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Tag Content
iUUCD ID IUUC-Ago-007862
Ensembl Protein ID AAS52096
UniProt Accession Q759U7; LIS1_ASHGO
Genbank Protein ID AAS52096.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID AE016817
Gene Name PAC1; LIS1; ADR176W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AGOS_ADR176W AAS52096 AAS52096
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.60e-24 81.5 382 418
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvllk 37
           gHt++v++++  +++l s+sdD +i++WDl tg +lk
   Q: 382  GHTSWVRDIKVRGRHLFSCSDDRSIRCWDLVTGQCLK 418
           8********99669*********************97 PP
   
Organism Ashbya gossypii
Functional Description
(View)

Functional Description


     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
 Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
Protein Sequence
(Fasta)
MSQHHILPQH QRADLNRSIC DYVQRCGAEE SLVVGLRQLF GLSAEECDAT RNGRDPDLLL 60
KKWNSIIRLH RKILDLEQKC QQLTEELEAV PTEAYGKAGR GVSHVLWTPR SNPTFQLDVG 120
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Protein Fasta Sequence


>IUUC-Ago-007862|E3,WD_repeat|Ashbya gossypii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGCCAGC ATCATATACT ACCTCAGCAT CAGCGGGCAG ACCTTAATAG GTCGATTTGC 60
GATTACGTAC AGCGGTGTGG GGCGGAGGAA TCGTTGGTGG TGGGTTTGCG CCAGCTGTTC 120
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Nucleotide Fasta Sequence


>IUUC-Ago-007862|E3,WD_repeat|Ashbya gossypii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR017252--Dynein_regulator_LIS1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005881--C:cytoplasmic microtubule
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0030473--P:nuclear migration along microtubule
GO:2000582--P:positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
GO:1903033--P:positive regulation of microtubule plus-end binding
KEGG ago:AGOS_ADR176W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 26.70 2.00e-36 144.00
IUUC-Apl-004024 Anas platyrhynchos 27.46 1.00e-39 154.00
IUUC-Aca-004564 Anolis carolinensis 28.21 7.00e-39 152.00
IUUC-Acl-008360 Aspergillus clavatus 29.95 5.00e-40 156.00
IUUC-Afl-008502 Aspergillus flavus 28.64 3.00e-30 123.00
IUUC-Afu-008848 Aspergillus fumigatus 31.24 7.00e-42 162.00
IUUC-Ani-009173 Aspergillus nidulans 27.85 3.00e-33 134.00
IUUC-Ang-009873 Aspergillus niger 28.07 2.00e-34 137.00
IUUC-Ate-010523 Aspergillus terreus 27.52 8.00e-37 145.00
IUUC-Ame-010969 Astyanax mexicanus 27.23 3.00e-39 153.00
IUUC-Bgr-011972 Blumeria graminis 26.86 1.00e-35 142.00
IUUC-Bta-013106 Bos taurus 27.23 2.00e-39 154.00
IUUC-Bci-013615 Botrytis cinerea 26.35 3.00e-34 137.00
IUUC-Cel-018459 Caenorhabditis elegans 26.72 3.00e-37 147.00
IUUC-Cja-018755 Callithrix jacchus 26.32 7.00e-37 145.00
IUUC-Cfa-020749 Canis familiaris 27.23 2.00e-39 154.00
IUUC-Cpo-022371 Cavia porcellus 27.23 2.00e-39 154.00
IUUC-Cin-025753 Ciona intestinalis 25.54 3.00e-33 134.00
IUUC-Csv-025817 Ciona savignyi 27.56 8.00e-36 142.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 27.74 7.00e-29 119.00
IUUC-Dre-027554 Danio rerio 27.46 3.00e-40 157.00
IUUC-Dno-029050 Dasypus novemcinctus 27.46 1.00e-39 155.00
IUUC-Dor-030222 Dipodomys ordii 30.25 8.00e-33 132.00
IUUC-Dse-031164 Dothistroma septosporum 27.38 3.00e-39 153.00
IUUC-Dme-031745 Drosophila melanogaster 28.70 2.00e-36 144.00
IUUC-Eca-034288 Equus caballus 26.70 6.00e-36 142.00
IUUC-Eeu-034984 Erinaceus europaeus 30.25 8.00e-33 132.00
IUUC-Fca-036498 Felis catus 27.23 2.00e-39 154.00
IUUC-Fal-036920 Ficedula albicollis 27.46 1.00e-39 154.00
IUUC-Fox-037996 Fusarium oxysporum 28.76 1.00e-37 148.00
IUUC-Fso-038160 Fusarium solani 26.53 3.00e-32 130.00
IUUC-Gmo-039166 Gadus morhua 26.67 3.00e-40 156.00
IUUC-Ggr-040051 Gaeumannomyces graminis 26.95 6.00e-34 136.00
IUUC-Gga-040623 Gallus gallus 27.46 1.00e-39 154.00
IUUC-Gac-041363 Gasterosteus aculeatus 27.49 6.00e-40 155.00
IUUC-Hsa-046358 Homo sapiens 27.23 2.00e-39 154.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 27.23 2.00e-39 154.00
IUUC-Kpa-049351 Komagataella pastoris 32.19 4.00e-51 193.00
IUUC-Lch-049936 Latimeria chalumnae 26.61 5.00e-39 152.00
IUUC-Loc-052476 Lepisosteus oculatus 26.93 5.00e-37 146.00
IUUC-Lma-053170 Leptosphaeria maculans 29.21 5.00e-37 146.00
IUUC-Laf-053713 Loxodonta africana 26.87 4.00e-37 146.00
IUUC-Mcc-054628 Macaca mulatta 27.46 9.00e-40 155.00
IUUC-Mor-056962 Magnaporthe oryzae 28.34 8.00e-39 152.00
IUUC-Mpo-057583 Magnaporthe poae 27.45 2.00e-33 134.00
IUUC-Mla-058819 Melampsora laricipopulina 27.52 1.00e-35 142.00
IUUC-Mga-059945 Meleagris gallopavo 27.46 1.00e-39 154.00
IUUC-Mvi-060403 Microbotryum violaceum 30.05 3.00e-41 160.00
IUUC-Mmr-061289 Microcebus murinus 26.70 2.00e-36 144.00
IUUC-Mdo-061912 Monodelphis domestica 27.23 4.00e-39 153.00
IUUC-Mmu-063253 Mus musculus 27.23 2.00e-39 154.00
IUUC-Mpu-066638 Mustela putorius furo 27.23 2.00e-39 154.00
IUUC-Mlu-067267 Myotis lucifugus 27.08 1.00e-37 148.00
IUUC-Nfi-068571 Neosartorya fischeri 29.73 7.00e-34 135.00
IUUC-Ncr-068895 Neurospora crassa 28.57 2.00e-35 140.00
IUUC-Nle-069087 Nomascus leucogenys 28.21 3.00e-33 133.00
IUUC-Opr-070579 Ochotona princeps 27.46 1.00e-39 155.00
IUUC-Ont-071905 Oreochromis niloticus 27.36 1.00e-40 157.00
IUUC-Oan-073072 Ornithorhynchus anatinus 27.23 2.00e-39 154.00
IUUC-Ocu-074180 Oryctolagus cuniculus 27.46 1.00e-39 155.00
IUUC-Ola-086815 Oryzias latipes 26.13 1.00e-39 155.00
IUUC-Oga-088219 Otolemur garnettii 26.70 2.00e-36 144.00
IUUC-Oar-090394 Ovis aries 27.23 2.00e-39 154.00
IUUC-Ptr-091517 Pan troglodytes 27.23 2.00e-39 154.00
IUUC-Pan-092421 Papio anubis 27.46 9.00e-40 155.00
IUUC-Psi-093370 Pelodiscus sinensis 27.46 2.00e-39 154.00
IUUC-Pno-094815 Phaeosphaeria nodorum 30.29 2.00e-41 160.00
IUUC-Pfo-096228 Poecilia formosa 27.13 5.00e-40 156.00
IUUC-Pab-098421 Pongo abelii 27.23 2.00e-39 154.00
IUUC-Pva-102960 Pteropus vampyrus 26.90 1.00e-39 155.00
IUUC-Pgr-103538 Puccinia graminis 27.96 2.00e-37 147.00
IUUC-Ptt-103990 Puccinia triticina 28.36 4.00e-12 64.30
IUUC-Pte-104261 Pyrenophora teres 29.16 9.00e-41 158.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 28.94 2.00e-40 157.00
IUUC-Rno-105123 Rattus norvegicus 27.23 2.00e-39 154.00
IUUC-Sce-106208 Saccharomyces cerevisiae 44.59 8.00e-113 398.00
IUUC-Sha-107010 Sarcophilus harrisii 27.23 4.00e-39 153.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 25.93 2.00e-28 117.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 26.75 5.00e-35 139.00
IUUC-Sre-115003 Sporisorium reilianum 27.44 2.00e-37 147.00
IUUC-Ssc-116148 Sus scrofa 27.23 2.00e-39 154.00
IUUC-Tgu-117299 Taeniopygia guttata 27.46 1.00e-39 155.00
IUUC-Tru-118179 Takifugu rubripes 26.57 3.00e-40 157.00
IUUC-Tsy-119493 Tarsius syrichta 27.75 2.00e-38 151.00
IUUC-Tni-120288 Tetraodon nigroviridis 27.19 3.00e-38 150.00
IUUC-Tre-121977 Trichoderma reesei 27.81 1.00e-33 135.00
IUUC-Tvi-122661 Trichoderma virens 27.66 5.00e-34 136.00
IUUC-Tme-127031 Tuber melanosporum 27.82 7.00e-35 139.00
IUUC-Ttr-128929 Tursiops truncatus 27.23 4.00e-39 153.00
IUUC-Uma-129347 Ustilago maydis 27.61 3.00e-37 147.00
IUUC-Vda-129837 Verticillium dahliae 28.54 7.00e-31 125.00
IUUC-Vpa-130532 Vicugna pacos 27.05 8.00e-24 102.00
IUUC-Xtr-131985 Xenopus tropicalis 27.92 9.00e-41 158.00
IUUC-Xma-133469 Xiphophorus maculatus 27.13 6.00e-40 155.00
IUUC-Yli-134403 Yarrowia lipolytica 26.72 2.00e-34 137.00
Created Date 25-Jun-2017

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