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Tag Content
UUCD2 ID IUUC-Oga-088734
UUCD1 version UUC-OtG-00802
Ensembl Protein ID ENSOGAP00000012423.2
UniProt Accession H0XA01; H0XA01_OTOGA
Genbank Protein ID ENSOGAP00000012423
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID AAQR03109190
Gene Name USP13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOGAG00000013871.2 ENSOGAT00000013875.2 ENSOGAP00000012423.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 4.10e-57 193.9 305 829
UBD/Alpha-Helix/UBA 8.20e-19 67.1 699 736
Active Site
Position(s) Description Evidence
314 Nucleophile {ECO:0000256|PIRSR:PIRSR016308-1}
792 Proton acceptor {ECO:0000256|PIRSR:PIRSR016308-1}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 305  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNG 392
           7******************************788777765.79*****************8888888888888877765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 393  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 452
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+  +
   Q: 453  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrrdaeanrrplpelvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAGV 538
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 539  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdvdess 626
           *********************997.*******************999888999999999999999998888888888888888887777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 627  vmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltmpgyggaasagasffgatgldnqppeeivaiitsmgfqrnqa 715
           77777777777777777777777777777777777777777777777777777777777777777766666666666666666666666 PP
   S: 268  ...........peekqke...........................................kkkYeLiavvvHsG.slssGHYvayvkn 301
                      +     +                                           +  YeL+a ++H+G s+ sGHYv+++k+
   Q: 716  iqalratnhnlE-----RaldwifshpefeedsdfviemennananiiseakpegprvkdgSGMYELFAFISHMGtSTMSGHYVCHIKK 799
           666555555550.....055555555555555555566666666677888888888888889*************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 800  -EGRWVIYNDHKVCAS--ERPPK---DLGYMYFYHR 829
           .9***********999..78888...89******97 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra+n nle+A+++++++
   Q: 699  EEIVAIITSMGFQRNQAIQALRATNHNLERALDWIFSH 736
           899*********************************97 PP
   
Organism Otolemur garnettii
Protein Sequence
(Fasta)
MPTIRVPRSG DRVYKNECAF SYDSPNSEGG LYVCMNTFLA FGREHVERHF RKTGQSVYMH 60
LKRHVREKVR GASGGALPKR RNSKIFLDLD TDDDLNSDDY EYEDEAKLVI FPDHYEIALP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Oga-088734|DUB,USP;UBD,UBA|Otolemur garnettii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATGGCTGCA GGAGACATCG GCGAGCTGCT GGTGCCCCAC ATGCCCACGA TCCGCGTGCC 60
CAGGTCTGGG GACAGGGTCT ACAAGAACGA GTGCGCCTTC TCCTACGACT CCCCAGTAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Oga-088734|DUB,USP;UBD,UBA|Otolemur garnettii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP
SMART

SM00165--UBA
SM00290--ZnF_UBP
Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001356 Ailuropoda melanoleuca 97.95 0.00e+00 1552.00
IUUC-Atr-002580 Amborella trichopoda 42.41 0.00e+00 640.00
IUUC-Apl-003712 Anas platyrhynchos 83.60 0.00e+00 1355.00
IUUC-Aca-004634 Anolis carolinensis 83.95 0.00e+00 1368.00
IUUC-Ame-011470 Astyanax mexicanus 74.47 0.00e+00 1268.00
IUUC-Bta-013349 Bos taurus 97.72 0.00e+00 1587.00
IUUC-Cja-019021 Callithrix jacchus 97.12 0.00e+00 1541.00
IUUC-Cfa-020614 Canis familiaris 98.44 0.00e+00 1558.00
IUUC-Cpo-022484 Cavia porcellus 97.67 0.00e+00 1507.00
IUUC-Csa-024078 Chlorocebus sabaeus 98.56 0.00e+00 1561.00
IUUC-Cho-024522 Choloepus hoffmanni 80.92 0.00e+00 1167.00
IUUC-Cme-027335 Cyanidioschyzon merolae 25.70 3.00e-53 204.00
IUUC-Dre-027651 Danio rerio 74.50 0.00e+00 1326.00
IUUC-Dno-028975 Dasypus novemcinctus 98.08 0.00e+00 1554.00
IUUC-Dor-030130 Dipodomys ordii 73.41 0.00e+00 1063.00
IUUC-Ete-032251 Echinops telfairi 82.28 0.00e+00 1275.00
IUUC-Eca-033568 Equus caballus 98.27 0.00e+00 1503.00
IUUC-Eeu-034612 Erinaceus europaeus 79.18 0.00e+00 1144.00
IUUC-Fca-036280 Felis catus 98.39 0.00e+00 1505.00
IUUC-Fal-036610 Ficedula albicollis 84.39 0.00e+00 1332.00
IUUC-Gmo-038906 Gadus morhua 72.53 0.00e+00 1231.00
IUUC-Gga-041215 Gallus gallus 83.97 0.00e+00 1402.00
IUUC-Gac-042441 Gasterosteus aculeatus 71.90 0.00e+00 1249.00
IUUC-Ggo-044446 Gorilla gorilla 98.08 0.00e+00 1556.00
IUUC-Hsa-046546 Homo sapiens 98.32 0.00e+00 1556.00
IUUC-Itr-048147 Ictidomys tridecemlineatus 89.20 0.00e+00 1424.00
IUUC-Lch-050425 Latimeria chalumnae 77.99 0.00e+00 1340.00
IUUC-Loc-052072 Lepisosteus oculatus 77.15 0.00e+00 1285.00
IUUC-Laf-053909 Loxodonta africana 96.29 0.00e+00 1543.00
IUUC-Mcc-054686 Macaca mulatta 98.56 0.00e+00 1560.00
IUUC-Meu-056361 Macropus eugenii 79.88 0.00e+00 1276.00
IUUC-Mga-059972 Meleagris gallopavo 78.99 0.00e+00 1298.00
IUUC-Mmr-060916 Microcebus murinus 96.88 0.00e+00 1555.00
IUUC-Mdo-062302 Monodelphis domestica 89.10 0.00e+00 1474.00
IUUC-Mmu-063639 Mus musculus 95.79 0.00e+00 1569.00
IUUC-Mpu-066533 Mustela putorius furo 98.32 0.00e+00 1558.00
IUUC-Mlu-067786 Myotis lucifugus 91.31 0.00e+00 1462.00
IUUC-Nle-069997 Nomascus leucogenys 98.12 0.00e+00 1489.00
IUUC-Ont-071859 Oreochromis niloticus 71.89 0.00e+00 1253.00
IUUC-Oan-072959 Ornithorhynchus anatinus 88.70 3.00e-128 450.00
IUUC-Ocu-074265 Oryctolagus cuniculus 98.08 0.00e+00 1551.00
IUUC-Ola-087344 Oryzias latipes 71.59 0.00e+00 1256.00
IUUC-Oar-089636 Ovis aries 97.65 0.00e+00 1568.00
IUUC-Ptr-090982 Pan troglodytes 98.32 0.00e+00 1559.00
IUUC-Pan-091991 Papio anubis 98.68 0.00e+00 1563.00
IUUC-Psi-093509 Pelodiscus sinensis 87.07 0.00e+00 1425.00
IUUC-Pfo-096029 Poecilia formosa 74.06 0.00e+00 1296.00
IUUC-Pab-098672 Pongo abelii 93.87 0.00e+00 1458.00
IUUC-Pca-100860 Procavia capensis 74.07 0.00e+00 1035.00
IUUC-Pva-102545 Pteropus vampyrus 90.02 0.00e+00 1415.00
IUUC-Rno-105210 Rattus norvegicus 95.31 0.00e+00 1555.00
IUUC-Sar-113733 Sorex araneus 95.54 0.00e+00 768.00
IUUC-Tgu-116591 Taeniopygia guttata 85.39 0.00e+00 1404.00
IUUC-Tru-118627 Takifugu rubripes 70.80 0.00e+00 1259.00
IUUC-Tsy-119278 Tarsius syrichta 89.10 0.00e+00 1345.00
IUUC-Tni-120804 Tetraodon nigroviridis 73.91 0.00e+00 1289.00
IUUC-Tbe-127699 Tupaia belangeri 79.70 0.00e+00 876.00
IUUC-Ttr-128295 Tursiops truncatus 88.60 0.00e+00 1405.00
IUUC-Vpa-130170 Vicugna pacos 86.49 0.00e+00 1324.00
IUUC-Xtr-132809 Xenopus tropicalis 74.37 0.00e+00 1246.00
Created Date 25-Jun-2017

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