iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tur-126487

Ensembl Protein ID

TRIUR3_18232-P1

UniProt Accession

M7ZLZ2; M7ZLZ2_TRIUA

Genbank Protein ID

EMS61122.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

KD100869

Gene Name

TRIUR3_18232

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIUR3_18232	TRIUR3_18232-T1	TRIUR3_18232-P1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.20e-100	336.0	1	508

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 5    irlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesit 98
           +++wG+++q++l++a+++l+++g++G+E lKnLvl+G+gs+tvvD+++ve+s+l+++FL+++   g+s+A++ + +l+eln+ v+++ +ees+ 
   Q: 1    MAIWGDQGQAALEKASICLLNCGPTGTEALKNLVLGGIGSVTVVDGSKVEQSDLGNNFLLDEGCLGQSRAKSICSFLQELNDAVKAKYVEESPA 94
           79******************************************************************************************** PP
   S: 99   eleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn....... 181
           +  ++++ Ff++f++V++++ ++++ +k++++c++a++ l+ ++++Gl G vrv+ik++ +++s++d   d++++ +P+++lk++         
   Q: 95   TMIDTNPsFFSQFTIVLATQLPESSLLKLDSICRSANIVLVAARSYGLTGLVRVSIKEHCVIESKPDhslDDLRLHNPWPELKQFAKsidicdk 188
           *****99******************************************************************************999999999 PP
   S: 182  ..aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspf 272
             +++++++++v++  l+e++a +++++ +++++ek+e+kd++++ + + de+n++ea+e + k   +  i++ i+q++++ +  +v+ s+s+f
   Q: 189  dpVVHKHTPYIVILVRLAEKWADAHDGQLPSTRQEKREFKDLIRAHMLNVDEDNYKEAVESSYKVSVTPGISDeIRQIIDD-SSSEVNLSSSDF 281
           99*******************************************************************************.55599******* PP
   S: 273  wv...........................................................................sfcsnaealq....... 284
           wv                                                                           +fc+n+++l+       
   Q: 282  WVlvaslkefianegngelplegtipdmtslteyyvslqkiyqakaesdclaiehrvksilkrigrdpdsisracikTFCKNTRKLKvcryrsm 375
           ***************************************************************************************6666655 PP
   S: 285  .......vpekvekdeevvkasap.....lylllralerfekkkgrkpgels...fekddds.avdlvtaaanlraeslgiep.kldddlikei 361
                  v     + +++++++++     +y+llra++r++++++r pg ++   f  +  + +++l++aa +   +++g+++  l++dli+e+
   Q: 376  eeefsspV---LSEVKKYFADEDScfamnFYVLLRAVDRLAANYSRLPGIFDstgFTSEIGEdVPRLKEAAVSVL-SDMGLKGsSLSEDLIAEV 465
           55543221...223333333333367788*******************966511144554446777877777666.****************** PP
   S: 362  agniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           ++++ ++i++++a++gG+a+qEviK+v+++f+pl+ +f+f+++
   Q: 466  CRFAGAEIHPVAAFIGGVASQEVIKLVTKQFVPLNGTFIFNGI 508
           ****************************************986 PP

Organism

Triticum urartu

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAIWGDQGQA ALEKASICLL NCGPTGTEAL KNLVLGGIGS VTVVDGSKVE QSDLGNNFLL 60
DEGCLGQSRA KSICSFLQEL NDAVKAKYVE ESPATMIDTN PSFFSQFTIV LATQLPESSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGTGAG AAATTTTGTA ATCGAGCTAT CTATTTGGAA CAAGCAATTC AGCATTATCA 60
AAACCTGCTT ATCCATGAGA CCAGGATAGC AACAACATTT CCTGTTACAA ATCCTTGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	99.03	0.00e+00	1025.00
IUUC-Aml-002333	Ailuropoda melanoleuca	42.05	9.00e-123	432.00
IUUC-Atr-002644	Amborella trichopoda	68.67	0.00e+00	710.00
IUUC-Apl-003446	Anas platyrhynchos	42.56	7.00e-118	416.00
IUUC-Aca-004450	Anolis carolinensis	40.49	4.00e-119	420.00
IUUC-Aly-005466	Arabidopsis lyrata	63.90	0.00e+00	710.00
IUUC-Ath-006692	Arabidopsis thaliana	64.86	0.00e+00	712.00
IUUC-Ago-007900	Ashbya gossypii	27.17	4.00e-37	148.00
IUUC-Acl-008333	Aspergillus clavatus	32.55	2.00e-67	249.00
IUUC-Afl-008529	Aspergillus flavus	32.23	2.00e-72	265.00
IUUC-Afu-009071	Aspergillus fumigatus	31.73	1.00e-65	243.00
IUUC-Ani-009443	Aspergillus nidulans	31.43	1.00e-60	226.00
IUUC-Ang-009669	Aspergillus niger	31.81	2.00e-70	259.00
IUUC-Aor-009914	Aspergillus oryzae	31.94	1.00e-70	259.00
IUUC-Ate-010450	Aspergillus terreus	31.39	5.00e-66	244.00
IUUC-Ame-011183	Astyanax mexicanus	39.73	3.00e-116	411.00
IUUC-Bgr-012111	Blumeria graminis	31.72	3.00e-58	218.00
IUUC-Bta-012583	Bos taurus	42.18	3.00e-124	437.00
IUUC-Bci-013892	Botrytis cinerea	31.02	6.00e-55	207.00
IUUC-Bdi-014592	Brachypodium distachyon	90.52	0.00e+00	936.00
IUUC-Bol-016399	Brassica oleracea	65.38	0.00e+00	723.00
IUUC-Bra-017506	Brassica rapa	64.02	0.00e+00	706.00
IUUC-Cel-018456	Caenorhabditis elegans	29.85	3.00e-64	238.00
IUUC-Cja-020007	Callithrix jacchus	41.78	3.00e-122	431.00
IUUC-Cfa-020324	Canis familiaris	41.98	1.00e-124	439.00
IUUC-Cpo-022248	Cavia porcellus	37.54	3.00e-65	241.00
IUUC-Csa-023149	Chlorocebus sabaeus	39.45	2.00e-99	355.00
IUUC-Cho-024537	Choloepus hoffmanni	34.97	1.00e-84	305.00
IUUC-Cin-025763	Ciona intestinalis	39.54	3.00e-105	374.00
IUUC-Csv-026113	Ciona savignyi	38.96	2.00e-102	365.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.05	4.00e-55	207.00
IUUC-Cne-026884	Cryptococcus neoformans	30.40	5.00e-64	237.00
IUUC-Dre-028140	Danio rerio	39.92	4.00e-118	417.00
IUUC-Dno-030033	Dasypus novemcinctus	41.39	7.00e-106	376.00
IUUC-Dse-031536	Dothistroma septosporum	29.58	2.00e-63	235.00
IUUC-Dme-031683	Drosophila melanogaster	37.31	9.00e-93	333.00
IUUC-Ete-032420	Echinops telfairi	38.10	7.00e-109	386.00
IUUC-Eca-033992	Equus caballus	40.31	2.00e-98	351.00
IUUC-Eeu-034713	Erinaceus europaeus	31.65	9.00e-33	133.00
IUUC-Fca-036548	Felis catus	41.60	9.00e-124	436.00
IUUC-Fal-037600	Ficedula albicollis	41.98	9.00e-115	406.00
IUUC-Fox-038037	Fusarium oxysporum	31.28	2.00e-67	249.00
IUUC-Fso-038387	Fusarium solani	30.95	3.00e-66	244.00
IUUC-Gmo-038562	Gadus morhua	39.58	1.00e-113	402.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.16	1.00e-50	193.00
IUUC-Gga-041129	Gallus gallus	41.83	8.00e-116	409.00
IUUC-Gac-042558	Gasterosteus aculeatus	40.34	1.00e-117	415.00
IUUC-Gma-043610	Glycine max	67.31	0.00e+00	717.00
IUUC-Ggo-045611	Gorilla gorilla	41.37	1.00e-121	429.00
IUUC-Hsa-046563	Homo sapiens	41.60	1.00e-122	432.00
IUUC-Hvu-047790	Hordeum vulgare	96.95	0.00e+00	752.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	41.79	2.00e-122	431.00
IUUC-Kpa-049309	Komagataella pastoris	33.46	3.00e-71	261.00
IUUC-Lch-050038	Latimeria chalumnae	41.41	2.00e-118	418.00
IUUC-Lpe-051535	Leersia perrieri	82.65	0.00e+00	792.00
IUUC-Loc-051917	Lepisosteus oculatus	37.50	7.00e-104	370.00
IUUC-Lma-053112	Leptosphaeria maculans	31.70	2.00e-68	252.00
IUUC-Laf-053690	Loxodonta africana	42.78	3.00e-125	441.00
IUUC-Mcc-055117	Macaca mulatta	41.29	1.00e-119	422.00
IUUC-Meu-056761	Macropus eugenii	34.85	6.00e-88	317.00
IUUC-Mor-057230	Magnaporthe oryzae	31.25	2.00e-64	238.00
IUUC-Mpo-057514	Magnaporthe poae	31.97	2.00e-59	222.00
IUUC-Mtr-058551	Medicago truncatula	64.92	0.00e+00	691.00
IUUC-Mla-059183	Melampsora laricipopulina	34.94	5.00e-83	300.00
IUUC-Mga-060144	Meleagris gallopavo	41.98	8.00e-115	406.00
IUUC-Mvi-060221	Microbotryum violaceum	32.95	2.00e-66	245.00
IUUC-Mmr-061325	Microcebus murinus	40.80	2.00e-119	421.00
IUUC-Mdo-062532	Monodelphis domestica	42.21	4.00e-123	434.00
IUUC-Mmu-063956	Mus musculus	41.41	2.00e-122	431.00
IUUC-Mac-064521	Musa acuminata	71.37	0.00e+00	775.00
IUUC-Mpu-066716	Mustela putorius furo	41.87	5.00e-114	404.00
IUUC-Mlu-067459	Myotis lucifugus	42.48	3.00e-125	441.00
IUUC-Nfi-068245	Neosartorya fischeri	32.03	8.00e-66	243.00
IUUC-Ncr-068910	Neurospora crassa	31.62	2.00e-64	239.00
IUUC-Nle-070034	Nomascus leucogenys	41.19	1.00e-119	422.00
IUUC-Opr-070552	Ochotona princeps	37.53	5.00e-91	327.00
IUUC-Ont-071426	Oreochromis niloticus	40.49	3.00e-119	421.00
IUUC-Oan-073389	Ornithorhynchus anatinus	39.47	3.00e-87	314.00
IUUC-Ocu-074911	Oryctolagus cuniculus	42.18	4.00e-124	437.00
IUUC-Oba-075437	Oryza barthii	87.43	0.00e+00	868.00
IUUC-Obr-076684	Oryza brachyantha	85.88	0.00e+00	807.00
IUUC-Ogl-077170	Oryza glaberrima	87.43	0.00e+00	868.00
IUUC-Ogu-078844	Oryza glumaepatula	86.41	0.00e+00	818.00
IUUC-Oin-079105	Oryza indica	87.43	0.00e+00	867.00
IUUC-Olo-080943	Oryza longistaminata	84.08	0.00e+00	787.00
IUUC-Oni-082891	Oryza nivara	84.53	0.00e+00	834.00
IUUC-Opu-083457	Oryza punctata	87.23	0.00e+00	864.00
IUUC-Oru-084960	Oryza rufipogon	84.08	0.00e+00	788.00
IUUC-Osa-085358	Oryza sativa	87.04	0.00e+00	862.00
IUUC-Ola-086420	Oryzias latipes	38.06	1.00e-75	275.00
IUUC-Olu-087625	Ostreococcus lucimarinus	28.91	1.00e-56	213.00
IUUC-Oga-088810	Otolemur garnettii	42.18	2.00e-123	435.00
IUUC-Oar-089196	Ovis aries	41.94	1.00e-122	432.00
IUUC-Ptr-090617	Pan troglodytes	41.60	6.00e-123	433.00
IUUC-Pan-092761	Papio anubis	41.79	7.00e-124	436.00
IUUC-Psi-093191	Pelodiscus sinensis	39.89	1.00e-119	422.00
IUUC-Pma-094380	Petromyzon marinus	39.55	1.00e-104	372.00
IUUC-Pno-095084	Phaeosphaeria nodorum	29.83	9.00e-57	214.00
IUUC-Ppa-095798	Physcomitrella patens	54.58	4.00e-170	590.00
IUUC-Pfo-096467	Poecilia formosa	40.08	1.00e-114	405.00
IUUC-Pab-098255	Pongo abelii	43.22	8.00e-104	369.00
IUUC-Pop-099722	Populus trichocarpa	68.67	0.00e+00	750.00
IUUC-Pca-100807	Procavia capensis	53.23	4.00e-56	211.00
IUUC-Ppe-101280	Prunus persica	67.31	0.00e+00	737.00
IUUC-Pva-102333	Pteropus vampyrus	41.02	2.00e-117	415.00
IUUC-Pgr-103401	Puccinia graminis	29.72	1.00e-65	243.00
IUUC-Ptt-103889	Puccinia triticina	28.47	3.00e-61	228.00
IUUC-Pte-104355	Pyrenophora teres	32.12	2.00e-66	245.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.00	1.00e-65	243.00
IUUC-Rno-105810	Rattus norvegicus	41.03	2.00e-120	425.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.60	4.00e-30	124.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.50	1.00e-72	266.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.85	4.00e-79	288.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.49	7.00e-56	210.00
IUUC-Smo-109296	Selaginella moellendorffii	52.41	5.00e-160	556.00
IUUC-Sit-110157	Setaria italica	86.85	0.00e+00	923.00
IUUC-Sly-111105	Solanum lycopersicum	64.60	0.00e+00	714.00
IUUC-Stu-112469	Solanum tuberosum	65.16	0.00e+00	722.00
IUUC-Sar-113083	Sorex araneus	42.03	2.00e-46	179.00
IUUC-Sbi-113813	Sorghum bicolor	86.65	0.00e+00	921.00
IUUC-Sre-115058	Sporisorium reilianum	33.33	6.00e-61	227.00
IUUC-Tgu-116772	Taeniopygia guttata	41.75	4.00e-112	397.00
IUUC-Tru-118686	Takifugu rubripes	38.78	6.00e-117	413.00
IUUC-Tni-120231	Tetraodon nigroviridis	39.05	1.00e-104	372.00
IUUC-Tca-121491	Theobroma cacao	67.31	0.00e+00	700.00
IUUC-Tre-122103	Trichoderma reesei	31.52	5.00e-70	257.00
IUUC-Tvi-122672	Trichoderma virens	31.20	2.00e-64	239.00
IUUC-Tae-125684	Triticum aestivum	98.84	0.00e+00	1021.00
IUUC-Tme-127097	Tuber melanosporum	33.94	2.00e-76	278.00
IUUC-Ttr-128465	Tursiops truncatus	38.90	4.00e-108	384.00
IUUC-Uma-129645	Ustilago maydis	32.05	8.00e-59	220.00
IUUC-Vda-129989	Verticillium dahliae	28.28	4.00e-46	177.00
IUUC-Vpa-130529	Vicugna pacos	39.66	1.00e-112	399.00
IUUC-Vvi-131059	Vitis vinifera	69.05	0.00e+00	752.00
IUUC-Xtr-132002	Xenopus tropicalis	42.20	6.00e-122	430.00
IUUC-Xma-133930	Xiphophorus maculatus	40.38	2.00e-118	418.00
IUUC-Yli-134505	Yarrowia lipolytica	33.91	4.00e-78	284.00
IUUC-Zma-135619	Zea mays	86.27	0.00e+00	872.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence