iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013016

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

WD repeat-containing protein 5

Genbank Nucleotide ID

DAAA02032365

Gene Name

WDR5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000047031.1	ENSBTAT00000066090.1	ENSBTAP00000056448.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-59	194.5	101	140
UBD/Beta-Prp	7.80e-89	297.9	14	306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH++ v+c++f +  +l+vsGs D ++++WD++tg++lk+
   Q: 101  GHSNYVFCCNFnPQsNLIVSGSFDESVRIWDVKTGKCLKT 140
           8***********666**********************986 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           tl gh k+v + vkfsp++++la++s+d+ ik+w + +gk+ +++sgh+ ++++v +s+d+++lv++s+D+t+k+wd+s+gkc+ tlkg
   Q: 14   TLAGHTKAVSS-VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG 101
           67777776666.***************************************************************************** PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++v +++f+p+++ +vsGs d+ +r+wd++tg+cl+ tl  h++ v+ v+++ dg+l+vs+s+D+ +r+Wd ++g++l+tl  ++++
   Q: 102  HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK-TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 189
           **************************************.********************************************999*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs...pnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
           +v  ++f++ngk+++++ ld+t+klwd+++g+c++t++gh++  +++ +      ++++vsgs+D+ ++iW+l++++++++lq+h + v
   Q: 190  PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANfsvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 278
           **********************************************98887899*********************************** PP
   S: 268  isvavlsfgdnvlvlgse..dskvniwkl 294
           is a+ ++++n++++++   d+++++wk 
   Q: 279  ISTAC-HPTENIIASAALenDKTIKLWKS 306
           *****.*******9998888*******96 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

QPTPVKPNYA LKFTLAGHTK AVSSVKFSPN GEWLASSSAD KLIKIWGAYD GKFEKTISGH 60
KLGISDVAWS SDSNLLVSAS DDKTLKIWDV SSGKCLKTLK GHSNYVFCCN FNPQSNLIVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCCCACAC CGGTGAAACC AAACTATGCT CTTAAATTCA CCCTGGCCGG CCACACGAAA 60
GCTGTGTCCT CTGTGAAGTT CAGCCCCAAC GGGGAGTGGC TGGCGAGTTC GTGTAGGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0071339--C:MLL1 complex
GO:0044666--C:MLL3/4 complex
GO:0048188--C:Set1C/COMPASS complex
GO:0046972--F:histone acetyltransferase activity (H4-K16 specific)
GO:0043995--F:histone acetyltransferase activity (H4-K5 specific)
GO:0043996--F:histone acetyltransferase activity (H4-K8 specific)
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0043966--P:histone H3 acetylation
GO:0035948--P:positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
GO:0001501--P:skeletal system development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000502	Aegilops tauschii	53.02	2.00e-89	322.00
IUUC-Aml-002420	Ailuropoda melanoleuca	99.68	0.00e+00	625.00
IUUC-Atr-002439	Amborella trichopoda	70.10	3.00e-129	454.00
IUUC-Apl-003436	Anas platyrhynchos	92.13	4.00e-163	566.00
IUUC-Aca-004259	Anolis carolinensis	99.67	7.00e-179	619.00
IUUC-Aly-005723	Arabidopsis lyrata	64.45	1.00e-116	412.00
IUUC-Ath-007308	Arabidopsis thaliana	65.45	2.00e-116	412.00
IUUC-Ago-007915	Ashbya gossypii	39.07	3.00e-45	175.00
IUUC-Acl-008045	Aspergillus clavatus	45.95	8.00e-83	301.00
IUUC-Afl-008596	Aspergillus flavus	44.66	6.00e-80	291.00
IUUC-Afu-009074	Aspergillus fumigatus	46.75	1.00e-82	300.00
IUUC-Ani-009318	Aspergillus nidulans	50.00	2.00e-82	300.00
IUUC-Ang-009775	Aspergillus niger	45.48	3.00e-82	299.00
IUUC-Aor-010222	Aspergillus oryzae	44.66	5.00e-80	291.00
IUUC-Ate-010583	Aspergillus terreus	48.75	3.00e-80	292.00
IUUC-Ame-011349	Astyanax mexicanus	99.02	9.00e-178	615.00
IUUC-Bgr-011968	Blumeria graminis	50.33	3.00e-84	305.00
IUUC-Bci-013948	Botrytis cinerea	51.15	7.00e-85	307.00
IUUC-Bdi-014263	Brachypodium distachyon	62.46	4.00e-120	424.00
IUUC-Bol-015900	Brassica oleracea	62.50	3.00e-113	401.00
IUUC-Bra-017143	Brassica rapa	62.17	2.00e-114	404.00
IUUC-Cel-018355	Caenorhabditis elegans	72.24	1.00e-131	462.00
IUUC-Cja-019936	Callithrix jacchus	99.68	0.00e+00	625.00
IUUC-Cfa-020596	Canis familiaris	99.68	0.00e+00	625.00
IUUC-Cpo-021318	Cavia porcellus	99.68	0.00e+00	625.00
IUUC-Cre-022935	Chlamydomonas reinhardtii	49.63	4.00e-79	288.00
IUUC-Csa-023053	Chlorocebus sabaeus	99.68	0.00e+00	625.00
IUUC-Cho-024642	Choloepus hoffmanni	87.83	1.00e-151	528.00
IUUC-Cin-025495	Ciona intestinalis	89.90	5.00e-167	580.00
IUUC-Csv-025988	Ciona savignyi	91.86	6.00e-163	566.00
IUUC-Cgl-026771	Colletotrichum gloeosporioides	33.02	9.00e-46	179.00
IUUC-Cne-027025	Cryptococcus neoformans	32.13	4.00e-53	201.00
IUUC-Cme-027119	Cyanidioschyzon merolae	52.91	3.00e-104	371.00
IUUC-Dre-027521	Danio rerio	99.01	4.00e-177	613.00
IUUC-Dno-029739	Dasypus novemcinctus	100.00	8.00e-178	615.00
IUUC-Dor-030966	Dipodomys ordii	100.00	3.00e-180	623.00
IUUC-Dse-031189	Dothistroma septosporum	48.91	2.00e-85	309.00
IUUC-Dme-031613	Drosophila melanogaster	94.72	4.00e-171	593.00
IUUC-Ete-033098	Echinops telfairi	82.68	2.00e-153	535.00
IUUC-Eca-033790	Equus caballus	99.68	0.00e+00	625.00
IUUC-Eeu-034805	Erinaceus europaeus	87.13	2.00e-150	524.00
IUUC-Fca-035901	Felis catus	99.68	0.00e+00	625.00
IUUC-Fal-037413	Ficedula albicollis	100.00	3.00e-179	620.00
IUUC-Fox-037876	Fusarium oxysporum	46.45	6.00e-58	217.00
IUUC-Gmo-039131	Gadus morhua	98.34	4.00e-174	603.00
IUUC-Ggr-040071	Gaeumannomyces graminis	40.27	3.00e-64	239.00
IUUC-Gga-040789	Gallus gallus	100.00	3.00e-179	620.00
IUUC-Gac-042634	Gasterosteus aculeatus	98.01	2.00e-173	601.00
IUUC-Gma-043692	Glycine max	66.34	9.00e-127	446.00
IUUC-Ggo-044443	Gorilla gorilla	99.68	0.00e+00	625.00
IUUC-Hsa-046290	Homo sapiens	99.68	0.00e+00	625.00
IUUC-Hvu-047077	Hordeum vulgare	59.15	2.00e-79	288.00
IUUC-Itr-048954	Ictidomys tridecemlineatus	99.68	0.00e+00	625.00
IUUC-Kpa-049404	Komagataella pastoris	45.26	3.00e-65	241.00
IUUC-Lch-049539	Latimeria chalumnae	99.03	8.00e-180	622.00
IUUC-Lpe-051082	Leersia perrieri	61.67	5.00e-119	420.00
IUUC-Loc-051743	Lepisosteus oculatus	99.02	9.00e-178	615.00
IUUC-Lma-053188	Leptosphaeria maculans	46.73	5.00e-85	308.00
IUUC-Laf-054432	Loxodonta africana	94.75	2.00e-177	614.00
IUUC-Mcc-055603	Macaca mulatta	99.68	0.00e+00	625.00
IUUC-Meu-056440	Macropus eugenii	92.13	2.00e-155	541.00
IUUC-Mor-056965	Magnaporthe oryzae	37.08	2.00e-67	250.00
IUUC-Mpo-057333	Magnaporthe poae	41.16	9.00e-61	228.00
IUUC-Mtr-057951	Medicago truncatula	65.58	7.00e-122	429.00
IUUC-Mla-058896	Melampsora laricipopulina	42.86	1.00e-71	263.00
IUUC-Mga-060046	Meleagris gallopavo	99.67	3.00e-179	620.00
IUUC-Mvi-060453	Microbotryum violaceum	48.45	6.00e-88	318.00
IUUC-Mmr-061020	Microcebus murinus	91.95	3.00e-170	590.00
IUUC-Mdo-062204	Monodelphis domestica	96.43	1.00e-176	612.00
IUUC-Mmu-063917	Mus musculus	99.68	0.00e+00	625.00
IUUC-Mac-065310	Musa acuminata	66.22	4.00e-122	430.00
IUUC-Mpu-066072	Mustela putorius furo	99.68	0.00e+00	625.00
IUUC-Mlu-068209	Myotis lucifugus	99.68	0.00e+00	625.00
IUUC-Nfi-068538	Neosartorya fischeri	46.43	5.00e-82	298.00
IUUC-Ncr-068651	Neurospora crassa	42.59	5.00e-72	265.00
IUUC-Nle-069383	Nomascus leucogenys	88.49	8.00e-153	532.00
IUUC-Opr-070937	Ochotona princeps	83.96	5.00e-142	496.00
IUUC-Ont-071458	Oreochromis niloticus	99.00	2.00e-175	607.00
IUUC-Oan-073597	Ornithorhynchus anatinus	100.00	6.00e-179	619.00
IUUC-Oba-075292	Oryza barthii	56.42	1.00e-98	352.00
IUUC-Obr-076723	Oryza brachyantha	54.90	3.00e-96	344.00
IUUC-Ogl-077251	Oryza glaberrima	60.39	1.00e-116	412.00
IUUC-Ogu-078882	Oryza glumaepatula	49.58	7.00e-103	367.00
IUUC-Oin-079601	Oryza indica	54.55	6.00e-112	397.00
IUUC-Olo-080976	Oryza longistaminata	62.95	5.00e-102	363.00
IUUC-Ome-081430	Oryza meridionalis	60.78	7.00e-117	413.00
IUUC-Oni-082182	Oryza nivara	49.18	1.00e-102	366.00
IUUC-Opu-083880	Oryza punctata	60.13	5.00e-116	410.00
IUUC-Oru-084935	Oryza rufipogon	53.65	3.00e-98	351.00
IUUC-Osa-085706	Oryza sativa	60.39	1.00e-116	412.00
IUUC-Ola-087134	Oryzias latipes	98.67	8.00e-175	605.00
IUUC-Olu-087660	Ostreococcus lucimarinus	42.50	5.00e-40	156.00
IUUC-Oga-088672	Otolemur garnettii	100.00	2.00e-178	618.00
IUUC-Oar-089860	Ovis aries	88.70	9.00e-153	532.00
IUUC-Ptr-091513	Pan troglodytes	99.68	0.00e+00	625.00
IUUC-Pan-092046	Papio anubis	99.68	0.00e+00	625.00
IUUC-Psi-093192	Pelodiscus sinensis	100.00	3.00e-179	620.00
IUUC-Pno-094881	Phaeosphaeria nodorum	48.04	3.00e-89	322.00
IUUC-Ppa-095367	Physcomitrella patens	72.58	3.00e-133	467.00
IUUC-Pfo-097434	Poecilia formosa	98.67	6.00e-175	606.00
IUUC-Pab-097773	Pongo abelii	93.83	2.00e-165	574.00
IUUC-Pop-099778	Populus trichocarpa	65.18	5.00e-121	427.00
IUUC-Pca-100281	Procavia capensis	80.66	2.00e-121	428.00
IUUC-Ppe-101341	Prunus persica	64.56	2.00e-122	431.00
IUUC-Pva-103020	Pteropus vampyrus	98.70	1.00e-179	622.00
IUUC-Pgr-103589	Puccinia graminis	39.27	2.00e-69	256.00
IUUC-Pte-104153	Pyrenophora teres	51.91	2.00e-93	336.00
IUUC-Pyt-104712	Pyrenophora triticirepentis	52.43	1.00e-78	286.00
IUUC-Rno-105858	Rattus norvegicus	99.68	0.00e+00	625.00
IUUC-Sce-106243	Saccharomyces cerevisiae	34.47	3.00e-40	158.00
IUUC-Sha-107101	Sarcophilus harrisii	99.35	2.00e-180	624.00
IUUC-Sja-107858	Schizosaccharomyces japonicus	51.17	3.00e-68	252.00
IUUC-Spo-108117	Schizosaccharomyces pombe	47.98	1.00e-63	236.00
IUUC-Smo-109155	Selaginella moellendorffii	71.85	1.00e-131	462.00
IUUC-Sit-110688	Setaria italica	62.00	6.00e-119	420.00
IUUC-Sly-110891	Solanum lycopersicum	68.90	4.00e-126	444.00
IUUC-Stu-112365	Solanum tuberosum	68.90	5.00e-126	443.00
IUUC-Sbi-114284	Sorghum bicolor	62.00	5.00e-118	417.00
IUUC-Sre-115180	Sporisorium reilianum	42.57	1.00e-66	246.00
IUUC-Ssc-116204	Sus scrofa	100.00	4.00e-178	616.00
IUUC-Tgu-117172	Taeniopygia guttata	100.00	3.00e-179	620.00
IUUC-Tru-118320	Takifugu rubripes	98.67	2.00e-175	608.00
IUUC-Tni-120660	Tetraodon nigroviridis	98.41	4.00e-107	380.00
IUUC-Tca-121051	Theobroma cacao	67.53	1.00e-124	439.00
IUUC-Tre-122237	Trichoderma reesei	45.98	6.00e-84	304.00
IUUC-Tvi-122635	Trichoderma virens	46.18	1.00e-84	306.00
IUUC-Tae-125819	Triticum aestivum	61.31	3.00e-120	424.00
IUUC-Tur-126217	Triticum urartu	55.84	3.00e-76	278.00
IUUC-Tme-127061	Tuber melanosporum	60.20	2.00e-111	395.00
IUUC-Tbe-127488	Tupaia belangeri	87.62	4.00e-154	537.00
IUUC-Ttr-129309	Tursiops truncatus	93.51	1.00e-166	578.00
IUUC-Uma-129585	Ustilago maydis	41.64	3.00e-73	268.00
IUUC-Vda-129907	Verticillium dahliae	44.71	2.00e-78	286.00
IUUC-Vpa-130384	Vicugna pacos	89.14	2.00e-154	538.00
IUUC-Vvi-131269	Vitis vinifera	66.56	5.00e-119	420.00
IUUC-Xtr-131945	Xenopus tropicalis	99.02	1.00e-177	615.00
IUUC-Xma-132997	Xiphophorus maculatus	98.67	6.00e-175	606.00
IUUC-Yli-134418	Yarrowia lipolytica	42.16	1.00e-75	276.00
IUUC-Zma-135765	Zea mays	61.67	7.00e-117	413.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence