iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089580

Ensembl Protein ID

ENSOARP00000007748.1

UniProt Accession

W5PBD7; W5PBD7_SHEEP

Genbank Protein ID

ENSOARP00000007748

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01017581

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000007227.1	ENSOART00000007863.1	ENSOARP00000007748.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-50	166.6	199	242
UBD/Beta-Prp	1.10e-60	205.5	108	305

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg+++vWD++ g++++
   Q: 199  GHSKWITALSWeplhanPEcRYVASSSKDGSVRVWDTTAGRCER 242
           8***************9889**********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t +gh + vls+s+sp+g+kl+sG +   i +wd +tg+ +   
   Q: 108  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCQGHRHWVLSISWSPDGKKLASGCKNGQILLWDPSTGKQVGRA 196
           6789************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++ +++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 197  LTGHSKWITALSWeplhaNPECRYVASSSKDGSVRVWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 283
           **********9873332257889**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderlvs 239
           tl+gh  +v+ +++s  d  l +
   Q: 284  TLQGHGHWVNTMALS-TDYALRT 305
           **************9.4444444 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MAATAAVGDE AATRDVQRLL VQFQDEGGQL LGSPFDVPVD ITPDKLQLVC NALLAQEDPL 60
PLAFYVHDAE IVSSLGRTLE SQAVETEKVL DIIYQPQAIF RVRAVTRCTS SLEGHSEAVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGACTCAT TGGAAAAGAC TCTGATGCTG GGAGGGATTG GGGGCAGGAG GAGAAGGGGA 60
CGACCGAGGA TGAGATGGCT GTATGGCATC ACGGACTCGA TGAACATGAA GCTGAGTGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

KEGG

oas:101118199

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	55.94	9.00e-140	489.00
IUUC-Aml-001793	Ailuropoda melanoleuca	96.82	0.00e+00	823.00
IUUC-Atr-002507	Amborella trichopoda	55.77	9.00e-138	483.00
IUUC-Apl-003964	Anas platyrhynchos	83.33	0.00e+00	694.00
IUUC-Aly-006396	Arabidopsis lyrata	52.55	6.00e-132	464.00
IUUC-Ath-007278	Arabidopsis thaliana	52.55	1.00e-131	462.00
IUUC-Ago-007951	Ashbya gossypii	44.24	5.00e-101	361.00
IUUC-Acl-008298	Aspergillus clavatus	41.92	1.00e-90	327.00
IUUC-Afl-008581	Aspergillus flavus	47.96	2.00e-80	292.00
IUUC-Afu-008906	Aspergillus fumigatus	41.30	9.00e-91	327.00
IUUC-Ani-009189	Aspergillus nidulans	40.75	3.00e-87	315.00
IUUC-Ang-009630	Aspergillus niger	43.65	1.00e-93	337.00
IUUC-Aor-010038	Aspergillus oryzae	42.76	5.00e-98	351.00
IUUC-Ate-010278	Aspergillus terreus	42.17	3.00e-91	328.00
IUUC-Ame-011890	Astyanax mexicanus	79.22	0.00e+00	708.00
IUUC-Bgr-012011	Blumeria graminis	43.81	2.00e-99	355.00
IUUC-Bta-012964	Bos taurus	98.78	0.00e+00	838.00
IUUC-Bci-013592	Botrytis cinerea	40.83	3.00e-91	329.00
IUUC-Bdi-015035	Brachypodium distachyon	56.30	2.00e-141	495.00
IUUC-Bol-015501	Brassica oleracea	53.83	7.00e-132	463.00
IUUC-Bra-017642	Brassica rapa	53.58	3.00e-131	461.00
IUUC-Cel-018430	Caenorhabditis elegans	56.58	1.00e-139	489.00
IUUC-Cja-019125	Callithrix jacchus	95.37	0.00e+00	816.00
IUUC-Cfa-021013	Canis familiaris	95.16	0.00e+00	739.00
IUUC-Cpo-021743	Cavia porcellus	94.13	0.00e+00	810.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	46.32	1.00e-103	370.00
IUUC-Csa-024270	Chlorocebus sabaeus	95.18	0.00e+00	825.00
IUUC-Cin-025795	Ciona intestinalis	64.20	1.00e-167	583.00
IUUC-Csv-025953	Ciona savignyi	65.19	3.00e-167	581.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	48.41	3.00e-83	301.00
IUUC-Cne-026901	Cryptococcus neoformans	47.52	1.00e-116	413.00
IUUC-Cme-027281	Cyanidioschyzon merolae	46.63	5.00e-91	328.00
IUUC-Dre-028515	Danio rerio	76.53	0.00e+00	687.00
IUUC-Dno-029596	Dasypus novemcinctus	95.52	0.00e+00	830.00
IUUC-Dor-030494	Dipodomys ordii	93.54	0.00e+00	812.00
IUUC-Dse-031538	Dothistroma septosporum	45.00	2.00e-102	366.00
IUUC-Dme-031974	Drosophila melanogaster	56.04	1.00e-139	489.00
IUUC-Ete-032948	Echinops telfairi	92.66	1.00e-95	343.00
IUUC-Eca-033399	Equus caballus	97.54	0.00e+00	824.00
IUUC-Eeu-035013	Erinaceus europaeus	96.62	3.00e-116	412.00
IUUC-Fca-035860	Felis catus	96.83	0.00e+00	822.00
IUUC-Fal-037069	Ficedula albicollis	85.48	1.00e-95	342.00
IUUC-Fox-038059	Fusarium oxysporum	43.27	7.00e-98	350.00
IUUC-Fso-038445	Fusarium solani	43.51	2.00e-98	353.00
IUUC-Gmo-039319	Gadus morhua	73.90	0.00e+00	654.00
IUUC-Ggr-040095	Gaeumannomyces graminis	43.75	2.00e-93	336.00
IUUC-Gga-040312	Gallus gallus	83.58	1.00e-101	361.00
IUUC-Gac-042267	Gasterosteus aculeatus	76.27	0.00e+00	650.00
IUUC-Gma-043974	Glycine max	54.66	1.00e-139	489.00
IUUC-Ggo-044637	Gorilla gorilla	95.58	0.00e+00	808.00
IUUC-Hsa-046128	Homo sapiens	95.47	0.00e+00	830.00
IUUC-Hvu-047373	Hordeum vulgare	55.31	6.00e-139	487.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	94.10	0.00e+00	823.00
IUUC-Kpa-049274	Komagataella pastoris	40.45	2.00e-100	359.00
IUUC-Lch-049907	Latimeria chalumnae	79.25	0.00e+00	703.00
IUUC-Lpe-050778	Leersia perrieri	55.88	2.00e-143	501.00
IUUC-Loc-051889	Lepisosteus oculatus	78.93	0.00e+00	711.00
IUUC-Lma-053041	Leptosphaeria maculans	46.95	3.00e-95	342.00
IUUC-Laf-053598	Loxodonta africana	95.69	0.00e+00	830.00
IUUC-Mcc-055660	Macaca mulatta	95.18	0.00e+00	824.00
IUUC-Meu-056197	Macropus eugenii	76.60	0.00e+00	671.00
IUUC-Mor-056949	Magnaporthe oryzae	42.21	4.00e-90	325.00
IUUC-Mtr-058530	Medicago truncatula	55.61	2.00e-137	482.00
IUUC-Mla-059133	Melampsora laricipopulina	43.76	3.00e-103	368.00
IUUC-Mga-059252	Meleagris gallopavo	83.72	3.00e-157	547.00
IUUC-Mvi-060522	Microbotryum violaceum	48.48	2.00e-113	402.00
IUUC-Mmr-061117	Microcebus murinus	95.67	0.00e+00	822.00
IUUC-Mdo-062892	Monodelphis domestica	87.23	0.00e+00	774.00
IUUC-Mmu-064108	Mus musculus	95.11	0.00e+00	788.00
IUUC-Mac-064430	Musa acuminata	56.79	1.00e-142	499.00
IUUC-Mpu-065882	Mustela putorius furo	95.60	0.00e+00	813.00
IUUC-Mlu-068123	Myotis lucifugus	95.85	0.00e+00	822.00
IUUC-Nfi-068484	Neosartorya fischeri	41.55	2.00e-90	326.00
IUUC-Ncr-068649	Neurospora crassa	40.24	1.00e-87	317.00
IUUC-Nle-069140	Nomascus leucogenys	95.82	0.00e+00	811.00
IUUC-Opr-070220	Ochotona princeps	86.51	0.00e+00	702.00
IUUC-Ont-072643	Oreochromis niloticus	78.21	0.00e+00	702.00
IUUC-Ocu-074007	Oryctolagus cuniculus	95.35	0.00e+00	787.00
IUUC-Oba-075904	Oryza barthii	56.54	2.00e-142	499.00
IUUC-Obr-076280	Oryza brachyantha	56.05	2.00e-141	495.00
IUUC-Ogl-077425	Oryza glaberrima	56.54	1.00e-142	499.00
IUUC-Ogu-078075	Oryza glumaepatula	56.79	4.00e-143	501.00
IUUC-Oin-079489	Oryza indica	56.54	6.00e-143	500.00
IUUC-Olo-080766	Oryza longistaminata	56.40	3.00e-142	498.00
IUUC-Ome-081905	Oryza meridionalis	56.54	2.00e-142	498.00
IUUC-Oni-083022	Oryza nivara	56.54	1.00e-142	499.00
IUUC-Opu-083615	Oryza punctata	56.54	1.00e-142	499.00
IUUC-Oru-085127	Oryza rufipogon	56.79	4.00e-143	501.00
IUUC-Osa-085744	Oryza sativa	56.79	6.00e-143	500.00
IUUC-Ola-087290	Oryzias latipes	74.94	0.00e+00	683.00
IUUC-Olu-087898	Ostreococcus lucimarinus	49.76	2.00e-115	409.00
IUUC-Oga-088980	Otolemur garnettii	95.58	0.00e+00	810.00
IUUC-Ptr-090845	Pan troglodytes	95.33	0.00e+00	805.00
IUUC-Pan-092836	Papio anubis	94.75	0.00e+00	828.00
IUUC-Psi-093965	Pelodiscus sinensis	83.33	3.00e-56	209.00
IUUC-Pno-095052	Phaeosphaeria nodorum	43.91	3.00e-95	342.00
IUUC-Ppa-095432	Physcomitrella patens	57.49	5.00e-143	500.00
IUUC-Pfo-096963	Poecilia formosa	68.45	3.00e-168	584.00
IUUC-Pab-097716	Pongo abelii	91.40	0.00e+00	765.00
IUUC-Pop-099224	Populus trichocarpa	55.66	2.00e-140	492.00
IUUC-Pca-100682	Procavia capensis	91.16	6.00e-161	559.00
IUUC-Ppe-101819	Prunus persica	55.77	2.00e-138	485.00
IUUC-Pva-102338	Pteropus vampyrus	96.99	0.00e+00	732.00
IUUC-Pgr-103583	Puccinia graminis	53.89	6.00e-109	387.00
IUUC-Ptt-103737	Puccinia triticina	44.74	2.00e-81	296.00
IUUC-Pte-104150	Pyrenophora teres	47.21	7.00e-96	344.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	46.95	2.00e-95	342.00
IUUC-Rno-105987	Rattus norvegicus	94.85	0.00e+00	810.00
IUUC-Sce-106315	Saccharomyces cerevisiae	44.08	8.00e-103	367.00
IUUC-Sha-107273	Sarcophilus harrisii	88.18	0.00e+00	783.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	42.51	3.00e-94	338.00
IUUC-Spo-108092	Schizosaccharomyces pombe	44.80	6.00e-94	338.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	41.36	2.00e-93	335.00
IUUC-Smo-108855	Selaginella moellendorffii	53.88	1.00e-134	473.00
IUUC-Sit-110329	Setaria italica	56.79	6.00e-142	498.00
IUUC-Sly-111830	Solanum lycopersicum	57.78	1.00e-144	506.00
IUUC-Stu-112603	Solanum tuberosum	57.78	2.00e-144	505.00
IUUC-Sar-113504	Sorex araneus	91.16	2.00e-75	276.00
IUUC-Sbi-114560	Sorghum bicolor	56.05	3.00e-139	488.00
IUUC-Sre-115133	Sporisorium reilianum	39.09	9.00e-102	364.00
IUUC-Ssc-115903	Sus scrofa	98.29	0.00e+00	833.00
IUUC-Tgu-116798	Taeniopygia guttata	83.62	0.00e+00	737.00
IUUC-Tru-118361	Takifugu rubripes	76.94	0.00e+00	688.00
IUUC-Tsy-118849	Tarsius syrichta	96.39	0.00e+00	831.00
IUUC-Tni-120094	Tetraodon nigroviridis	76.83	0.00e+00	685.00
IUUC-Tca-121634	Theobroma cacao	55.28	1.00e-138	486.00
IUUC-Tre-122051	Trichoderma reesei	42.58	1.00e-91	330.00
IUUC-Tvi-122322	Trichoderma virens	44.50	1.00e-96	346.00
IUUC-Tae-123133	Triticum aestivum	55.80	5.00e-140	491.00
IUUC-Tur-126766	Triticum urartu	52.06	6.00e-136	477.00
IUUC-Tme-127175	Tuber melanosporum	48.54	2.00e-109	389.00
IUUC-Tbe-127779	Tupaia belangeri	94.55	0.00e+00	721.00
IUUC-Ttr-128224	Tursiops truncatus	92.64	0.00e+00	704.00
IUUC-Uma-129537	Ustilago maydis	39.51	9.00e-103	367.00
IUUC-Vda-129927	Verticillium dahliae	42.69	5.00e-93	335.00
IUUC-Vpa-130658	Vicugna pacos	82.65	0.00e+00	691.00
IUUC-Vvi-131659	Vitis vinifera	56.02	3.00e-141	494.00
IUUC-Xtr-132918	Xenopus tropicalis	74.46	0.00e+00	676.00
IUUC-Xma-133700	Xiphophorus maculatus	77.91	0.00e+00	696.00
IUUC-Yli-134478	Yarrowia lipolytica	47.07	2.00e-111	396.00
IUUC-Zma-135835	Zea mays	53.36	2.00e-136	478.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence