iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088536

Ensembl Protein ID

ENSOGAP00000017140.1

UniProt Accession

H0XM00; H0XM00_OTOGA

Genbank Protein ID

ENSOGAP00000017140

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03133408

Gene Name

RFFL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000024777.1	ENSOGAT00000028738.1	ENSOGAP00000017140.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	90.63	1.00e-180	630.00	IUUC-Hsa-045798

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MWATCCNWFC LDGQPDEGPP PQGARTQAYS NPGYSSFPSP TGSEPSCKGC GAHFANTARK 60
QICLDCKKNF CMTCSSQEGN GPRLCLLCQR FRATAFQREE LMKMKVKDLR DYLSLHDIST 120

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Nucleotide Sequence
(Fasta)

ATGTGGGCAA CCTGCTGCAA CTGGTTCTGC CTGGATGGAC AGCCTGACGA GGGCCCACCA 60
CCCCAGGGAG CCAGGACGCA GGCCTACTCC AACCCTGGGT ACAGCTCCTT CCCTTCCCCA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0002947--C:tumor necrosis factor receptor superfamily complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001630	Ailuropoda melanoleuca	85.95	4.00e-180	623.00
IUUC-Apl-004124	Anas platyrhynchos	65.38	4.00e-122	431.00
IUUC-Aly-005548	Arabidopsis lyrata	47.06	2.00e-08	55.10
IUUC-Ame-011616	Astyanax mexicanus	57.10	5.00e-102	364.00
IUUC-Bta-012374	Bos taurus	85.91	4.00e-176	610.00
IUUC-Cja-019780	Callithrix jacchus	90.93	0.00e+00	646.00
IUUC-Cfa-021252	Canis familiaris	90.91	1.00e-179	622.00
IUUC-Cpo-022047	Cavia porcellus	87.05	0.00e+00	634.00
IUUC-Csa-023161	Chlorocebus sabaeus	92.29	0.00e+00	660.00
IUUC-Cho-024316	Choloepus hoffmanni	88.12	5.00e-147	513.00
IUUC-Dre-028596	Danio rerio	54.42	1.00e-105	376.00
IUUC-Dno-029333	Dasypus novemcinctus	90.08	0.00e+00	650.00
IUUC-Ete-033163	Echinops telfairi	84.81	5.00e-164	570.00
IUUC-Eca-033994	Equus caballus	92.01	0.00e+00	659.00
IUUC-Eeu-035162	Erinaceus europaeus	83.67	1.00e-121	428.00
IUUC-Fca-036418	Felis catus	90.08	0.00e+00	649.00
IUUC-Fal-037427	Ficedula albicollis	67.03	6.00e-130	457.00
IUUC-Gga-041053	Gallus gallus	66.57	1.00e-126	446.00
IUUC-Ggo-045436	Gorilla gorilla	92.84	0.00e+00	668.00
IUUC-Hsa-045798	Homo sapiens	92.84	0.00e+00	668.00
IUUC-Itr-048077	Ictidomys tridecemlineatus	88.43	0.00e+00	630.00
IUUC-Lch-050639	Latimeria chalumnae	61.71	2.00e-119	421.00
IUUC-Laf-053355	Loxodonta africana	84.70	1.00e-175	608.00
IUUC-Mcc-055222	Macaca mulatta	90.08	0.00e+00	637.00
IUUC-Meu-056692	Macropus eugenii	74.10	5.00e-153	533.00
IUUC-Mga-059298	Meleagris gallopavo	66.30	5.00e-126	444.00
IUUC-Mmr-061792	Microcebus murinus	93.92	0.00e+00	648.00
IUUC-Mdo-062986	Monodelphis domestica	78.51	1.00e-157	549.00
IUUC-Mmu-063356	Mus musculus	87.88	1.00e-180	625.00
IUUC-Mpu-066273	Mustela putorius furo	89.81	0.00e+00	650.00
IUUC-Mlu-066953	Myotis lucifugus	87.88	0.00e+00	635.00
IUUC-Nle-070075	Nomascus leucogenys	92.84	0.00e+00	666.00
IUUC-Opr-070838	Ochotona princeps	87.05	3.00e-180	624.00
IUUC-Ont-071967	Oreochromis niloticus	74.13	1.00e-55	209.00
IUUC-Ocu-074807	Oryctolagus cuniculus	89.81	0.00e+00	642.00
IUUC-Obr-076159	Oryza brachyantha	39.29	1.00e-07	48.90
IUUC-Ola-086903	Oryzias latipes	68.46	2.00e-55	209.00
IUUC-Oar-089838	Ovis aries	86.19	2.00e-176	611.00
IUUC-Ptr-090962	Pan troglodytes	92.56	0.00e+00	667.00
IUUC-Pan-092853	Papio anubis	91.74	0.00e+00	657.00
IUUC-Psi-093164	Pelodiscus sinensis	69.23	9.00e-125	439.00
IUUC-Pma-094104	Petromyzon marinus	44.10	2.00e-55	209.00
IUUC-Pab-098304	Pongo abelii	93.11	0.00e+00	666.00
IUUC-Pca-100316	Procavia capensis	87.05	4.00e-176	610.00
IUUC-Ppe-101490	Prunus persica	37.80	2.00e-09	57.00
IUUC-Pva-102612	Pteropus vampyrus	74.66	1.00e-148	519.00
IUUC-Rno-105449	Rattus norvegicus	87.02	0.00e+00	629.00
IUUC-Sha-107578	Sarcophilus harrisii	77.13	5.00e-150	523.00
IUUC-Sit-110649	Setaria italica	40.00	2.00e-09	54.70
IUUC-Sar-113638	Sorex araneus	83.75	2.00e-173	601.00
IUUC-Ssc-116401	Sus scrofa	90.08	0.00e+00	654.00
IUUC-Tru-118765	Takifugu rubripes	48.52	7.00e-78	283.00
IUUC-Tsy-118850	Tarsius syrichta	87.13	8.00e-146	509.00
IUUC-Tbe-128086	Tupaia belangeri	81.27	3.00e-166	577.00
IUUC-Ttr-128249	Tursiops truncatus	69.61	9.00e-137	479.00
IUUC-Vpa-130816	Vicugna pacos	86.05	3.00e-40	158.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence