iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088895

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03164110

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000010427.2	ENSOGAT00000010432.2	ENSOGAP00000009332.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.70e-199	663.2	402	876

Active Site

Position(s)	Description	Evidence
586	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+ +++llvGag++GcEllK+++l+G+     g +tv Dmd+ve+snl+rqFLfra+d+g++KAevaa+a++ l
   Q: 402  YDGQIAVFGAGFQEKLSCQRYLLVGAGAIGCELLKAFALMGLgaggsGALTVADMDHVEYSNLSRQFLFRAQDIGRPKAEVAAAAAQVL 490
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           npd +v+a + ++++++e+i+   Ff+++d+V++ald+++ar +v+ +c+++ +pl+e+gt G++G ++v+++++te ys++     ++
   Q: 491  NPDLKVTALTHPLNPTTEHIYgdhFFSQVDGVAAALDSFQARHYVAARCTHYLKPLLEAGTQGTWGSASVFMPHVTEGYSAPAsaaASE 579
           ************************************************************************************999** PP
   S: 168  qktiPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavka 244
           + + P+ct++ +p+++eht++wa            + +n ++  e+g +  l ++++ +++  +++v   l++ +++++++++ +a+ +
   Q: 580  DASHPVCTVRYFPTTVEHTLKWArdefeglfrlsaETINRYQHYETGCT-SLTDMNEPQTLILLKPVLGVLRA-RPQSWQDCVVWAFGH 666
           *******************************777666666665454444.45568999999999999766665.7************** PP
   S: 245  fakttinsikqllksfecdivtkskspfwv................................................sfcsnaealqv 285
           ++ +++++ikqll++f++d+v ++++pfw                                                 ++ ++ +++  
   Q: 667  WQLRFHYGIKQLLRHFPPDKVLEDGTPFWFglkqcphplefdisqdthllyvlaaanlyaqmhglpgsqdqtalrgmlKLLPQPDSQHL 755
           ******************************************************************************99999999999 PP
   S: 286  pekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniip 367
            +  +++ e   asa+     l+ l  +le ++  + +kp  l fekd ds  ++d+vtaaa+lr +++g+++ +++ + k+i+g+iip
   Q: 756  ASIFTSNLELALASAEsgpeqLKELHNVLEVWSMGSLLKP--LIFEKDNDSnfHMDFVTAAASLRSQNYGLSS-VNRAQCKRIVGQIIP 841
           999888888877777788999******************9..*******************************.*************** PP
   S: 368  aiattnavvgGlaaqEviKvvsg..kfeplknffl 400
           aiatt+ +v+Gl+++E++Kvv++  +  ++++ +l
   Q: 842  AIATTTTAVAGLVCLELYKVVDKprPLGAFRHSYL 876
           **********************9544455665555 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

LDEELYSRQL YVLGSPAMQR IQKAKVLLSG LQGLGAEVAK NLVLMGVGSL TLHDPNPTCW 60
SDLAAQLFLS EKDLGRSRAE ASQDLLAQLN RAVQVFVHTG DITEDLLLDF QVVVLTASKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGATGAGG AACTATACTC AAGACAGCTG TGAGGCCTGA GGTGGGGTAG AGAGTAGGGT 60
GGCCTTGAGA CCTCCAATCT ATAACTACAT GCCCTCCCTA CATCCCATCC ACAGGTATGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	75.60	0.00e+00	1367.00
IUUC-Bta-012665	Bos taurus	73.95	0.00e+00	1274.00
IUUC-Cja-019047	Callithrix jacchus	79.34	0.00e+00	1432.00
IUUC-Cfa-021225	Canis familiaris	75.77	0.00e+00	1385.00
IUUC-Cpo-022336	Cavia porcellus	69.90	0.00e+00	1269.00
IUUC-Csa-023462	Chlorocebus sabaeus	81.13	0.00e+00	1421.00
IUUC-Cho-024436	Choloepus hoffmanni	74.26	1.00e-89	324.00
IUUC-Dno-029347	Dasypus novemcinctus	75.95	0.00e+00	1372.00
IUUC-Dor-030997	Dipodomys ordii	72.68	0.00e+00	1303.00
IUUC-Ete-033124	Echinops telfairi	73.93	0.00e+00	917.00
IUUC-Eca-033929	Equus caballus	78.36	0.00e+00	1460.00
IUUC-Eeu-034717	Erinaceus europaeus	66.71	0.00e+00	915.00
IUUC-Fca-036564	Felis catus	76.90	0.00e+00	1377.00
IUUC-Ggo-044480	Gorilla gorilla	81.01	0.00e+00	1446.00
IUUC-Hsa-046498	Homo sapiens	79.54	0.00e+00	1400.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	76.14	0.00e+00	1371.00
IUUC-Laf-054119	Loxodonta africana	75.37	0.00e+00	1385.00
IUUC-Mcc-055597	Macaca mulatta	79.19	0.00e+00	1362.00
IUUC-Meu-056534	Macropus eugenii	53.62	0.00e+00	823.00
IUUC-Mdo-063058	Monodelphis domestica	54.65	0.00e+00	957.00
IUUC-Mmu-063578	Mus musculus	70.02	0.00e+00	1297.00
IUUC-Mpu-066255	Mustela putorius furo	75.80	0.00e+00	1369.00
IUUC-Mlu-067814	Myotis lucifugus	72.13	0.00e+00	1251.00
IUUC-Nle-069193	Nomascus leucogenys	80.66	0.00e+00	1424.00
IUUC-Opr-070715	Ochotona princeps	70.26	0.00e+00	1264.00
IUUC-Ocu-074162	Oryctolagus cuniculus	73.91	0.00e+00	1337.00
IUUC-Oar-089579	Ovis aries	72.94	0.00e+00	1263.00
IUUC-Ptr-090581	Pan troglodytes	79.74	0.00e+00	1383.00
IUUC-Pan-092458	Papio anubis	80.93	0.00e+00	1420.00
IUUC-Pab-098653	Pongo abelii	76.07	0.00e+00	1330.00
IUUC-Pca-100578	Procavia capensis	69.63	0.00e+00	776.00
IUUC-Pva-102914	Pteropus vampyrus	74.91	0.00e+00	1091.00
IUUC-Rno-106066	Rattus norvegicus	70.18	0.00e+00	1306.00
IUUC-Sha-107368	Sarcophilus harrisii	57.94	0.00e+00	1050.00
IUUC-Ssc-115743	Sus scrofa	78.03	0.00e+00	1413.00
IUUC-Tbe-127587	Tupaia belangeri	73.07	0.00e+00	1177.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence