iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Meu-056232

Ensembl Protein ID

ENSMEUP00000003256.1

UniProt Accession

P79373; PRGR_MACEU

Genbank Protein ID

AAB49508.2

Protein Name

Progesterone receptor; Nuclear receptor subfamily 3 group C member 3

Genbank Nucleotide ID

S83227

Gene Name

ESR1; PGR; NR3C3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMEUG00000003564.1	ENSMEUT00000003573.1	ENSMEUP00000003256.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	85.38	0.00e+00	915.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Macropus eugenii

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.

Protein Sequence
(Fasta)

MTMTLHTKSS GVALLHQIQG NELEPLNRQQ LKIPLDRPLG EMYVDSNKTG VYSYPEGAAY 60
DFNTAAAPVY GSSNLTYAPN SETFSSNGLG GFHSLNNVSP NPLVLLHPPT QLSPFLHHHS 120

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Nucleotide Sequence
(Fasta)

ATGACCATGA CCCTTCACAC CAAATCGTCT GGAGTGGCCC TGCTCCACCA GATCCAAGGC 60
AATGAGCTGG AACCCCTGAA TCGCCAGCAG CTGAAGATCC CCCTGGATCG ACCCCTGGGA 120

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Sequence Source

Ensembl

Keyword

KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0449--Lipoprotein
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt

Pfam

PF00104--Hormone_recep

PRINTS

PR00398--STRDHORMONER

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0005496--F:steroid binding
GO:0003707--F:steroid hormone receptor activity
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	91.96	0.00e+00	777.00
IUUC-Apl-003688	Anas platyrhynchos	83.49	0.00e+00	846.00
IUUC-Aca-005222	Anolis carolinensis	81.48	0.00e+00	922.00
IUUC-Ame-010731	Astyanax mexicanus	51.40	6.00e-134	470.00
IUUC-Bta-013112	Bos taurus	81.01	0.00e+00	894.00
IUUC-Cja-019408	Callithrix jacchus	86.72	0.00e+00	933.00
IUUC-Cfa-020694	Canis familiaris	84.37	0.00e+00	908.00
IUUC-Cpo-021426	Cavia porcellus	79.70	0.00e+00	855.00
IUUC-Cre-022648	Chlamydomonas reinhardtii	30.23	1.70e+00	26.90
IUUC-Csa-023736	Chlorocebus sabaeus	89.92	0.00e+00	834.00
IUUC-Dre-027698	Danio rerio	55.32	2.00e-130	459.00
IUUC-Dno-029477	Dasypus novemcinctus	87.23	0.00e+00	740.00
IUUC-Dor-030572	Dipodomys ordii	88.74	0.00e+00	731.00
IUUC-Ete-032849	Echinops telfairi	69.03	0.00e+00	631.00
IUUC-Eca-033605	Equus caballus	82.02	0.00e+00	899.00
IUUC-Eeu-034683	Erinaceus europaeus	90.19	3.00e-108	384.00
IUUC-Fca-035928	Felis catus	92.15	0.00e+00	775.00
IUUC-Fal-036754	Ficedula albicollis	82.68	0.00e+00	944.00
IUUC-Gmo-038872	Gadus morhua	55.26	2.00e-111	395.00
IUUC-Gga-040988	Gallus gallus	82.54	0.00e+00	933.00
IUUC-Gac-042015	Gasterosteus aculeatus	61.50	1.00e-126	446.00
IUUC-Ggo-044749	Gorilla gorilla	86.22	0.00e+00	926.00
IUUC-Hsa-046944	Homo sapiens	85.52	0.00e+00	914.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	84.54	0.00e+00	915.00
IUUC-Loc-052414	Lepisosteus oculatus	59.44	0.00e+00	649.00
IUUC-Mcc-054781	Macaca mulatta	86.70	0.00e+00	929.00
IUUC-Mga-059319	Meleagris gallopavo	82.54	0.00e+00	932.00
IUUC-Mmr-061636	Microcebus murinus	84.78	3.00e-160	557.00
IUUC-Mdo-062661	Monodelphis domestica	95.93	0.00e+00	1059.00
IUUC-Mmu-063330	Mus musculus	82.80	0.00e+00	870.00
IUUC-Mpu-065757	Mustela putorius furo	83.56	0.00e+00	928.00
IUUC-Mlu-067712	Myotis lucifugus	85.40	0.00e+00	807.00
IUUC-Nle-069283	Nomascus leucogenys	85.02	0.00e+00	895.00
IUUC-Opr-070391	Ochotona princeps	83.36	0.00e+00	932.00
IUUC-Ont-071369	Oreochromis niloticus	50.18	3.00e-117	415.00
IUUC-Oan-073734	Ornithorhynchus anatinus	77.49	1.00e-139	488.00
IUUC-Ocu-074292	Oryctolagus cuniculus	85.79	0.00e+00	927.00
IUUC-Oba-075103	Oryza barthii	29.73	3.00e-03	36.60
IUUC-Ogu-079042	Oryza glumaepatula	29.73	6.00e-04	38.90
IUUC-Olo-080944	Oryza longistaminata	29.73	1.00e-03	36.20
IUUC-Oni-082560	Oryza nivara	29.73	2.00e-03	36.60
IUUC-Ola-087052	Oryzias latipes	52.48	5.00e-125	441.00
IUUC-Oga-088586	Otolemur garnettii	85.95	0.00e+00	911.00
IUUC-Oar-090156	Ovis aries	89.01	0.00e+00	789.00
IUUC-Ptr-091321	Pan troglodytes	86.36	0.00e+00	926.00
IUUC-Pan-092851	Papio anubis	86.87	0.00e+00	931.00
IUUC-Psi-093434	Pelodiscus sinensis	82.85	0.00e+00	963.00
IUUC-Ppa-095617	Physcomitrella patens	38.64	1.50e+00	29.30
IUUC-Pfo-097379	Poecilia formosa	57.99	1.00e-132	466.00
IUUC-Pab-097735	Pongo abelii	86.20	0.00e+00	924.00
IUUC-Pva-102125	Pteropus vampyrus	83.84	0.00e+00	911.00
IUUC-Rno-106121	Rattus norvegicus	82.50	0.00e+00	868.00
IUUC-Sha-107547	Sarcophilus harrisii	95.93	0.00e+00	1058.00
IUUC-Sar-113650	Sorex araneus	75.60	4.00e-171	593.00
IUUC-Tgu-117175	Taeniopygia guttata	82.33	0.00e+00	941.00
IUUC-Tru-117545	Takifugu rubripes	52.40	1.00e-133	470.00
IUUC-Tsy-119586	Tarsius syrichta	71.98	0.00e+00	774.00
IUUC-Tni-120121	Tetraodon nigroviridis	50.73	1.00e-133	469.00
IUUC-Tbe-127548	Tupaia belangeri	79.73	2.00e-178	619.00
IUUC-Ttr-128374	Tursiops truncatus	77.98	0.00e+00	811.00
IUUC-Vpa-130464	Vicugna pacos	80.87	2.00e-150	525.00
IUUC-Xtr-132171	Xenopus tropicalis	72.67	0.00e+00	760.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence