iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000020980.3	ENSMMUT00000029505.3	ENSMMUP00000027608.2
ENSMMUG00000020980.3	ENSMMUT00000029506.3	ENSMMUP00000027609.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.00e-213	711.1	415	890

Active Site

Position(s)	Description	Evidence
599	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+++++llvGag++GcEllK ++l+G+     g +tvvDmd++e snl+rqFLfr +d+g++KAevaa+a+++l
   Q: 415  YDGQIAVFGAGLQEKLSRQHYLLVGAGAIGCELLKVFALVGLgarnsGGLTVVDMDHIERSNLSRQFLFRSQDIGRPKAEVAAAAARRL 503
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           npd +v + ++++++++e+i+   Ff+ +d+V++ald+++arr+v+ +c+++ +pl+e+gtlG+ G ++v+++++te+y+++     ++
   Q: 504  NPDLQVIPLTYPLDPTTEHIYgdnFFSHVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTLGTRGSAKVFMPHVTEAYRAPAsaaASE 592
           ************************************************************************************999** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           +  +P+ct++++p++aeht++wa        +l ++++++++++++ l+++d  ++++ +++v   l+  + +n+++++++a+ +++ +
   Q: 593  DAPYPVCTVRHFPSTAEHTLQWArdefeglfRLSAETINHHQQAHTSLADMDGPQTLTLLKPVLGVLRV-RAQNWQDCVAWALGHWKLC 680
           ***************************************************************888887.5999*************** PP
   S: 249  tinsikqllksfecdivtkskspfwv.................................................sfcsnaealqvpek 288
           ++++ikqll++f++++v + ++ +                                                   ++ ++ + +q+ + 
   Q: 681  FHYGIKQLLRHFPPNKVLTPTPCTHTcsltpmplllflvwlqdmhllyvlaaanlyaqmhglpgsqdstalrellKLLPQPDPQQMAPI 769
           ****************999998887799************************************************************* PP
   S: 289  vekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaia 370
            +++ e  +asa+     l+ l +ale +   + +kp  l+fekddds  +vd+v+aaa+lr++++gi+p +++ + k+i+g+iipaia
   Q: 770  FASNLELASASAEfgpeqLKELNKALEFWTVGPPLKP--LMFEKDDDSnfHVDFVAAAASLRCQNYGIPP-VSRAQSKRIVGQIIPAIA 855
           ************9***********************9..*******************************.****************** PP
   S: 371  ttnavvgGlaaqEviKvvsg..kfeplknfflfda 403
           tt+a+v+Gl+ +E++Kvv g  + +++++ ++++a
   Q: 856  TTTAAVAGLLGLELYKVVGGprPRSAFRHSYVHLA 890
           *******************9766777888777766 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MDALDASKLL DEELYSRQLY VLGSPAMQRI QGARVLVSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLAAQFLLSE QDLERSRAEA SQELLAQLNR AVQVVVHTGD ITEDLLLDFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTACAGCAGG GCACTGGCCC CTACTGTCAC CGCCTCCTAA ACAAAGACCC TCTCTCTGAG 60
CGCTGCAGCC TACTGTTCGG CCCCAGGTTT GAGGATGGAT GCCCTAGATG CTTCGAAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	78.09	0.00e+00	1439.00
IUUC-Bta-012665	Bos taurus	74.85	0.00e+00	1321.00
IUUC-Cja-019047	Callithrix jacchus	89.05	0.00e+00	1685.00
IUUC-Cfa-021225	Canis familiaris	78.84	0.00e+00	1490.00
IUUC-Cpo-022336	Cavia porcellus	70.10	0.00e+00	1276.00
IUUC-Csa-023462	Chlorocebus sabaeus	96.84	0.00e+00	1771.00
IUUC-Cho-024436	Choloepus hoffmanni	75.53	1.00e-96	347.00
IUUC-Dno-029347	Dasypus novemcinctus	78.50	0.00e+00	1441.00
IUUC-Dor-030997	Dipodomys ordii	74.26	0.00e+00	1342.00
IUUC-Ete-033124	Echinops telfairi	74.26	0.00e+00	941.00
IUUC-Eca-033929	Equus caballus	80.97	0.00e+00	1538.00
IUUC-Eeu-034717	Erinaceus europaeus	67.63	0.00e+00	926.00
IUUC-Fca-036564	Felis catus	80.91	0.00e+00	1488.00
IUUC-Ggo-044480	Gorilla gorilla	94.12	0.00e+00	1710.00
IUUC-Hsa-046498	Homo sapiens	93.98	0.00e+00	1691.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	76.90	0.00e+00	1396.00
IUUC-Laf-054119	Loxodonta africana	77.61	0.00e+00	1457.00
IUUC-Meu-056534	Macropus eugenii	48.35	0.00e+00	852.00
IUUC-Mdo-063058	Monodelphis domestica	55.26	0.00e+00	980.00
IUUC-Mmu-063578	Mus musculus	72.86	0.00e+00	1379.00
IUUC-Mpu-066255	Mustela putorius furo	79.04	0.00e+00	1480.00
IUUC-Mlu-067814	Myotis lucifugus	75.29	0.00e+00	1328.00
IUUC-Nle-069193	Nomascus leucogenys	93.58	0.00e+00	1716.00
IUUC-Opr-070715	Ochotona princeps	72.29	0.00e+00	1344.00
IUUC-Ocu-074162	Oryctolagus cuniculus	76.85	0.00e+00	1421.00
IUUC-Oga-088895	Otolemur garnettii	79.19	0.00e+00	1451.00
IUUC-Oar-089579	Ovis aries	74.16	0.00e+00	1308.00
IUUC-Ptr-090581	Pan troglodytes	94.17	0.00e+00	1657.00
IUUC-Pan-092458	Papio anubis	97.63	0.00e+00	1783.00
IUUC-Pab-098653	Pongo abelii	87.87	0.00e+00	1588.00
IUUC-Pca-100578	Procavia capensis	73.91	0.00e+00	822.00
IUUC-Pva-102914	Pteropus vampyrus	76.80	0.00e+00	1157.00
IUUC-Rno-106066	Rattus norvegicus	71.67	0.00e+00	1376.00
IUUC-Sha-107368	Sarcophilus harrisii	58.52	0.00e+00	1073.00
IUUC-Ssc-115743	Sus scrofa	80.47	0.00e+00	1474.00
IUUC-Tbe-127587	Tupaia belangeri	79.72	0.00e+00	1058.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence