iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-116064

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

FP476002

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000004154.3	ENSSSCT00000034426.1	ENSSSCP00000030947.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	6.80e-40	136.9	93	262
UBD/ZnF/ZnF_A20	1.20e-24	86.2	751	785

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe... 74
           ++lkt+gDGnCL++A+sq+++gv+d+d+ l++al+++L+e+ ++++    q es + +ef+e++         +e++++ k+++++   
   Q: 93   VALKTNGDGNCLMHAASQYMWGVQDTDLvLRKALFSTLKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwTEEWDNLIKMASTDtpv 181
           789**********************************************9************************************777 PP
   S: 75   ak.g......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           a+ g      eeihif+L++iL+rpiiv+++++l+s          kvggi+lpl++p+++ +++pivL+Y+s H+ +Lv+
   Q: 182  ARsGlqynslEEIHIFVLCNILRRPIIVISDKMLRSlesgsnfaplKVGGIYLPLHWPAQEcYRYPIVLGYDSQHFVPLVT 262
           6644999999*********************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           dp+ ++C++ +C+++Gn+++ngyC++C++++++++
   Q: 751  DPPTQRCRApACDHFGNAKCNGYCNECFQFKQMYG 785
           89*******************************96 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MAEQLLPLAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KSMHRYTLEM FRTCQFCPQF 60
REIIHKALID RNIQASLESQ KKLNWCREVR KLVALKTNGD GNCLMHAASQ YMWGVQDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGCGGCCA AGCGCTGCAA ACTAGGAGGC CGCGGGGGCG GAGCGGCTCG AGCGGCTGTC 60
CGGAGAACAG CCGCGGCGGC AGCTGGCGAG ATCCACACCC CCGGCCGGCG GCCAGCAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0006955--P:immune response
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	89.75	0.00e+00	1467.00
IUUC-Apl-003501	Anas platyrhynchos	65.91	0.00e+00	1042.00
IUUC-Aca-004245	Anolis carolinensis	63.56	0.00e+00	1047.00
IUUC-Ame-011789	Astyanax mexicanus	47.02	0.00e+00	704.00
IUUC-Bta-012664	Bos taurus	90.70	0.00e+00	1441.00
IUUC-Cja-019895	Callithrix jacchus	88.23	0.00e+00	1436.00
IUUC-Cfa-020754	Canis familiaris	89.62	0.00e+00	1465.00
IUUC-Cpo-021780	Cavia porcellus	86.49	0.00e+00	1407.00
IUUC-Csa-023568	Chlorocebus sabaeus	88.86	0.00e+00	1460.00
IUUC-Cho-024300	Choloepus hoffmanni	89.80	0.00e+00	653.00
IUUC-Dre-028577	Danio rerio	49.81	0.00e+00	687.00
IUUC-Dno-029382	Dasypus novemcinctus	82.78	0.00e+00	1328.00
IUUC-Dor-030874	Dipodomys ordii	84.81	0.00e+00	1357.00
IUUC-Ete-032721	Echinops telfairi	91.13	0.00e+00	800.00
IUUC-Eca-033596	Equus caballus	86.20	0.00e+00	1395.00
IUUC-Eeu-035159	Erinaceus europaeus	84.71	0.00e+00	1083.00
IUUC-Fca-035847	Felis catus	88.99	0.00e+00	1451.00
IUUC-Fal-036681	Ficedula albicollis	65.01	0.00e+00	1049.00
IUUC-Gmo-038521	Gadus morhua	60.78	1.00e-147	516.00
IUUC-Gga-040975	Gallus gallus	63.83	0.00e+00	1047.00
IUUC-Gac-042216	Gasterosteus aculeatus	61.99	2.00e-153	536.00
IUUC-Ggo-045258	Gorilla gorilla	88.61	0.00e+00	1457.00
IUUC-Hsa-046071	Homo sapiens	88.86	0.00e+00	1459.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	88.61	0.00e+00	1433.00
IUUC-Lch-050326	Latimeria chalumnae	57.97	0.00e+00	907.00
IUUC-Loc-051945	Lepisosteus oculatus	46.09	3.00e-176	612.00
IUUC-Laf-053722	Loxodonta africana	86.58	0.00e+00	1416.00
IUUC-Mcc-055503	Macaca mulatta	88.73	0.00e+00	1457.00
IUUC-Meu-056481	Macropus eugenii	73.91	0.00e+00	1166.00
IUUC-Mga-059690	Meleagris gallopavo	62.86	0.00e+00	983.00
IUUC-Mmr-061233	Microcebus murinus	87.50	0.00e+00	1410.00
IUUC-Mdo-062446	Monodelphis domestica	80.18	0.00e+00	1295.00
IUUC-Mmu-063436	Mus musculus	86.50	0.00e+00	1365.00
IUUC-Mpu-066808	Mustela putorius furo	90.38	0.00e+00	1476.00
IUUC-Mlu-067339	Myotis lucifugus	88.10	0.00e+00	1424.00
IUUC-Nle-069888	Nomascus leucogenys	88.61	0.00e+00	1458.00
IUUC-Opr-070303	Ochotona princeps	86.51	0.00e+00	1404.00
IUUC-Ont-072283	Oreochromis niloticus	60.63	8.00e-149	520.00
IUUC-Oan-072925	Ornithorhynchus anatinus	75.31	0.00e+00	1212.00
IUUC-Ocu-073889	Oryctolagus cuniculus	87.36	0.00e+00	1389.00
IUUC-Ola-087417	Oryzias latipes	61.35	7.00e-150	524.00
IUUC-Oga-088708	Otolemur garnettii	85.82	0.00e+00	1342.00
IUUC-Oar-089271	Ovis aries	91.34	0.00e+00	1461.00
IUUC-Ptr-091296	Pan troglodytes	88.86	0.00e+00	1458.00
IUUC-Pan-092474	Papio anubis	88.86	0.00e+00	1459.00
IUUC-Psi-093447	Pelodiscus sinensis	68.39	0.00e+00	1098.00
IUUC-Pfo-096511	Poecilia formosa	61.11	2.00e-150	526.00
IUUC-Pab-098700	Pongo abelii	88.73	0.00e+00	1458.00
IUUC-Pca-100246	Procavia capensis	73.67	0.00e+00	1166.00
IUUC-Pva-102606	Pteropus vampyrus	78.93	2.00e-180	625.00
IUUC-Rno-105818	Rattus norvegicus	85.75	0.00e+00	1390.00
IUUC-Sha-106559	Sarcophilus harrisii	78.31	0.00e+00	1266.00
IUUC-Sit-110516	Setaria italica	45.24	2.90e-02	34.30
IUUC-Sar-113454	Sorex araneus	93.60	0.00e+00	646.00
IUUC-Tgu-117212	Taeniopygia guttata	64.94	0.00e+00	1046.00
IUUC-Tru-118230	Takifugu rubripes	61.59	2.00e-152	532.00
IUUC-Tsy-119066	Tarsius syrichta	85.77	0.00e+00	1401.00
IUUC-Tni-119825	Tetraodon nigroviridis	48.42	0.00e+00	685.00
IUUC-Tur-126383	Triticum urartu	50.00	6.10e-02	28.50
IUUC-Tbe-127601	Tupaia belangeri	95.73	0.00e+00	669.00
IUUC-Ttr-128930	Tursiops truncatus	92.23	0.00e+00	1474.00
IUUC-Vpa-130450	Vicugna pacos	96.76	0.00e+00	815.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence