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Tag Content
UUCD2 ID IUUC-Cpo-021886
UUCD1 version UUC-CaP-01076
Ensembl Protein ID ENSCPOP00000008431.2
UniProt Accession H0VEI6; H0VEI6_CAVPO
Genbank Protein ID ENSCPOP00000008431
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID AAKN02042018
Gene Name USP16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCPOG00000009390.3 ENSCPOT00000009475.2 ENSCPOP00000008431.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 4.80e-92 308.7 199 825
Active Site
Position(s) Description Evidence
208 Nucleophile ECO:0000256|HAMAP-Rule:MF_03062}
761 Proton acceptor ECO:0000256|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 199  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtiikiE---------PpdlaltepleinLEPPGPLTVAMSQFLNEMQETKKGI 278
           5******************************85555555540.........34555555566668899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 279  VTPKELFAQVCKKAVRFRGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSVPSFVDRIFGGELT 367
           *************************************************************99999999******************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 368  STIMCDECRTVSLVHESFLDLSLPVLDDQSVKKNvndkdlkktmkdnskeseeekdndsylkerkdspsgtskhlqkrarkqrkggaqn 456
           *****************************99888******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 457  errqqkiqgkvlhlndiytidqpedeyetevslqevdikynhisqeevtheefcvnqkdlngqekaiesithnqrsiaevdiinvnmdn 545
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 546  dlddlmssteytrtsdgaclkegshgevdissdfkhlnlngtlepdevnieilndghipvtklyevvsedpetafytlanreafstdec 634
           ***************************************************************************************** PP
   S: 186  slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           s+q+cL +ft++e+l+++nk+ ce c+++                   a+k++ ++  P+vL+lhLkRf  ++++ s +k+nk+++fp+
   Q: 635  SIQHCLYQFTRNEKLRDANKLLCEVCTRRHYngpkanikgerkyvytnAKKQMLISLAPPVLTLHLKRF--QQAGFSLRKVNKHIKFPE 721
           ***************************444455555555555555555*********************..99**************** PP
   S: 258  eLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtevke 319
            Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++v+ 
   Q: 722  ILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKArtannhlsnlvlhgdipqefemesTKGQWFHISDTHVQAVPT 810
           **********9999887777999************************9999999999999999999998888999************** PP
   S: 320  eevleetgstaYvlfYkr 337
           ++vl+   s+aY+lfY+r
   Q: 811  TKVLN---SQAYLLFYER 825
           *****...********98 PP
   
Organism Cavia porcellus
Functional Description
(View)

Functional Description


     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
 Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MGKKRTKGKT IPVDDASESL EPMCRHIRKG LEQGNLKKAL VNVEWNICQD CKMDNKIKDK 60
SEEETEENPS IWLCLKCGHQ GCGRNSQEQH ALKHYMIPRS ESHCLVLGLD NWSVWCYVCD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cpo-021886|DUB,USP|Cavia porcellus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGAAAGA AACGGACAAA GGGAAAAACT ATTCCAGTTG ATGATGCTTC TGAATCTTTA 60
GGTATATTTA TTTCACTAAT TAAATCTTAA GCACTTATAT TCCTAAATGG ATGTTTTATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cpo-021886|DUB,USP|Cavia porcellus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 35.81 1.00e-27 119.00
IUUC-Aml-001931 Ailuropoda melanoleuca 80.84 0.00e+00 1266.00
IUUC-Atr-003015 Amborella trichopoda 30.77 4.00e-36 147.00
IUUC-Apl-004145 Anas platyrhynchos 58.98 0.00e+00 865.00
IUUC-Aca-004314 Anolis carolinensis 56.18 0.00e+00 854.00
IUUC-Aly-006422 Arabidopsis lyrata 29.14 2.00e-30 128.00
IUUC-Ath-006732 Arabidopsis thaliana 33.53 1.00e-34 142.00
IUUC-Ame-011659 Astyanax mexicanus 42.89 8.00e-94 338.00
IUUC-Bta-013362 Bos taurus 80.48 0.00e+00 1277.00
IUUC-Bdi-014624 Brachypodium distachyon 31.10 7.00e-30 126.00
IUUC-Bol-015941 Brassica oleracea 29.93 5.00e-34 139.00
IUUC-Bra-016751 Brassica rapa 29.22 1.00e-31 132.00
IUUC-Cja-019177 Callithrix jacchus 81.69 0.00e+00 1319.00
IUUC-Cfa-020051 Canis familiaris 81.69 0.00e+00 1294.00
IUUC-Csa-024103 Chlorocebus sabaeus 81.45 0.00e+00 1325.00
IUUC-Cho-024315 Choloepus hoffmanni 73.61 1.00e-119 423.00
IUUC-Cin-025775 Ciona intestinalis 49.65 1.00e-39 154.00
IUUC-Csv-026075 Ciona savignyi 51.79 4.00e-57 216.00
IUUC-Cme-027348 Cyanidioschyzon merolae 38.51 1.00e-19 91.30
IUUC-Dre-028388 Danio rerio 45.80 6.00e-180 624.00
IUUC-Dno-029409 Dasypus novemcinctus 79.04 0.00e+00 1283.00
IUUC-Dor-030443 Dipodomys ordii 64.60 1.00e-160 560.00
IUUC-Ete-032807 Echinops telfairi 72.92 8.00e-170 590.00
IUUC-Eca-033479 Equus caballus 81.33 0.00e+00 1321.00
IUUC-Eeu-034835 Erinaceus europaeus 75.58 6.00e-175 607.00
IUUC-Fca-036320 Felis catus 81.06 0.00e+00 1328.00
IUUC-Fal-037029 Ficedula albicollis 58.19 0.00e+00 840.00
IUUC-Gmo-039480 Gadus morhua 47.28 1.00e-103 370.00
IUUC-Gga-040527 Gallus gallus 59.35 0.00e+00 872.00
IUUC-Gac-042343 Gasterosteus aculeatus 44.96 4.00e-179 621.00
IUUC-Gma-044402 Glycine max 28.97 1.00e-33 138.00
IUUC-Ggo-045598 Gorilla gorilla 81.33 0.00e+00 1318.00
IUUC-Hsa-046598 Homo sapiens 81.54 0.00e+00 1320.00
IUUC-Hvu-047146 Hordeum vulgare 35.90 7.00e-27 116.00
IUUC-Itr-047951 Ictidomys tridecemlineatus 80.88 0.00e+00 1321.00
IUUC-Lch-050536 Latimeria chalumnae 56.90 1.00e-119 424.00
IUUC-Lpe-050703 Leersia perrieri 29.36 5.00e-29 123.00
IUUC-Loc-051814 Lepisosteus oculatus 52.71 4.00e-118 419.00
IUUC-Laf-053732 Loxodonta africana 79.24 0.00e+00 1287.00
IUUC-Mcc-054661 Macaca mulatta 81.81 0.00e+00 1328.00
IUUC-Meu-055967 Macropus eugenii 64.93 8.00e-132 464.00
IUUC-Mtr-057945 Medicago truncatula 30.36 3.00e-35 144.00
IUUC-Mga-059551 Meleagris gallopavo 59.26 0.00e+00 875.00
IUUC-Mmr-061747 Microcebus murinus 82.47 0.00e+00 1307.00
IUUC-Mdo-062220 Monodelphis domestica 65.62 0.00e+00 978.00
IUUC-Mmu-063582 Mus musculus 72.80 0.00e+00 1130.00
IUUC-Mac-064941 Musa acuminata 32.26 1.00e-37 151.00
IUUC-Mpu-066339 Mustela putorius furo 81.20 0.00e+00 1315.00
IUUC-Mlu-067511 Myotis lucifugus 75.66 0.00e+00 1202.00
IUUC-Nle-069252 Nomascus leucogenys 81.93 0.00e+00 1329.00
IUUC-Opr-070969 Ochotona princeps 77.28 0.00e+00 1206.00
IUUC-Ont-071786 Oreochromis niloticus 49.76 3.00e-111 395.00
IUUC-Ocu-074704 Oryctolagus cuniculus 81.90 0.00e+00 1275.00
IUUC-Oba-075094 Oryza barthii 29.31 1.00e-30 128.00
IUUC-Obr-076743 Oryza brachyantha 30.58 3.00e-31 130.00
IUUC-Ogl-077739 Oryza glaberrima 29.31 1.00e-30 128.00
IUUC-Ogu-078851 Oryza glumaepatula 29.31 1.00e-30 128.00
IUUC-Oin-079402 Oryza indica 29.31 1.00e-30 128.00
IUUC-Olo-080431 Oryza longistaminata 29.31 1.00e-30 128.00
IUUC-Ome-081580 Oryza meridionalis 29.31 8.00e-31 129.00
IUUC-Oni-082644 Oryza nivara 29.31 1.00e-30 128.00
IUUC-Opu-083452 Oryza punctata 28.75 6.00e-30 126.00
IUUC-Oru-084546 Oryza rufipogon 29.31 1.00e-30 128.00
IUUC-Osa-085858 Oryza sativa 29.31 1.00e-30 128.00
IUUC-Ola-086795 Oryzias latipes 45.90 1.00e-105 377.00
IUUC-Oga-088713 Otolemur garnettii 80.00 0.00e+00 1295.00
IUUC-Oar-089887 Ovis aries 80.96 0.00e+00 1288.00
IUUC-Ptr-091670 Pan troglodytes 81.33 0.00e+00 1320.00
IUUC-Pan-092293 Papio anubis 81.81 0.00e+00 1328.00
IUUC-Psi-093101 Pelodiscus sinensis 61.76 0.00e+00 912.00
IUUC-Ppa-095622 Physcomitrella patens 29.67 2.00e-36 148.00
IUUC-Pfo-097202 Poecilia formosa 44.24 0.00e+00 632.00
IUUC-Pab-098773 Pongo abelii 86.31 0.00e+00 1067.00
IUUC-Pop-099136 Populus trichocarpa 29.67 1.00e-40 161.00
IUUC-Pca-101069 Procavia capensis 68.57 0.00e+00 829.00
IUUC-Ppe-101794 Prunus persica 31.29 5.00e-38 152.00
IUUC-Pva-103092 Pteropus vampyrus 81.07 2.00e-178 619.00
IUUC-Rno-105237 Rattus norvegicus 72.74 0.00e+00 1161.00
IUUC-Sha-106889 Sarcophilus harrisii 66.22 0.00e+00 1017.00
IUUC-Ssl-108648 Sclerotinia sclerotiorum 28.16 1.00e-11 65.10
IUUC-Sit-110283 Setaria italica 31.70 2.00e-30 127.00
IUUC-Sly-111487 Solanum lycopersicum 26.24 2.00e-39 157.00
IUUC-Stu-112820 Solanum tuberosum 28.89 3.00e-40 160.00
IUUC-Sar-113530 Sorex araneus 75.87 0.00e+00 1199.00
IUUC-Sbi-113785 Sorghum bicolor 39.35 8.00e-25 109.00
IUUC-Ssc-116091 Sus scrofa 79.57 0.00e+00 1277.00
IUUC-Tgu-117478 Taeniopygia guttata 57.01 0.00e+00 824.00
IUUC-Tru-118640 Takifugu rubripes 48.40 1.00e-108 387.00
IUUC-Tsy-119042 Tarsius syrichta 67.88 0.00e+00 814.00
IUUC-Tni-120015 Tetraodon nigroviridis 43.06 3.00e-165 575.00
IUUC-Tca-121701 Theobroma cacao 29.11 9.00e-40 159.00
IUUC-Tae-125351 Triticum aestivum 36.41 3.00e-25 110.00
IUUC-Tur-126788 Triticum urartu 36.41 3.00e-25 110.00
IUUC-Tbe-127309 Tupaia belangeri 68.85 0.00e+00 1008.00
IUUC-Ttr-128271 Tursiops truncatus 80.94 0.00e+00 1305.00
IUUC-Vpa-130674 Vicugna pacos 80.10 0.00e+00 1204.00
IUUC-Xtr-131869 Xenopus tropicalis 49.26 0.00e+00 767.00
IUUC-Xma-134195 Xiphophorus maculatus 44.39 2.00e-176 612.00
IUUC-Zma-135157 Zea mays 30.98 1.00e-26 115.00
Created Date 25-Jun-2017

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