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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046061
UUCD1 version UUC-HoS-01264
Ensembl Protein ID ENSP00000452898.1
UniProt Accession Q8TEB1; B3KQ83; D3DS56; Q5D039; Q86U00; Q86U39; Q8NDN2; Q9H2J0; Q9H3A3; Q9H5C9; DCA11_HUMAN
Genbank Protein ID AAG44727.1; BAB15698.1; BAG51945.1; BAB85041.1; CAD61885.1; CAD62308.1; EAW66110.1; EAW66111.1; EAW66112.1; EAW66113.1; EAW66114.1; AAH08858.2; AAH67132.1; AAG35498.1; CAD38691.1
Protein Name DDB1- and CUL4-associated factor 11; WD repeat-containing protein 23
Genbank Nucleotide ID AF267858; AK027223; AK057636; AK074296; BX161405; BX247970; AL136295; CH471078; CH471078; CH471078; CH471078; BC008858; BC067132; AF130070; AL833831
Gene Name DCAF11; WDR23; GL014; PRO2389
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100897.17 ENST00000559115.5 ENSP00000452898.1
ENSG00000100897.17 ENST00000557802.5 ENSP00000453462.1
ENSG00000100897.17 ENST00000560901.5 ENSP00000453132.1
ENSG00000100897.17 ENST00000558706.5 ENSP00000453803.1
ENSG00000100897.17 ENST00000558914.5 ENSP00000453035.1
ENSG00000100897.17 ENST00000396941.8 ENSP00000380146.4
ENSG00000100897.17 ENST00000396936.5 ENSP00000380142.1
ENSG00000100897.17 ENST00000559144.1 ENSP00000453115.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 16964240
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.40e-25 88.7 482 514
UBD/Beta-Prp 1.40e-46 160.7 270 516
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           H++ v+++++   +  +vs+s+Dg++++W +r+
   Q: 482  HKACVRDVSWhpFEEKIVSSSWDGNLRLWQYRQ 514
           9999******965599*************9775 PP
   

   UBD/Beta-Prp
   S: 15   cvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.....tgkcvhtlkghedsvlsl 100
           ++++s d++ ++ g  dg++ v+d ++     ++++he+ v+av f + ++ il +g++D++ kvwd +     ++k+v +l gh+d ++ +
   Q: 270  SIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSqILFSGGDDAICKVWDRRtmredDPKPVGALAGHQDGITFI 361
           47889999999****************9999999**********99875545**************8877778899**************** PP
   S: 101  sfspsgdklvsGshdrtirvwdletgqclee.....................................tlsghdgvvncvv.....vhpdg. 149
           ++  +  +l+s s+d+ti++wd++  +  e                                      t +gh  + + ++     +h++g 
   Q: 362  DSKGDARYLISNSKDQTIKLWDIRRFSSREGmeasrqaatqqnwdyrwqqvpkkawrklklpgdsslmTYRGHGVLHTLIRcrfspIHSTGq 453
           ****99*****************9999887789999*******************************9888886655555433344799999 PP
   S: 150  nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtge 213
           + + sG+  ++v ++dl +g ++++lt  h+  v+ +s+++  + +vs s dg ++lw++++ e
   Q: 454  QFIYSGCSTGKVVVYDLLSGHIVKKLTN-HKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAE 516
           9999**********************97.******************************99554 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Protein Sequence
(Fasta)
MGSRNSSSAG SGSGDPSEGL PRRGAGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG 60
GGAANLQFIQ ALLDSEEEND RAWDGRLGDR YNPPVDATPD TRELEFNEIK TQVELATGQL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046061|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAAGACGCG TGTATTAGGG AACGTCTGCA AAGACCGCGG CGGAAAGCCA GGGATTGTCT 60
TAAAAAATTG TCAGACCGGA TAAAGGGAGG TCTAAAAGGG GACCGTCCCA AGAGCAAGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046061|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR017399--DCAF11/LEC14B
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0016567--P:protein ubiquitination
KEGG hsa:80344
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000659 Aegilops tauschii 42.36 1.00e-65 244.00
IUUC-Aml-001732 Ailuropoda melanoleuca 95.27 0.00e+00 968.00
IUUC-Atr-002856 Amborella trichopoda 42.82 2.00e-79 289.00
IUUC-Aca-005081 Anolis carolinensis 80.20 0.00e+00 839.00
IUUC-Aly-006571 Arabidopsis lyrata 42.24 1.00e-91 330.00
IUUC-Ath-007313 Arabidopsis thaliana 42.72 2.00e-92 333.00
IUUC-Acl-008126 Aspergillus clavatus 36.10 2.00e-58 220.00
IUUC-Afl-008513 Aspergillus flavus 34.88 1.00e-60 228.00
IUUC-Afu-008765 Aspergillus fumigatus 32.08 3.00e-57 216.00
IUUC-Ani-009456 Aspergillus nidulans 36.80 7.00e-64 238.00
IUUC-Ang-009781 Aspergillus niger 33.16 2.00e-52 201.00
IUUC-Aor-010093 Aspergillus oryzae 34.88 1.00e-60 228.00
IUUC-Ate-010456 Aspergillus terreus 35.45 3.00e-60 226.00
IUUC-Ame-011825 Astyanax mexicanus 70.12 1.00e-175 608.00
IUUC-Bgr-012310 Blumeria graminis 33.70 3.00e-57 216.00
IUUC-Bta-013043 Bos taurus 95.09 0.00e+00 964.00
IUUC-Bci-013758 Botrytis cinerea 36.36 5.00e-60 226.00
IUUC-Bdi-014294 Brachypodium distachyon 46.69 7.00e-88 317.00
IUUC-Bol-016186 Brassica oleracea 44.05 5.00e-86 312.00
IUUC-Bra-018035 Brassica rapa 44.05 6.00e-86 311.00
IUUC-Cel-018145 Caenorhabditis elegans 42.59 2.00e-86 313.00
IUUC-Cja-018940 Callithrix jacchus 97.62 0.00e+00 995.00
IUUC-Cfa-020064 Canis familiaris 95.84 0.00e+00 967.00
IUUC-Cpo-022220 Cavia porcellus 93.17 0.00e+00 977.00
IUUC-Cre-022728 Chlamydomonas reinhardtii 50.84 1.00e-65 242.00
IUUC-Csa-023158 Chlorocebus sabaeus 99.01 0.00e+00 1004.00
IUUC-Cho-024797 Choloepus hoffmanni 75.42 2.00e-94 339.00
IUUC-Cgl-026444 Colletotrichum gloeosporioides 37.77 5.00e-62 232.00
IUUC-Cne-026917 Cryptococcus neoformans 36.72 7.00e-51 195.00
IUUC-Cme-027273 Cyanidioschyzon merolae 29.89 1.00e-44 175.00
IUUC-Dre-028711 Danio rerio 69.09 0.00e+00 717.00
IUUC-Dno-029851 Dasypus novemcinctus 94.31 0.00e+00 954.00
IUUC-Dor-030952 Dipodomys ordii 85.80 0.00e+00 830.00
IUUC-Dse-031288 Dothistroma septosporum 31.41 2.00e-57 217.00
IUUC-Dme-031925 Drosophila melanogaster 36.78 2.00e-80 293.00
IUUC-Ete-032983 Echinops telfairi 87.02 0.00e+00 843.00
IUUC-Eca-033499 Equus caballus 95.65 0.00e+00 996.00
IUUC-Eeu-035179 Erinaceus europaeus 89.86 0.00e+00 763.00
IUUC-Fca-035615 Felis catus 96.83 0.00e+00 946.00
IUUC-Fox-037867 Fusarium oxysporum 37.53 8.00e-57 214.00
IUUC-Fso-038274 Fusarium solani 36.03 8.00e-58 218.00
IUUC-Gmo-038731 Gadus morhua 67.57 0.00e+00 708.00
IUUC-Ggr-039861 Gaeumannomyces graminis 33.41 4.00e-57 216.00
IUUC-Gac-041615 Gasterosteus aculeatus 68.88 0.00e+00 712.00
IUUC-Gma-043167 Glycine max 40.85 1.00e-89 323.00
IUUC-Hvu-047177 Hordeum vulgare 56.16 9.00e-62 229.00
IUUC-Itr-048985 Ictidomys tridecemlineatus 94.84 0.00e+00 965.00
IUUC-Lch-050257 Latimeria chalumnae 55.73 5.00e-156 544.00
IUUC-Lpe-051521 Leersia perrieri 44.79 1.00e-85 310.00
IUUC-Lma-053067 Leptosphaeria maculans 36.01 8.00e-54 205.00
IUUC-Laf-054259 Loxodonta africana 96.86 0.00e+00 973.00
IUUC-Mcc-054958 Macaca mulatta 98.94 0.00e+00 978.00
IUUC-Meu-056889 Macropus eugenii 84.66 0.00e+00 879.00
IUUC-Mor-057196 Magnaporthe oryzae 35.92 3.00e-58 219.00
IUUC-Mpo-057340 Magnaporthe poae 32.03 5.00e-54 206.00
IUUC-Mtr-058464 Medicago truncatula 41.51 9.00e-90 324.00
IUUC-Mla-058873 Melampsora laricipopulina 30.21 2.00e-50 194.00
IUUC-Mvi-060439 Microbotryum violaceum 34.45 2.00e-63 237.00
IUUC-Mmr-061329 Microcebus murinus 92.73 0.00e+00 967.00
IUUC-Mdo-062123 Monodelphis domestica 82.64 0.00e+00 863.00
IUUC-Mmu-063616 Mus musculus 93.49 0.00e+00 953.00
IUUC-Mac-064473 Musa acuminata 42.60 4.00e-81 295.00
IUUC-Mpu-066351 Mustela putorius furo 96.24 0.00e+00 847.00
IUUC-Mlu-067043 Myotis lucifugus 96.85 0.00e+00 945.00
IUUC-Nfi-068552 Neosartorya fischeri 34.76 7.00e-57 215.00
IUUC-Ncr-068715 Neurospora crassa 36.68 3.00e-57 216.00
IUUC-Nle-070052 Nomascus leucogenys 99.05 0.00e+00 1024.00
IUUC-Opr-070605 Ochotona princeps 83.74 0.00e+00 880.00
IUUC-Ont-072411 Oreochromis niloticus 69.33 0.00e+00 698.00
IUUC-Ocu-074078 Oryctolagus cuniculus 95.89 0.00e+00 941.00
IUUC-Oba-075901 Oryza barthii 43.23 4.00e-85 308.00
IUUC-Obr-076556 Oryza brachyantha 44.13 1.00e-84 306.00
IUUC-Ogl-077227 Oryza glaberrima 43.49 1.00e-85 310.00
IUUC-Ogu-078264 Oryza glumaepatula 42.31 6.00e-81 295.00
IUUC-Oin-079655 Oryza indica 43.49 8.00e-86 310.00
IUUC-Olo-080362 Oryza longistaminata 41.03 5.00e-74 271.00
IUUC-Ome-081712 Oryza meridionalis 43.46 6.00e-86 311.00
IUUC-Oni-083108 Oryza nivara 43.49 8.00e-86 310.00
IUUC-Opu-084070 Oryza punctata 43.49 6.00e-84 304.00
IUUC-Oru-085194 Oryza rufipogon 43.23 6.00e-85 308.00
IUUC-Osa-086287 Oryza sativa 41.88 1.00e-84 306.00
IUUC-Ola-086329 Oryzias latipes 68.32 0.00e+00 712.00
IUUC-Oga-088779 Otolemur garnettii 94.84 0.00e+00 970.00
IUUC-Oar-089262 Ovis aries 95.09 0.00e+00 963.00
IUUC-Ptr-091346 Pan troglodytes 95.07 0.00e+00 1007.00
IUUC-Pan-092716 Papio anubis 99.21 0.00e+00 1007.00
IUUC-Pma-094148 Petromyzon marinus 73.08 5.00e-129 453.00
IUUC-Pno-095116 Phaeosphaeria nodorum 35.22 1.00e-52 201.00
IUUC-Ppa-095260 Physcomitrella patens 44.56 1.00e-92 334.00
IUUC-Pfo-096424 Poecilia formosa 67.21 0.00e+00 707.00
IUUC-Pab-098091 Pongo abelii 94.88 0.00e+00 973.00
IUUC-Pop-099095 Populus trichocarpa 42.86 5.00e-89 321.00
IUUC-Pca-100153 Procavia capensis 96.07 0.00e+00 958.00
IUUC-Ppe-102075 Prunus persica 40.95 1.00e-88 320.00
IUUC-Pva-102598 Pteropus vampyrus 94.52 0.00e+00 957.00
IUUC-Pgr-103327 Puccinia graminis 34.22 5.00e-53 202.00
IUUC-Ptt-103861 Puccinia triticina 26.54 6.00e-28 118.00
IUUC-Pte-104286 Pyrenophora teres 35.12 3.00e-62 233.00
IUUC-Pyt-104745 Pyrenophora triticirepentis 38.31 2.00e-52 200.00
IUUC-Rno-104890 Rattus norvegicus 93.89 0.00e+00 956.00
IUUC-Sha-106540 Sarcophilus harrisii 84.49 0.00e+00 867.00
IUUC-Ssl-108528 Sclerotinia sclerotiorum 32.72 7.00e-49 188.00
IUUC-Smo-109019 Selaginella moellendorffii 41.32 5.00e-84 305.00
IUUC-Sit-110726 Setaria italica 39.69 1.00e-87 317.00
IUUC-Sly-110856 Solanum lycopersicum 43.33 3.00e-92 332.00
IUUC-Stu-112589 Solanum tuberosum 41.27 3.00e-81 295.00
IUUC-Sar-113742 Sorex araneus 93.75 0.00e+00 947.00
IUUC-Sbi-114505 Sorghum bicolor 44.05 3.00e-71 261.00
IUUC-Sre-115073 Sporisorium reilianum 35.66 4.00e-53 202.00
IUUC-Ssc-116019 Sus scrofa 93.57 0.00e+00 950.00
IUUC-Tru-118536 Takifugu rubripes 68.28 0.00e+00 706.00
IUUC-Tsy-119518 Tarsius syrichta 96.15 0.00e+00 991.00
IUUC-Tni-120264 Tetraodon nigroviridis 68.26 0.00e+00 705.00
IUUC-Tca-121554 Theobroma cacao 42.64 1.00e-87 317.00
IUUC-Tre-122144 Trichoderma reesei 35.31 1.00e-56 214.00
IUUC-Tvi-122472 Trichoderma virens 34.31 4.00e-59 223.00
IUUC-Tae-124083 Triticum aestivum 45.98 2.00e-84 306.00
IUUC-Tur-126714 Triticum urartu 37.61 2.00e-73 270.00
IUUC-Tme-127050 Tuber melanosporum 33.98 4.00e-69 256.00
IUUC-Tbe-127495 Tupaia belangeri 96.63 0.00e+00 982.00
IUUC-Ttr-128553 Tursiops truncatus 95.27 0.00e+00 977.00
IUUC-Uma-129557 Ustilago maydis 37.92 6.00e-54 206.00
IUUC-Vda-129951 Verticillium dahliae 35.10 2.00e-59 223.00
IUUC-Vpa-130542 Vicugna pacos 83.19 5.00e-102 364.00
IUUC-Vvi-131266 Vitis vinifera 43.88 3.00e-90 325.00
IUUC-Xtr-132525 Xenopus tropicalis 74.34 0.00e+00 719.00
IUUC-Xma-133165 Xiphophorus maculatus 67.61 0.00e+00 712.00
IUUC-Yli-134635 Yarrowia lipolytica 26.42 5.00e-22 99.80
IUUC-Zma-135833 Zea mays 42.94 5.00e-81 295.00
Created Date 25-Jun-2017

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