iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090914

UUCD1 version

UUC-PaT-00991

Ensembl Protein ID

ENSPTRP00000025343.3

UniProt Accession

H2QM68; H2QM68_PANTR

Genbank Protein ID

JAA01485.1; JAA12436.1; JAA22348.1; JAA42177.1

Protein Name

Ubiquitin-conjugating enzyme E2E 1

Genbank Nucleotide ID

AACZ03023636; GABF01009709; GABD01010752; GABE01002562

Gene Name

UBE2E1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000014693.3	ENSPTRT00000027484.3	ENSPTRP00000025343.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	3.10e-50	169.5	51	186

Active Site

Position(s)	Description	Evidence
131	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel++++ dpp+++sa+p+ + +++ew+ +ilGp++++YeggvF l+i+f+++YPfkPPkv+f t+i+h+n++++G +Cl+ilk  
   Q: 51   RIQKELADITLDPPPNCSAGPKGD-NIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHCNINSQGVICLDILK-- 136
           9***********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           ++Wspal++++vllsi+sll+++np++pl  ++a+++ +nr+e+++++r+
   Q: 137  DNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQ 186
           *********************************************99985 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSDDDSRAST SSSSSSSSNQ QTEKETNTPK KKESKVSMSK NSKLLSTSAK RIQKELADIT 60
LDPPPNCSAG PKGDNIYEWR STILGPPGSV YEGGVFFLDI TFTPEYPFKP PKVTFRTRIY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAGGAGGA GGCGGCGGCG GAGGAGTGGT GTGTGTGCGA GCGTGTGTGG CTGGGGGAAG 60
CCATTGCCTG TTTAATAGTT GCTGTTGCTG CACTTCCGCT TCTCTCCCAG CGAGAGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0042296--F:ISG15 transferase activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0032020--P:ISG15-protein conjugation
GO:0070936--P:protein K48-linked ubiquitination

KEGG

ptr:750105

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001532	Ailuropoda melanoleuca	100.00	8.00e-94	335.00
IUUC-Apl-004207	Anas platyrhynchos	99.43	4.00e-93	333.00
IUUC-Aca-005103	Anolis carolinensis	99.43	2.00e-93	334.00
IUUC-Ame-011419	Astyanax mexicanus	95.10	1.00e-81	295.00
IUUC-Cja-019311	Callithrix jacchus	100.00	1.00e-93	335.00
IUUC-Cfa-020017	Canis familiaris	100.00	1.00e-93	335.00
IUUC-Cpo-022266	Cavia porcellus	100.00	1.00e-93	335.00
IUUC-Cre-022791	Chlamydomonas reinhardtii	80.41	2.00e-70	256.00
IUUC-Csa-023538	Chlorocebus sabaeus	100.00	1.00e-93	335.00
IUUC-Cho-024986	Choloepus hoffmanni	76.27	1.00e-74	271.00
IUUC-Cin-025161	Ciona intestinalis	84.38	1.00e-75	275.00
IUUC-Csv-025982	Ciona savignyi	84.38	3.00e-82	297.00
IUUC-Cme-027286	Cyanidioschyzon merolae	70.91	2.00e-69	254.00
IUUC-Dre-027449	Danio rerio	87.86	2.00e-83	301.00
IUUC-Dno-029441	Dasypus novemcinctus	100.00	4.00e-75	272.00
IUUC-Dor-030450	Dipodomys ordii	100.00	4.00e-64	235.00
IUUC-Dme-032042	Drosophila melanogaster	87.12	5.00e-83	300.00
IUUC-Ete-032397	Echinops telfairi	98.29	4.00e-101	359.00
IUUC-Eeu-034931	Erinaceus europaeus	86.29	1.00e-80	291.00
IUUC-Fca-035467	Felis catus	100.00	7.00e-94	335.00
IUUC-Fal-036907	Ficedula albicollis	99.43	2.00e-93	334.00
IUUC-Gmo-039645	Gadus morhua	87.86	8.00e-84	302.00
IUUC-Gga-040403	Gallus gallus	99.43	2.00e-93	334.00
IUUC-Gac-042007	Gasterosteus aculeatus	92.22	3.00e-80	290.00
IUUC-Ggo-045507	Gorilla gorilla	100.00	1.00e-93	335.00
IUUC-Hsa-046576	Homo sapiens	100.00	1.00e-93	335.00
IUUC-Itr-048197	Ictidomys tridecemlineatus	100.00	4.00e-75	272.00
IUUC-Lch-050322	Latimeria chalumnae	95.43	3.00e-98	350.00
IUUC-Loc-052673	Lepisosteus oculatus	89.14	5.00e-86	309.00
IUUC-Laf-054313	Loxodonta africana	100.00	1.00e-93	335.00
IUUC-Mcc-055072	Macaca mulatta	97.90	1.00e-83	301.00
IUUC-Meu-056590	Macropus eugenii	100.00	6.00e-85	305.00
IUUC-Mmr-060791	Microcebus murinus	100.00	1.00e-93	335.00
IUUC-Mmu-063297	Mus musculus	98.86	1.00e-102	364.00
IUUC-Mpu-065698	Mustela putorius furo	99.43	2.00e-103	367.00
IUUC-Mlu-067897	Myotis lucifugus	97.90	1.00e-83	301.00
IUUC-Nle-069622	Nomascus leucogenys	100.00	1.00e-93	335.00
IUUC-Ont-071689	Oreochromis niloticus	92.44	5.00e-92	329.00
IUUC-Oan-073006	Ornithorhynchus anatinus	100.00	5.00e-75	272.00
IUUC-Ocu-074055	Oryctolagus cuniculus	100.00	1.00e-93	335.00
IUUC-Ola-086636	Oryzias latipes	92.94	3.00e-83	300.00
IUUC-Olu-087783	Ostreococcus lucimarinus	75.71	1.00e-63	234.00
IUUC-Oga-088863	Otolemur garnettii	100.00	1.00e-93	335.00
IUUC-Oar-089803	Ovis aries	99.43	2.00e-103	367.00
IUUC-Pan-092786	Papio anubis	100.00	1.00e-93	335.00
IUUC-Psi-093923	Pelodiscus sinensis	100.00	1.00e-93	335.00
IUUC-Pma-094642	Petromyzon marinus	95.24	5.00e-71	258.00
IUUC-Ppa-095789	Physcomitrella patens	76.67	2.00e-68	250.00
IUUC-Pfo-096966	Poecilia formosa	91.23	6.00e-83	299.00
IUUC-Pab-098614	Pongo abelii	100.00	1.00e-93	335.00
IUUC-Pop-099024	Populus trichocarpa	62.24	7.00e-56	209.00
IUUC-Pva-102561	Pteropus vampyrus	97.90	1.00e-83	301.00
IUUC-Rno-105518	Rattus norvegicus	98.27	2.00e-100	357.00
IUUC-Sha-106897	Sarcophilus harrisii	100.00	1.00e-85	308.00
IUUC-Ssc-116298	Sus scrofa	97.96	5.00e-85	305.00
IUUC-Tgu-116958	Taeniopygia guttata	100.00	3.00e-89	320.00
IUUC-Tru-118531	Takifugu rubripes	93.71	2.00e-80	291.00
IUUC-Tni-120349	Tetraodon nigroviridis	94.51	6.00e-82	296.00
IUUC-Tca-121777	Theobroma cacao	59.72	3.00e-53	201.00
IUUC-Tbe-127690	Tupaia belangeri	95.80	6.00e-82	295.00
IUUC-Ttr-128356	Tursiops truncatus	96.57	8.00e-89	318.00
IUUC-Vpa-130232	Vicugna pacos	96.45	2.00e-79	287.00
IUUC-Xtr-132547	Xenopus tropicalis	100.00	1.00e-86	312.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence