iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013285

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02055080

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000012749.6	ENSBTAT00000061262.2	ENSBTAP00000053839.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	9.40e-145	483.9	994	1544

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++i+ed ++ ll+l+++l+ a+R+++++++ +l++ +++    
   Q: 994  PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDIAED-RRGLLHLSSRLNGALRHEQNFASCFLPDEEAA---- 1058
           689***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q+++ ++++ ++   + +d+Yl+++ea+ n+++++aa++++++++t+Ll++ve+++++       + 
   Q: 1059 ----QALGKTCWEALVSPLVQNITCPDEEGVSPLgWLLDQYLECREAAHNPQSRAAAFSSRVRRLTHLLVHVEPCEAP-------PS 1134
           ....9*************************************************************************.......** PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
           + a++r k++++ +++++L++r+l+  ++++l+++++++++eq++ +lt+ ++++d   +V+r++e+++ lqk++se+F+++a+Fl 
   Q: 1135 VAATPRPKGRNRSHDWSSLATRGLPssIMRNLTRCWRAVVEEQVHSFLTSRWRDDD---FVPRYCEHFSNLQKASSELFGPRAAFLL 1218
           ************************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++ +++k ++l+aa+++E++Ar+iDq++++s ++g++++e++aql+++l+ + ++s++++   Fe+yY++++a+RLl   + 
   Q: 1219 ALQNGCAGALLKLPFLRAAHVSEQFARHIDQRIQGSrIGGARGMEMLAQLQRCLETVLIFSGLEIattFEHYYQHYMADRLLG--VG 1303
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+ +L ++M+++l++Se+l+rqF+                                            
   Q: 1304 SSWLEGAVLEQI----GPCFPTRLpQQMLRSLSTSEELQRQFHvyqlqrldqellkledtekkiqvsrdasasgrghergtgeeael 1386
           ************....*********************************************************************** PP
   S: 453  ........................eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........l 503
                                   e ++ ++e +++e+svlvLs+++Wpta  ++t  ++++LPa+l+ t++++++fY        l
   Q: 1387 eagavaaaaaagvageeeeeeeedESEDLYYEGAMPEVSVLVLSPRCWPTAsiCHTlnPRTCLPAYLRGTLNRYSNFYnkrqtypaL 1473
           *********************999999999*********************9999899***************************** PP
   S: 504  ekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk 579
           e+ ++R+LqW++ lgrael++    g ++l+Vst+Qm++LL+fn+ ++vsve+l   ++lp+++L++++++L+ss+
   Q: 1474 ERAPQRRLQWTW-LGRAELQF----GDQTLHVSTVQMWLLLHFNELKAVSVESLLSLSGLPPDVLNQAVGPLTSSR 1544
           ************.********....*************************************************98 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDD GEGGSNHVDC 60
KAEHILLWMS NDEIYANCHK MLGEDGQVIG PSQETAGEAG ALDKSVLGEM ETDVKSLIQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGGGGG AACTCCGTTA CAGGGAATTC AGGGTGCCCC TGGGGCCCGG CTTGCACGCT 60
TATCCAGACG AGCTGATCCG CCAGCGAGTG GGCCATGATG GGCATCCTGA GTACCAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	86.17	0.00e+00	2786.00
IUUC-Cja-019033	Callithrix jacchus	80.42	0.00e+00	2603.00
IUUC-Cfa-020695	Canis familiaris	85.86	0.00e+00	1754.00
IUUC-Cpo-021513	Cavia porcellus	76.75	0.00e+00	2480.00
IUUC-Csa-023798	Chlorocebus sabaeus	83.87	0.00e+00	2725.00
IUUC-Dor-030234	Dipodomys ordii	80.97	0.00e+00	2719.00
IUUC-Ete-032612	Echinops telfairi	75.73	0.00e+00	907.00
IUUC-Eca-033408	Equus caballus	88.06	0.00e+00	2790.00
IUUC-Fca-035483	Felis catus	88.01	0.00e+00	2840.00
IUUC-Gmo-038795	Gadus morhua	45.36	0.00e+00	926.00
IUUC-Gac-041628	Gasterosteus aculeatus	47.34	0.00e+00	1147.00
IUUC-Ggo-044721	Gorilla gorilla	84.34	0.00e+00	2694.00
IUUC-Hsa-046406	Homo sapiens	84.45	0.00e+00	2730.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	83.36	0.00e+00	2689.00
IUUC-Lch-049956	Latimeria chalumnae	43.99	0.00e+00	1063.00
IUUC-Laf-054068	Loxodonta africana	84.96	0.00e+00	2772.00
IUUC-Mcc-055464	Macaca mulatta	83.81	0.00e+00	2711.00
IUUC-Meu-056198	Macropus eugenii	56.34	0.00e+00	1293.00
IUUC-Mmr-061464	Microcebus murinus	86.94	0.00e+00	2797.00
IUUC-Mdo-062018	Monodelphis domestica	58.60	0.00e+00	1365.00
IUUC-Mmu-063413	Mus musculus	75.60	0.00e+00	2373.00
IUUC-Mpu-066146	Mustela putorius furo	86.85	0.00e+00	2716.00
IUUC-Mlu-067036	Myotis lucifugus	86.75	0.00e+00	2800.00
IUUC-Opr-070670	Ochotona princeps	75.65	0.00e+00	2426.00
IUUC-Oan-073451	Ornithorhynchus anatinus	51.80	0.00e+00	1175.00
IUUC-Ocu-074155	Oryctolagus cuniculus	81.93	0.00e+00	2623.00
IUUC-Oga-089084	Otolemur garnettii	86.18	0.00e+00	2852.00
IUUC-Oar-090029	Ovis aries	95.73	0.00e+00	3094.00
IUUC-Ptr-091282	Pan troglodytes	85.83	0.00e+00	2780.00
IUUC-Pan-091883	Papio anubis	83.87	0.00e+00	2737.00
IUUC-Pab-098383	Pongo abelii	85.22	0.00e+00	2207.00
IUUC-Pca-100519	Procavia capensis	75.41	0.00e+00	825.00
IUUC-Pva-102417	Pteropus vampyrus	84.91	0.00e+00	2257.00
IUUC-Rno-105962	Rattus norvegicus	76.40	0.00e+00	2478.00
IUUC-Ssc-115899	Sus scrofa	83.01	0.00e+00	2511.00
IUUC-Tsy-118860	Tarsius syrichta	83.49	0.00e+00	1124.00
IUUC-Tbe-127660	Tupaia belangeri	81.36	0.00e+00	1391.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence