iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013147

Ensembl Protein ID

ENSBTAP00000005932.5

UniProt Accession

F1N6T8; F1N6T8_BOVIN

Genbank Protein ID

ENSBTAP00000005932

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02032350

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000004511.5	ENSBTAT00000005932.5	ENSBTAP00000005932.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.30e-18	66.0	664	715

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 664  ARYNFAARDLRELSLREGDVVKIYSRIGGDQGWWKG--ETSGRVGWFPSTYVEE 715
           67**********************************..9*************86 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

EHGVGEDIYD CVPCEDDGDD IYEDIIKVEV QQPMKMGMTE DDKRNCCLLE IQETEAKYYR 60
TLEDIEKNYV TPLRLVLSPV DMAAIFINLE DLIKVHHSFL RAIDVSMMAG GSSLAKVFLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCACGGCG TGGGAGAGGA CATCTATGAC TGCGTCCCGT GCGAGGATGA CGGGGACGAC 60
ATCTATGAGG ACATCATCAA GGTGGAGGTG CAGCAGCCCA TGGTGAGCCT GCCTGCCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	92.59	0.00e+00	1260.00
IUUC-Apl-003262	Anas platyrhynchos	89.15	0.00e+00	1244.00
IUUC-Aca-004628	Anolis carolinensis	64.85	0.00e+00	834.00
IUUC-Ath-007352	Arabidopsis thaliana	37.70	3.00e-04	40.40
IUUC-Ame-011608	Astyanax mexicanus	75.58	0.00e+00	1113.00
IUUC-Cja-018877	Callithrix jacchus	89.29	0.00e+00	1215.00
IUUC-Cfa-020315	Canis familiaris	90.96	0.00e+00	1258.00
IUUC-Cpo-021543	Cavia porcellus	92.24	0.00e+00	1280.00
IUUC-Csa-024204	Chlorocebus sabaeus	90.09	0.00e+00	1276.00
IUUC-Dre-028308	Danio rerio	77.93	0.00e+00	1140.00
IUUC-Dno-029584	Dasypus novemcinctus	87.35	0.00e+00	1157.00
IUUC-Dor-031014	Dipodomys ordii	79.47	0.00e+00	1041.00
IUUC-Eca-033448	Equus caballus	90.67	0.00e+00	1259.00
IUUC-Eeu-035182	Erinaceus europaeus	83.70	1.00e-152	533.00
IUUC-Fca-035460	Felis catus	92.49	0.00e+00	1282.00
IUUC-Fal-036684	Ficedula albicollis	86.94	0.00e+00	1231.00
IUUC-Gmo-038816	Gadus morhua	74.55	0.00e+00	1050.00
IUUC-Gga-040999	Gallus gallus	85.67	0.00e+00	1217.00
IUUC-Gac-041353	Gasterosteus aculeatus	75.93	0.00e+00	1082.00
IUUC-Ggo-044558	Gorilla gorilla	92.46	0.00e+00	1286.00
IUUC-Hsa-046208	Homo sapiens	92.46	0.00e+00	1287.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	88.91	0.00e+00	1188.00
IUUC-Loc-052827	Lepisosteus oculatus	79.89	0.00e+00	1150.00
IUUC-Laf-054009	Loxodonta africana	88.69	0.00e+00	1236.00
IUUC-Mcc-055054	Macaca mulatta	92.32	0.00e+00	1285.00
IUUC-Meu-056269	Macropus eugenii	83.96	0.00e+00	747.00
IUUC-Mga-060106	Meleagris gallopavo	89.15	0.00e+00	1242.00
IUUC-Mmr-061118	Microcebus murinus	91.79	0.00e+00	1274.00
IUUC-Mdo-062380	Monodelphis domestica	85.91	0.00e+00	1239.00
IUUC-Mmu-063135	Mus musculus	93.18	0.00e+00	1309.00
IUUC-Mpu-066135	Mustela putorius furo	90.13	0.00e+00	1268.00
IUUC-Nle-069465	Nomascus leucogenys	85.08	0.00e+00	1161.00
IUUC-Ont-071945	Oreochromis niloticus	78.57	0.00e+00	1101.00
IUUC-Oan-073384	Ornithorhynchus anatinus	87.40	0.00e+00	1209.00
IUUC-Ola-087499	Oryzias latipes	75.42	0.00e+00	1070.00
IUUC-Oga-088444	Otolemur garnettii	89.71	0.00e+00	1257.00
IUUC-Oar-089576	Ovis aries	92.43	0.00e+00	1260.00
IUUC-Ptr-090507	Pan troglodytes	93.74	0.00e+00	1293.00
IUUC-Pan-092325	Papio anubis	88.73	0.00e+00	1243.00
IUUC-Psi-094021	Pelodiscus sinensis	85.52	0.00e+00	1208.00
IUUC-Pma-094372	Petromyzon marinus	52.88	0.00e+00	699.00
IUUC-Pfo-096732	Poecilia formosa	78.20	0.00e+00	1110.00
IUUC-Pab-098426	Pongo abelii	75.72	0.00e+00	1016.00
IUUC-Pca-100295	Procavia capensis	92.00	0.00e+00	1296.00
IUUC-Rno-105332	Rattus norvegicus	92.35	0.00e+00	1233.00
IUUC-Sha-106529	Sarcophilus harrisii	92.63	0.00e+00	1271.00
IUUC-Ssc-116176	Sus scrofa	94.32	0.00e+00	1308.00
IUUC-Tgu-116917	Taeniopygia guttata	89.15	0.00e+00	1238.00
IUUC-Tru-118398	Takifugu rubripes	78.03	0.00e+00	979.00
IUUC-Tni-120819	Tetraodon nigroviridis	78.56	0.00e+00	1123.00
IUUC-Xtr-132747	Xenopus tropicalis	76.01	0.00e+00	1068.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence