     gs+tv Dmd++e snl+rqFLfr++d+g++KAevaaea+ +l
   Q: 415  YDGQIAVFGAGFQKKLSHQHYLLVGAGAIGCELLKNFALVGLgtrgsGSVTVADMDHIERSNLSRQFLFRPQDIGRPKAEVAAEAALRL 503
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           n+d +v++ + ++++ +e+i+   Ff+++d+V++ald+++arr+v+ +c+++ +pl+e+gt G+lG+++v+++++te y+++     ++
   Q: 504  NSDLQVTSFTHQLDPSTEDIYgdnFFSRMDGVAAALDSFQARRYVAVRCTHYLKPLLEAGTQGTLGHASVFMPHVTEPYRAPAsatASE 592
           ***********************************************************************************9999** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           +  +P+ct++++p+++eht++wa        +l+++++++++++ + l+++d+ + ++ +++v   l++ +++++++++ +a+ +++ +
   Q: 593  DAPYPVCTVRHFPSTVEHTVQWArdefeglfHLAAETINHHQQALTSLADTDRPQVLTLLQAVLGVLRE-RPQTWQDCVVWALGHWQLR 680
           ***************************************************************766555.7****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekv 289
           + +si qllk+f++d+v ++++ fw+                                                ++ ++   +   +  
   Q: 681  FCYSIMQLLKHFPPDKVLEDGTLFWSgskrcpqplefdasqdthflyvlaaanlyaqmhglpgsqdktglrellKLLPLPGPQDLAPIF 769
           ****************************9999999999999999888888888888888777777777776666444444444433444 PP
   S: 290  ekdeevvkasap....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiatt 372
           + d     asa+    +  l +ale ++  + +kp  l+fekd ds  ++d+v+aaa+lra+++gi p +++++ k+i+g+iipaiatt
   Q: 770  ANDLDPALASAEfgpeQLKLHEALEFWSVGPHLKP--LRFEKDNDSnfHMDFVAAAASLRAQNYGILP-ANRMQSKRIVGRIIPAIATT 855
           44443333333366667778899***********9..*********9*********************.******************** PP
   S: 373  navvgGlaaqEviKvvsg..kfeplknfflfd 402
           +a+v+Gl+++E++Kvv g     ++++ +l++
   Q: 856  SAAVAGLVVLELYKVVGGaqSLGAFRHSYLHL 887
           ****************9954444566666665 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MDVLETSKSL DEELYSRQMY VLGLPAMQRI QGAKVLLSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLAAQFFLSK RDLERSRAEA CQELVAKLNE SVQVCIHTGD LTEDLLLDFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATGTCC TGGAGACCTC CAAGTCACTG GATGAGGAGC TGTACTCACG GCAGATGTGA 60
GGCTTGGGGA GGGGAGTGGG GAGAGAAGTG GGGTGGCCTT CTGACCTCTG ATCTCCAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

KEGG

ecb:100052809

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	81.67	0.00e+00	1558.00
IUUC-Bta-012665	Bos taurus	76.66	0.00e+00	1399.00
IUUC-Cja-019047	Callithrix jacchus	79.25	0.00e+00	1522.00
IUUC-Cfa-021225	Canis familiaris	83.20	0.00e+00	1628.00
IUUC-Cpo-022336	Cavia porcellus	70.24	0.00e+00	1319.00
IUUC-Csa-023462	Chlorocebus sabaeus	82.71	0.00e+00	1518.00
IUUC-Cho-024436	Choloepus hoffmanni	80.59	3.00e-106	379.00
IUUC-Dno-029347	Dasypus novemcinctus	80.45	0.00e+00	1491.00
IUUC-Dor-030997	Dipodomys ordii	74.01	0.00e+00	1395.00
IUUC-Ete-033124	Echinops telfairi	75.15	0.00e+00	979.00
IUUC-Eeu-034717	Erinaceus europaeus	69.36	0.00e+00	1000.00
IUUC-Fca-036564	Felis catus	83.63	0.00e+00	1598.00
IUUC-Ggo-044480	Gorilla gorilla	82.27	0.00e+00	1518.00
IUUC-Hsa-046498	Homo sapiens	81.92	0.00e+00	1485.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	76.68	0.00e+00	1437.00
IUUC-Laf-054119	Loxodonta africana	79.15	0.00e+00	1544.00
IUUC-Mcc-055597	Macaca mulatta	80.97	0.00e+00	1454.00
IUUC-Meu-056534	Macropus eugenii	49.65	0.00e+00	892.00
IUUC-Mdo-063058	Monodelphis domestica	56.85	0.00e+00	1052.00
IUUC-Mmu-063578	Mus musculus	71.81	0.00e+00	1414.00
IUUC-Mpu-066255	Mustela putorius furo	80.87	0.00e+00	1556.00
IUUC-Mlu-067814	Myotis lucifugus	75.81	0.00e+00	1360.00
IUUC-Nle-069193	Nomascus leucogenys	81.62	0.00e+00	1506.00
IUUC-Opr-070715	Ochotona princeps	72.33	0.00e+00	1358.00
IUUC-Oan-073306	Ornithorhynchus anatinus	54.07	0.00e+00	738.00
IUUC-Ocu-074162	Oryctolagus cuniculus	76.07	0.00e+00	1419.00
IUUC-Oga-088895	Otolemur garnettii	78.36	0.00e+00	1437.00
IUUC-Oar-089579	Ovis aries	76.36	0.00e+00	1393.00
IUUC-Ptr-090581	Pan troglodytes	82.38	0.00e+00	1463.00
IUUC-Pan-092458	Papio anubis	82.91	0.00e+00	1517.00
IUUC-Pab-098653	Pongo abelii	76.68	0.00e+00	1423.00
IUUC-Pca-100578	Procavia capensis	74.29	0.00e+00	891.00
IUUC-Pva-102914	Pteropus vampyrus	80.62	0.00e+00	1246.00
IUUC-Rno-106066	Rattus norvegicus	72.71	0.00e+00	1449.00
IUUC-Sha-107368	Sarcophilus harrisii	59.90	0.00e+00	1146.00
IUUC-Ssc-115743	Sus scrofa	82.21	0.00e+00	1571.00
IUUC-Tbe-127587	Tupaia belangeri	73.26	0.00e+00	1236.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence