iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000007528.4	ENSCAFT00000050004.2	ENSCAFP00000036523.1
ENSCAFG00000007528.4	ENSCAFT00000012052.3	ENSCAFP00000011172.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.70e-130	433.1	545	876

Active Site

Position(s)	Description	Evidence
846	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 545  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 632
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 633  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 718
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 719  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 806
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilke.kLlyAieetkgF 333
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lke k l+Aie  ++F
   Q: 807  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEdKNLFAIELFESF 876
           *******************************************************984668899887777 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

LFHVQVYRPV GGMSGSGSQL GSMGSLTMKS QLQITVISAK LKENKKNWFG PSPYVEVTVD 60
GQSKKTEKCN NTNSPKWKQP LTVIVTPVSK LHFRVWSHQT LKSDVLLGTA ALDIFETLKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCAACAAGC CCTTCAGGTG TTTCTGATGC ACAATAGCTT TTGGGAACCA CAGCTACAGT 60
CTTTAGAGGT TCTGGGGAAG GGGGCATACT TTAAAAAAAA AAAAAAAAAA AAAGCCTAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	97.60	0.00e+00	1615.00
IUUC-Apl-003752	Anas platyrhynchos	82.87	0.00e+00	1422.00
IUUC-Aca-005338	Anolis carolinensis	80.54	0.00e+00	1410.00
IUUC-Ame-011081	Astyanax mexicanus	86.96	0.00e+00	1063.00
IUUC-Bta-012782	Bos taurus	95.84	0.00e+00	1557.00
IUUC-Cja-018899	Callithrix jacchus	91.47	0.00e+00	1533.00
IUUC-Cpo-022073	Cavia porcellus	95.61	0.00e+00	1603.00
IUUC-Csa-023252	Chlorocebus sabaeus	95.26	0.00e+00	1600.00
IUUC-Cho-024695	Choloepus hoffmanni	88.52	0.00e+00	1583.00
IUUC-Dre-028451	Danio rerio	74.46	0.00e+00	1272.00
IUUC-Dno-029884	Dasypus novemcinctus	95.26	0.00e+00	1634.00
IUUC-Eca-033793	Equus caballus	96.34	0.00e+00	1628.00
IUUC-Eeu-034716	Erinaceus europaeus	91.29	0.00e+00	860.00
IUUC-Fca-035605	Felis catus	97.65	0.00e+00	1641.00
IUUC-Fal-037126	Ficedula albicollis	83.28	0.00e+00	1422.00
IUUC-Gmo-038596	Gadus morhua	79.22	0.00e+00	988.00
IUUC-Gga-040832	Gallus gallus	83.37	0.00e+00	1442.00
IUUC-Gac-041520	Gasterosteus aculeatus	87.05	0.00e+00	1092.00
IUUC-Ggo-044535	Gorilla gorilla	92.11	0.00e+00	1585.00
IUUC-Hsa-046564	Homo sapiens	91.61	0.00e+00	1592.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	94.76	0.00e+00	1536.00
IUUC-Lch-050454	Latimeria chalumnae	75.03	0.00e+00	1333.00
IUUC-Loc-052647	Lepisosteus oculatus	73.88	0.00e+00	1325.00
IUUC-Laf-054383	Loxodonta africana	96.31	0.00e+00	1625.00
IUUC-Mcc-055532	Macaca mulatta	95.26	0.00e+00	1602.00
IUUC-Mga-059661	Meleagris gallopavo	82.75	0.00e+00	1435.00
IUUC-Mmr-061135	Microcebus murinus	95.95	0.00e+00	1635.00
IUUC-Mdo-062505	Monodelphis domestica	86.78	0.00e+00	1482.00
IUUC-Mmu-063375	Mus musculus	93.89	0.00e+00	1556.00
IUUC-Mpu-066203	Mustela putorius furo	97.15	0.00e+00	1611.00
IUUC-Mlu-067837	Myotis lucifugus	95.89	0.00e+00	1625.00
IUUC-Nle-069244	Nomascus leucogenys	94.35	0.00e+00	1581.00
IUUC-Opr-070585	Ochotona princeps	89.18	0.00e+00	1541.00
IUUC-Ont-071798	Oreochromis niloticus	86.18	0.00e+00	1110.00
IUUC-Oan-073679	Ornithorhynchus anatinus	65.62	0.00e+00	955.00
IUUC-Ocu-074298	Oryctolagus cuniculus	95.96	0.00e+00	1600.00
IUUC-Ola-086526	Oryzias latipes	84.16	0.00e+00	1091.00
IUUC-Oga-088167	Otolemur garnettii	88.69	0.00e+00	1480.00
IUUC-Oar-090316	Ovis aries	79.86	0.00e+00	1171.00
IUUC-Ptr-090819	Pan troglodytes	90.83	0.00e+00	1551.00
IUUC-Pan-092454	Papio anubis	94.95	0.00e+00	1614.00
IUUC-Psi-093319	Pelodiscus sinensis	81.52	0.00e+00	1401.00
IUUC-Pfo-097346	Poecilia formosa	83.28	0.00e+00	1075.00
IUUC-Pab-097580	Pongo abelii	84.88	0.00e+00	1435.00
IUUC-Pca-100923	Procavia capensis	78.15	0.00e+00	1332.00
IUUC-Pva-103209	Pteropus vampyrus	94.80	0.00e+00	1551.00
IUUC-Rno-104924	Rattus norvegicus	92.40	0.00e+00	1569.00
IUUC-Sha-107175	Sarcophilus harrisii	88.19	0.00e+00	1474.00
IUUC-Sar-113761	Sorex araneus	85.49	0.00e+00	1455.00
IUUC-Tgu-116632	Taeniopygia guttata	78.90	0.00e+00	1296.00
IUUC-Tru-118442	Takifugu rubripes	87.26	0.00e+00	1089.00
IUUC-Tsy-119198	Tarsius syrichta	88.90	0.00e+00	1489.00
IUUC-Tni-120168	Tetraodon nigroviridis	85.92	0.00e+00	1045.00
IUUC-Tbe-127756	Tupaia belangeri	86.34	0.00e+00	847.00
IUUC-Ttr-128504	Tursiops truncatus	90.73	0.00e+00	1180.00
IUUC-Vpa-130103	Vicugna pacos	81.70	0.00e+00	1369.00
IUUC-Xtr-132885	Xenopus tropicalis	76.10	0.00e+00	1352.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence