iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sbi-113813

UUCD1 version

UUC-SoB-01604

Ensembl Protein ID

Sb01g003290.1

UniProt Accession

A0A1B6QH59; A0A1B6QH59_SORBI

Genbank Protein ID

KXG37258.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

CM000760

Gene Name

SORBI_001G035200

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Sb01g003290	Sb01g003290.1	Sb01g003290.1
Sb01g003290	Sb01g003290.2	Sb01g003290.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.40e-109	367.1	14	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahees 96
           YDRQ+r+wG+++q++l++a+++l+++g++G+E lKnLvl+G+gs+tvvD+++ve s+l+++FL+++   g+++A++ + +l+eln+ v+++++ee 
   Q: 14   YDRQLRIWGDQGQAALEKASICLLNCGPTGTEALKNLVLGGIGSVTVVDGSKVEASDLGNNFLLDEGCLGQPRAKSICSFLQELNDAVKAKFVEEF 109
           ************************************************************************************************ PP
   S: 97   iteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn....... 181
           +  l ++++ Ff++f+vV++++ ++++ +k++++c++a++ l+ ++++Gl G vrv++k++ +++s++d   d++++ +P+ +lk++         
   Q: 110  PAHLIDTNPsFFSQFTVVIATQLPESSLLKLDDICRKADIVLVAARSYGLTGLVRVSVKEHCVIESKPDhflDDLRLHNPWTELKQFAKsidindk 205
           ***************************************************************************************888999999 PP
   S: 182  ..aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv 274
             +++++++++v++  l+e++a +++++ +++++ek+e+kd++++ + + deen++ea+  + k   +  i++ i+q++++   ++v++s+s+fw+
   Q: 206  dpVVHKHTPYIVILVRLAEKWADAHDGNMPSTRQEKKEFKDLIRAHMLNIDEENYKEAVDSSYKVSVTPGISNeIRQIIDD-DSAEVNSSSSDFWI 300
           99*******************************************************************************.56699********* PP
   S: 275  ...........................................................................sfcsnaealq........... 284
                                                                                      +fc+n+++l+           
   Q: 301  lvaalkefiakegngelplegtipdmtslteyyvslqkiyqakaefdclalehhvkeilkrigrdpdsisrayikTFCKNSRKLRicryrsfeeef 396
           *************************************************************************************77777777666 PP
   S: 285  vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagniipaiattna 374
           + + v + +++++++++     +y+llra++r++++++r pg+++ e d+d +++l+t aa+   +++g+++  l++dli+e+++++ ++i++++a
   Q: 397  SSPMVSEIQRYFTDEDYsyamnFYILLRAVDRLAANYSRLPGVFDSEIDED-IPRLKTVAASVL-SEMGLNGaSLSEDLITEMCRFGGAEIHPVAA 490
           6699999999999999999********************************.999999999887.******************************* PP
   S: 375  vvgGlaaqEviKvvsgkfeplknfflfdae 404
           +vgG+a+qEviK+v+++f+pl+ +f+f+++
   Q: 491  FVGGVASQEVIKLVTKQFVPLRGTFIFNGI 520
           ***************************986 PP

Organism

Sorghum bicolor

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAATGVVAEP KTKYDRQLRI WGDQGQAALE KASICLLNCG PTGTEALKNL VLGGIGSVTV 60
VDGSKVEASD LGNNFLLDEG CLGQPRAKSI CSFLQELNDA VKAKFVEEFP AHLIDTNPSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTATTCCT CGCCGGAGCA TAGCGGGGCG AAGCATCCGA ACTCCGAAAA CCCCAGGGCA 60
GCGAACGCAG CGGCCAACCG TCCCCTCCGC CCCGCCCCGC AGCCATGGCT GCCACCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	86.70	0.00e+00	936.00
IUUC-Aml-002333	Ailuropoda melanoleuca	44.24	4.00e-134	470.00
IUUC-Atr-002644	Amborella trichopoda	69.02	0.00e+00	756.00
IUUC-Apl-003446	Anas platyrhynchos	42.69	1.00e-121	429.00
IUUC-Aca-004450	Anolis carolinensis	43.18	1.00e-129	456.00
IUUC-Aly-005466	Arabidopsis lyrata	67.05	0.00e+00	763.00
IUUC-Ath-006692	Arabidopsis thaliana	67.56	0.00e+00	763.00
IUUC-Ago-007900	Ashbya gossypii	27.22	2.00e-40	159.00
IUUC-Acl-008333	Aspergillus clavatus	33.15	5.00e-70	257.00
IUUC-Afl-008529	Aspergillus flavus	33.94	3.00e-76	278.00
IUUC-Afu-009071	Aspergillus fumigatus	32.19	5.00e-67	247.00
IUUC-Ani-009443	Aspergillus nidulans	31.84	2.00e-64	239.00
IUUC-Ang-009669	Aspergillus niger	31.44	3.00e-69	254.00
IUUC-Aor-009914	Aspergillus oryzae	33.63	2.00e-74	272.00
IUUC-Ate-010450	Aspergillus terreus	31.51	6.00e-69	254.00
IUUC-Ame-011183	Astyanax mexicanus	41.39	9.00e-125	439.00
IUUC-Bgr-012111	Blumeria graminis	32.66	8.00e-63	233.00
IUUC-Bta-012583	Bos taurus	44.59	3.00e-135	474.00
IUUC-Bci-013892	Botrytis cinerea	31.99	8.00e-60	223.00
IUUC-Bdi-014592	Brachypodium distachyon	88.29	0.00e+00	944.00
IUUC-Bol-016399	Brassica oleracea	67.69	0.00e+00	767.00
IUUC-Bra-017506	Brassica rapa	65.52	0.00e+00	745.00
IUUC-Cel-018456	Caenorhabditis elegans	30.96	2.00e-71	262.00
IUUC-Cja-020007	Callithrix jacchus	44.34	1.00e-133	469.00
IUUC-Cfa-020324	Canis familiaris	44.40	1.00e-135	475.00
IUUC-Cpo-022248	Cavia porcellus	41.19	3.00e-71	261.00
IUUC-Csa-023149	Chlorocebus sabaeus	42.03	5.00e-106	377.00
IUUC-Cho-024537	Choloepus hoffmanni	37.45	9.00e-91	326.00
IUUC-Cin-025763	Ciona intestinalis	41.49	8.00e-113	399.00
IUUC-Csv-026113	Ciona savignyi	38.69	1.00e-105	376.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.14	2.00e-59	222.00
IUUC-Cne-026884	Cryptococcus neoformans	31.85	2.00e-69	255.00
IUUC-Cme-027210	Cyanidioschyzon merolae	25.56	1.00e-14	74.30
IUUC-Dre-028140	Danio rerio	42.13	6.00e-130	456.00
IUUC-Dno-030033	Dasypus novemcinctus	44.28	2.00e-117	414.00
IUUC-Dor-030513	Dipodomys ordii	54.05	1.00e-28	119.00
IUUC-Dse-031536	Dothistroma septosporum	30.85	2.00e-67	249.00
IUUC-Dme-031683	Drosophila melanogaster	38.09	6.00e-101	360.00
IUUC-Ete-032420	Echinops telfairi	40.16	2.00e-114	405.00
IUUC-Eca-033992	Equus caballus	42.79	5.00e-105	374.00
IUUC-Eeu-034713	Erinaceus europaeus	34.90	1.00e-39	156.00
IUUC-Fca-036548	Felis catus	44.03	1.00e-134	472.00
IUUC-Fal-037600	Ficedula albicollis	42.86	6.00e-121	426.00
IUUC-Fox-038037	Fusarium oxysporum	31.45	7.00e-69	253.00
IUUC-Fso-038387	Fusarium solani	31.91	7.00e-68	250.00
IUUC-Gmo-038562	Gadus morhua	41.64	8.00e-124	436.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.68	6.00e-56	211.00
IUUC-Gga-041129	Gallus gallus	42.35	1.00e-123	435.00
IUUC-Gac-042558	Gasterosteus aculeatus	42.75	6.00e-129	453.00
IUUC-Gma-043610	Glycine max	69.60	0.00e+00	765.00
IUUC-Ggo-045611	Gorilla gorilla	44.16	8.00e-133	466.00
IUUC-Hsa-046563	Homo sapiens	44.40	5.00e-134	470.00
IUUC-Hvu-047790	Hordeum vulgare	86.38	0.00e+00	687.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	44.59	5.00e-134	470.00
IUUC-Kpa-049309	Komagataella pastoris	35.28	5.00e-78	284.00
IUUC-Lch-050038	Latimeria chalumnae	44.21	6.00e-126	443.00
IUUC-Lpe-051535	Leersia perrieri	84.82	0.00e+00	841.00
IUUC-Loc-051917	Lepisosteus oculatus	40.22	1.00e-112	399.00
IUUC-Lma-053112	Leptosphaeria maculans	33.03	2.00e-74	272.00
IUUC-Laf-053690	Loxodonta africana	44.59	8.00e-136	476.00
IUUC-Mcc-055117	Macaca mulatta	44.07	3.00e-131	461.00
IUUC-Meu-056761	Macropus eugenii	37.07	2.00e-98	352.00
IUUC-Mor-057230	Magnaporthe oryzae	31.94	6.00e-67	247.00
IUUC-Mpo-057514	Magnaporthe poae	31.62	2.00e-63	235.00
IUUC-Mtr-058551	Medicago truncatula	66.60	0.00e+00	734.00
IUUC-Mla-059183	Melampsora laricipopulina	35.49	4.00e-88	318.00
IUUC-Mga-060144	Meleagris gallopavo	42.42	1.00e-119	422.00
IUUC-Mvi-060221	Microbotryum violaceum	34.35	3.00e-75	275.00
IUUC-Mmr-061325	Microcebus murinus	43.60	8.00e-131	459.00
IUUC-Mdo-062532	Monodelphis domestica	44.89	2.00e-133	468.00
IUUC-Mmu-063956	Mus musculus	44.03	9.00e-134	469.00
IUUC-Mac-064521	Musa acuminata	73.43	0.00e+00	833.00
IUUC-Mpu-066716	Mustela putorius furo	44.25	1.00e-125	442.00
IUUC-Mlu-067459	Myotis lucifugus	45.28	3.00e-136	477.00
IUUC-Nfi-068245	Neosartorya fischeri	32.67	5.00e-68	251.00
IUUC-Ncr-068910	Neurospora crassa	31.99	3.00e-67	248.00
IUUC-Nle-070034	Nomascus leucogenys	43.27	1.00e-126	445.00
IUUC-Opr-070552	Ochotona princeps	40.44	2.00e-103	368.00
IUUC-Ont-071426	Oreochromis niloticus	42.16	1.00e-128	452.00
IUUC-Oan-073389	Ornithorhynchus anatinus	40.99	8.00e-93	333.00
IUUC-Ocu-074911	Oryctolagus cuniculus	45.05	1.00e-136	479.00
IUUC-Oba-075437	Oryza barthii	89.25	0.00e+00	913.00
IUUC-Obr-076684	Oryza brachyantha	88.25	0.00e+00	853.00
IUUC-Ogl-077170	Oryza glaberrima	89.25	0.00e+00	913.00
IUUC-Ogu-078844	Oryza glumaepatula	88.53	0.00e+00	863.00
IUUC-Oin-079105	Oryza indica	89.25	0.00e+00	912.00
IUUC-Olo-080943	Oryza longistaminata	86.44	0.00e+00	837.00
IUUC-Oni-082891	Oryza nivara	86.56	0.00e+00	882.00
IUUC-Opu-083457	Oryza punctata	89.25	0.00e+00	911.00
IUUC-Oru-084960	Oryza rufipogon	85.86	0.00e+00	838.00
IUUC-Osa-085358	Oryza sativa	89.06	0.00e+00	907.00
IUUC-Ola-086420	Oryzias latipes	40.16	5.00e-81	293.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.56	5.00e-62	231.00
IUUC-Oga-088810	Otolemur garnettii	44.40	5.00e-135	473.00
IUUC-Oar-089196	Ovis aries	44.53	7.00e-134	469.00
IUUC-Ptr-090617	Pan troglodytes	44.40	3.00e-134	471.00
IUUC-Pan-092761	Papio anubis	44.59	3.00e-135	474.00
IUUC-Psi-093191	Pelodiscus sinensis	41.31	3.00e-124	437.00
IUUC-Pma-094380	Petromyzon marinus	41.45	3.00e-113	401.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.28	3.00e-64	239.00
IUUC-Ppa-095798	Physcomitrella patens	55.28	2.00e-179	621.00
IUUC-Pfo-096467	Poecilia formosa	42.12	6.00e-124	436.00
IUUC-Pab-098255	Pongo abelii	45.39	3.00e-112	397.00
IUUC-Pop-099722	Populus trichocarpa	69.98	0.00e+00	801.00
IUUC-Pca-100807	Procavia capensis	52.41	2.00e-54	205.00
IUUC-Ppe-101280	Prunus persica	68.64	0.00e+00	785.00
IUUC-Pva-102333	Pteropus vampyrus	43.04	5.00e-127	447.00
IUUC-Pgr-103401	Puccinia graminis	30.39	6.00e-73	267.00
IUUC-Ptt-103889	Puccinia triticina	28.12	8.00e-62	230.00
IUUC-Pte-104355	Pyrenophora teres	33.82	2.00e-72	265.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	33.82	1.00e-72	266.00
IUUC-Rno-105810	Rattus norvegicus	43.66	5.00e-132	463.00
IUUC-Sce-106397	Saccharomyces cerevisiae	29.89	2.00e-35	142.00
IUUC-Sha-106770	Sarcophilus harrisii	50.38	1.00e-72	265.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.40	2.00e-80	292.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.72	5.00e-82	297.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.69	1.00e-60	226.00
IUUC-Smo-109296	Selaginella moellendorffii	54.79	1.00e-167	581.00
IUUC-Sit-110157	Setaria italica	92.25	0.00e+00	1024.00
IUUC-Sly-111105	Solanum lycopersicum	66.67	0.00e+00	768.00
IUUC-Stu-112469	Solanum tuberosum	67.04	0.00e+00	776.00
IUUC-Sar-113083	Sorex araneus	35.78	4.00e-92	331.00
IUUC-Sre-115058	Sporisorium reilianum	34.99	7.00e-68	250.00
IUUC-Tgu-116772	Taeniopygia guttata	43.26	5.00e-120	423.00
IUUC-Tru-118686	Takifugu rubripes	41.42	2.00e-127	448.00
IUUC-Tsy-119111	Tarsius syrichta	45.42	5.00e-64	237.00
IUUC-Tni-120231	Tetraodon nigroviridis	40.15	3.00e-112	397.00
IUUC-Tca-121491	Theobroma cacao	69.22	0.00e+00	755.00
IUUC-Tre-122103	Trichoderma reesei	33.58	1.00e-75	276.00
IUUC-Tvi-122672	Trichoderma virens	32.52	5.00e-69	254.00
IUUC-Tae-125316	Triticum aestivum	88.10	0.00e+00	942.00
IUUC-Tur-126487	Triticum urartu	86.65	0.00e+00	913.00
IUUC-Tme-127097	Tuber melanosporum	34.81	1.00e-80	293.00
IUUC-Ttr-128465	Tursiops truncatus	41.37	7.00e-119	420.00
IUUC-Uma-129645	Ustilago maydis	33.48	6.00e-65	241.00
IUUC-Vda-129989	Verticillium dahliae	29.21	3.00e-52	198.00
IUUC-Vpa-130529	Vicugna pacos	42.30	3.00e-124	437.00
IUUC-Vvi-131059	Vitis vinifera	70.75	0.00e+00	789.00
IUUC-Xtr-132002	Xenopus tropicalis	44.49	2.00e-130	458.00
IUUC-Xma-133930	Xiphophorus maculatus	42.24	1.00e-127	449.00
IUUC-Yli-134505	Yarrowia lipolytica	33.52	4.00e-79	288.00
IUUC-Zma-135619	Zea mays	96.79	0.00e+00	1017.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence