iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020253

Ensembl Protein ID

ENSCAFP00000023632.3

UniProt Accession

F1PWY2; F1PWY2_CANLF

Genbank Protein ID

ENSCAFP00000023632

Protein Name

Presenilin

Genbank Nucleotide ID

AAEX03005265

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000016039.3	ENSCAFT00000025451.3	ENSCAFP00000023632.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.90e-08	33.5	278	316

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 316
           89********************************99986 PP

Organism

Canis familiaris

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MLTFMASDSE EEVCDERTSL MSAESPPPRC CQEARQGLED GENAAQWRSQ DSEEDFEDDA 60
DHYVCGGVPG QPSGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGTAGGACC AGCCTCGGCG CCCTGGGGAG CCACCCCGCC CCAGCCCCCC CACCCGGGCG 60
TTCCTGACGT CACTGGCGCT CAGCGGCCGA CAGATATCGA GTAAGATTGT TGATCCGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0043025--C:neuronal cell body
GO:0005637--C:nuclear inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	91.07	0.00e+00	648.00
IUUC-Apl-003959	Anas platyrhynchos	77.02	7.00e-163	566.00
IUUC-Aca-005160	Anolis carolinensis	75.96	2.00e-159	555.00
IUUC-Ame-010686	Astyanax mexicanus	75.92	5.00e-148	517.00
IUUC-Bta-013097	Bos taurus	95.55	0.00e+00	720.00
IUUC-Cja-018824	Callithrix jacchus	94.42	0.00e+00	723.00
IUUC-Cpo-021401	Cavia porcellus	95.54	0.00e+00	738.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.56	1.00e-29	124.00
IUUC-Csa-023369	Chlorocebus sabaeus	95.76	0.00e+00	740.00
IUUC-Dre-028526	Danio rerio	70.34	1.00e-143	502.00
IUUC-Dor-031127	Dipodomys ordii	90.18	0.00e+00	678.00
IUUC-Ete-033081	Echinops telfairi	84.40	4.00e-94	338.00
IUUC-Eca-034387	Equus caballus	94.87	0.00e+00	690.00
IUUC-Eeu-034846	Erinaceus europaeus	80.29	3.00e-148	518.00
IUUC-Fca-035396	Felis catus	97.76	0.00e+00	782.00
IUUC-Fal-037457	Ficedula albicollis	76.96	1.00e-161	562.00
IUUC-Gga-040706	Gallus gallus	76.70	2.00e-157	548.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.32	7.00e-130	457.00
IUUC-Ggo-045338	Gorilla gorilla	95.98	0.00e+00	740.00
IUUC-Hsa-046455	Homo sapiens	95.98	0.00e+00	740.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	96.21	0.00e+00	744.00
IUUC-Lch-049638	Latimeria chalumnae	67.66	4.00e-145	508.00
IUUC-Loc-052427	Lepisosteus oculatus	73.94	4.00e-155	541.00
IUUC-Laf-053758	Loxodonta africana	89.14	0.00e+00	720.00
IUUC-Mcc-054755	Macaca mulatta	95.98	0.00e+00	740.00
IUUC-Mmr-060890	Microcebus murinus	94.20	0.00e+00	723.00
IUUC-Mdo-062197	Monodelphis domestica	79.57	9.00e-179	619.00
IUUC-Mmu-063823	Mus musculus	93.97	0.00e+00	729.00
IUUC-Mac-064858	Musa acuminata	43.27	4.00e-23	101.00
IUUC-Mpu-066181	Mustela putorius furo	97.99	0.00e+00	761.00
IUUC-Nle-069596	Nomascus leucogenys	95.44	0.00e+00	691.00
IUUC-Opr-070344	Ochotona princeps	93.30	0.00e+00	739.00
IUUC-Ont-071867	Oreochromis niloticus	70.79	9.00e-133	466.00
IUUC-Oan-073378	Ornithorhynchus anatinus	74.45	2.00e-152	532.00
IUUC-Ocu-074652	Oryctolagus cuniculus	93.75	0.00e+00	696.00
IUUC-Ola-086707	Oryzias latipes	66.98	1.00e-105	375.00
IUUC-Oga-088560	Otolemur garnettii	94.24	0.00e+00	695.00
IUUC-Oar-089200	Ovis aries	94.65	0.00e+00	690.00
IUUC-Ptr-090569	Pan troglodytes	95.76	0.00e+00	738.00
IUUC-Pan-091742	Papio anubis	95.98	0.00e+00	740.00
IUUC-Psi-093297	Pelodiscus sinensis	75.86	2.00e-132	465.00
IUUC-Pma-094612	Petromyzon marinus	77.57	2.00e-127	449.00
IUUC-Ppa-095431	Physcomitrella patens	31.40	1.00e-27	117.00
IUUC-Pab-098531	Pongo abelii	95.76	0.00e+00	740.00
IUUC-Pca-101120	Procavia capensis	91.52	0.00e+00	702.00
IUUC-Pva-102934	Pteropus vampyrus	85.94	0.00e+00	691.00
IUUC-Rno-106052	Rattus norvegicus	93.53	0.00e+00	746.00
IUUC-Sha-106876	Sarcophilus harrisii	79.32	1.00e-175	609.00
IUUC-Spo-108191	Schizosaccharomyces pombe	32.43	9.60e-01	28.50
IUUC-Ssc-115380	Sus scrofa	96.88	0.00e+00	769.00
IUUC-Tgu-117280	Taeniopygia guttata	77.61	6.00e-163	566.00
IUUC-Tbe-127632	Tupaia belangeri	94.71	1.00e-178	619.00
IUUC-Ttr-129008	Tursiops truncatus	94.42	0.00e+00	723.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence