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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064306
UUCD1 version UUC-MuM-00887
Ensembl Protein ID ENSMUSP00000022986.6
UniProt Accession Q9CPU7; FBX32_MOUSE
Genbank Protein ID AAL49563.1; BAB29555.1; BAB29463.1; AAH27211.1
Protein Name F-box only protein 32; Atrogin-1; Muscle atrophy F-box protein
Genbank Nucleotide ID AF441120; AK014793; AK014612; BC027211
Gene Name Fbxo32
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022358.6 ENSMUST00000022986.6 ENSMUSP00000022986.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 96.62 0.00e+00 717.00 IUUC-Hsa-046173
E3 adaptor/Cullin RING/SCF/F-box 98.03 0.00e+00 717.00 IUUC-Rno-105610
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity).
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity).
Protein Sequence
(Fasta)
MPFLGQDWRS PGQSWVKTAD GWKRFLDEKS GSFVSDLSSY CNKEVYSKEN LFSSLNYDVA 60
AKKRKKDIQN SKTKTQYFHQ EKWIYVHKGS TKERHGYCTL GEAFNRLDFS TAILDSRRFN 120
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Protein Fasta Sequence


>IUUC-Mmu-064306|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
GACGGGGCAG CGGCCCGGGA TAAATACTGC GCTCGGGCAG CCGCTCAGCA TTCCCAGAGT 60
CAGGAGGCGA CCTTCCCCAA CGCCTGCGCC CCTGTGAGTG CAAGGATCCC CGCGCCCACC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064306|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030018--C:Z disc
GO:0004842--F:ubiquitin-protein transferase activity
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0016567--P:protein ubiquitination
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
KEGG mmu:67731
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001986 Ailuropoda melanoleuca 96.06 0.00e+00 715.00
IUUC-Apl-003973 Anas platyrhynchos 89.34 4.00e-174 603.00
IUUC-Aca-004945 Anolis carolinensis 86.76 0.00e+00 639.00
IUUC-Aor-009979 Aspergillus oryzae 46.15 1.20e+00 28.50
IUUC-Ame-011383 Astyanax mexicanus 74.08 3.00e-162 564.00
IUUC-Bta-013522 Bos taurus 95.21 0.00e+00 710.00
IUUC-Bci-013735 Botrytis cinerea 30.19 1.30e+00 28.90
IUUC-Bdi-014435 Brachypodium distachyon 37.50 2.00e-04 39.70
IUUC-Bol-015763 Brassica oleracea 28.81 4.00e-02 31.60
IUUC-Cel-018348 Caenorhabditis elegans 26.40 7.00e-33 134.00
IUUC-Cja-019893 Callithrix jacchus 96.62 0.00e+00 717.00
IUUC-Cfa-021053 Canis familiaris 95.49 0.00e+00 711.00
IUUC-Cpo-021330 Cavia porcellus 95.49 0.00e+00 709.00
IUUC-Csa-023160 Chlorocebus sabaeus 96.90 0.00e+00 718.00
IUUC-Cho-024993 Choloepus hoffmanni 74.59 1.00e-126 445.00
IUUC-Cin-025462 Ciona intestinalis 28.94 5.00e-25 107.00
IUUC-Csv-025908 Ciona savignyi 29.87 2.00e-40 159.00
IUUC-Cme-027326 Cyanidioschyzon merolae 24.60 4.00e-03 34.30
IUUC-Dre-028707 Danio rerio 74.79 3.00e-159 554.00
IUUC-Dno-029334 Dasypus novemcinctus 95.21 0.00e+00 710.00
IUUC-Dor-030350 Dipodomys ordii 95.89 0.00e+00 673.00
IUUC-Dme-031699 Drosophila melanogaster 27.91 4.00e-30 125.00
IUUC-Ete-033123 Echinops telfairi 74.76 3.00e-130 457.00
IUUC-Eca-033246 Equus caballus 96.06 0.00e+00 711.00
IUUC-Eeu-035339 Erinaceus europaeus 95.24 3.00e-130 457.00
IUUC-Fca-035805 Felis catus 96.30 0.00e+00 705.00
IUUC-Fal-037424 Ficedula albicollis 89.01 0.00e+00 673.00
IUUC-Gmo-039533 Gadus morhua 52.46 1.00e-103 369.00
IUUC-Gga-040478 Gallus gallus 90.14 0.00e+00 677.00
IUUC-Gac-042238 Gasterosteus aculeatus 73.41 3.00e-157 547.00
IUUC-Ggo-045515 Gorilla gorilla 96.90 0.00e+00 718.00
IUUC-Hsa-046173 Homo sapiens 96.62 0.00e+00 717.00
IUUC-Itr-048038 Ictidomys tridecemlineatus 96.34 0.00e+00 715.00
IUUC-Lch-049820 Latimeria chalumnae 80.85 9.00e-174 602.00
IUUC-Loc-051732 Lepisosteus oculatus 77.18 1.00e-167 582.00
IUUC-Laf-053789 Loxodonta africana 94.96 0.00e+00 678.00
IUUC-Mcc-055119 Macaca mulatta 96.90 0.00e+00 718.00
IUUC-Meu-056262 Macropus eugenii 78.80 2.00e-95 342.00
IUUC-Mga-059869 Meleagris gallopavo 82.58 8.00e-171 592.00
IUUC-Mmr-061443 Microcebus murinus 96.90 0.00e+00 719.00
IUUC-Mdo-062355 Monodelphis domestica 92.68 0.00e+00 696.00
IUUC-Mpu-066902 Mustela putorius furo 96.32 0.00e+00 627.00
IUUC-Mlu-067076 Myotis lucifugus 95.21 0.00e+00 704.00
IUUC-Nle-069716 Nomascus leucogenys 96.90 0.00e+00 718.00
IUUC-Opr-070514 Ochotona princeps 68.29 7.00e-27 114.00
IUUC-Ont-072007 Oreochromis niloticus 73.46 3.00e-155 541.00
IUUC-Oan-073321 Ornithorhynchus anatinus 92.81 5.00e-157 546.00
IUUC-Ocu-074320 Oryctolagus cuniculus 96.34 0.00e+00 685.00
IUUC-Obr-076772 Oryza brachyantha 39.13 2.00e-03 33.90
IUUC-Ogu-078178 Oryza glumaepatula 29.73 1.00e-02 34.30
IUUC-Oin-079543 Oryza indica 29.73 1.00e-02 34.30
IUUC-Oni-082751 Oryza nivara 29.73 1.00e-02 34.30
IUUC-Oru-084545 Oryza rufipogon 29.73 1.00e-02 34.30
IUUC-Osa-085485 Oryza sativa 29.73 1.00e-02 34.30
IUUC-Ola-087193 Oryzias latipes 72.63 1.00e-157 549.00
IUUC-Oga-088558 Otolemur garnettii 96.34 0.00e+00 717.00
IUUC-Oar-090092 Ovis aries 94.93 0.00e+00 707.00
IUUC-Ptr-091443 Pan troglodytes 96.34 0.00e+00 712.00
IUUC-Pan-092207 Papio anubis 96.90 0.00e+00 718.00
IUUC-Psi-093282 Pelodiscus sinensis 88.55 0.00e+00 667.00
IUUC-Pma-094448 Petromyzon marinus 65.64 3.00e-141 494.00
IUUC-Pfo-096873 Poecilia formosa 73.18 9.00e-159 552.00
IUUC-Pab-097940 Pongo abelii 59.72 2.00e-121 428.00
IUUC-Pca-101124 Procavia capensis 94.08 0.00e+00 696.00
IUUC-Pva-102791 Pteropus vampyrus 95.77 0.00e+00 710.00
IUUC-Rno-105610 Rattus norvegicus 98.03 0.00e+00 717.00
IUUC-Sha-106684 Sarcophilus harrisii 93.24 0.00e+00 698.00
IUUC-Smo-109491 Selaginella moellendorffii 20.88 2.50e-02 33.50
IUUC-Sar-113077 Sorex araneus 86.08 4.00e-161 560.00
IUUC-Ssc-115993 Sus scrofa 93.24 0.00e+00 684.00
IUUC-Tgu-117376 Taeniopygia guttata 88.40 4.00e-173 600.00
IUUC-Tru-118690 Takifugu rubripes 73.18 1.00e-158 552.00
IUUC-Tsy-119123 Tarsius syrichta 57.92 7.00e-73 267.00
IUUC-Tni-120740 Tetraodon nigroviridis 72.35 6.00e-159 553.00
IUUC-Tae-124742 Triticum aestivum 32.22 8.00e-05 40.00
IUUC-Tbe-127713 Tupaia belangeri 85.76 7.00e-159 552.00
IUUC-Ttr-128339 Tursiops truncatus 96.34 0.00e+00 715.00
IUUC-Vpa-130070 Vicugna pacos 94.20 2.00e-78 285.00
IUUC-Xtr-132470 Xenopus tropicalis 82.54 2.00e-179 621.00
IUUC-Xma-133649 Xiphophorus maculatus 72.63 7.00e-159 553.00
Created Date 25-Jun-2017

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