iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036578

Ensembl Protein ID

ENSFCAP00000004918.3

UniProt Accession

M3W3U6; M3W3U6_FELCA

Genbank Protein ID

ENSFCAP00000004918

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AANG02114739

Gene Name

ABL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000005305.3	ENSFCAT00000005306.3	ENSFCAP00000004918.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-12	47.0	36	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++q+++W +     ++ +G +P+n+++ ++
   Q: 36   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNQNGEWSEV--RSKNGQGWVPSNYITPVN 93
           67899************************.*********98..788899*********997 PP

Organism

Felis catus

Protein Sequence
(Fasta)

EALHRPYGCD VEPQALNEAI RWSSKENLLG ATESDPNLFV ALYDFVASGD NTLSITKGEK 60
LRVLGYNQNG EWSEVRSKNG QGWVPSNYIT PVNSLEKHSW YHGPVSRSAA EYLLSSLING 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGCCTTGC ACCGCCCCTA TGGTTGTGAT GTTGAACCCC AGGCACTGAA TGAAGCCATC 60
AGGTGGAGCT CCAAGGAGAA CTTACTTGGA GCCACTGAGA GTGACCCTAA TCTCTTTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0071300--P:cellular response to retinoic acid
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0010976--P:positive regulation of neuron projection development
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0010863--P:positive regulation of phospholipase C activity
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002263	Ailuropoda melanoleuca	90.13	0.00e+00	1815.00
IUUC-Atr-002778	Amborella trichopoda	32.49	4.00e-23	103.00
IUUC-Apl-003389	Anas platyrhynchos	79.58	0.00e+00	1573.00
IUUC-Bta-013370	Bos taurus	89.51	0.00e+00	1792.00
IUUC-Cja-018894	Callithrix jacchus	89.79	0.00e+00	1813.00
IUUC-Cfa-020398	Canis familiaris	98.68	0.00e+00	1228.00
IUUC-Cpo-022367	Cavia porcellus	87.68	0.00e+00	1709.00
IUUC-Csa-023386	Chlorocebus sabaeus	90.13	0.00e+00	1811.00
IUUC-Cho-024714	Choloepus hoffmanni	95.24	0.00e+00	1373.00
IUUC-Dre-027741	Danio rerio	65.35	0.00e+00	1289.00
IUUC-Dno-029246	Dasypus novemcinctus	89.31	0.00e+00	1823.00
IUUC-Dor-030416	Dipodomys ordii	81.79	0.00e+00	1597.00
IUUC-Ete-032899	Echinops telfairi	79.96	1.00e-137	484.00
IUUC-Eca-033387	Equus caballus	90.40	0.00e+00	1772.00
IUUC-Eeu-035058	Erinaceus europaeus	80.90	0.00e+00	1667.00
IUUC-Fal-037491	Ficedula albicollis	82.34	0.00e+00	1698.00
IUUC-Gmo-038509	Gadus morhua	77.06	0.00e+00	1108.00
IUUC-Gga-040638	Gallus gallus	81.97	0.00e+00	1655.00
IUUC-Gac-042550	Gasterosteus aculeatus	76.73	0.00e+00	1137.00
IUUC-Ggo-044487	Gorilla gorilla	89.78	0.00e+00	1806.00
IUUC-Hsa-046636	Homo sapiens	89.87	0.00e+00	1805.00
IUUC-Itr-048685	Ictidomys tridecemlineatus	89.27	0.00e+00	1781.00
IUUC-Lch-049530	Latimeria chalumnae	72.40	0.00e+00	1417.00
IUUC-Loc-051933	Lepisosteus oculatus	74.46	0.00e+00	1234.00
IUUC-Laf-053802	Loxodonta africana	89.74	0.00e+00	1834.00
IUUC-Mcc-054836	Macaca mulatta	90.22	0.00e+00	1824.00
IUUC-Mga-059277	Meleagris gallopavo	81.88	0.00e+00	1675.00
IUUC-Mmr-061206	Microcebus murinus	89.18	0.00e+00	1743.00
IUUC-Mdo-062281	Monodelphis domestica	94.42	0.00e+00	1190.00
IUUC-Mmu-063847	Mus musculus	87.92	0.00e+00	1684.00
IUUC-Mpu-066309	Mustela putorius furo	98.52	0.00e+00	1227.00
IUUC-Mlu-068070	Myotis lucifugus	89.69	0.00e+00	1799.00
IUUC-Nle-070062	Nomascus leucogenys	98.36	0.00e+00	1223.00
IUUC-Opr-070534	Ochotona princeps	83.84	0.00e+00	951.00
IUUC-Ont-072440	Oreochromis niloticus	75.75	0.00e+00	1125.00
IUUC-Oan-073526	Ornithorhynchus anatinus	82.82	0.00e+00	1411.00
IUUC-Ocu-074051	Oryctolagus cuniculus	88.20	0.00e+00	1698.00
IUUC-Ola-086752	Oryzias latipes	95.27	0.00e+00	914.00
IUUC-Oga-088767	Otolemur garnettii	83.69	0.00e+00	1636.00
IUUC-Oar-089800	Ovis aries	89.69	0.00e+00	1798.00
IUUC-Ptr-090857	Pan troglodytes	98.52	0.00e+00	1224.00
IUUC-Pan-092279	Papio anubis	90.13	0.00e+00	1806.00
IUUC-Psi-093573	Pelodiscus sinensis	82.76	0.00e+00	1631.00
IUUC-Pfo-096543	Poecilia formosa	76.29	0.00e+00	1105.00
IUUC-Pab-097949	Pongo abelii	89.99	0.00e+00	1796.00
IUUC-Pca-100370	Procavia capensis	85.94	0.00e+00	1277.00
IUUC-Pva-103220	Pteropus vampyrus	81.80	0.00e+00	1548.00
IUUC-Rno-105924	Rattus norvegicus	86.02	0.00e+00	1689.00
IUUC-Sha-107114	Sarcophilus harrisii	83.30	0.00e+00	1579.00
IUUC-Sit-110219	Setaria italica	30.30	6.00e-20	92.80
IUUC-Ssc-115968	Sus scrofa	89.45	0.00e+00	1849.00
IUUC-Tgu-117301	Taeniopygia guttata	82.06	0.00e+00	1623.00
IUUC-Tru-118410	Takifugu rubripes	65.36	0.00e+00	1259.00
IUUC-Tni-119991	Tetraodon nigroviridis	71.93	0.00e+00	1144.00
IUUC-Tbe-127362	Tupaia belangeri	94.97	0.00e+00	1402.00
IUUC-Ttr-129291	Tursiops truncatus	89.24	0.00e+00	1792.00
IUUC-Vpa-130800	Vicugna pacos	94.85	0.00e+00	1436.00
IUUC-Xtr-132965	Xenopus tropicalis	81.35	0.00e+00	1188.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence