iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000020175.2	ENSPANT00000016137.2	ENSPANP00000007026.1
ENSPANG00000020175.2	ENSPANT00000016138.1	ENSPANP00000010903.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.80e-218	725.7	415	890

Active Site

Position(s)	Description	Evidence
599	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+++++llvGag++GcEllK ++l+G+     g +tvvDmd++e snl+rqFLfr +d+g++KAevaa+a+++l
   Q: 415  YDGQIAVFGAGFQEKLSRQHYLLVGAGAIGCELLKVFALVGLgarnsGGLTVVDMDHIERSNLSRQFLFRSQDIGRPKAEVAAAAARRL 503
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           npd +v + ++++++++e+i+   Ff+ +d+V++ald+++arr+v+ +c+++ +pl+e+gtlG+ G ++v+++++te+y+++     ++
   Q: 504  NPDLQVIPLTYPLDPTTEHIYgdnFFSHVDGVAAALDSFQARRYVAARCTHYLKPLLEAGTLGTRGSAKVFMPHVTEAYRAPAsaaASE 592
           ************************************************************************************999** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           +  +P+ct++++p++aeht++wa        +l ++++++++++++ l+++d  ++++ +++v   l+  +++n+++++++a+ +++ +
   Q: 593  DAPYPVCTVRHFPSTAEHTLQWArdefeglfRLSAETINHHQQAHTSLADMDGPQTLTLLKPVLGVLRV-RPQNWQDCVAWALGHWKLR 680
           ***************************************************************888777.6****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekv 289
           ++++ikqll++f++++v ++++pfw+                                                ++ ++ + +q+ +  
   Q: 681  FHYGIKQLLRHFPPNKVLEDGTPFWSgpkqcpqplefdtnqdmhllyvlaaanlyaqmhglpgsqdstalrellKLLPQPDPQQMAPIF 769
           ***************************************************************************************** PP
   S: 290  ekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiat 371
           +++ e  +asa+     l+ l +ale +   + +kp  l+fekddds  +vd+v+aaa+lr++++gi+p +++ + k+i+g+iipaiat
   Q: 770  ASNLELASASAEfgpeqLKELNKALEFWTVGPPLKP--LMFEKDDDSnfHVDFVAAAASLRCQNYGIPP-VSRAQSKRIVGQIIPAIAT 855
           ***********9***********************9..*******************************.******************* PP
   S: 372  tnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           t+a+v+Gl+ +E++Kvv g  + +++++ +l++ae
   Q: 856  TTAAVAGLLGLELYKVVGGprPRSAFRHSYLHLAE 890
           *******************7777789988888765 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MDALDASKLL DEELYSRQLY VLGSPAMQRI QGARVLVSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLAAQFLLSE QDLERSRAEA SQELLAQLNR AVQVVVHTGD ITEDLLLDFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATGCCC TAGATGCTTC GAAGCTGCTG GATGAGGAGC TGTATTCAAG ACAGCTGTGA 60
GGCCCGAGGT GAGGGGTGGA GAATGGGGGA TGGTCTTCAG ACCTTGATCT GCAACTGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	80.67	0.00e+00	1503.00
IUUC-Bta-012665	Bos taurus	76.88	0.00e+00	1387.00
IUUC-Cja-019047	Callithrix jacchus	91.11	0.00e+00	1747.00
IUUC-Cfa-021225	Canis familiaris	81.32	0.00e+00	1553.00
IUUC-Cpo-022336	Cavia porcellus	72.20	0.00e+00	1343.00
IUUC-Csa-023462	Chlorocebus sabaeus	99.01	0.00e+00	1833.00
IUUC-Cho-024436	Choloepus hoffmanni	75.53	1.00e-96	347.00
IUUC-Dno-029347	Dasypus novemcinctus	80.34	0.00e+00	1496.00
IUUC-Dor-030997	Dipodomys ordii	75.99	0.00e+00	1398.00
IUUC-Ete-033124	Echinops telfairi	74.41	0.00e+00	943.00
IUUC-Eca-033929	Equus caballus	82.91	0.00e+00	1601.00
IUUC-Eeu-034717	Erinaceus europaeus	69.13	0.00e+00	971.00
IUUC-Fca-036564	Felis catus	82.64	0.00e+00	1541.00
IUUC-Ggo-044480	Gorilla gorilla	96.31	0.00e+00	1773.00
IUUC-Hsa-046498	Homo sapiens	96.15	0.00e+00	1753.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	78.73	0.00e+00	1453.00
IUUC-Laf-054119	Loxodonta africana	79.55	0.00e+00	1514.00
IUUC-Mcc-055597	Macaca mulatta	97.63	0.00e+00	1783.00
IUUC-Meu-056534	Macropus eugenii	54.37	0.00e+00	844.00
IUUC-Mdo-063058	Monodelphis domestica	56.65	0.00e+00	1024.00
IUUC-Mmu-063578	Mus musculus	74.23	0.00e+00	1415.00
IUUC-Mpu-066255	Mustela putorius furo	80.87	0.00e+00	1541.00
IUUC-Mlu-067814	Myotis lucifugus	76.80	0.00e+00	1378.00
IUUC-Nle-069193	Nomascus leucogenys	95.36	0.00e+00	1765.00
IUUC-Opr-070715	Ochotona princeps	74.31	0.00e+00	1406.00
IUUC-Oan-073306	Ornithorhynchus anatinus	54.51	0.00e+00	744.00
IUUC-Ocu-074162	Oryctolagus cuniculus	78.87	0.00e+00	1484.00
IUUC-Oga-088895	Otolemur garnettii	80.93	0.00e+00	1506.00
IUUC-Oar-089579	Ovis aries	76.19	0.00e+00	1372.00
IUUC-Ptr-090581	Pan troglodytes	96.37	0.00e+00	1719.00
IUUC-Pab-098653	Pongo abelii	89.92	0.00e+00	1645.00
IUUC-Pca-100578	Procavia capensis	77.12	0.00e+00	884.00
IUUC-Pva-102914	Pteropus vampyrus	79.31	0.00e+00	1212.00
IUUC-Rno-106066	Rattus norvegicus	73.90	0.00e+00	1427.00
IUUC-Sha-107368	Sarcophilus harrisii	59.92	0.00e+00	1116.00
IUUC-Ssc-115743	Sus scrofa	82.51	0.00e+00	1539.00
IUUC-Tbe-127587	Tupaia belangeri	74.92	0.00e+00	1234.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence