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Tag Content
UUCD2 ID IUUC-Bta-012359
UUCD1 version UUC-BoT-01152
Ensembl Protein ID ENSBTAP00000008257.4
UniProt Accession Q1RMU2; CYLD_BOVIN
Genbank Protein ID AAI14711.1
Protein Name Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD
Genbank Nucleotide ID BC114710
Gene Name CYLD; CYLD1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000006291.4 ENSBTAT00000008257.4 ENSBTAP00000008257.4
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.10e-24 87.4 590 946
Active Site
Position(s) Description Evidence
598 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092}
868 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092}
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 590  GIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 676
           999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  ek++k +  +i++l++ ++ ++ +k    ++c  ++  r+ + ++l 
   Q: 677  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLECSFINSnLKfaeAPSCLIIQmPRFGKDFKLF 763
           ****************99..88999999999999**************************9854144444799****99********** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++ + +   k+k++++      +lh kR   +       +  + v++p+
   Q: 764  KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDPDISAG-KIKQFCKtcnaQVHLHPKRL--N-------HKYNPVSLPK 839
           ****99998...***************987655********9984443.66666663335689999999..2.......3356788886 PP
   S: 258  eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg 327
            L   d ++ c+        ++k eL+av++ +      HYva+vk  k++  Wl fd               +Vt+++e  e l+++ 
   Q: 840  DLpdwDWRHGCIP-------CQKMELFAVLCIET----SHYVAFVKYGKDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSL 917
           6511144444555.......9**********999....9********777788*****9999********9999999987688888777 PP
   S: 328  ...................staYvlfYkr 337
                              ++aY+++Y++
   Q: 918  ddlhsldsrriqgcarrllCDAYMCMYQS 946
           999999999******************85 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (By similarity). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (By similarity). Negative regulator of Wnt signaling (By similarity). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (By similarity). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (By similarity). Required for normal cell cycle progress and normal cytokinesis (By similarity). Inhibits nuclear translocation of NF-kappa-B (By similarity). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (By similarity). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Also able to remove linear ('Met-1'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and, together with OTULIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity).
 Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (By similarity). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (By similarity). Negative regulator of Wnt signaling (By similarity). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (By similarity). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (By similarity). Required for normal cell cycle progress and normal cytokinesis (By similarity). Inhibits nuclear translocation of NF-kappa-B (By similarity). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (By similarity). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Also able to remove linear ('Met-1'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and, together with OTULIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity).
Protein Sequence
(Fasta)
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQNI QDRSVGLSRI 60
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012359|DUB,USP|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTTGGCTGC GCGGGGGCCC TCGCGTCTGA GGTAAATACT AGGGCGGTGG GTGTGGGACG 60
GCAGGGCCAG CCGGGGAAGC GGGCTAGAGA GACTGGGGAA GGGGCGACGC CCCGCCCCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012359|DUB,USP|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0378--Hydrolase
KW-0391--Immunity
KW-0399--Innate immunity
KW-0472--Membrane
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0048471--C:perinuclear region of cytoplasm
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0070266--P:necroptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:0070536--P:protein K63-linked deubiquitination
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG bta:536421
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 97.18 0.00e+00 1916.00
IUUC-Apl-003356 Anas platyrhynchos 87.32 0.00e+00 1690.00
IUUC-Aca-004402 Anolis carolinensis 80.94 0.00e+00 1518.00
IUUC-Ame-011581 Astyanax mexicanus 68.44 0.00e+00 1234.00
IUUC-Cel-018528 Caenorhabditis elegans 34.91 6.00e-56 213.00
IUUC-Cja-018797 Callithrix jacchus 95.92 0.00e+00 1892.00
IUUC-Cfa-020264 Canis familiaris 97.27 0.00e+00 1917.00
IUUC-Cpo-022057 Cavia porcellus 96.44 0.00e+00 1905.00
IUUC-Csa-023093 Chlorocebus sabaeus 96.96 0.00e+00 1905.00
IUUC-Cho-024486 Choloepus hoffmanni 81.53 2.00e-174 606.00
IUUC-Cin-025179 Ciona intestinalis 43.69 1.00e-115 410.00
IUUC-Dre-028233 Danio rerio 67.25 0.00e+00 1260.00
IUUC-Dno-029496 Dasypus novemcinctus 96.22 0.00e+00 1901.00
IUUC-Dor-030919 Dipodomys ordii 89.54 0.00e+00 1739.00
IUUC-Dme-032159 Drosophila melanogaster 46.34 4.00e-124 438.00
IUUC-Ete-032734 Echinops telfairi 90.17 0.00e+00 1766.00
IUUC-Eca-033350 Equus caballus 97.90 0.00e+00 1928.00
IUUC-Eeu-034566 Erinaceus europaeus 98.39 9.00e-115 408.00
IUUC-Fca-035632 Felis catus 96.45 0.00e+00 1337.00
IUUC-Fal-037313 Ficedula albicollis 82.29 0.00e+00 1577.00
IUUC-Gmo-039239 Gadus morhua 67.46 0.00e+00 1217.00
IUUC-Gga-040668 Gallus gallus 87.32 0.00e+00 1687.00
IUUC-Gac-042630 Gasterosteus aculeatus 67.64 0.00e+00 1202.00
IUUC-Ggo-044462 Gorilla gorilla 96.55 0.00e+00 1898.00
IUUC-Hsa-045846 Homo sapiens 96.55 0.00e+00 1898.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 94.90 0.00e+00 846.00
IUUC-Lch-050303 Latimeria chalumnae 70.44 0.00e+00 1296.00
IUUC-Loc-052190 Lepisosteus oculatus 69.72 0.00e+00 1282.00
IUUC-Laf-054480 Loxodonta africana 91.73 0.00e+00 753.00
IUUC-Mcc-055849 Macaca mulatta 96.65 0.00e+00 1901.00
IUUC-Meu-056755 Macropus eugenii 83.33 0.00e+00 886.00
IUUC-Mga-059561 Meleagris gallopavo 86.94 0.00e+00 1680.00
IUUC-Mmr-060942 Microcebus murinus 96.97 0.00e+00 1899.00
IUUC-Mdo-062618 Monodelphis domestica 92.26 0.00e+00 1835.00
IUUC-Mmu-063843 Mus musculus 94.67 0.00e+00 1811.00
IUUC-Mpu-066919 Mustela putorius furo 97.17 0.00e+00 1916.00
IUUC-Mlu-066983 Myotis lucifugus 90.66 0.00e+00 1768.00
IUUC-Nle-069893 Nomascus leucogenys 96.65 0.00e+00 1898.00
IUUC-Opr-071181 Ochotona princeps 87.71 0.00e+00 1589.00
IUUC-Ont-071697 Oreochromis niloticus 68.89 0.00e+00 1197.00
IUUC-Oan-073658 Ornithorhynchus anatinus 90.24 0.00e+00 1774.00
IUUC-Ocu-074954 Oryctolagus cuniculus 96.65 0.00e+00 1907.00
IUUC-Ola-086523 Oryzias latipes 66.22 0.00e+00 1186.00
IUUC-Oga-089003 Otolemur garnettii 96.97 0.00e+00 1913.00
IUUC-Oar-090376 Ovis aries 98.96 0.00e+00 1951.00
IUUC-Ptr-090520 Pan troglodytes 94.77 0.00e+00 1847.00
IUUC-Pan-092281 Papio anubis 96.96 0.00e+00 1905.00
IUUC-Psi-093047 Pelodiscus sinensis 88.70 0.00e+00 1617.00
IUUC-Pma-094575 Petromyzon marinus 55.50 1.00e-66 245.00
IUUC-Pfo-096358 Poecilia formosa 66.43 0.00e+00 1143.00
IUUC-Pab-097740 Pongo abelii 96.23 0.00e+00 1892.00
IUUC-Pca-100461 Procavia capensis 86.59 0.00e+00 1525.00
IUUC-Pva-102134 Pteropus vampyrus 86.09 0.00e+00 1671.00
IUUC-Rno-105807 Rattus norvegicus 93.28 0.00e+00 1781.00
IUUC-Sha-107236 Sarcophilus harrisii 93.16 0.00e+00 1784.00
IUUC-Sar-113366 Sorex araneus 98.00 0.00e+00 932.00
IUUC-Tgu-117201 Taeniopygia guttata 84.31 0.00e+00 1616.00
IUUC-Tru-117953 Takifugu rubripes 67.85 0.00e+00 1197.00
IUUC-Tsy-119610 Tarsius syrichta 94.77 0.00e+00 1862.00
IUUC-Tni-120743 Tetraodon nigroviridis 53.67 4.00e-137 482.00
IUUC-Tbe-128155 Tupaia belangeri 78.40 0.00e+00 753.00
IUUC-Ttr-128942 Tursiops truncatus 92.68 0.00e+00 1802.00
IUUC-Vpa-130281 Vicugna pacos 87.23 0.00e+00 1669.00
IUUC-Xtr-132627 Xenopus tropicalis 75.92 0.00e+00 1402.00
Created Date 25-Jun-2017

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