iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012884

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39

Genbank Nucleotide ID

BC108091

Gene Name

CIAO1; WDR39

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000015659.2	ENSBTAT00000020797.2	ENSBTAP00000020797.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.70e-44	147.3	192	222
UBD/Beta-Prp	6.60e-61	206.2	13	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v++laf ++  +l+s+sdD t+++W+
   Q: 192  GHESTVWSLAFdPSgQRLASCSDDRTVRIWR 222
           8***********6669**************8 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrsl.sgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtl 90
           +h++s++  +++ p ++lla+ + d+++++w  +  +    + l +gh+ +v+ v +sp g++l+++s D+t ++w  + ++++cv tl
   Q: 13   AHPDSRCWFLAWNPAGTLLASCGGDRSVRIWGREGDSWicKSVLcEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNEDDFECVTTL 101
           688999999999*******************99876664356668*******************************99999******** PP
   S: 91   kghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk..llrtl 175
           +ghe++v s+++ psg+ l++ s+d+ + vw+++++ ++e   +l+ h++ v +vv+hp++ ll+s+s+D tv+l++ + ++  +  tl
   Q: 102  EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECvsVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDwvCCATL 190
           *********************************9987776566*********************************9977754499*** PP
   S: 176  tgghtdsvyslsfdsngkelvsgsldgtvklw 207
           +g h++ v sl+fd++g++l+s+s+d+tv++w
   Q: 191  EG-HESTVWSLAFDPSGQRLASCSDDRTVRIW 221
           *9.***************************** PP

Organism

Bos taurus

Functional Description
(View)

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Protein Sequence
(Fasta)

MKDSLVLLSR ILAHPDSRCW FLAWNPAGTL LASCGGDRSV RIWGREGDSW ICKSVLCEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NEDDFECVTT LEGHENEVKS VAWAPSGNLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAGGCAGC GCAGCCGAAG CAGCGGGCGC TTCATTTCCA GGGTGGACCC TGGCAGTCGG 60
GCCCAAGGGT TTTGCTCTGT GGGAACCGCA GTCGGAGCGG CTAGCTCTGC TCATTTTTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly

KEGG

bta:540069

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000874	Aegilops tauschii	42.37	3.00e-67	249.00
IUUC-Aml-001317	Ailuropoda melanoleuca	94.69	4.00e-178	617.00
IUUC-Atr-003029	Amborella trichopoda	51.61	9.00e-93	333.00
IUUC-Apl-004042	Anas platyrhynchos	76.52	3.00e-55	206.00
IUUC-Aly-006458	Arabidopsis lyrata	48.41	4.00e-85	308.00
IUUC-Ath-006671	Arabidopsis thaliana	48.99	1.00e-85	309.00
IUUC-Ago-007820	Ashbya gossypii	40.59	3.00e-59	221.00
IUUC-Acl-008042	Aspergillus clavatus	31.86	3.00e-49	189.00
IUUC-Afl-008639	Aspergillus flavus	32.94	1.00e-53	203.00
IUUC-Afu-008899	Aspergillus fumigatus	32.42	3.00e-49	189.00
IUUC-Ani-009453	Aspergillus nidulans	32.33	2.00e-50	193.00
IUUC-Ang-009758	Aspergillus niger	34.91	4.00e-51	195.00
IUUC-Aor-010212	Aspergillus oryzae	32.94	1.00e-53	203.00
IUUC-Ate-010314	Aspergillus terreus	33.33	1.00e-53	203.00
IUUC-Ame-010676	Astyanax mexicanus	77.84	1.00e-158	551.00
IUUC-Bgr-012095	Blumeria graminis	30.22	3.00e-38	152.00
IUUC-Bci-013622	Botrytis cinerea	33.43	1.00e-38	154.00
IUUC-Bdi-014614	Brachypodium distachyon	49.11	2.00e-85	308.00
IUUC-Bol-016439	Brassica oleracea	47.65	2.00e-83	301.00
IUUC-Bra-016830	Brassica rapa	46.61	7.00e-82	297.00
IUUC-Cel-018709	Caenorhabditis elegans	40.98	6.00e-64	237.00
IUUC-Cja-019822	Callithrix jacchus	93.22	9.00e-176	608.00
IUUC-Cfa-020823	Canis familiaris	94.40	3.00e-178	617.00
IUUC-Cre-022811	Chlamydomonas reinhardtii	48.67	3.00e-80	291.00
IUUC-Csa-023754	Chlorocebus sabaeus	93.51	4.00e-177	613.00
IUUC-Cin-025395	Ciona intestinalis	57.01	2.00e-114	405.00
IUUC-Csv-025943	Ciona savignyi	55.56	1.00e-111	395.00
IUUC-Cgl-026435	Colletotrichum gloeosporioides	30.45	5.00e-37	148.00
IUUC-Cne-026939	Cryptococcus neoformans	31.24	7.00e-46	177.00
IUUC-Cme-027239	Cyanidioschyzon merolae	41.77	6.00e-45	175.00
IUUC-Dre-028172	Danio rerio	75.00	2.00e-155	541.00
IUUC-Dno-029472	Dasypus novemcinctus	94.16	1.00e-149	521.00
IUUC-Dor-031134	Dipodomys ordii	81.42	6.00e-146	509.00
IUUC-Dse-031535	Dothistroma septosporum	30.33	7.00e-47	181.00
IUUC-Dme-032020	Drosophila melanogaster	58.97	7.00e-118	416.00
IUUC-Eca-033700	Equus caballus	94.10	1.00e-177	615.00
IUUC-Eeu-035010	Erinaceus europaeus	91.74	9.00e-171	592.00
IUUC-Fca-036309	Felis catus	86.18	9.00e-167	578.00
IUUC-Fal-037243	Ficedula albicollis	74.42	2.00e-85	308.00
IUUC-Fox-038058	Fusarium oxysporum	33.51	6.00e-44	172.00
IUUC-Fso-038459	Fusarium solani	33.25	3.00e-40	159.00
IUUC-Gmo-039375	Gadus morhua	74.93	5.00e-140	490.00
IUUC-Ggr-040002	Gaeumannomyces graminis	34.55	3.00e-40	159.00
IUUC-Gga-040294	Gallus gallus	77.68	5.00e-127	447.00
IUUC-Gac-042499	Gasterosteus aculeatus	75.15	8.00e-139	486.00
IUUC-Gma-043543	Glycine max	49.85	4.00e-88	317.00
IUUC-Ggo-045181	Gorilla gorilla	93.51	4.00e-177	613.00
IUUC-Hsa-046528	Homo sapiens	93.51	4.00e-177	613.00
IUUC-Hvu-047341	Hordeum vulgare	58.51	7.00e-57	213.00
IUUC-Itr-048790	Ictidomys tridecemlineatus	93.81	5.00e-177	613.00
IUUC-Kpa-049353	Komagataella pastoris	36.44	3.00e-57	215.00
IUUC-Lch-049763	Latimeria chalumnae	79.23	2.00e-161	561.00
IUUC-Lpe-051500	Leersia perrieri	45.28	7.00e-81	293.00
IUUC-Loc-052021	Lepisosteus oculatus	79.94	6.00e-153	533.00
IUUC-Lma-053331	Leptosphaeria maculans	34.75	2.00e-54	207.00
IUUC-Laf-054558	Loxodonta africana	92.33	5.00e-175	606.00
IUUC-Mcc-055374	Macaca mulatta	93.22	2.00e-176	610.00
IUUC-Meu-056042	Macropus eugenii	75.69	4.00e-109	387.00
IUUC-Mor-057187	Magnaporthe oryzae	32.19	1.00e-40	160.00
IUUC-Mtr-058072	Medicago truncatula	49.41	2.00e-87	315.00
IUUC-Mla-059108	Melampsora laricipopulina	31.97	4.00e-52	198.00
IUUC-Mga-059370	Meleagris gallopavo	63.74	4.00e-99	354.00
IUUC-Mvi-060495	Microbotryum violaceum	37.90	5.00e-57	214.00
IUUC-Mmr-060902	Microcebus murinus	94.40	6.00e-179	619.00
IUUC-Mdo-062510	Monodelphis domestica	90.27	5.00e-166	576.00
IUUC-Mmu-063575	Mus musculus	91.74	6.00e-174	602.00
IUUC-Mac-065322	Musa acuminata	50.60	7.00e-90	323.00
IUUC-Mpu-065925	Mustela putorius furo	94.10	1.00e-177	615.00
IUUC-Mlu-067755	Myotis lucifugus	93.81	1.00e-178	618.00
IUUC-Nfi-068327	Neosartorya fischeri	32.58	6.00e-50	191.00
IUUC-Ncr-068845	Neurospora crassa	32.12	1.00e-32	134.00
IUUC-Nle-069406	Nomascus leucogenys	91.45	3.00e-171	593.00
IUUC-Opr-070416	Ochotona princeps	73.16	4.00e-128	451.00
IUUC-Ont-071936	Oreochromis niloticus	75.67	2.00e-142	498.00
IUUC-Oan-073452	Ornithorhynchus anatinus	91.52	6.00e-75	272.00
IUUC-Ocu-074791	Oryctolagus cuniculus	93.22	5.00e-177	613.00
IUUC-Oba-075636	Oryza barthii	49.55	2.00e-88	319.00
IUUC-Obr-076742	Oryza brachyantha	47.90	2.00e-75	275.00
IUUC-Ogl-077766	Oryza glaberrima	49.55	2.00e-88	319.00
IUUC-Ogu-079039	Oryza glumaepatula	49.55	7.00e-89	320.00
IUUC-Oin-079315	Oryza indica	48.63	2.00e-76	279.00
IUUC-Olo-080669	Oryza longistaminata	44.01	1.00e-80	293.00
IUUC-Ome-081490	Oryza meridionalis	49.55	1.00e-88	320.00
IUUC-Oni-082572	Oryza nivara	49.55	2.00e-88	319.00
IUUC-Opu-083732	Oryza punctata	49.70	1.00e-88	320.00
IUUC-Oru-084763	Oryza rufipogon	49.55	2.00e-88	319.00
IUUC-Osa-085372	Oryza sativa	49.55	2.00e-88	319.00
IUUC-Ola-087379	Oryzias latipes	72.94	2.00e-137	482.00
IUUC-Olu-087801	Ostreococcus lucimarinus	35.96	9.00e-46	177.00
IUUC-Oga-089076	Otolemur garnettii	94.69	2.00e-178	617.00
IUUC-Oar-090022	Ovis aries	98.23	0.00e+00	641.00
IUUC-Ptr-090809	Pan troglodytes	93.51	4.00e-177	613.00
IUUC-Pan-091685	Papio anubis	93.51	5.00e-179	620.00
IUUC-Psi-093046	Pelodiscus sinensis	86.65	8.00e-165	572.00
IUUC-Pma-094181	Petromyzon marinus	65.07	3.00e-131	461.00
IUUC-Pno-094882	Phaeosphaeria nodorum	34.79	5.00e-55	208.00
IUUC-Ppa-095172	Physcomitrella patens	47.97	2.00e-84	306.00
IUUC-Pfo-096396	Poecilia formosa	72.70	4.00e-139	487.00
IUUC-Pab-098427	Pongo abelii	92.92	2.00e-174	604.00
IUUC-Pop-100016	Populus trichocarpa	51.63	1.00e-90	326.00
IUUC-Pca-101048	Procavia capensis	93.22	6.00e-176	609.00
IUUC-Ppe-102050	Prunus persica	47.43	2.00e-86	311.00
IUUC-Pva-103117	Pteropus vampyrus	94.40	5.00e-179	619.00
IUUC-Pgr-103307	Puccinia graminis	33.87	5.00e-57	215.00
IUUC-Ptt-103938	Puccinia triticina	39.10	2.00e-49	189.00
IUUC-Pte-104315	Pyrenophora teres	33.09	1.00e-55	210.00
IUUC-Pyt-104825	Pyrenophora triticirepentis	33.09	2.00e-55	209.00
IUUC-Rno-105523	Rattus norvegicus	92.04	2.00e-174	604.00
IUUC-Sce-106297	Saccharomyces cerevisiae	42.27	4.00e-64	238.00
IUUC-Sha-106981	Sarcophilus harrisii	90.72	5.00e-139	486.00
IUUC-Sja-107715	Schizosaccharomyces japonicus	39.71	7.00e-58	218.00
IUUC-Spo-108214	Schizosaccharomyces pombe	42.12	4.00e-58	219.00
IUUC-Smo-109034	Selaginella moellendorffii	45.88	2.00e-82	299.00
IUUC-Sit-110663	Setaria italica	51.04	5.00e-90	324.00
IUUC-Sly-110898	Solanum lycopersicum	48.82	1.00e-82	299.00
IUUC-Stu-112647	Solanum tuberosum	51.87	8.00e-71	259.00
IUUC-Sbi-114288	Sorghum bicolor	48.66	2.00e-85	309.00
IUUC-Sre-115065	Sporisorium reilianum	43.54	8.00e-75	274.00
IUUC-Ssc-115960	Sus scrofa	91.10	0.00e+00	631.00
IUUC-Tru-118382	Takifugu rubripes	72.40	3.00e-148	517.00
IUUC-Tsy-119585	Tarsius syrichta	84.66	6.00e-155	539.00
IUUC-Tni-120133	Tetraodon nigroviridis	74.85	4.00e-143	500.00
IUUC-Tca-121167	Theobroma cacao	49.26	6.00e-82	297.00
IUUC-Tre-122119	Trichoderma reesei	29.41	2.00e-41	162.00
IUUC-Tvi-122407	Trichoderma virens	29.86	1.00e-41	163.00
IUUC-Tae-125748	Triticum aestivum	48.96	8.00e-82	296.00
IUUC-Tur-126682	Triticum urartu	49.62	3.00e-67	248.00
IUUC-Tme-127095	Tuber melanosporum	36.13	1.00e-61	230.00
IUUC-Tbe-128004	Tupaia belangeri	94.99	3.00e-179	620.00
IUUC-Ttr-129284	Tursiops truncatus	93.86	1.00e-175	608.00
IUUC-Uma-129527	Ustilago maydis	44.12	2.00e-74	273.00
IUUC-Vda-129854	Verticillium dahliae	31.31	2.00e-38	152.00
IUUC-Vpa-130681	Vicugna pacos	99.14	2.00e-51	195.00
IUUC-Vvi-131004	Vitis vinifera	53.75	4.00e-88	317.00
IUUC-Xtr-131928	Xenopus tropicalis	81.01	5.00e-154	536.00
IUUC-Xma-134290	Xiphophorus maculatus	72.11	1.00e-135	475.00
IUUC-Yli-134364	Yarrowia lipolytica	43.31	8.00e-67	247.00
IUUC-Zma-135658	Zea mays	49.27	1.00e-86	313.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence