iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033317

UUCD1 version

UUC-EqC-00064

Ensembl Protein ID

ENSECAP00000013978.1

UniProt Accession

F6QI66; F6QI66_HORSE

Protein Name

Uncharacterized protein

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000015733.1	ENSECAT00000017229.1	ENSECAP00000013978.1
ENSECAG00000015733.1	ENSECAT00000017233.1	ENSECAP00000013982.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.90e-101	338.9	733	1056

Active Site

Position(s)	Description	Evidence
1025	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 733  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 814
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sl+dl+e+ p++ +s+++++++ e+d+ee+ ++l+f+++ e++g t+++eL+ +G+++ V+++N++e+v+++
   Q: 815  HFPLALYKKLLKKKPSLDDLKELVPDVGRSMQQLLDYPEDDVEET-FCLNFTITVENFGATEVKELIVNGADTAVNKQNRKEFVDAY 900
           *************************************99999997.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l+lF+++el+ ++ G++++d+++l+++t+ykg+y +++p+i+ Fwev++e+  e++k+f
   Q: 901  VDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEQNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQF 987
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk     i+   + ++ lP s+TCfn+L+LP+Y++ke+l++kL+ Ai++++gF+l
   Q: 988  LLFLTGSDRIPILGMKSLK---LAIQStGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1056
           *******************...5666658899**************************************86 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKKVRDVG CGLRHTVFVL HDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTCTGTTG ATGTGAGTAG GATCAGTTTG AGGGCACTTT AAAAACCTAG TTCCTGCTAG 60
GTTTTCCCCT CCTCTTCTGC TTCTGCTCAT CTCTTGCCTA CCTGATCTTA CTGAGAGTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	97.07	0.00e+00	1982.00
IUUC-Apl-003295	Anas platyrhynchos	87.15	0.00e+00	1849.00
IUUC-Aca-004336	Anolis carolinensis	85.09	0.00e+00	1804.00
IUUC-Ame-010768	Astyanax mexicanus	72.68	0.00e+00	1564.00
IUUC-Bta-013279	Bos taurus	96.50	0.00e+00	1970.00
IUUC-Cja-019023	Callithrix jacchus	95.84	0.00e+00	1957.00
IUUC-Cfa-021074	Canis familiaris	97.16	0.00e+00	1982.00
IUUC-Cpo-021461	Cavia porcellus	93.48	0.00e+00	1905.00
IUUC-Csa-024261	Chlorocebus sabaeus	96.03	0.00e+00	1965.00
IUUC-Cho-024513	Choloepus hoffmanni	76.35	0.00e+00	1453.00
IUUC-Cin-025232	Ciona intestinalis	42.48	0.00e+00	810.00
IUUC-Dre-028829	Danio rerio	74.25	0.00e+00	1550.00
IUUC-Dno-029445	Dasypus novemcinctus	92.57	0.00e+00	1587.00
IUUC-Dor-030158	Dipodomys ordii	95.82	0.00e+00	873.00
IUUC-Dme-032103	Drosophila melanogaster	44.88	0.00e+00	889.00
IUUC-Ete-033072	Echinops telfairi	84.86	0.00e+00	1684.00
IUUC-Fca-035682	Felis catus	96.59	0.00e+00	1962.00
IUUC-Fal-036969	Ficedula albicollis	85.81	0.00e+00	1825.00
IUUC-Gmo-038671	Gadus morhua	73.66	0.00e+00	1570.00
