iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033578

UUCD1 version

UUC-EqC-00588

Ensembl Protein ID

ENSECAP00000004712.1

UniProt Accession

F7ADG7; F7ADG7_HORSE

Protein Name

Uncharacterized protein

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000006211.1	ENSECAT00000006616.1	ENSECAP00000004712.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.10e-07	30.6	19	58
E3 activity/RING/U-box	2.30e-07	30.9	15	78

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl++  + p++  CgH f+++C+  +      ++   +CP+Cr
   Q: 19   CPICLDPTVE-PMSIECGHSFCHECISEV-----GKNVGSICPVCR 58
           ********99.***************999.....5666667****8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ee  CpI l++  +P+ +++G+++  ++I +  ++ g+ cPv+r+++  ++l Pn  l +++++
   Q: 15   EEVTCPICLDPTVEPMSIECGHSFCHECISEVGKNVGSICPVCRHKFMLRNLRPNRQLANMVDS 78
           6889***************************9999999*******************9999876 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

VTAMASAMPL EMMWEEVTCP ICLDPTVEPM SIECGHSFCH ECISEVGKNV GSICPVCRHK 60
FMLRNLRPNR QLANMVDSLR KISQGAKEGT QGERCEVHGE RLHLYCEEDG KVLCLVCSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTACCGCTA TGGCCTCTGC AATGCCTTTG GAAATGATGT GGGAGGAGGT CACGTGCCCT 60
ATCTGCCTGG ATCCCACAGT GGAGCCTATG AGCATTGAAT GTGGCCACAG CTTCTGCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	79.10	0.00e+00	785.00
IUUC-Aca-004891	Anolis carolinensis	42.07	6.00e-95	341.00
IUUC-Ate-010384	Aspergillus terreus	38.46	3.00e-07	48.10
IUUC-Bta-013083	Bos taurus	72.62	0.00e+00	681.00
IUUC-Cja-019002	Callithrix jacchus	80.65	0.00e+00	768.00
IUUC-Cfa-020415	Canis familiaris	77.30	0.00e+00	769.00
IUUC-Cpo-021948	Cavia porcellus	70.30	0.00e+00	681.00
IUUC-Csa-023135	Chlorocebus sabaeus	81.58	0.00e+00	707.00
IUUC-Cho-024493	Choloepus hoffmanni	67.84	3.00e-100	357.00
IUUC-Dno-030061	Dasypus novemcinctus	70.97	0.00e+00	706.00
IUUC-Ete-033168	Echinops telfairi	68.40	9.00e-169	585.00
IUUC-Eeu-034749	Erinaceus europaeus	58.26	1.00e-135	476.00
IUUC-Fca-035468	Felis catus	74.54	0.00e+00	732.00
IUUC-Fal-036705	Ficedula albicollis	41.19	6.00e-77	281.00
IUUC-Ggr-039833	Gaeumannomyces graminis	31.52	1.00e-07	50.80
IUUC-Gac-042446	Gasterosteus aculeatus	36.31	2.00e-68	253.00
IUUC-Ggo-045190	Gorilla gorilla	80.94	0.00e+00	743.00
IUUC-Hsa-046583	Homo sapiens	81.37	0.00e+00	745.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	77.78	0.00e+00	704.00
IUUC-Lch-049548	Latimeria chalumnae	36.19	4.00e-75	275.00
IUUC-Laf-053455	Loxodonta africana	75.78	0.00e+00	682.00
IUUC-Mcc-054609	Macaca mulatta	81.37	0.00e+00	706.00
IUUC-Mmr-061369	Microcebus murinus	76.24	0.00e+00	635.00
IUUC-Mdo-062418	Monodelphis domestica	43.40	2.00e-100	358.00
IUUC-Mmu-063166	Mus musculus	69.33	0.00e+00	643.00
IUUC-Mpu-066889	Mustela putorius furo	76.87	0.00e+00	763.00
IUUC-Mlu-067647	Myotis lucifugus	81.84	0.00e+00	719.00
IUUC-Nle-069567	Nomascus leucogenys	80.94	0.00e+00	744.00
IUUC-Opr-071178	Ochotona princeps	66.38	1.00e-175	609.00
IUUC-Ont-072675	Oreochromis niloticus	32.15	2.00e-63	236.00
IUUC-Oar-090413	Ovis aries	77.99	0.00e+00	707.00
IUUC-Ptr-091187	Pan troglodytes	81.37	0.00e+00	745.00
IUUC-Pan-092231	Papio anubis	81.37	0.00e+00	706.00
IUUC-Psi-093179	Pelodiscus sinensis	44.57	2.00e-96	346.00
IUUC-Ppa-095897	Physcomitrella patens	46.43	1.00e-09	57.00
IUUC-Pfo-096972	Poecilia formosa	32.80	1.00e-66	247.00
IUUC-Pab-098079	Pongo abelii	76.49	3.00e-147	514.00
IUUC-Pca-100639	Procavia capensis	73.26	4.00e-146	511.00
IUUC-Pva-102476	Pteropus vampyrus	78.68	0.00e+00	739.00
IUUC-Rno-105054	Rattus norvegicus	69.23	8.00e-167	579.00
IUUC-Sha-106630	Sarcophilus harrisii	42.00	1.00e-92	333.00
IUUC-Sar-113204	Sorex araneus	75.80	0.00e+00	676.00
IUUC-Ssc-116291	Sus scrofa	78.25	0.00e+00	736.00
IUUC-Tru-118630	Takifugu rubripes	32.71	3.00e-59	222.00
IUUC-Tsy-118803	Tarsius syrichta	62.85	1.00e-149	522.00
IUUC-Tbe-127337	Tupaia belangeri	64.26	2.00e-114	404.00
IUUC-Ttr-128914	Tursiops truncatus	77.19	0.00e+00	661.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence