iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059975

UUCD1 version

UUC-MeG-00381

Ensembl Protein ID

ENSMGAP00000008460.2

UniProt Accession

G1N861; G1N861_MELGA

Protein Name

Uncharacterized protein

Gene Name

TRIM25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000008272.2	ENSMGAT00000009257.2	ENSMGAP00000008460.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.00e-06	27.9	15	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+ f   p+++pCgH f+a+Cl   w      + + f+CP Cr
   Q: 15   CSICLCIFNV-PVTVPCGHNFCASCLeLTW----TDQVRDFSCPQCR 56
           ********77.*******************....8999********8 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

QSEPNLLALE EELTCSICLC IFNVPVTVPC GHNFCASCLE LTWTDQVRDF SCPQCRTTFP 60
GRPQLRKNTV LCRVVEQLRA AGPGTGGRTM SARRKSGRRQ APIYCDSCMQ AAATHTCLTC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTCGGAGC CGAACCTGTT GGCGCTGGAG GAGGAGCTGA CGTGCTCCAT CTGCCTCTGC 60
ATCTTCAACG TCCCCGTGAC GGTGCCGTGC GGGCACAACT TCTGCGCCTC CTGCCTGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0003723--F:RNA binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002424	Ailuropoda melanoleuca	50.72	1.00e-174	605.00
IUUC-Apl-004101	Anas platyrhynchos	71.27	0.00e+00	835.00
IUUC-Aca-005025	Anolis carolinensis	52.57	0.00e+00	675.00
IUUC-Ame-011783	Astyanax mexicanus	27.40	3.00e-53	202.00
IUUC-Bta-012735	Bos taurus	49.38	4.00e-178	617.00
IUUC-Cja-019996	Callithrix jacchus	46.55	3.00e-90	325.00
IUUC-Cfa-020466	Canis familiaris	49.21	2.00e-177	615.00
IUUC-Cpo-021737	Cavia porcellus	46.20	1.00e-166	579.00
IUUC-Csa-023217	Chlorocebus sabaeus	49.84	4.00e-174	604.00
IUUC-Cho-024346	Choloepus hoffmanni	37.63	2.00e-46	179.00
IUUC-Dre-028781	Danio rerio	27.54	1.00e-64	240.00
IUUC-Dno-030082	Dasypus novemcinctus	50.24	2.00e-180	625.00
IUUC-Dor-030335	Dipodomys ordii	33.99	1.00e-68	254.00
IUUC-Ete-032923	Echinops telfairi	45.30	6.00e-151	526.00
IUUC-Eca-033411	Equus caballus	47.99	2.00e-171	595.00
IUUC-Eeu-034656	Erinaceus europaeus	47.55	7.00e-91	327.00
IUUC-Fca-035371	Felis catus	49.05	4.00e-174	604.00
IUUC-Fal-037008	Ficedula albicollis	61.13	0.00e+00	779.00
IUUC-Gmo-038668	Gadus morhua	37.22	4.00e-112	397.00
IUUC-Gga-040608	Gallus gallus	79.74	0.00e+00	951.00
IUUC-Gac-041409	Gasterosteus aculeatus	39.36	3.00e-67	249.00
IUUC-Ggo-044518	Gorilla gorilla	49.60	3.00e-170	591.00
IUUC-Hsa-045828	Homo sapiens	49.36	3.00e-171	594.00
IUUC-Itr-049070	Ictidomys tridecemlineatus	45.06	9.00e-151	526.00
IUUC-Lch-050490	Latimeria chalumnae	29.49	2.00e-78	286.00
IUUC-Loc-052864	Lepisosteus oculatus	38.19	4.00e-119	421.00
IUUC-Laf-054325	Loxodonta africana	50.14	2.00e-98	352.00
IUUC-Mcc-054920	Macaca mulatta	49.68	3.00e-173	601.00
IUUC-Meu-056367	Macropus eugenii	63.22	8.00e-66	244.00
IUUC-Mmr-060748	Microcebus murinus	49.20	3.00e-171	594.00
IUUC-Mdo-062904	Monodelphis domestica	48.51	1.00e-160	559.00
IUUC-Mmu-063891	Mus musculus	48.33	1.00e-175	609.00
IUUC-Mpu-066473	Mustela putorius furo	50.31	3.00e-179	621.00
IUUC-Mlu-068185	Myotis lucifugus	49.53	5.00e-175	607.00
IUUC-Nle-070177	Nomascus leucogenys	49.52	2.00e-173	601.00
IUUC-Opr-070558	Ochotona princeps	39.64	5.00e-87	314.00
IUUC-Ont-071368	Oreochromis niloticus	36.63	3.00e-62	233.00
IUUC-Oan-073277	Ornithorhynchus anatinus	28.44	3.00e-22	99.40
IUUC-Ocu-074461	Oryctolagus cuniculus	47.73	1.00e-92	333.00
IUUC-Ola-086993	Oryzias latipes	25.04	3.00e-56	212.00
IUUC-Oga-088937	Otolemur garnettii	46.29	9.00e-162	563.00
IUUC-Oar-089781	Ovis aries	47.54	2.00e-115	409.00
IUUC-Ptr-090771	Pan troglodytes	49.68	2.00e-170	592.00
IUUC-Pan-092830	Papio anubis	49.84	4.00e-173	600.00
IUUC-Psi-093664	Pelodiscus sinensis	59.35	0.00e+00	720.00
IUUC-Pma-094147	Petromyzon marinus	27.29	4.00e-53	202.00
IUUC-Pfo-096906	Poecilia formosa	27.67	1.00e-66	246.00
IUUC-Pab-097588	Pongo abelii	49.84	5.00e-171	593.00
IUUC-Pca-100890	Procavia capensis	49.85	5.00e-92	331.00
IUUC-Pva-102314	Pteropus vampyrus	50.00	4.00e-166	577.00
IUUC-Rno-105234	Rattus norvegicus	46.61	2.00e-88	319.00
IUUC-Sce-106362	Saccharomyces cerevisiae	40.00	2.00e-09	56.20
IUUC-Sha-106807	Sarcophilus harrisii	46.68	2.00e-164	572.00
IUUC-Sar-113283	Sorex araneus	45.13	2.00e-76	278.00
IUUC-Ssc-115878	Sus scrofa	54.02	8.00e-63	233.00
IUUC-Tgu-117026	Taeniopygia guttata	61.72	3.00e-180	624.00
IUUC-Tru-117794	Takifugu rubripes	36.42	2.00e-105	376.00
IUUC-Tsy-119001	Tarsius syrichta	31.41	2.00e-20	93.20
IUUC-Tni-120778	Tetraodon nigroviridis	28.27	5.00e-63	234.00
IUUC-Tbe-127580	Tupaia belangeri	41.78	2.00e-75	275.00
IUUC-Ttr-128648	Tursiops truncatus	58.48	1.00e-79	290.00
IUUC-Vpa-130254	Vicugna pacos	66.47	3.00e-73	268.00
IUUC-Xtr-132892	Xenopus tropicalis	43.80	8.00e-81	293.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence