iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004553

Ensembl Protein ID

ENSACAP00000012195.3

UniProt Accession

G1KMB1; G1KMB1_ANOCA

Protein Name

Tyrosine-protein kinase

Gene Name

FRK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000012316.3	ENSACAT00000012443.3	ENSACAP00000012195.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.20e-11	42.3	64	128

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk........elegkrGlfPenFvek 61
            +++ +l+dy+a ++d+Lt+++Gd+++v+  ++  e W+++            ++++G +P+n v+ 
   Q: 64   TRTFVALFDYQARTEDDLTFRAGDKLEVL--DTSQESWWVARLleengysrPGRKRQGYIPANHVAP 128
           57899************************..777889**998899999988889999******9975 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MGNCCQKSCA CLQPYVPWLF EACNCGLGEK DGEKDVQVLE PPVISGPQGI EGFSMPPLPL 60
QDQTRTFVAL FDYQARTEDD LTFRAGDKLE VLDTSQESWW VARLLEENGY SRPGRKRQGY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTATTAAA GCAACCGGAT CATCAGGTTA GTTATTCATT ACCAGGAGCT ACAAAGTTTG 60
CAGATATTCA CTTTGTAGAG AAGTACATTT AAAGAGGCTA AGGCAGCAAG GAAGAAAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

acs:100565945

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003394	Anas platyrhynchos	63.06	0.00e+00	693.00
IUUC-Cja-019885	Callithrix jacchus	68.24	0.00e+00	738.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	30.21	1.00e-20	93.60
IUUC-Cin-025605	Ciona intestinalis	55.22	1.00e-151	529.00
IUUC-Dre-028274	Danio rerio	59.16	4.00e-178	617.00
IUUC-Dno-029689	Dasypus novemcinctus	68.27	0.00e+00	720.00
IUUC-Dme-031976	Drosophila melanogaster	56.84	3.00e-171	594.00
IUUC-Eeu-034770	Erinaceus europaeus	59.41	4.00e-140	491.00
IUUC-Fal-036892	Ficedula albicollis	66.73	0.00e+00	706.00
IUUC-Gga-041072	Gallus gallus	67.54	0.00e+00	709.00
IUUC-Loc-052913	Lepisosteus oculatus	59.23	5.00e-177	613.00
IUUC-Mga-059456	Meleagris gallopavo	67.74	0.00e+00	706.00
IUUC-Mmr-061480	Microcebus murinus	66.73	0.00e+00	701.00
IUUC-Mlu-067167	Myotis lucifugus	67.19	0.00e+00	699.00
IUUC-Nle-069786	Nomascus leucogenys	67.86	0.00e+00	733.00
IUUC-Ont-072417	Oreochromis niloticus	64.09	8.00e-179	619.00
IUUC-Obr-076765	Oryza brachyantha	27.37	6.00e-21	96.30
IUUC-Opu-083800	Oryza punctata	26.44	3.00e-21	97.80
IUUC-Ola-086419	Oryzias latipes	62.45	8.00e-175	606.00
IUUC-Pan-092732	Papio anubis	67.49	0.00e+00	727.00
IUUC-Psi-093899	Pelodiscus sinensis	70.70	0.00e+00	776.00
IUUC-Pma-094230	Petromyzon marinus	58.66	1.00e-162	566.00
IUUC-Pfo-096035	Poecilia formosa	61.90	1.00e-171	595.00
IUUC-Rno-105269	Rattus norvegicus	68.18	0.00e+00	722.00
IUUC-Sbi-113999	Sorghum bicolor	29.82	1.00e-20	95.10
IUUC-Tgu-116491	Taeniopygia guttata	73.48	0.00e+00	704.00
IUUC-Tru-117795	Takifugu rubripes	58.44	8.00e-159	553.00
IUUC-Tni-120512	Tetraodon nigroviridis	64.79	0.00e+00	630.00
IUUC-Ttr-128817	Tursiops truncatus	66.92	0.00e+00	715.00
IUUC-Vpa-130389	Vicugna pacos	63.67	0.00e+00	658.00
IUUC-Xtr-132360	Xenopus tropicalis	58.85	0.00e+00	654.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence