iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011574

Ensembl Protein ID

ENSAMXP00000021059.1

UniProt Accession

W5LMJ7; W5LMJ7_ASTMX

Genbank Protein ID

ENSAMXP00000021059

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01043682

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000020449.1	ENSAMXT00000021059.1	ENSAMXP00000021059.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.50e-73	247.1	4095	4455

Active Site

Position(s)	Description	Evidence
4429	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq++ l+l+        + +++k+ l p p s+     +++l +f+G+llg+a++
   Q: 4095 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSTALSLLllcpsaaANRNKGKCILMPCPISY----AEEQLLHFFGQLLGIAIR 4177
           5667788********************************99988887767777999999999999....689*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelykslkeikena.esdieelgldltfsvseei...............lgetke 153
            + +l+l+l  sf+k l+g  l++ +dl+e d  +++++k+ ++   e+++e+l+++++++ ++ +                 + +e
   Q: 4178 ADVPLPLDLLGSFWKGLVGDVLDVdSDLQEADLLTFNYIKKFESVSdEAELEALCAEISSQNHSGEspdspsrpcctftyiTMSGEE 4264
           ************************9*************666665542778888888888886666689999******9977666677 PP
   S: 154  eeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggy 239
           +eL++gG+n  V +eNk+ Y + v ++r++e +  e+++a+r+G+ ++ipl+ll+++++ e+el +cG ++i++e lk++t+y+ g+
   Q: 4265 VELCQGGRNLAVSWENKDIYARSVRSLRIRElQNVECMNAVRAGLGSIIPLQLLTILSPLEMELRTCGLPYINLEFLKAHTMYQVGL 4351
           77*****************************9******************************************************* PP
   S: 240  tedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLPeY 313
           +e++++i++Fw +le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d r ++++TC+++ kLP+Y
   Q: 4352 METDQHIEFFWTALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgamGSPDLRHIRVETCMFMVKLPQY 4438
           *******************************************999999999888888888899666679***************** PP
   S: 314  sskeilkekLlyAieet 330
           ss +++ ekL+yAi+++
   Q: 4439 SSLDVMLEKLRYAIHYR 4455
           **************986 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MGSGAVDSSQ WLSVKEETIF LHDGLIRVTD LAELPSEIGA SEQGDAEQEI LTFETKNPVE 60
LADRLRSVCG NQSNAYARLL EYRLNALRGL WGAQRQLALE EQQEREGTTA AAGAGAGADD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTTTAGGA AAATATGGCG TCTCACTCAC AGCTGTGCGG GTTTTATTAT CTAGCTAGCT 60
TACTGCTAAT AAACCGAGCA GGGTAATTCG TGGTGTGATA CTCGTATACG GGGCGTAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	80.92	0.00e+00	4477.00
IUUC-Apl-004161	Anas platyrhynchos	84.29	0.00e+00	3027.00
IUUC-Aca-005341	Anolis carolinensis	76.90	0.00e+00	5725.00
IUUC-Bta-012514	Bos taurus	76.94	0.00e+00	1526.00
IUUC-Cja-019148	Callithrix jacchus	80.17	0.00e+00	4450.00
IUUC-Cfa-020499	Canis familiaris	81.88	0.00e+00	4900.00
IUUC-Cpo-021894	Cavia porcellus	84.60	0.00e+00	2409.00
IUUC-Csa-023079	Chlorocebus sabaeus	79.59	0.00e+00	6498.00
IUUC-Cho-024415	Choloepus hoffmanni	77.57	0.00e+00	4217.00
IUUC-Dre-027452	Danio rerio	86.67	0.00e+00	5460.00
IUUC-Dno-029595	Dasypus novemcinctus	81.11	0.00e+00	4982.00
IUUC-Dor-030849	Dipodomys ordii	84.93	0.00e+00	1556.00
IUUC-Ete-032563	Echinops telfairi	71.14	0.00e+00	910.00
IUUC-Eca-034202	Equus caballus	80.76	0.00e+00	4459.00
IUUC-Eeu-035175	Erinaceus europaeus	83.00	0.00e+00	947.00
IUUC-Fca-036295	Felis catus	83.41	0.00e+00	4398.00
IUUC-Fal-037003	Ficedula albicollis	79.20	0.00e+00	5694.00
IUUC-Gmo-038579	Gadus morhua	89.93	0.00e+00	2993.00
IUUC-Gga-040961	Gallus gallus	81.70	0.00e+00	5125.00
IUUC-Gac-041899	Gasterosteus aculeatus	90.48	0.00e+00	3070.00
IUUC-Ggo-045099	Gorilla gorilla	81.43	0.00e+00	5355.00
IUUC-Hsa-046331	Homo sapiens	79.82	0.00e+00	6398.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	76.71	0.00e+00	1533.00
IUUC-Lch-049923	Latimeria chalumnae	74.49	0.00e+00	2303.00
IUUC-Loc-052630	Lepisosteus oculatus	86.25	0.00e+00	4091.00
IUUC-Laf-053394	Loxodonta africana	82.12	0.00e+00	4736.00
IUUC-Mcc-055763	Macaca mulatta	79.22	0.00e+00	6519.00
IUUC-Meu-056039	Macropus eugenii	80.16	0.00e+00	3009.00
IUUC-Mga-059500	Meleagris gallopavo	81.12	0.00e+00	4502.00
IUUC-Mmr-060868	Microcebus murinus	76.12	0.00e+00	6306.00
IUUC-Mdo-062772	Monodelphis domestica	81.17	0.00e+00	5093.00
IUUC-Mmu-063606	Mus musculus	81.17	0.00e+00	5103.00
IUUC-Mpu-065860	Mustela putorius furo	78.84	0.00e+00	4348.00
IUUC-Mlu-067376	Myotis lucifugus	80.70	0.00e+00	4474.00
IUUC-Nle-069693	Nomascus leucogenys	77.80	0.00e+00	6186.00
IUUC-Opr-071065	Ochotona princeps	78.10	0.00e+00	942.00
IUUC-Ont-072470	Oreochromis niloticus	87.95	0.00e+00	4882.00
IUUC-Oan-073693	Ornithorhynchus anatinus	83.77	0.00e+00	3008.00
IUUC-Ocu-074032	Oryctolagus cuniculus	78.28	0.00e+00	6529.00
IUUC-Ola-087433	Oryzias latipes	88.92	0.00e+00	1682.00
IUUC-Oga-088546	Otolemur garnettii	83.00	0.00e+00	4281.00
IUUC-Oar-089643	Ovis aries	79.61	0.00e+00	677.00
IUUC-Ptr-090504	Pan troglodytes	79.32	0.00e+00	5989.00
IUUC-Pan-092543	Papio anubis	79.50	0.00e+00	6490.00
IUUC-Psi-093952	Pelodiscus sinensis	79.15	0.00e+00	4345.00
IUUC-Pfo-096356	Poecilia formosa	88.20	0.00e+00	5443.00
IUUC-Pab-098240	Pongo abelii	79.57	0.00e+00	6552.00
IUUC-Pca-100994	Procavia capensis	83.36	0.00e+00	2523.00
IUUC-Pva-102263	Pteropus vampyrus	80.08	0.00e+00	4404.00
IUUC-Rno-104888	Rattus norvegicus	82.19	0.00e+00	4750.00
IUUC-Sha-106944	Sarcophilus harrisii	80.37	0.00e+00	4488.00
IUUC-Sar-113556	Sorex araneus	76.85	0.00e+00	872.00
IUUC-Ssc-116187	Sus scrofa	85.76	0.00e+00	2902.00
IUUC-Tgu-116655	Taeniopygia guttata	84.38	0.00e+00	3029.00
IUUC-Tru-118093	Takifugu rubripes	89.59	0.00e+00	3156.00
IUUC-Tni-119739	Tetraodon nigroviridis	88.51	0.00e+00	1680.00
IUUC-Tbe-127962	Tupaia belangeri	63.49	0.00e+00	877.00
IUUC-Ttr-128819	Tursiops truncatus	84.54	0.00e+00	2141.00
IUUC-Vpa-130482	Vicugna pacos	79.57	0.00e+00	3745.00
IUUC-Xtr-132222	Xenopus tropicalis	77.96	0.00e+00	5893.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence