iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088858

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03071231

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000017226.2	ENSOGAT00000017232.2	ENSOGAP00000015432.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.70e-83	278.9	635	956

Active Site

Position(s)	Description	Evidence
926	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +++l+k+l+v+f+gE g + gGv ref+ +l++++ +p++g+f+y e+ +++++p + ++    e+ ++F f+G+l+g++l++ ++ ++
   Q: 635  NENLRKELWVSFSGEIGYEVGGVRREFFCCLFEKMTQPEYGMFTYPEEASYMWFPVRPKY----EEKRYF-FFGVLCGLSLFNFNVANI 718
           57899******************************************************9....566777.99**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           p++ +++k+llg+  sledl+e+ p + ksl+ +++++     + ++   f ++ ++  ++++ +L+++G++i V+++Nk++Yv++ v+
   Q: 719  PFPLALFKKLLGQIPSLEDLKELSPVFGKSLQMLLDHE-----DDDFVEVFYIHFNVHWDRDDADLVSDGSRILVNQTNKRDYVSKCVD 802
           ***********************************884.....444555566666778899**************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           y ++ ++k  +e+f++Gf++v ++e++s+F++ +l+ ++ G++++d+e+++k+++y+++y++++p+i +Fwe++++++ ee+k+fL F+
   Q: 803  YVFNISVKAAYEEFQRGFYKVHDKEIISIFHPDQLRDVMLGNTDYDWETFEKKAQYEQDYSSSHPTILMFWEAFHKLKLEEKKKFLVFL 891
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           T ++r  ++ ++++k  +f + +++++++  +++TCf++L LP+Ys++e ++e L+ Ai++++gF+
   Q: 892  TATDRTQIKDLKNMK-IIFRYIENSTESDPMRAHTCFSVLYLPKYSTMERMEEALQGAINNSRGFG 956
           ***************.55666667999*************************************96 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MERRPPRRAR GCTRSAPGSA PGSRSAGTGS AQPPRAQLWL FPGAAGLHGA LLARAQATRQ 60
ICCARGRLAV LEHGGAGVQV HPGLAGSDGA GKPKYLKLEK KMKIHSMDQG REHLLVLSSD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCGGA GGCCGCCGAG GAGGGCGCGG GGCTGCACGC GCTCTGCTCC GGGGTCGGCC 60
CCCGGCTCCC GCTCCGCCGG GACCGGCTCC GCGCAGCCGC CCCGCGCGCA GCTCTGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-012422	Bos taurus	73.94	0.00e+00	1328.00
IUUC-Cja-018751	Callithrix jacchus	73.95	0.00e+00	875.00
IUUC-Csa-023204	Chlorocebus sabaeus	66.34	0.00e+00	1084.00
IUUC-Dno-029795	Dasypus novemcinctus	70.77	0.00e+00	828.00
IUUC-Dor-030862	Dipodomys ordii	65.15	0.00e+00	718.00
IUUC-Ete-032585	Echinops telfairi	54.61	0.00e+00	707.00
IUUC-Eeu-035282	Erinaceus europaeus	59.44	8.00e-121	427.00
IUUC-Laf-053921	Loxodonta africana	64.14	0.00e+00	1226.00
IUUC-Mcc-054850	Macaca mulatta	66.45	0.00e+00	1089.00
IUUC-Mmr-060783	Microcebus murinus	75.05	0.00e+00	743.00
IUUC-Nle-069986	Nomascus leucogenys	75.90	0.00e+00	866.00
IUUC-Opr-070513	Ochotona princeps	72.21	0.00e+00	798.00
IUUC-Ptr-091216	Pan troglodytes	64.48	0.00e+00	1019.00
IUUC-Pan-091706	Papio anubis	65.51	0.00e+00	1167.00
IUUC-Pab-097883	Pongo abelii	79.09	0.00e+00	634.00
IUUC-Pca-100320	Procavia capensis	59.35	0.00e+00	1134.00
IUUC-Sar-113605	Sorex araneus	73.87	2.00e-148	519.00
IUUC-Ssc-116076	Sus scrofa	70.41	8.00e-150	523.00
IUUC-Tsy-119240	Tarsius syrichta	65.06	0.00e+00	640.00
IUUC-Tbe-127787	Tupaia belangeri	70.11	2.00e-178	619.00
IUUC-Ttr-128191	Tursiops truncatus	64.43	0.00e+00	1196.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence