iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046303

Ensembl Protein ID

ENSP00000323670.3

UniProt Accession

O95365; D6W619; O00456; Q14D41; Q5XG86; ZBT7A_HUMAN

Genbank Protein ID

AAC72973.1; AAB58414.1; EAW69267.1; EAW69268.1; EAW69270.1; EAW69271.1; EAW69272.1; AAH84568.1; AAI13512.1

Protein Name

Zinc finger and BTB domain-containing protein 7A; Factor binding IST protein 1; Factor that binds to inducer of short transcripts protein 1; HIV-1 1st-binding protein 1; Leukemia/lymphoma-related factor; POZ and Krueppel erythroid myeloid ontogenic factor; TTF-I-interacting peptide 21; Zinc finger protein 857A

Genbank Nucleotide ID

AF097916; AF000561; CH471139; CH471139; CH471139; CH471139; CH471139; BC084568; BC113511

Gene Name

ZBTB7A; FBI1; LRF; ZBTB7; ZNF857A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000178951.8	ENST00000322357.8	ENSP00000323670.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	JASPAR	circBase
circRNADb	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.50e-15	58.9	34	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv++ v+g+ef++h++vLaa+S++F++lf+++    + ++ +ei+ v++e++ al++F Yt +l+ 
   Q: 34   CDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQ-QNVYEIDFVSAEALTALMDFAYTATLTV 99
           8**********************************666.9**********************99975 PP

Organism

Homo sapiens

Functional Description
(View)

Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).

Protein Sequence
(Fasta)

MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS VLAACSQYFK 60
KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS TANVGDILSA ARLLEIPAVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCTGCG GCACCTTTAA GACAAGGGAG GACCCCTCTT GCCCTCGGAG AAACCAGGAA 60
GGGAGTCGCG AGCATCATAC GGGGCTTTGG CTGTACTGTA CAGTTACTGT AGGGGCAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0035035--F:histone acetyltransferase binding
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0030154--P:cell differentiation
GO:0007275--P:multicellular organism development
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:51341

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001947	Ailuropoda melanoleuca	98.78	6.00e-87	312.00
IUUC-Apl-003455	Anas platyrhynchos	65.52	0.00e+00	682.00
IUUC-Ame-011315	Astyanax mexicanus	65.14	1.00e-80	294.00
IUUC-Bta-012885	Bos taurus	92.86	0.00e+00	818.00
IUUC-Cja-019289	Callithrix jacchus	94.02	0.00e+00	845.00
IUUC-Cfa-020143	Canis familiaris	88.67	0.00e+00	805.00
IUUC-Cpo-021474	Cavia porcellus	81.59	0.00e+00	791.00
IUUC-Csa-024242	Chlorocebus sabaeus	99.49	0.00e+00	793.00
IUUC-Dre-027425	Danio rerio	49.72	9.00e-128	450.00
IUUC-Dno-029452	Dasypus novemcinctus	88.13	0.00e+00	669.00
IUUC-Dor-031002	Dipodomys ordii	94.59	0.00e+00	694.00
IUUC-Eeu-034736	Erinaceus europaeus	88.89	1.00e-81	296.00
IUUC-Fal-037513	Ficedula albicollis	67.86	0.00e+00	692.00
IUUC-Gga-040265	Gallus gallus	65.47	0.00e+00	646.00
IUUC-Gac-041962	Gasterosteus aculeatus	70.23	3.00e-85	308.00
IUUC-Ggo-045371	Gorilla gorilla	71.95	0.00e+00	650.00
IUUC-Itr-047921	Ictidomys tridecemlineatus	93.75	6.00e-90	324.00
IUUC-Lch-049776	Latimeria chalumnae	58.58	9.00e-163	566.00
IUUC-Loc-052112	Lepisosteus oculatus	57.60	3.00e-82	299.00
IUUC-Meu-056706	Macropus eugenii	69.18	0.00e+00	706.00
IUUC-Mga-060164	Meleagris gallopavo	65.47	0.00e+00	652.00
IUUC-Mmr-061124	Microcebus murinus	93.53	0.00e+00	735.00
IUUC-Mdo-061864	Monodelphis domestica	87.38	4.00e-105	375.00
IUUC-Mmu-063777	Mus musculus	84.91	0.00e+00	743.00
IUUC-Mpu-065739	Mustela putorius furo	95.05	0.00e+00	807.00
IUUC-Mlu-067158	Myotis lucifugus	90.32	0.00e+00	783.00
IUUC-Opr-070700	Ochotona princeps	81.25	0.00e+00	732.00
IUUC-Ont-071557	Oreochromis niloticus	66.06	1.00e-79	291.00
IUUC-Oan-073589	Ornithorhynchus anatinus	74.39	2.00e-106	379.00
IUUC-Oga-089163	Otolemur garnettii	96.41	0.00e+00	869.00
IUUC-Oar-089886	Ovis aries	90.00	0.00e+00	763.00
IUUC-Ptr-091558	Pan troglodytes	100.00	0.00e+00	874.00
IUUC-Pan-092337	Papio anubis	99.66	0.00e+00	793.00
IUUC-Psi-093220	Pelodiscus sinensis	66.67	0.00e+00	676.00
IUUC-Pma-094176	Petromyzon marinus	44.12	1.00e-27	117.00
IUUC-Pfo-096769	Poecilia formosa	63.56	6.00e-77	281.00
IUUC-Pab-097551	Pongo abelii	100.00	0.00e+00	665.00
IUUC-Pva-102777	Pteropus vampyrus	84.70	0.00e+00	738.00
IUUC-Rno-106040	Rattus norvegicus	86.62	0.00e+00	819.00
IUUC-Sha-107596	Sarcophilus harrisii	70.22	0.00e+00	670.00
IUUC-Ssc-116026	Sus scrofa	94.69	0.00e+00	869.00
IUUC-Tru-118073	Takifugu rubripes	50.70	3.00e-121	429.00
IUUC-Tni-120736	Tetraodon nigroviridis	67.39	1.00e-83	303.00
IUUC-Ttr-128563	Tursiops truncatus	92.04	0.00e+00	778.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence