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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046711
UUCD1 version UUC-HoS-00495
Ensembl Protein ID ENSP00000374252.3
UniProt Accession A6NK59; C9JX97; Q8WXK2; Q92816; ASB14_HUMAN
Genbank Protein ID AAL57351.1; ENSP00000374252
Protein Name Ankyrin repeat and SOCS box protein 14
Genbank Nucleotide ID AF403032; AL832472
Gene Name ASB14
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000239388.8 ENST00000487349.5 ENSP00000419199.1
ENSG00000239388.8 ENST00000389601.3 ENSP00000374252.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDInWeb_IM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 3.20e-13 51.0 522 575
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrl...kaidkLPLPksLkdYLlyedy 52
           s++  + ++prSL+hLCRl+Ir+c+g+ +l      + LPLP++Lk Y ly++y
   Q: 522  SEIHFILTNPRSLKHLCRLKIRKCMGRLHLrcpVFMSFLPLPNRLKAYVLYKEY 575
           56667889*******************999999999****************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MDNYTSDEDI DEDFDTQLII QQSLQDIYKP GTAQHAPKDE SLHSFLSADY KKIVETIEKV 60
GKEDALSHLT KYHSAFGEAD EIGWIPLHKA AVQLNRKILE ITLSASDPSL WEQTTHNGET 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046711|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTCCTTAAC AGTGAAAACT TCACTGCTGT CCTAGAGGAT AAAACAAAAG GTAAAAAGTC 60
TTTGAAATGT GACCAAATGT ATTCTATGCT AAAACTGACA TTTTTCTTTT AAAACCATTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046711|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF07525--SOCS_box
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction
KEGG hsa:142686
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002363 Ailuropoda melanoleuca 87.93 0.00e+00 1042.00
IUUC-Aca-004698 Anolis carolinensis 68.76 0.00e+00 810.00
IUUC-Ame-011755 Astyanax mexicanus 58.00 0.00e+00 639.00
IUUC-Bta-012815 Bos taurus 87.07 0.00e+00 1023.00
IUUC-Cfa-020424 Canis familiaris 89.12 0.00e+00 1071.00
IUUC-Cpo-021360 Cavia porcellus 85.27 0.00e+00 915.00
IUUC-Csa-023643 Chlorocebus sabaeus 96.79 0.00e+00 1158.00
IUUC-Cho-024625 Choloepus hoffmanni 88.25 0.00e+00 1015.00
IUUC-Dre-028430 Danio rerio 57.57 0.00e+00 649.00
IUUC-Dno-029358 Dasypus novemcinctus 88.78 0.00e+00 1014.00
IUUC-Ete-032474 Echinops telfairi 87.29 1.00e-152 532.00
IUUC-Eca-033290 Equus caballus 90.63 0.00e+00 1094.00
IUUC-Fca-036127 Felis catus 89.46 0.00e+00 1097.00
IUUC-Fal-036752 Ficedula albicollis 68.89 0.00e+00 841.00
IUUC-Gmo-038541 Gadus morhua 53.30 1.00e-126 446.00
IUUC-Ggo-044832 Gorilla gorilla 98.13 0.00e+00 1186.00
IUUC-Itr-048503 Ictidomys tridecemlineatus 90.09 0.00e+00 998.00
IUUC-Lch-049522 Latimeria chalumnae 65.48 0.00e+00 789.00
IUUC-Loc-052295 Lepisosteus oculatus 61.90 0.00e+00 733.00
IUUC-Laf-053731 Loxodonta africana 89.92 0.00e+00 908.00
IUUC-Mcc-055608 Macaca mulatta 97.79 0.00e+00 1164.00
IUUC-Mmr-061503 Microcebus murinus 85.03 0.00e+00 1018.00
IUUC-Mdo-062143 Monodelphis domestica 76.03 0.00e+00 932.00
IUUC-Mmu-063331 Mus musculus 82.65 0.00e+00 1000.00
IUUC-Mpu-066906 Mustela putorius furo 89.16 0.00e+00 1056.00
IUUC-Mlu-067649 Myotis lucifugus 88.78 0.00e+00 1067.00
IUUC-Nle-069010 Nomascus leucogenys 97.79 0.00e+00 1180.00
IUUC-Ont-071371 Oreochromis niloticus 54.20 6.00e-170 590.00
IUUC-Ocu-074690 Oryctolagus cuniculus 84.50 0.00e+00 1036.00
IUUC-Ola-086832 Oryzias latipes 62.90 2.00e-124 438.00
IUUC-Oga-088283 Otolemur garnettii 89.63 0.00e+00 1069.00
IUUC-Oar-089883 Ovis aries 88.61 0.00e+00 1040.00
IUUC-Ptr-091644 Pan troglodytes 98.30 0.00e+00 1185.00
IUUC-Pan-091872 Papio anubis 96.60 0.00e+00 1139.00
IUUC-Psi-093213 Pelodiscus sinensis 72.78 0.00e+00 738.00
IUUC-Pfo-096806 Poecilia formosa 54.62 2.00e-167 582.00
IUUC-Pab-097990 Pongo abelii 97.38 0.00e+00 1142.00
IUUC-Pca-100617 Procavia capensis 85.52 0.00e+00 1053.00
IUUC-Pva-102496 Pteropus vampyrus 89.61 0.00e+00 1040.00
IUUC-Rno-106061 Rattus norvegicus 82.28 0.00e+00 1001.00
IUUC-Sha-106898 Sarcophilus harrisii 76.87 0.00e+00 920.00
IUUC-Tgu-117124 Taeniopygia guttata 73.26 0.00e+00 795.00
IUUC-Tru-118408 Takifugu rubripes 56.32 2.00e-159 555.00
IUUC-Tsy-118858 Tarsius syrichta 92.77 0.00e+00 829.00
IUUC-Tni-120453 Tetraodon nigroviridis 59.96 2.00e-178 618.00
IUUC-Ttr-129150 Tursiops truncatus 88.95 0.00e+00 1085.00
IUUC-Vpa-130731 Vicugna pacos 88.51 0.00e+00 1075.00
Created Date 25-Jun-2017

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