IUUC-Gga-041174	Gallus gallus	86.85	0.00e+00	1848.00
IUUC-Gac-042600	Gasterosteus aculeatus	73.68	0.00e+00	1512.00
IUUC-Gma-043616	Glycine max	36.99	6.00e-52	198.00
IUUC-Ggo-044589	Gorilla gorilla	95.74	0.00e+00	1991.00
IUUC-Hsa-046772	Homo sapiens	95.74	0.00e+00	1988.00
IUUC-Lch-050147	Latimeria chalumnae	79.48	0.00e+00	1411.00
IUUC-Loc-052684	Lepisosteus oculatus	80.70	0.00e+00	1702.00
IUUC-Laf-053844	Loxodonta africana	95.36	0.00e+00	1951.00
IUUC-Mcc-055531	Macaca mulatta	93.80	0.00e+00	1949.00
IUUC-Mga-060151	Meleagris gallopavo	86.21	0.00e+00	1534.00
IUUC-Mmr-060954	Microcebus murinus	96.03	0.00e+00	1960.00
IUUC-Mdo-062246	Monodelphis domestica	90.84	0.00e+00	1746.00
IUUC-Mmu-063369	Mus musculus	94.13	0.00e+00	1943.00
IUUC-Mpu-065936	Mustela putorius furo	96.54	0.00e+00	1820.00
IUUC-Mlu-067326	Myotis lucifugus	95.55	0.00e+00	1921.00
IUUC-Nle-069453	Nomascus leucogenys	95.27	0.00e+00	1940.00
IUUC-Ont-071720	Oreochromis niloticus	74.43	0.00e+00	1568.00
IUUC-Oan-073464	Ornithorhynchus anatinus	91.55	0.00e+00	1769.00
IUUC-Ocu-074207	Oryctolagus cuniculus	93.48	0.00e+00	1802.00
IUUC-Ogu-078796	Oryza glumaepatula	34.90	1.00e-46	180.00
IUUC-Olo-080768	Oryza longistaminata	37.58	3.00e-52	199.00
IUUC-Ome-081908	Oryza meridionalis	34.23	3.00e-47	182.00
IUUC-Oni-082049	Oryza nivara	34.90	1.00e-46	180.00
IUUC-Oru-084712	Oryza rufipogon	34.90	1.00e-46	180.00
IUUC-Osa-086078	Oryza sativa	34.90	1.00e-46	180.00
IUUC-Ola-086762	Oryzias latipes	73.67	0.00e+00	1524.00
IUUC-Oga-088435	Otolemur garnettii	95.84	0.00e+00	1957.00
IUUC-Oar-089233	Ovis aries	96.50	0.00e+00	1970.00
IUUC-Ptr-091368	Pan troglodytes	95.93	0.00e+00	1993.00
IUUC-Pan-092300	Papio anubis	96.03	0.00e+00	1965.00
IUUC-Psi-093406	Pelodiscus sinensis	88.36	0.00e+00	1875.00
IUUC-Pma-094113	Petromyzon marinus	70.93	0.00e+00	1129.00
IUUC-Ppa-095354	Physcomitrella patens	32.50	2.00e-148	520.00
IUUC-Pfo-097021	Poecilia formosa	72.47	0.00e+00	1566.00
IUUC-Pab-098327	Pongo abelii	96.03	0.00e+00	1993.00
IUUC-Pca-101075	Procavia capensis	92.31	0.00e+00	786.00
IUUC-Pva-102909	Pteropus vampyrus	86.00	0.00e+00	1689.00
IUUC-Rno-105457	Rattus norvegicus	94.89	0.00e+00	1963.00
IUUC-Sha-106632	Sarcophilus harrisii	91.86	0.00e+00	1907.00
IUUC-Sit-110415	Setaria italica	36.60	3.00e-52	199.00
IUUC-Sar-113679	Sorex araneus	86.22	0.00e+00	1110.00
IUUC-Tgu-116849	Taeniopygia guttata	82.31	0.00e+00	1725.00
IUUC-Tru-118206	Takifugu rubripes	72.68	0.00e+00	1469.00
IUUC-Tsy-119521	Tarsius syrichta	81.55	0.00e+00	1569.00
IUUC-Tni-120233	Tetraodon nigroviridis	71.36	0.00e+00	1451.00
IUUC-Tbe-127941	Tupaia belangeri	78.56	0.00e+00	1325.00
IUUC-Ttr-128926	Tursiops truncatus	95.85	0.00e+00	1149.00
IUUC-Vpa-130448	Vicugna pacos	96.22	0.00e+00	1966.00
IUUC-Xtr-132719	Xenopus tropicalis	69.85	0.00e+00	1371.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence