iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC	COSMIC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	miRcode
RAID2
Protein-protein Interaction
IID	HINT	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-11	45.3	837	898

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqn......ddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + ++y+y++ +      ++eL l++Gd +++   +  + g  +g+  + g+rGl+P+nFve++ 
   Q: 837  FMAQYNYNPFEgpndhpEGELPLTAGDYIYIF-GDMDEDGFYEGE-LDDGRRGLVPSNFVEQIP 898
           5677777663222223379************9.9999*******5.999************985 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAKDSPSPLG ASPKKPGCSS PAAAVLENQR RELEKLRAEL EAERAGWRAE RRRFAARERQ 60
LREEAERERR QLADRLRSKW EAQRSRELRQ LQEEMQRERE AEIRQLLRWK EAEQRQLQQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGCCACCT GACCCAAATA CACCACCTGA ACCCACGACC AGGTATGCCC ACACCCCATG 60
GGTGGCCTTA ACACACACAC CCTGCCCCTT TCTCCAAGTA CAGGAGCAGC AGCCCAGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50853--FN3
PS50002--SH3

Pfam

PF07653--SH3_2
PF14604--SH3_9

SMART

SM00060--FN3
SM00326--SH3

KEGG

hsa:150221

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Eca-033941	Equus caballus	69.94	0.00e+00	1753.00
IUUC-Mmr-061493	Microcebus murinus	73.83	0.00e+00	1741.00
IUUC-Ocu-074737	Oryctolagus cuniculus	62.10	0.00e+00	1090.00
IUUC-Oga-088745	Otolemur garnettii	71.78	0.00e+00	1894.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence