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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105852
UUCD1 version UUC-RaN-00016
Ensembl Protein ID ENSRNOP00000028295.5
UniProt Accession A2RRU4; SCAP_RAT
Genbank Protein ID AAI31853.1
Protein Name Sterol regulatory element-binding protein cleavage-activating protein
Genbank Nucleotide ID BC131852
Gene Name Scap
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000020853.7 ENSRNOT00000028295.7 ENSRNOP00000028295.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.60e-15 55.5 1114 1147
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd.tl.lvsGsdDgtikvWDlrtg 33
           gH++ +t +   d t+ l+sG+ Dg i +WD+ tg
   Q: 1114 GHSGAITTVYI-DqTMvLASGGQDGAICLWDVLTG 1147
           8********88.446648*************9887 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
 Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
Protein Sequence
(Fasta)
MTLTERLREK ISQAFYNHGL LCASYPIPII LFTGLCILAC CYPLLKLPLP GTGPVEFSTP 60
VKGYSPPPAD SDHKQGEPSE QPEWYVGAPV AYIQQIFVKS SVSPWHRNLL AVDVFRSPLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105852|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGGGGAGC TGCGCGGGCG CCGGGCGGCC GGGAGGGAGA GGGCGGGCTC GAAACACCGG 60
ATCGCGGGCC AGGAGCGCGC AGGCCGCTCT CCGCCGCTCC GTCGCCGCCG CCCGGGAGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105852|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0153--Cholesterol metabolism
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0753--Steroid metabolism
KW-1207--Sterol metabolism
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0853--WD repeat
Interpro

IPR002469--Peptidase_S9B_N
IPR027295--Quinoprotein_ADH-like_fam
IPR030225--SCAP
IPR000731--SSD
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50156--SSD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12349--Sterol-sensing
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0012507--C:ER to Golgi transport vesicle membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0043234--C:protein complex
GO:0015485--F:cholesterol binding
GO:0032403--F:protein complex binding
GO:0007568--P:aging
GO:0008203--P:cholesterol metabolic process
GO:0045540--P:regulation of cholesterol biosynthetic process
GO:0042304--P:regulation of fatty acid biosynthetic process
GO:0001666--P:response to hypoxia
GO:0032868--P:response to insulin
GO:0032933--P:SREBP signaling pathway
KEGG rno:301024
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001802 Ailuropoda melanoleuca 95.20 0.00e+00 1099.00
IUUC-Apl-003294 Anas platyrhynchos 76.92 0.00e+00 1727.00
IUUC-Aca-004424 Anolis carolinensis 69.95 0.00e+00 1502.00
IUUC-Bta-013478 Bos taurus 90.77 0.00e+00 2039.00
IUUC-Cel-018160 Caenorhabditis elegans 30.07 2.00e-67 251.00
IUUC-Cja-019123 Callithrix jacchus 89.84 0.00e+00 2031.00
IUUC-Cfa-021082 Canis familiaris 90.54 0.00e+00 2011.00
IUUC-Cpo-022477 Cavia porcellus 84.22 0.00e+00 1879.00
IUUC-Csa-023176 Chlorocebus sabaeus 89.67 0.00e+00 2026.00
IUUC-Cin-025490 Ciona intestinalis 37.92 1.00e-89 324.00
IUUC-Csv-026115 Ciona savignyi 36.73 3.00e-132 466.00
IUUC-Dre-028008 Danio rerio 68.17 0.00e+00 1524.00
IUUC-Dno-028887 Dasypus novemcinctus 90.92 0.00e+00 1213.00
IUUC-Dor-030467 Dipodomys ordii 93.28 0.00e+00 878.00
IUUC-Dme-032087 Drosophila melanogaster 32.78 7.00e-109 389.00
IUUC-Ete-032372 Echinops telfairi 77.25 0.00e+00 1665.00
IUUC-Eca-033896 Equus caballus 91.87 0.00e+00 2109.00
IUUC-Eeu-035099 Erinaceus europaeus 83.77 0.00e+00 1204.00
IUUC-Fca-035616 Felis catus 93.90 0.00e+00 1105.00
IUUC-Fal-037231 Ficedula albicollis 74.85 0.00e+00 1656.00
IUUC-Gmo-039439 Gadus morhua 73.90 0.00e+00 678.00
IUUC-Gac-041516 Gasterosteus aculeatus 67.48 0.00e+00 1493.00
IUUC-Hsa-046674 Homo sapiens 92.49 0.00e+00 2162.00
IUUC-Itr-048879 Ictidomys tridecemlineatus 91.63 0.00e+00 2119.00
IUUC-Lch-049689 Latimeria chalumnae 70.81 0.00e+00 1627.00
IUUC-Loc-052417 Lepisosteus oculatus 54.38 1.00e-131 463.00
IUUC-Laf-053795 Loxodonta africana 90.51 0.00e+00 2053.00
IUUC-Mcc-055502 Macaca mulatta 92.33 0.00e+00 2118.00
IUUC-Mga-059805 Meleagris gallopavo 76.89 0.00e+00 1731.00
IUUC-Mmr-060997 Microcebus murinus 92.34 0.00e+00 2150.00
IUUC-Mdo-062940 Monodelphis domestica 81.68 0.00e+00 1818.00
IUUC-Mmu-063255 Mus musculus 98.12 0.00e+00 2277.00
IUUC-Mpu-066158 Mustela putorius furo 90.69 0.00e+00 2075.00
IUUC-Mlu-067201 Myotis lucifugus 87.16 0.00e+00 1991.00
IUUC-Nle-069145 Nomascus leucogenys 93.63 0.00e+00 1360.00
IUUC-Opr-070797 Ochotona princeps 86.63 0.00e+00 1941.00
IUUC-Ont-071553 Oreochromis niloticus 66.98 0.00e+00 1486.00
IUUC-Ocu-074598 Oryctolagus cuniculus 92.57 0.00e+00 2089.00
IUUC-Ola-086650 Oryzias latipes 84.72 8.00e-110 389.00
IUUC-Oar-089287 Ovis aries 85.02 0.00e+00 1103.00
IUUC-Pan-092004 Papio anubis 92.82 0.00e+00 2119.00
IUUC-Psi-093028 Pelodiscus sinensis 71.42 0.00e+00 1524.00
IUUC-Pma-094145 Petromyzon marinus 50.70 0.00e+00 1117.00
IUUC-Pfo-096320 Poecilia formosa 67.72 0.00e+00 1500.00
IUUC-Pab-097862 Pongo abelii 92.80 0.00e+00 2169.00
IUUC-Pca-100862 Procavia capensis 77.81 0.00e+00 1619.00
IUUC-Pva-103050 Pteropus vampyrus 90.44 0.00e+00 1327.00
IUUC-Sha-107312 Sarcophilus harrisii 81.85 0.00e+00 1831.00
IUUC-Sar-113311 Sorex araneus 86.48 0.00e+00 789.00
IUUC-Ssc-116356 Sus scrofa 90.62 0.00e+00 2113.00
IUUC-Tgu-116896 Taeniopygia guttata 61.74 3.00e-152 532.00
IUUC-Tru-118197 Takifugu rubripes 67.99 0.00e+00 1502.00
IUUC-Tni-119823 Tetraodon nigroviridis 66.33 0.00e+00 1479.00
IUUC-Ttr-129164 Tursiops truncatus 90.86 0.00e+00 2038.00
IUUC-Xtr-132819 Xenopus tropicalis 69.21 0.00e+00 1610.00
Created Date 25-Jun-2017

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