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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Ath-007115
Ensembl Protein ID AT5G58760.1
UniProt Accession Q6NQ88; Q9LUY5; DDB2_ARATH
Genbank Protein ID BAA97344.1; AED97095.1; AAQ65193.1; BAD42887.1
Protein Name Protein DAMAGED DNA-BINDING 2; UV-damaged DNA-binding protein 2
Genbank Nucleotide ID AB020755; CP002688; BT010570; AK175124
Gene Name DDB2; At5g58760; MZN1.20
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G58760 AT5G58760.1 AT5G58760.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
PINAHINT
Post-translational Modifications (PTMs)
dbPPTdbPTM
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.40e-19 68.7 313 345
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 4    dsvtclaf....sdtllvsGsdDgtikvWDlrtg 33
           ++v++l+     +  ll+s+++D+  ++WD+r+ 
   Q: 313  SKVCGLDCnpvqP-ELLLSCGNDHFARIWDMRKL 345
           6788888887544.99**************9875 PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex including DDB1A and CUL4 (By similarity). Required for DNA repair. Binds to DDB1A to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair.
 May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex including DDB1A and CUL4 (By similarity). Required for DNA repair. Binds to DDB1A to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair.
Protein Sequence
(Fasta)
MSSTRSRRKR DPEIVIARDT DSELSSSEEE EEEEDNYPFS ESEEEDEAVK NGGKIELEKN 60
KAKGKAPITV KLIKKVCKVC KQPGHEAGFK GATYIDCPMK PCFLCKMPGH TTMSCPHRVV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ath-007115|E3,WD_repeat|Arabidopsis thaliana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTTAGTTTG TGTCCGCTGC GTCGTATCAA ACCCAAAAAG AAACAAAACT GTTTGATTCG 60
TACTCTCTTC CTTTTGTCGG GTCGTGAGAT TTTTACCGAA AATGAGTTCA ACGAGGAGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-007115|E3,WD_repeat|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033312--DDB2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR001878--Znf_CCHC
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0003684--F:damaged DNA binding
GO:0046872--F:metal ion binding
GO:0006281--P:DNA repair
GO:0016567--P:protein ubiquitination
GO:0010224--P:response to UV-B
KEGG ath:AT5G58760
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000470 Aegilops tauschii 66.51 0.00e+00 656.00
IUUC-Aml-002203 Ailuropoda melanoleuca 30.49 8.00e-35 140.00
IUUC-Atr-002957 Amborella trichopoda 69.56 0.00e+00 681.00
IUUC-Apl-003832 Anas platyrhynchos 33.72 2.00e-41 162.00
IUUC-Aca-004358 Anolis carolinensis 31.07 2.00e-43 169.00
IUUC-Aly-006296 Arabidopsis lyrata 95.41 0.00e+00 966.00
IUUC-Ame-010817 Astyanax mexicanus 33.13 3.00e-42 165.00
IUUC-Bta-012914 Bos taurus 32.01 6.00e-40 157.00
IUUC-Bdi-014261 Brachypodium distachyon 66.82 0.00e+00 671.00
IUUC-Bol-015317 Brassica oleracea 85.29 0.00e+00 853.00
IUUC-Bra-016848 Brassica rapa 82.84 0.00e+00 836.00
IUUC-Cja-018967 Callithrix jacchus 29.46 5.00e-35 141.00
IUUC-Cfa-021238 Canis familiaris 29.88 1.00e-32 133.00
IUUC-Cpo-022063 Cavia porcellus 30.46 1.00e-34 139.00
IUUC-Csa-023382 Chlorocebus sabaeus 30.06 4.00e-35 141.00
IUUC-Cho-024931 Choloepus hoffmanni 22.50 1.00e-09 57.80
IUUC-Cin-025651 Ciona intestinalis 28.00 1.00e-26 114.00
IUUC-Cne-027093 Cryptococcus neoformans 26.24 3.00e-10 59.70
IUUC-Dre-028732 Danio rerio 31.45 2.00e-35 143.00
IUUC-Dor-030461 Dipodomys ordii 32.74 1.00e-28 120.00
IUUC-Ete-033038 Echinops telfairi 29.82 2.00e-32 132.00
IUUC-Eca-033772 Equus caballus 30.70 1.00e-36 147.00
IUUC-Eeu-035234 Erinaceus europaeus 28.29 1.00e-13 70.90
IUUC-Fca-036095 Felis catus 29.94 1.00e-32 133.00
IUUC-Gmo-039683 Gadus morhua 34.36 3.00e-45 175.00
IUUC-Gga-040530 Gallus gallus 34.02 8.00e-43 167.00
IUUC-Gac-041517 Gasterosteus aculeatus 32.45 2.00e-37 149.00
IUUC-Gma-043378 Glycine max 78.57 0.00e+00 769.00
IUUC-Ggo-045364 Gorilla gorilla 30.06 6.00e-36 144.00
IUUC-Hsa-046354 Homo sapiens 30.06 6.00e-36 144.00
IUUC-Hvu-047151 Hordeum vulgare 70.03 7.00e-128 449.00
IUUC-Itr-048304 Ictidomys tridecemlineatus 32.22 1.00e-38 152.00
IUUC-Lpe-051256 Leersia perrieri 62.71 0.00e+00 641.00
IUUC-Loc-052398 Lepisosteus oculatus 31.59 8.00e-41 160.00
IUUC-Laf-053562 Loxodonta africana 31.12 1.00e-35 143.00
IUUC-Mcc-055197 Macaca mulatta 29.76 1.00e-29 122.00
IUUC-Meu-056151 Macropus eugenii 31.34 1.00e-32 132.00
IUUC-Mtr-057940 Medicago truncatula 75.67 0.00e+00 739.00
IUUC-Mga-059923 Meleagris gallopavo 34.11 2.00e-44 173.00
IUUC-Mvi-060555 Microbotryum violaceum 24.20 3.00e-16 79.70
IUUC-Mmr-061465 Microcebus murinus 30.18 2.00e-31 129.00
IUUC-Mdo-063063 Monodelphis domestica 31.53 1.00e-39 156.00
IUUC-Mmu-064294 Mus musculus 31.42 7.00e-38 150.00
IUUC-Mac-065598 Musa acuminata 67.31 0.00e+00 681.00
IUUC-Mpu-066831 Mustela putorius furo 28.66 3.00e-32 132.00
IUUC-Mlu-067222 Myotis lucifugus 30.89 2.00e-34 139.00
IUUC-Nle-069581 Nomascus leucogenys 30.36 2.00e-36 145.00
IUUC-Opr-070644 Ochotona princeps 31.12 6.00e-36 144.00
IUUC-Ont-072605 Oreochromis niloticus 31.46 2.00e-37 149.00
IUUC-Oan-072973 Ornithorhynchus anatinus 32.54 6.00e-42 164.00
IUUC-Ocu-074615 Oryctolagus cuniculus 31.93 1.00e-36 147.00
IUUC-Oba-075283 Oryza barthii 65.71 5.00e-180 623.00
IUUC-Obr-076605 Oryza brachyantha 66.37 0.00e+00 664.00
IUUC-Ogl-077512 Oryza glaberrima 66.74 0.00e+00 638.00
IUUC-Ogu-078329 Oryza glumaepatula 65.93 3.00e-180 624.00
IUUC-Oin-079980 Oryza indica 65.93 5.00e-180 623.00
IUUC-Olo-080516 Oryza longistaminata 67.54 3.00e-176 610.00
IUUC-Ome-081415 Oryza meridionalis 66.15 0.00e+00 636.00
IUUC-Oni-082985 Oryza nivara 65.93 5.00e-180 623.00
IUUC-Opu-084159 Oryza punctata 68.53 0.00e+00 658.00
IUUC-Oru-085137 Oryza rufipogon 67.04 0.00e+00 643.00
IUUC-Osa-085614 Oryza sativa 67.04 0.00e+00 642.00
IUUC-Ola-087044 Oryzias latipes 31.58 2.00e-39 156.00
IUUC-Oga-088274 Otolemur garnettii 31.42 1.00e-37 149.00
IUUC-Oar-089826 Ovis aries 32.01 9.00e-40 157.00
IUUC-Ptr-091631 Pan troglodytes 30.06 6.00e-36 144.00
IUUC-Pan-092535 Papio anubis 30.06 8.00e-36 144.00
IUUC-Psi-093815 Pelodiscus sinensis 33.14 9.00e-39 154.00
IUUC-Pma-094474 Petromyzon marinus 31.82 5.00e-37 147.00
IUUC-Ppa-095414 Physcomitrella patens 59.06 2.00e-169 588.00
IUUC-Pfo-096559 Poecilia formosa 33.24 5.00e-40 158.00
IUUC-Pab-098528 Pongo abelii 30.06 7.00e-36 144.00
IUUC-Pop-100064 Populus trichocarpa 75.35 0.00e+00 775.00
IUUC-Pca-100803 Procavia capensis 29.88 4.00e-35 141.00
IUUC-Ppe-101966 Prunus persica 76.55 0.00e+00 760.00
IUUC-Pva-103213 Pteropus vampyrus 30.51 9.00e-37 147.00
IUUC-Rno-105087 Rattus norvegicus 31.27 3.00e-39 155.00
IUUC-Sha-107466 Sarcophilus harrisii 33.24 1.00e-43 169.00
IUUC-Smo-108958 Selaginella moellendorffii 56.56 2.00e-161 561.00
IUUC-Sit-109968 Setaria italica 66.06 3.00e-180 624.00
IUUC-Sly-111495 Solanum lycopersicum 70.42 0.00e+00 701.00
IUUC-Sar-113272 Sorex araneus 28.88 2.00e-33 135.00
IUUC-Sbi-114706 Sorghum bicolor 62.53 8.00e-169 586.00
IUUC-Ssc-115437 Sus scrofa 31.71 3.00e-34 138.00
IUUC-Tgu-116602 Taeniopygia guttata 32.56 1.00e-41 163.00
IUUC-Tru-118698 Takifugu rubripes 32.61 2.00e-35 142.00
IUUC-Tsy-119027 Tarsius syrichta 30.00 2.00e-28 119.00
IUUC-Tni-119787 Tetraodon nigroviridis 31.99 4.00e-43 168.00
IUUC-Tca-121447 Theobroma cacao 74.67 0.00e+00 742.00
IUUC-Tae-124613 Triticum aestivum 66.82 0.00e+00 672.00
IUUC-Tur-126724 Triticum urartu 66.82 0.00e+00 668.00
IUUC-Tbe-127680 Tupaia belangeri 28.62 2.00e-26 112.00
IUUC-Vvi-131001 Vitis vinifera 75.50 0.00e+00 754.00
IUUC-Xtr-132266 Xenopus tropicalis 32.26 1.00e-42 166.00
IUUC-Xma-133034 Xiphophorus maculatus 31.99 3.00e-37 149.00
Created Date 25-Jun-2017

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