iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-068980

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

TRIM22

Genbank Nucleotide ID

ADFV01111917

Gene Name

TRIM22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000026965.1	ENSNLET00000022151.1	ENSNLEP00000021082.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.50e-09	38.2	15	60
E3 activity/RING/U-box	1.50e-07	31.4	9	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle + + pl+l+CgH f++ C+  k++ +   s++e +CP+C+
   Q: 15   CPICLELLTE-PLSLDCGHSFCQACItAKIKESVIISRGESSCPVCQ 60
           ********99.***************7555899999**********7 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl......asggktcPvtrqplteedlvPnltlrrliq 66
           + +e  CpI lel ++P  l +G+++ +++I   +      ++g+++cPv+++++++ +l Pn  l ++++
   Q: 9    IEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIkesviiSRGESSCPVCQTRFQPGNLRPNRHLANIVE 79
           567899*************************999955555566666******************9988776 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MDFSVKVDIE KEVTCPICLE LLTEPLSLDC GHSFCQACIT AKIKESVIIS RGESSCPVCQ 60
TRFQPGNLRP NRHLANIVER VKEVKMSPQE GQKRDVCEQH GKKLQIFCKE DGKVICWVCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGTTTAT TGTTATGTAA GTTCTTGTTC AGCTTCCTTT GTTTTCTTTC ACTTCTGAGA 60
ACTTAACTTT CGTTTCTCAC TCGGCTCCTG TGGGGAAACT CATTTGTGGA GACCAGCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0008270--F:zinc ion binding
GO:0010508--P:positive regulation of autophagy
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0070206--P:protein trimerization
GO:0032880--P:regulation of protein localization

KEGG

nle:100589657

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002371	Ailuropoda melanoleuca	68.88	0.00e+00	714.00
IUUC-Acl-008013	Aspergillus clavatus	58.82	2.00e-06	47.80
IUUC-Cfa-021080	Canis familiaris	67.47	0.00e+00	690.00
IUUC-Cre-022597	Chlamydomonas reinhardtii	33.75	9.00e-10	57.80
IUUC-Csa-023785	Chlorocebus sabaeus	90.76	0.00e+00	909.00
IUUC-Eeu-034968	Erinaceus europaeus	49.57	1.00e-115	409.00
IUUC-Ggo-044550	Gorilla gorilla	96.99	0.00e+00	944.00
IUUC-Hsa-046363	Homo sapiens	97.59	0.00e+00	984.00
IUUC-Itr-048069	Ictidomys tridecemlineatus	53.43	1.00e-138	486.00
IUUC-Laf-053647	Loxodonta africana	65.66	0.00e+00	645.00
IUUC-Mcc-054743	Macaca mulatta	92.37	0.00e+00	930.00
IUUC-Mor-056977	Magnaporthe oryzae	58.82	4.00e-06	47.40
IUUC-Mpu-066674	Mustela putorius furo	66.47	0.00e+00	692.00
IUUC-Oga-088267	Otolemur garnettii	55.31	1.00e-145	509.00
IUUC-Ptr-091300	Pan troglodytes	97.19	0.00e+00	976.00
IUUC-Pan-092605	Papio anubis	82.33	0.00e+00	795.00
IUUC-Pab-098535	Pongo abelii	97.99	0.00e+00	985.00
IUUC-Rno-105401	Rattus norvegicus	55.62	4.00e-148	517.00
IUUC-Ssc-115715	Sus scrofa	54.67	4.00e-143	501.00
IUUC-Tsy-119330	Tarsius syrichta	76.10	0.00e+00	733.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence