iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074032

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02061508

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000021959.2	ENSOCUT00000025354.2	ENSOCUP00000023034.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-76	258.4	4063	4423

Active Site

Position(s)	Description	Evidence
4397	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG llg+a++
   Q: 4063 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGHLLGMAIR 4145
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelykslkeikena.esdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y+++k  ++ + e+++e+l+++++++  +  ++                 + 
   Q: 4146 ADVPLPLDLLPSFWKTLVGEPLDPdQDLQEADILTYNYVKIFENINdETELEALCAEIASQhlA--TEspdspskpcckftylTMTG 4230
           **************************************88777554277888888888888532..334689999****99655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G+++pV++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+ ++ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ 
   Q: 4231 EEVELCSRGRHVPVAWENKDIYAAAIRSLRLRElQNVECVTAVRAGLGSIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQV 4317
           6667*****************************9***************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++      d+r ++++TC++++kLP
   Q: 4318 GLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGPPDSRHIRVETCMFMIKLP 4404
           *********************************************99999999988888888889966667**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei  +kL++Ai+++
   Q: 4405 QYSSLEITLDKLRCAIHYR 4423
           ****************986 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MGSSAAAAAA AADSAQWLSV KEETIFLHDG LIRVTDLAEL PSEILGAPEA ADTDLEILTF 60
ETKNPTELAE RLRSVCGNQS NAYARLLEYR LNALRGLWNA QRQLALEEQH ERESSGDEET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTTCGT CGGCGGCCGC GGCCGCCGCG GCCGCGGACT CGGCGCAGTG GCTCTCGGTG 60
AAGGAGGAGA CCATCTTCCT GCACGACGGG CTCATCCGGG TCACCGACCT GGCCGAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	95.10	0.00e+00	7060.00
IUUC-Apl-004161	Anas platyrhynchos	91.40	0.00e+00	5072.00
IUUC-Aca-005341	Anolis carolinensis	87.79	0.00e+00	6534.00
IUUC-Ame-011574	Astyanax mexicanus	80.24	0.00e+00	4983.00
IUUC-Bta-012514	Bos taurus	94.40	0.00e+00	1852.00
IUUC-Cja-019148	Callithrix jacchus	95.63	0.00e+00	5174.00
IUUC-Cfa-020499	Canis familiaris	96.06	0.00e+00	7597.00
IUUC-Cpo-021894	Cavia porcellus	91.36	0.00e+00	2745.00
IUUC-Csa-023079	Chlorocebus sabaeus	96.96	0.00e+00	7839.00
IUUC-Cho-024415	Choloepus hoffmanni	91.85	0.00e+00	5014.00
IUUC-Dre-027452	Danio rerio	78.72	0.00e+00	4982.00
IUUC-Dno-029595	Dasypus novemcinctus	95.69	0.00e+00	7757.00
IUUC-Dor-030849	Dipodomys ordii	95.16	0.00e+00	1769.00
IUUC-Ete-032563	Echinops telfairi	88.45	0.00e+00	1567.00
IUUC-Eca-034202	Equus caballus	95.47	0.00e+00	7018.00
IUUC-Eeu-035175	Erinaceus europaeus	94.21	0.00e+00	1023.00
IUUC-Fca-036295	Felis catus	95.77	0.00e+00	6955.00
IUUC-Fal-037003	Ficedula albicollis	91.49	0.00e+00	6615.00
IUUC-Gmo-038579	Gadus morhua	84.49	0.00e+00	2828.00
IUUC-Gga-040961	Gallus gallus	91.74	0.00e+00	7598.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.06	0.00e+00	2872.00
IUUC-Ggo-045099	Gorilla gorilla	96.56	0.00e+00	6272.00
IUUC-Hsa-046331	Homo sapiens	96.99	0.00e+00	7720.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	94.84	0.00e+00	2058.00
IUUC-Lch-049923	Latimeria chalumnae	83.54	0.00e+00	2622.00
IUUC-Loc-052630	Lepisosteus oculatus	83.17	0.00e+00	3966.00
IUUC-Laf-053394	Loxodonta africana	95.73	0.00e+00	7437.00
IUUC-Mcc-055763	Macaca mulatta	96.51	0.00e+00	7859.00
IUUC-Meu-056039	Macropus eugenii	88.17	0.00e+00	4973.00
IUUC-Mga-059500	Meleagris gallopavo	90.39	0.00e+00	6830.00
IUUC-Mmr-060868	Microcebus murinus	93.44	0.00e+00	7639.00
IUUC-Mdo-062772	Monodelphis domestica	93.32	0.00e+00	7712.00
IUUC-Mmu-063606	Mus musculus	95.79	0.00e+00	7873.00
IUUC-Mpu-065860	Mustela putorius furo	93.28	0.00e+00	6925.00
IUUC-Mlu-067376	Myotis lucifugus	94.96	0.00e+00	5276.00
IUUC-Nle-069693	Nomascus leucogenys	94.69	0.00e+00	7485.00
IUUC-Opr-071065	Ochotona princeps	94.01	0.00e+00	1216.00
IUUC-Ont-072470	Oreochromis niloticus	81.65	0.00e+00	4593.00
IUUC-Oan-073693	Ornithorhynchus anatinus	91.36	0.00e+00	5104.00
IUUC-Ola-087433	Oryzias latipes	82.78	0.00e+00	1575.00
IUUC-Oga-088546	Otolemur garnettii	96.58	0.00e+00	6832.00
IUUC-Oar-089643	Ovis aries	90.15	0.00e+00	729.00
IUUC-Ptr-090504	Pan troglodytes	95.94	0.00e+00	7175.00
IUUC-Pan-092543	Papio anubis	96.85	0.00e+00	7821.00
IUUC-Psi-093952	Pelodiscus sinensis	88.57	0.00e+00	6727.00
IUUC-Pfo-096356	Poecilia formosa	80.25	0.00e+00	6701.00
IUUC-Pab-098240	Pongo abelii	96.78	0.00e+00	7906.00
IUUC-Pca-100994	Procavia capensis	95.83	0.00e+00	2961.00
IUUC-Pva-102263	Pteropus vampyrus	94.33	0.00e+00	7007.00
IUUC-Rno-104888	Rattus norvegicus	95.58	0.00e+00	7363.00
IUUC-Sha-106944	Sarcophilus harrisii	91.45	0.00e+00	6955.00
IUUC-Sar-113556	Sorex araneus	84.45	0.00e+00	919.00
IUUC-Ssc-116187	Sus scrofa	96.37	0.00e+00	5033.00
IUUC-Tgu-116655	Taeniopygia guttata	91.12	0.00e+00	5022.00
IUUC-Tru-118093	Takifugu rubripes	83.12	0.00e+00	2981.00
IUUC-Tni-119739	Tetraodon nigroviridis	82.88	0.00e+00	1598.00
IUUC-Tbe-127962	Tupaia belangeri	91.63	0.00e+00	1194.00
IUUC-Ttr-128819	Tursiops truncatus	90.86	0.00e+00	2772.00
IUUC-Vpa-130482	Vicugna pacos	93.21	0.00e+00	4421.00
IUUC-Xtr-132222	Xenopus tropicalis	85.31	0.00e+00	6472.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence