iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000015734.7	ENSRNOT00000021366.7	ENSRNOP00000021366.6
ENSRNOG00000015734.7	ENSRNOT00000083587.1	ENSRNOP00000068717.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.70e-107	357.8	541	867

Active Site

Position(s)	Description	Evidence
836	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e  +  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 541  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEATRLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 624
           689****************************************99998777765.89898....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 625  HFPMVVYRKLMGKKGTFCDLGDSHPILYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVSLYS 711
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt++s +i+ Fwe++++f++e+++ fLq
   Q: 712  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQ 800
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 801  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 867
           *****************...8888866666**************************************97 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MATACKRSSG ESQSEDIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE FCASCPTFLR 60
MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG ASNNSEIKMN KKEEFKEVDY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCGGGATAC TCGGTCCGCC CACCTAGTCT TCTCGTCCTC GTTCGCGAGA TCCGTGTTTC 60
TCCCAAGATG GTGGCGCTCC TCTTTGGGTG ACTACAGGAG ACGACAGGGC CTTTCGTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:361585

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	95.32	0.00e+00	1565.00
IUUC-Atr-003144	Amborella trichopoda	47.77	7.00e-96	344.00
IUUC-Apl-003742	Anas platyrhynchos	89.55	0.00e+00	1565.00
IUUC-Aca-004873	Anolis carolinensis	91.74	0.00e+00	1585.00
IUUC-Ame-011166	Astyanax mexicanus	85.20	0.00e+00	1436.00
IUUC-Bta-013286	Bos taurus	94.97	0.00e+00	1564.00
IUUC-Cja-019707	Callithrix jacchus	95.39	0.00e+00	1595.00
IUUC-Cfa-020154	Canis familiaris	94.71	0.00e+00	1571.00
IUUC-Cpo-021292	Cavia porcellus	95.19	0.00e+00	1575.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	1.00e-82	299.00
IUUC-Csa-023378	Chlorocebus sabaeus	95.76	0.00e+00	1609.00
IUUC-Cho-025059	Choloepus hoffmanni	91.46	0.00e+00	1477.00
IUUC-Cin-025643	Ciona intestinalis	43.97	0.00e+00	701.00
IUUC-Csv-026282	Ciona savignyi	45.25	0.00e+00	671.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.75	6.00e-102	365.00
IUUC-Dre-027901	Danio rerio	84.60	0.00e+00	1418.00
IUUC-Dno-029320	Dasypus novemcinctus	94.86	0.00e+00	1599.00
IUUC-Dor-030756	Dipodomys ordii	93.32	0.00e+00	733.00
IUUC-Dme-032035	Drosophila melanogaster	39.77	2.00e-167	583.00
IUUC-Eca-033843	Equus caballus	94.73	0.00e+00	1524.00
IUUC-Eeu-035109	Erinaceus europaeus	94.35	0.00e+00	1527.00
IUUC-Fca-036344	Felis catus	93.16	0.00e+00	1582.00
IUUC-Fal-036747	Ficedula albicollis	89.55	0.00e+00	1565.00
IUUC-Gmo-038840	Gadus morhua	63.60	0.00e+00	1098.00
IUUC-Gga-040399	Gallus gallus	89.43	0.00e+00	1563.00
IUUC-Gac-041933	Gasterosteus aculeatus	83.16	0.00e+00	1373.00
IUUC-Ggo-044804	Gorilla gorilla	95.63	0.00e+00	1600.00
IUUC-Hsa-045727	Homo sapiens	95.63	0.00e+00	1600.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	92.37	0.00e+00	1494.00
IUUC-Lch-050197	Latimeria chalumnae	88.98	0.00e+00	1519.00
IUUC-Loc-052743	Lepisosteus oculatus	87.07	0.00e+00	1499.00
IUUC-Lma-053245	Leptosphaeria maculans	34.13	2.00e-57	218.00
IUUC-Laf-053615	Loxodonta africana	93.89	0.00e+00	1575.00
IUUC-Mcc-054934	Macaca mulatta	95.84	0.00e+00	1598.00
IUUC-Meu-056061	Macropus eugenii	94.68	0.00e+00	1339.00
IUUC-Mga-059271	Meleagris gallopavo	87.95	0.00e+00	1526.00
IUUC-Mmr-061288	Microcebus murinus	95.72	0.00e+00	1598.00
IUUC-Mdo-062975	Monodelphis domestica	93.51	0.00e+00	1578.00
IUUC-Mmu-063674	Mus musculus	97.59	0.00e+00	1618.00
IUUC-Mpu-066568	Mustela putorius furo	95.21	0.00e+00	1611.00
IUUC-Mlu-067522	Myotis lucifugus	86.72	0.00e+00	1477.00
IUUC-Nle-069505	Nomascus leucogenys	95.63	0.00e+00	1600.00
IUUC-Opr-070570	Ochotona princeps	87.53	0.00e+00	1436.00
IUUC-Ont-071527	Oreochromis niloticus	83.12	0.00e+00	1441.00
IUUC-Oan-073446	Ornithorhynchus anatinus	88.31	0.00e+00	1036.00
IUUC-Ocu-074922	Oryctolagus cuniculus	93.64	0.00e+00	1609.00
IUUC-Ola-086996	Oryzias latipes	82.67	0.00e+00	1452.00
IUUC-Oga-088261	Otolemur garnettii	96.00	0.00e+00	1575.00
IUUC-Oar-090024	Ovis aries	94.97	0.00e+00	1564.00
IUUC-Ptr-090455	Pan troglodytes	95.63	0.00e+00	1600.00
IUUC-Pan-092509	Papio anubis	93.69	0.00e+00	1431.00
IUUC-Psi-092974	Pelodiscus sinensis	89.65	0.00e+00	1534.00
IUUC-Pma-094643	Petromyzon marinus	71.95	0.00e+00	1259.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.84	1.00e-57	218.00
IUUC-Pfo-096905	Poecilia formosa	83.66	0.00e+00	1444.00
IUUC-Pab-097840	Pongo abelii	93.78	0.00e+00	1532.00
IUUC-Pca-100869	Procavia capensis	94.38	0.00e+00	1555.00
IUUC-Pva-103040	Pteropus vampyrus	95.54	0.00e+00	661.00
IUUC-Sha-107651	Sarcophilus harrisii	93.51	0.00e+00	1580.00
IUUC-Smo-108858	Selaginella moellendorffii	49.66	2.00e-117	416.00
IUUC-Sar-113293	Sorex araneus	94.85	0.00e+00	1560.00
IUUC-Ssc-115979	Sus scrofa	94.84	0.00e+00	1557.00
IUUC-Tgu-116901	Taeniopygia guttata	89.55	0.00e+00	1565.00
IUUC-Tru-118368	Takifugu rubripes	84.61	0.00e+00	1443.00
IUUC-Tsy-119516	Tarsius syrichta	91.77	0.00e+00	1461.00
IUUC-Tni-120143	Tetraodon nigroviridis	82.54	0.00e+00	1436.00
IUUC-Tbe-127484	Tupaia belangeri	89.45	0.00e+00	1065.00
IUUC-Ttr-129078	Tursiops truncatus	94.73	0.00e+00	1538.00
IUUC-Vpa-130312	Vicugna pacos	86.96	0.00e+00	1315.00
IUUC-Xtr-132881	Xenopus tropicalis	89.55	0.00e+00	1523.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence