iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
PINA	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPPT	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18502747; 19384408; 19704769; 20514240; 26008766
E3 activity/RING/PHD	PHD	18502747; 19384408; 19704769; 20514240; 26008766

Classification

Family	E-value	Score	Start	End
E3 activity/RING/PHD	2.30e-11	44.6	113	166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..CrewfHpaClkls.....veeelpnsekwiCpkCr 52
           + C vCg++ e++ s+++Ce+  C+ w+H++C+ l+      +++lp+s  ++C+ Cr
   Q: 113  VRC-VCGNSLETD-SMIQCEDprCHVWQHVGCVILPdkpmdGNPPLPES--FYCEICR 166
           579.*******88.7*********************9999999999999..******8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 SUMO protein ligase involved in regulation processes. Mediates SUMO/ attachment to PHR1, a MYB transcriptional activator controlling the phosphate deficiency responses (PubMed:15894620). Functions as an upstream negative regulator of salicylic acid (SA) accumulation and subsequent SA-mediated systemic acquired resistance (SAR) signaling. Probably not involved in jasmonic acid (JA)-mediated defense response. Participates in abiotic stress-induced sumoylation. Controls heat shock-induced SUMO1 and SUMO2 conjugation and facilitates basal thermotolerance. Involved in freezing tolerance by mediating sumoylation of ICE1, a transcription activator of the cold signaling regulator CBF3/DREB1A. Acts as positive regulator of drought stress tolerance. Acts as floral repressor that promotes FLC expression by repressing FLD activity through sumoylation. Acts as negative regulator of abscisic acid (ABA) signaling through ABI5 sumoylation. Mediates sumoylation of SCE1, GTE3 and GTE5.

Protein Sequence
(Fasta)

MDLEANCKEK LSYFRIKELK DVLTQLGLSK QGKKQELVDR ILTLLSDEQA ARLLSKKNTV 60
AKEAVAKLVD DTYRKMQVSG ASDLASKGQV SSDTSNLKVK GEPEDPFQPE IKVRCVCGNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCTGGGTTT GGTTGTCTTT TTATTTTCCT CTTCCTTGGC CAAAGAAAAT CTTATCGTAG 60
CTGTGAAAAC CCTAGTTTCT AATCATCTCA ATTCTCTCAT TAACCTATCA ATTTCGATAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0287--Flowering
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0611--Plant defense
KW-1185--Reference proteome
KW-0346--Stress response
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003034--SAP_dom
IPR031141--SIZ1_plant
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR004181--Znf_MIZ
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50800--SAP
PS01359--ZF_PHD_1
PS51044--ZF_SP_RING

Pfam

PF02037--SAP
PF02891--zf-MIZ

SMART

SM00249--PHD
SM00513--SAP

Gene Ontology

GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016049--P:cell growth
GO:0031668--P:cellular response to extracellular stimulus
GO:0016036--P:cellular response to phosphate starvation
GO:0006952--P:defense response
GO:0010247--P:detection of phosphate ion
GO:0048589--P:developmental growth
GO:0009553--P:embryo sac development
GO:0009908--P:flower development
GO:0010286--P:heat acclimation
GO:0009910--P:negative regulation of flower development
GO:0010113--P:negative regulation of systemic acquired resistance
GO:0048481--P:plant ovule development
GO:0010183--P:pollen tube guidance
GO:0016925--P:protein sumoylation
GO:0009787--P:regulation of abscisic acid-activated signaling pathway
GO:0040008--P:regulation of growth
GO:0090352--P:regulation of nitrate assimilation
GO:2000070--P:regulation of response to water deprivation
GO:0010337--P:regulation of salicylic acid metabolic process
GO:0050826--P:response to freezing
GO:0009414--P:response to water deprivation

KEGG

ath:AT5G60410

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000121	Aegilops tauschii	52.15	0.00e+00	818.00
IUUC-Atr-002963	Amborella trichopoda	53.01	0.00e+00	809.00
IUUC-Apl-003376	Anas platyrhynchos	29.36	9.00e-18	84.70
IUUC-Aly-006507	Arabidopsis lyrata	95.36	0.00e+00	1644.00
IUUC-Bdi-014054	Brachypodium distachyon	51.96	0.00e+00	855.00
IUUC-Bol-015575	Brassica oleracea	81.75	0.00e+00	1416.00
IUUC-Bra-017793	Brassica rapa	80.73	0.00e+00	1385.00
IUUC-Cel-018231	Caenorhabditis elegans	34.02	1.00e-14	74.70
IUUC-Cfa-020481	Canis familiaris	32.54	1.00e-17	84.30
IUUC-Cre-022902	Chlamydomonas reinhardtii	25.93	2.00e-05	43.10
IUUC-Cme-027209	Cyanidioschyzon merolae	31.82	3.00e-09	56.60
IUUC-Dse-031254	Dothistroma septosporum	25.00	2.00e-17	83.60
IUUC-Dme-032018	Drosophila melanogaster	28.85	9.00e-18	84.70
IUUC-Fox-038010	Fusarium oxysporum	30.00	1.00e-07	50.80
IUUC-Ggr-039896	Gaeumannomyces graminis	25.97	6.00e-19	88.20
IUUC-Gga-040755	Gallus gallus	29.36	1.00e-17	84.70
IUUC-Gac-042204	Gasterosteus aculeatus	29.82	6.00e-19	88.60
IUUC-Gma-043219	Glycine max	65.05	0.00e+00	1117.00
IUUC-Hvu-047523	Hordeum vulgare	48.00	0.00e+00	627.00
IUUC-Lch-049611	Latimeria chalumnae	30.28	2.00e-18	87.00
IUUC-Lpe-050930	Leersia perrieri	51.35	0.00e+00	836.00
IUUC-Loc-052851	Lepisosteus oculatus	30.37	2.00e-17	83.60
IUUC-Laf-053486	Loxodonta africana	32.54	1.00e-17	84.30
IUUC-Mtr-058191	Medicago truncatula	62.87	0.00e+00	1057.00
IUUC-Mga-059790	Meleagris gallopavo	29.36	9.00e-18	84.30
IUUC-Mvi-060421	Microbotryum violaceum	26.35	5.00e-22	99.00
IUUC-Mac-064545	Musa acuminata	51.69	0.00e+00	861.00
IUUC-Mpu-066609	Mustela putorius furo	32.54	1.00e-17	84.30
IUUC-Nfi-068603	Neosartorya fischeri	24.81	3.00e-16	80.50
IUUC-Ont-071607	Oreochromis niloticus	28.90	3.00e-18	86.30
IUUC-Oan-073567	Ornithorhynchus anatinus	29.36	1.00e-17	84.30
IUUC-Oba-075465	Oryza barthii	51.83	0.00e+00	830.00
IUUC-Obr-076593	Oryza brachyantha	51.57	0.00e+00	846.00
IUUC-Ogl-076986	Oryza glaberrima	52.29	0.00e+00	857.00
IUUC-Ogu-078528	Oryza glumaepatula	41.75	1.00e-180	626.00
IUUC-Oin-079468	Oryza indica	51.65	0.00e+00	827.00
IUUC-Olo-080754	Oryza longistaminata	53.46	0.00e+00	818.00
IUUC-Ome-081939	Oryza meridionalis	50.29	0.00e+00	639.00
IUUC-Oni-082630	Oryza nivara	51.76	0.00e+00	835.00
IUUC-Opu-083453	Oryza punctata	52.04	0.00e+00	844.00
IUUC-Oru-084397	Oryza rufipogon	51.76	0.00e+00	837.00
IUUC-Osa-085396	Oryza sativa	52.24	0.00e+00	859.00
IUUC-Ola-086471	Oryzias latipes	29.36	8.00e-18	85.10
IUUC-Olu-087742	Ostreococcus lucimarinus	32.61	4.00e-17	81.60
IUUC-Oga-088527	Otolemur garnettii	33.07	2.00e-17	84.00
IUUC-Oar-089470	Ovis aries	32.54	1.00e-17	84.00
IUUC-Psi-093900	Pelodiscus sinensis	29.36	1.00e-18	87.40
IUUC-Ppa-095158	Physcomitrella patens	45.18	7.00e-140	490.00
IUUC-Pfo-096236	Poecilia formosa	29.20	3.00e-18	86.30
IUUC-Pop-099241	Populus trichocarpa	65.69	0.00e+00	1091.00
IUUC-Ppe-101666	Prunus persica	68.06	0.00e+00	1184.00
IUUC-Pva-103134	Pteropus vampyrus	24.70	3.00e-15	76.30
IUUC-Smo-109174	Selaginella moellendorffii	47.86	5.00e-140	491.00
IUUC-Sit-110164	Setaria italica	50.59	0.00e+00	795.00
IUUC-Sly-111822	Solanum lycopersicum	62.54	0.00e+00	1073.00
IUUC-Stu-112120	Solanum tuberosum	57.29	1.00e-175	608.00
IUUC-Sar-113126	Sorex araneus	32.54	1.00e-17	84.30
IUUC-Sbi-114516	Sorghum bicolor	49.29	8.00e-178	616.00
IUUC-Tsy-119069	Tarsius syrichta	32.54	1.00e-17	84.00
IUUC-Tca-121168	Theobroma cacao	67.31	0.00e+00	1190.00
IUUC-Tae-123882	Triticum aestivum	52.01	0.00e+00	841.00
IUUC-Tur-126304	Triticum urartu	48.88	0.00e+00	651.00
IUUC-Tbe-127466	Tupaia belangeri	33.33	1.00e-15	77.40
IUUC-Vpa-130624	Vicugna pacos	32.54	1.00e-17	84.00
IUUC-Vvi-131637	Vitis vinifera	64.83	0.00e+00	1098.00
IUUC-Xma-134201	Xiphophorus maculatus	28.95	4.00e-18	85.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence