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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063735
Ensembl Protein ID ENSMUSP00000036270.7
UniProt Accession Q9R0C8; A2CFD7; Q7TS85; Q8BRV2; Q8CCF5; Q8R076; Q9JLS6; VAV3_MOUSE
Genbank Protein ID AAF09171.1; AAF20330.2; BAC28212.1; BAC30879.2; BAE27637.1; CAM14541.1; CAM14541.1; CAM14541.1; CAM16459.1; CAM16459.1; CAM16459.1; CAM18527.1; CAM18527.1; CAM18527.1; CAM28077.1; CAM28077.1; CAM28077.1; CAM28077.1; CAM28109.1; CAM28109.1; CAM28111.1; CAM28111.1; CAM28111.1; CAM28111.1; CAM28160.1; CAM28160.1; CAM28160.1; CAM28160.1; CAM28169.1; CAM28169.1; CAM28172.1; CAM28172.1; CAM28172.1; CAM28172.1; AAH27242.1; AAH52739.1
Protein Name Guanine nucleotide exchange factor VAV3
Genbank Nucleotide ID AF067816; AF140280; AK033253; AK041249; AK147053; AL731716; AL671857; AL671987; AL671857; AL671987; AL731716; AL671987; AL731716; AL671857; CR936838; CR936848; CR936849; CR938729; CR938729; CR936848; CR938729; CR936838; CR936848; CR936849; CR936849; CR936838; CR936848; CR938729; CR936848; CR938729; CR936848; CR936838; CR936849; CR938729; BC027242; BC052739
Gene Name Vav3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000033721.16 ENSMUST00000046864.13 ENSMUSP00000036270.7
ENSMUSG00000033721.16 ENSMUST00000106576.2 ENSMUSP00000102186.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarmiRNAMapRAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.60e-14 54.0 794 845
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGd+v++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 794  IARYDFCARDMRELSLLKGDMVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 845
           688*********************9.999999*****..9*************86 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.
 Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.
Protein Sequence
(Fasta)
MEPWKQCAQW LIHSKVLPPN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RPHSINLKEI 60
NLRPQMSQFL CLKNIRTFLA ACCDTFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063735|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCAGCCAGGG CGGCGGGCAC GCTCGCACCC GCGCCTCCGG GGACTCGCGG ACCGCACAGA 60
CCGGCCAGGC GCGCTGGGCA TGCTCAGTCG CGGGGCGCCA GGCTCGCCAG TCGGAAGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063735|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0877--Alternative promoter usage
KW-0025--Alternative splicing
KW-0037--Angiogenesis
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003096--SM22_calponin
PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN
SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0005154--F:epidermal growth factor receptor binding
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0001525--P:angiogenesis
GO:0050853--P:B cell receptor signaling pathway
GO:0016477--P:cell migration
GO:0030031--P:cell projection assembly
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0043087--P:regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion
KEGG mmu:57257
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001362 Ailuropoda melanoleuca 95.04 0.00e+00 1586.00
IUUC-Apl-003734 Anas platyrhynchos 86.65 0.00e+00 1356.00
IUUC-Aca-004477 Anolis carolinensis 81.71 0.00e+00 1390.00
IUUC-Ame-011279 Astyanax mexicanus 67.02 0.00e+00 1122.00
IUUC-Bta-012722 Bos taurus 94.10 0.00e+00 1573.00
IUUC-Cja-018941 Callithrix jacchus 95.35 0.00e+00 1570.00
IUUC-Cfa-020266 Canis familiaris 95.39 0.00e+00 1414.00
IUUC-Cpo-021966 Cavia porcellus 95.33 0.00e+00 1383.00
IUUC-Csa-023892 Chlorocebus sabaeus 94.76 0.00e+00 1451.00
IUUC-Csv-025995 Ciona savignyi 35.73 2.00e-149 523.00
IUUC-Dre-028199 Danio rerio 66.02 0.00e+00 1120.00
IUUC-Dno-029474 Dasypus novemcinctus 94.69 0.00e+00 1581.00
IUUC-Eca-033961 Equus caballus 95.13 0.00e+00 1439.00
IUUC-Eeu-034719 Erinaceus europaeus 75.00 0.00e+00 785.00
IUUC-Fca-036572 Felis catus 94.37 0.00e+00 1541.00
IUUC-Fal-036802 Ficedula albicollis 84.69 0.00e+00 1477.00
IUUC-Gmo-039409 Gadus morhua 70.15 0.00e+00 1177.00
IUUC-Gga-040884 Gallus gallus 85.83 0.00e+00 1473.00
IUUC-Gac-041395 Gasterosteus aculeatus 71.56 0.00e+00 1247.00
IUUC-Ggo-044460 Gorilla gorilla 93.04 0.00e+00 1374.00
IUUC-Hsa-046099 Homo sapiens 92.23 0.00e+00 1571.00
IUUC-Itr-048144 Ictidomys tridecemlineatus 91.57 0.00e+00 1384.00
IUUC-Lch-049650 Latimeria chalumnae 80.75 7.00e-108 382.00
IUUC-Loc-052487 Lepisosteus oculatus 73.27 0.00e+00 1247.00
IUUC-Laf-054564 Loxodonta africana 93.86 0.00e+00 1568.00
IUUC-Mcc-054622 Macaca mulatta 91.77 0.00e+00 1565.00
IUUC-Meu-056680 Macropus eugenii 84.77 0.00e+00 1408.00
IUUC-Mga-060013 Meleagris gallopavo 82.15 0.00e+00 1393.00
IUUC-Mmr-061251 Microcebus murinus 90.72 0.00e+00 1591.00
IUUC-Mdo-061875 Monodelphis domestica 92.56 0.00e+00 1560.00
IUUC-Mpu-065856 Mustela putorius furo 94.92 0.00e+00 1582.00
IUUC-Mlu-068108 Myotis lucifugus 89.26 0.00e+00 1501.00
IUUC-Nle-069863 Nomascus leucogenys 90.79 0.00e+00 1533.00
IUUC-Opr-070372 Ochotona princeps 82.92 0.00e+00 1034.00
IUUC-Ont-072286 Oreochromis niloticus 71.99 0.00e+00 1236.00
IUUC-Ocu-074194 Oryctolagus cuniculus 95.99 0.00e+00 1597.00
IUUC-Ola-086336 Oryzias latipes 70.24 0.00e+00 1219.00
IUUC-Oar-089272 Ovis aries 93.86 0.00e+00 1608.00
IUUC-Ptr-090652 Pan troglodytes 93.17 0.00e+00 1577.00
IUUC-Pan-092550 Papio anubis 91.37 0.00e+00 1387.00
IUUC-Psi-093784 Pelodiscus sinensis 80.20 0.00e+00 1254.00
IUUC-Pfo-097308 Poecilia formosa 69.44 0.00e+00 1229.00
IUUC-Pab-098698 Pongo abelii 93.03 0.00e+00 1573.00
IUUC-Pva-102262 Pteropus vampyrus 94.96 0.00e+00 1524.00
IUUC-Rno-105421 Rattus norvegicus 97.76 0.00e+00 1669.00
IUUC-Sha-107325 Sarcophilus harrisii 92.56 0.00e+00 1579.00
IUUC-Sar-113456 Sorex araneus 89.02 0.00e+00 1503.00
IUUC-Tgu-116595 Taeniopygia guttata 82.94 0.00e+00 1386.00
IUUC-Tru-117884 Takifugu rubripes 67.17 0.00e+00 1211.00
IUUC-Tsy-119429 Tarsius syrichta 86.78 0.00e+00 1306.00
IUUC-Tni-119951 Tetraodon nigroviridis 69.24 0.00e+00 1159.00
IUUC-Tbe-127995 Tupaia belangeri 83.75 1.00e-174 607.00
IUUC-Ttr-128281 Tursiops truncatus 94.33 0.00e+00 1573.00
IUUC-Xtr-132427 Xenopus tropicalis 72.27 0.00e+00 1285.00
Created Date 25-Jun-2017

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