iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120658

UUCD1 version

UUC-TeN-01173

Ensembl Protein ID

ENSTNIP00000010846.1

UniProt Accession

H3CRG2; H3CRG2_TETNG

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000008024.1	ENSTNIT00000011028.1	ENSTNIP00000010846.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.80e-59	199.4	322	849
UBD/Alpha-Helix/UBA	1.40e-16	60.2	719	757

Active Site

Position(s)	Description	Evidence
331	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
812	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkk....................avs 69
           tG++NlgN+CY+NSv+Q+L+ +p++ + + + +  k+ +e+pk+p++++ ++++kl   l++++ +                     ++
   Q: 322  TGMRNLGNSCYLNSVMQVLFTVPDFESKYVS-NIDKIIDEAPKDPTQDFKTQVAKLGYGLLSGEYSkpapdpgeendtseprgdqiGIA 409
           7******************************.8888889999******************63333333455555555566666777*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ +++ ++efs+++qqDaqEfl ++++ +e+++                             ++    ++ F++ ++++i+c++
   Q: 410  PRMFKALVGRGHPEFSTNRQQDAQEFLLHFINMVERNC-----------------------------RSGPNPTEAFRFLVEEKIVCQQ 469
           **************************************.............................556667899************* PP
   S: 159  cdnvssreepfldlslpvpgkeetkke........................slqdcLesftkeeelegenkyycekckkkqeaekklkl 223
            ++ + ++   + ++lpvp+++ t+                           +  c+++ +++e l++   ++++  ++k++a+k++++
   Q: 470  SQKAKYTQRVDYIIQLPVPMDQATNAAeelqeaerrreegdpsaptvraqiPFAACMAALSEPEVLTD---FWSSAVQAKTTATKTTRF 555
           **********************9887799**************************************7...****************** PP
   S: 224  kklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts............................................. 267
            ++P+ L++++k+f+f  + ++++k++ ++++p++Ldls   ++                                             
   Q: 556  ASFPDHLVIQIKKFTFGLD-WVPKKLDVSIDVPDTLDLSALRATgqqpgeellpevappplmtpdvevkgilgshgneeddslyspllc 643
           ****************997.*******************98888666777777677777666666666666666666666666666666 PP
   S: 268  ......................................................................peekqke............ 274
                                                                                 p     +            
   Q: 644  tppsapvlddstvchlcemgfpleacrravyytgntgidaatnwimshiddpdfaaplvlpgcssgagttP-----Tesvseehletiv 727
           66666666666666666666666666666665555555555555555555555555555555555555551.....0555556666666 PP
   S: 275  ................................................................kkkYeLiavvvHsG.slssGHYvay 298
                                                                           + kYeL+a ++H+G s+ +GHYv++
   Q: 728  smgftrdqatkalratsnvlqravdwifshmddlecmdiseggrsaaesesarepppgprvrdgPGKYELFAFISHMGtSTMCGHYVCH 816
           6666666666777777777777777777777777777788888888888888899999999999************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +k+ +++W+ f+D+kV ++  e+  +   + +Y++fY+r
   Q: 817  IKK-DQQWVIFNDQKVCAS--EKPPK---DMGYLYFYRR 849
           ***.999*********999..78888...99******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +e+ le +v+MGF+r++a +aLra++n l++Av++++++
   Q: 719  SEEHLETIVSMGFTRDQATKALRATSNVLQRAVDWIFSH 757
           7899*********************************97 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

MADVGEVLMS VLSTIRVPKP GDRVHKDECA LSFASPESEG GLYVCMNSFL GFGSQYVERH 60
YARTGQRAYL HIKRTRKAKE DDNNSGSGHP PKKKPTRLAI GIEGGFDVEP DHYEEDIKVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGACG TCGGGGAGGT ATTAATGTCC GTTTTGTCCA CCATTCGTGT TCCGAAACCC 60
GGAGACCGTG TGCACAAAGA CGAATGCGCC TTGTCATTTG CCTCGCCGGT GAGCTATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	41.28	2.00e-170	592.00
IUUC-Aml-002104	Ailuropoda melanoleuca	67.06	0.00e+00	1165.00
IUUC-Atr-002580	Amborella trichopoda	43.99	0.00e+00	679.00
IUUC-Apl-003774	Anas platyrhynchos	67.36	0.00e+00	1135.00
IUUC-Aca-005368	Anolis carolinensis	65.70	0.00e+00	1159.00
IUUC-Aly-005727	Arabidopsis lyrata	44.92	0.00e+00	683.00
IUUC-Ath-006974	Arabidopsis thaliana	45.04	0.00e+00	686.00
IUUC-Ago-007890	Ashbya gossypii	27.36	5.00e-69	255.00
IUUC-Acl-008057	Aspergillus clavatus	34.12	3.00e-121	429.00
IUUC-Afl-008547	Aspergillus flavus	34.94	2.00e-106	379.00
IUUC-Afu-008805	Aspergillus fumigatus	32.92	1.00e-105	377.00
IUUC-Ani-009441	Aspergillus nidulans	31.85	2.00e-90	327.00
IUUC-Ang-009720	Aspergillus niger	32.51	1.00e-107	384.00
IUUC-Aor-010111	Aspergillus oryzae	33.18	7.00e-116	411.00
IUUC-Ate-010531	Aspergillus terreus	32.20	4.00e-101	362.00
IUUC-Ame-011893	Astyanax mexicanus	83.18	0.00e+00	1254.00
IUUC-Bgr-012183	Blumeria graminis	32.21	1.00e-111	397.00
IUUC-Bta-013179	Bos taurus	67.80	0.00e+00	1178.00
IUUC-Bci-013858	Botrytis cinerea	32.91	2.00e-118	420.00
IUUC-Bdi-014904	Brachypodium distachyon	43.27	0.00e+00	641.00
IUUC-Bol-015536	Brassica oleracea	45.21	0.00e+00	683.00
IUUC-Bra-017939	Brassica rapa	45.22	0.00e+00	691.00
IUUC-Cel-018625	Caenorhabditis elegans	33.10	1.00e-121	430.00
IUUC-Cja-019063	Callithrix jacchus	66.63	0.00e+00	1151.00
IUUC-Cfa-020976	Canis familiaris	66.27	0.00e+00	1149.00
IUUC-Cpo-022265	Cavia porcellus	65.96	0.00e+00	1142.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	40.35	8.00e-112	397.00
IUUC-Csa-024177	Chlorocebus sabaeus	64.44	0.00e+00	1026.00
IUUC-Cho-024702	Choloepus hoffmanni	62.54	0.00e+00	688.00
IUUC-Cin-025411	Ciona intestinalis	48.05	0.00e+00	782.00
IUUC-Csv-026347	Ciona savignyi	45.02	0.00e+00	756.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	33.33	7.00e-103	368.00
IUUC-Cne-026831	Cryptococcus neoformans	35.27	8.00e-118	417.00
IUUC-Dre-027982	Danio rerio	85.56	0.00e+00	1374.00
IUUC-Dno-029034	Dasypus novemcinctus	67.69	0.00e+00	1171.00
IUUC-Dor-030479	Dipodomys ordii	66.08	2.00e-144	506.00
IUUC-Dse-031467	Dothistroma septosporum	33.18	1.00e-117	417.00
IUUC-Dme-032075	Drosophila melanogaster	46.54	0.00e+00	746.00
IUUC-Ete-032865	Echinops telfairi	61.43	0.00e+00	1033.00
IUUC-Eca-034059	Equus caballus	67.17	0.00e+00	1170.00
IUUC-Eeu-035304	Erinaceus europaeus	63.57	0.00e+00	1058.00
IUUC-Fca-035515	Felis catus	67.45	0.00e+00	1175.00
IUUC-Fal-037271	Ficedula albicollis	66.05	0.00e+00	1085.00
IUUC-Fox-037745	Fusarium oxysporum	34.71	4.00e-121	428.00
IUUC-Fso-038158	Fusarium solani	34.47	1.00e-118	420.00
IUUC-Gmo-039071	Gadus morhua	84.43	0.00e+00	1360.00
IUUC-Ggr-040098	Gaeumannomyces graminis	33.61	2.00e-114	406.00
IUUC-Gga-040635	Gallus gallus	67.71	0.00e+00	1197.00
IUUC-Gac-042528	Gasterosteus aculeatus	86.43	0.00e+00	1398.00
IUUC-Gma-043614	Glycine max	43.95	0.00e+00	659.00
IUUC-Ggo-044602	Gorilla gorilla	67.22	0.00e+00	1168.00
IUUC-Hsa-045959	Homo sapiens	67.22	0.00e+00	1168.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	67.61	0.00e+00	1169.00
IUUC-Lch-049648	Latimeria chalumnae	66.63	0.00e+00	1134.00
IUUC-Lpe-051523	Leersia perrieri	43.48	0.00e+00	650.00
IUUC-Loc-052520	Lepisosteus oculatus	71.95	0.00e+00	1144.00
IUUC-Lma-053216	Leptosphaeria maculans	33.22	2.00e-103	370.00
IUUC-Laf-054327	Loxodonta africana	67.22	0.00e+00	1160.00
IUUC-Mcc-055443	Macaca mulatta	67.22	0.00e+00	1169.00
IUUC-Meu-056298	Macropus eugenii	67.83	0.00e+00	805.00
IUUC-Mor-057106	Magnaporthe oryzae	34.97	2.00e-122	432.00
IUUC-Mpo-057589	Magnaporthe poae	34.23	2.00e-119	423.00
IUUC-Mtr-058680	Medicago truncatula	45.17	0.00e+00	685.00
IUUC-Mla-058903	Melampsora laricipopulina	32.81	9.00e-110	391.00
IUUC-Mga-059669	Meleagris gallopavo	66.83	0.00e+00	1129.00
IUUC-Mvi-060476	Microbotryum violaceum	33.72	6.00e-111	395.00
IUUC-Mmr-060575	Microcebus murinus	67.33	0.00e+00	1169.00
IUUC-Mdo-062183	Monodelphis domestica	66.78	0.00e+00	1131.00
IUUC-Mmu-063592	Mus musculus	67.45	0.00e+00	1173.00
IUUC-Mpu-066082	Mustela putorius furo	65.69	0.00e+00	1141.00
IUUC-Mlu-067345	Myotis lucifugus	67.45	0.00e+00	1162.00
IUUC-Nfi-068558	Neosartorya fischeri	34.56	1.00e-117	417.00
IUUC-Ncr-068960	Neurospora crassa	33.29	4.00e-105	375.00
IUUC-Nle-070173	Nomascus leucogenys	65.92	0.00e+00	1142.00
IUUC-Opr-070556	Ochotona princeps	68.39	0.00e+00	1187.00
IUUC-Ont-071502	Oreochromis niloticus	89.46	0.00e+00	1417.00
IUUC-Ocu-074861	Oryctolagus cuniculus	66.04	0.00e+00	1148.00
IUUC-Oba-075109	Oryza barthii	43.93	0.00e+00	659.00
IUUC-Obr-076292	Oryza brachyantha	44.11	0.00e+00	648.00
IUUC-Ogl-077065	Oryza glaberrima	44.99	0.00e+00	684.00
IUUC-Ogu-078776	Oryza glumaepatula	43.34	0.00e+00	670.00
IUUC-Oin-080048	Oryza indica	44.52	0.00e+00	678.00
IUUC-Olo-080711	Oryza longistaminata	41.90	2.00e-172	599.00
IUUC-Ome-081506	Oryza meridionalis	42.45	1.00e-174	606.00
IUUC-Oni-082320	Oryza nivara	42.79	0.00e+00	654.00
IUUC-Opu-083801	Oryza punctata	43.34	0.00e+00	642.00
IUUC-Oru-085139	Oryza rufipogon	43.20	0.00e+00	653.00
IUUC-Osa-085713	Oryza sativa	45.10	0.00e+00	687.00
IUUC-Ola-086951	Oryzias latipes	90.28	0.00e+00	1388.00
IUUC-Olu-087822	Ostreococcus lucimarinus	40.24	2.00e-165	575.00
IUUC-Oga-088625	Otolemur garnettii	67.49	0.00e+00	1159.00
IUUC-Oar-089995	Ovis aries	67.56	0.00e+00	1164.00
IUUC-Ptr-090640	Pan troglodytes	66.51	0.00e+00	1164.00
IUUC-Pan-091974	Papio anubis	67.33	0.00e+00	1162.00
IUUC-Psi-093957	Pelodiscus sinensis	67.94	0.00e+00	1207.00
IUUC-Pma-094242	Petromyzon marinus	69.11	9.00e-152	529.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.18	3.00e-98	352.00
IUUC-Ppa-095901	Physcomitrella patens	46.19	0.00e+00	723.00
IUUC-Pfo-097148	Poecilia formosa	89.11	0.00e+00	1412.00
IUUC-Pab-098068	Pongo abelii	62.09	0.00e+00	1029.00
IUUC-Pop-098943	Populus trichocarpa	45.62	0.00e+00	688.00
IUUC-Pca-100738	Procavia capensis	67.99	0.00e+00	814.00
IUUC-Ppe-101315	Prunus persica	44.37	0.00e+00	655.00
IUUC-Pva-102154	Pteropus vampyrus	67.14	0.00e+00	1164.00
IUUC-Pgr-103343	Puccinia graminis	33.33	1.00e-96	347.00
IUUC-Ptt-103928	Puccinia triticina	29.92	3.00e-94	339.00
IUUC-Pte-104306	Pyrenophora teres	33.57	2.00e-99	357.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.49	7.00e-100	358.00
IUUC-Rno-105801	Rattus norvegicus	67.45	0.00e+00	1170.00
IUUC-Sce-106304	Saccharomyces cerevisiae	27.39	1.00e-62	234.00
IUUC-Sha-107635	Sarcophilus harrisii	65.53	0.00e+00	1136.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	29.41	2.00e-90	326.00
IUUC-Spo-108144	Schizosaccharomyces pombe	30.96	2.00e-101	363.00
IUUC-Smo-108848	Selaginella moellendorffii	45.17	0.00e+00	673.00
IUUC-Sit-110728	Setaria italica	44.06	0.00e+00	706.00
IUUC-Sly-111523	Solanum lycopersicum	43.94	0.00e+00	698.00
IUUC-Sbi-114419	Sorghum bicolor	44.19	0.00e+00	690.00
IUUC-Sre-115225	Sporisorium reilianum	32.96	1.00e-108	387.00
IUUC-Ssc-115686	Sus scrofa	67.49	0.00e+00	1167.00
IUUC-Tgu-117346	Taeniopygia guttata	67.75	0.00e+00	1181.00
IUUC-Tru-118350	Takifugu rubripes	93.24	0.00e+00	1508.00
IUUC-Tca-121585	Theobroma cacao	45.23	0.00e+00	670.00
IUUC-Tre-122043	Trichoderma reesei	32.87	8.00e-109	387.00
IUUC-Tvi-122303	Trichoderma virens	32.67	1.00e-110	394.00
IUUC-Tae-123798	Triticum aestivum	43.45	0.00e+00	669.00
IUUC-Tur-126732	Triticum urartu	41.29	0.00e+00	628.00
IUUC-Tme-126909	Tuber melanosporum	33.69	6.00e-110	391.00
IUUC-Tbe-127261	Tupaia belangeri	62.15	0.00e+00	724.00
IUUC-Uma-129599	Ustilago maydis	33.81	2.00e-115	409.00
IUUC-Vda-129688	Verticillium dahliae	33.53	4.00e-112	398.00
IUUC-Vvi-131116	Vitis vinifera	43.40	0.00e+00	651.00
IUUC-Xtr-131953	Xenopus tropicalis	66.43	0.00e+00	1098.00
IUUC-Xma-133837	Xiphophorus maculatus	88.99	0.00e+00	1411.00
IUUC-Yli-134510	Yarrowia lipolytica	34.79	8.00e-118	417.00
IUUC-Zma-135786	Zea mays	43.06	0.00e+00	660.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence