iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115856

Ensembl Protein ID

ENSSSCP00000020063.1

UniProt Accession

I3L7Q7; I3L7Q7_PIG

Genbank Protein ID

ENSSSCP00000020063

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEMK01019445

Gene Name

CBLB

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000022486.1	ENSSSCT00000023448.1	ENSSSCP00000020063.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.60e-08	32.9	242	281

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    ++s ++  CP Cr
   Q: 242  CKICAENDKD-VKIEPCGHLMCTSCLTAW----QESDGQ-GCPFCR 281
           99********.******************....555555.5****8 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MYEEQSQDRR NLTKLSLIFS HMLAEIKAIF PNGQFQGDNF RITKADAAEF WRKFFGDKTI 60
VPWKVFRQCL HEVHQISSGL EAMALKSTID LTCNDYISVF EFDIFTRLFQ PWGSILRNWN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTAATTT CTCTTTCCAA GAACTAAGAT TCCAGATGGC AAATTCTATG AATGGCAGAA 60
ACCCTGGTGG TCGAGGAGGA AACCCCCGAA AAGGACGAAT TTTGGGTATT ATTGATGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001412	Ailuropoda melanoleuca	96.94	0.00e+00	1438.00
IUUC-Apl-004148	Anas platyrhynchos	85.36	0.00e+00	1260.00
IUUC-Aca-005204	Anolis carolinensis	80.37	0.00e+00	1182.00
IUUC-Ame-011919	Astyanax mexicanus	61.76	0.00e+00	822.00
IUUC-Bta-013044	Bos taurus	97.42	0.00e+00	1442.00
IUUC-Cja-018813	Callithrix jacchus	86.67	0.00e+00	1305.00
IUUC-Cfa-021054	Canis familiaris	96.95	0.00e+00	1466.00
IUUC-Cpo-022514	Cavia porcellus	90.02	0.00e+00	1398.00
IUUC-Csa-024110	Chlorocebus sabaeus	96.60	0.00e+00	1449.00
IUUC-Cho-024886	Choloepus hoffmanni	85.17	0.00e+00	987.00
IUUC-Dre-027480	Danio rerio	61.93	0.00e+00	813.00
IUUC-Dno-028923	Dasypus novemcinctus	97.18	0.00e+00	1435.00
IUUC-Ete-032406	Echinops telfairi	91.20	0.00e+00	1357.00
IUUC-Eca-033849	Equus caballus	95.89	0.00e+00	1451.00
IUUC-Fca-036224	Felis catus	97.30	0.00e+00	1434.00
IUUC-Fal-036860	Ficedula albicollis	96.27	0.00e+00	779.00
IUUC-Gga-040159	Gallus gallus	81.01	0.00e+00	1203.00
IUUC-Gac-042312	Gasterosteus aculeatus	57.32	0.00e+00	768.00
IUUC-Ggo-045175	Gorilla gorilla	86.65	0.00e+00	1297.00
IUUC-Hsa-046306	Homo sapiens	96.60	0.00e+00	1449.00
IUUC-Lch-049931	Latimeria chalumnae	61.03	0.00e+00	838.00
IUUC-Loc-052524	Lepisosteus oculatus	66.74	0.00e+00	884.00
IUUC-Laf-053635	Loxodonta africana	92.38	0.00e+00	1368.00
IUUC-Mcc-055536	Macaca mulatta	96.48	0.00e+00	1448.00
IUUC-Meu-056045	Macropus eugenii	75.94	0.00e+00	1062.00
IUUC-Mga-060177	Meleagris gallopavo	92.16	0.00e+00	965.00
IUUC-Mmr-061088	Microcebus murinus	97.65	0.00e+00	1472.00
IUUC-Mdo-062020	Monodelphis domestica	90.49	0.00e+00	1341.00
IUUC-Mmu-063114	Mus musculus	88.62	0.00e+00	1352.00
IUUC-Mpu-066632	Mustela putorius furo	98.12	0.00e+00	1485.00
IUUC-Mlu-067145	Myotis lucifugus	96.83	0.00e+00	1465.00
IUUC-Opr-070194	Ochotona princeps	100.00	0.00e+00	689.00
IUUC-Oan-073165	Ornithorhynchus anatinus	88.41	0.00e+00	1357.00
IUUC-Ocu-074723	Oryctolagus cuniculus	96.36	0.00e+00	1460.00
IUUC-Oga-088021	Otolemur garnettii	95.78	0.00e+00	1438.00
IUUC-Oar-089809	Ovis aries	97.30	0.00e+00	1444.00
IUUC-Ptr-090834	Pan troglodytes	96.60	0.00e+00	1449.00
IUUC-Pan-092225	Papio anubis	96.48	0.00e+00	1449.00
IUUC-Psi-093317	Pelodiscus sinensis	85.61	0.00e+00	1301.00
IUUC-Pab-097595	Pongo abelii	96.71	0.00e+00	1451.00
IUUC-Pca-100844	Procavia capensis	81.49	0.00e+00	1084.00
IUUC-Pva-103216	Pteropus vampyrus	88.38	0.00e+00	1351.00
IUUC-Rno-105381	Rattus norvegicus	93.54	0.00e+00	1434.00
IUUC-Sha-107574	Sarcophilus harrisii	90.06	0.00e+00	1333.00
IUUC-Sar-113500	Sorex araneus	84.05	0.00e+00	1209.00
IUUC-Tgu-116866	Taeniopygia guttata	84.51	0.00e+00	1229.00
IUUC-Tsy-119167	Tarsius syrichta	96.45	0.00e+00	992.00
IUUC-Tbe-127830	Tupaia belangeri	92.98	0.00e+00	942.00
IUUC-Ttr-128631	Tursiops truncatus	97.89	0.00e+00	1478.00
IUUC-Vpa-130713	Vicugna pacos	96.98	0.00e+00	1251.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence