iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-116441

Ensembl Protein ID

ENSSSCP00000020366.1

UniProt Accession

I3L8K6; I3L8K6_PIG

Genbank Protein ID

ENSSSCP00000020366

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

FP340172

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000024295.1	ENSSSCT00000027338.1	ENSSSCP00000020366.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	35.74	2.00e-35	146.00	IUUC-Ath-007192
E3 activity/RING/RING	81.85	3.00e-120	428.00	IUUC-Dme-031700
E3 activity/RING/RING	99.07	8.00e-156	547.00	IUUC-Hsa-046179
E3 activity/RING/RING	97.22	2.00e-153	538.00	IUUC-Mmu-063206
E3 activity/RING/RING	97.53	1.00e-153	538.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Sus scrofa

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRPSSTGPS ANKPCNKQPP PQPQHAPSPA APPAAATISA AGPGSSAVPA AAAVISGPGG 60
GGGAGPVSPQ HHELTSLFEC PVCFDYVLPP ILQCQAGHLV CNQCRQKLSC CPTCRGALTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCAGCCCCG CCTAAAGTTG CCCTTCTGGT TTGCGCCCGC GGGACGCGTC AGCGTGTCTC 60
CCCGGGGTGT GGCTAAAGGA CTTCAGCGAC GCCTTTCCGA AGGGCGGCCC CCTCCGCAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ssc:100622531

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	36.11	6.00e-40	157.00
IUUC-Aml-001409	Ailuropoda melanoleuca	99.61	3.00e-156	543.00
IUUC-Atr-002857	Amborella trichopoda	36.36	8.00e-41	160.00
IUUC-Apl-003813	Anas platyrhynchos	84.52	2.00e-130	457.00
IUUC-Aca-005014	Anolis carolinensis	84.52	2.00e-130	457.00
IUUC-Aly-006522	Arabidopsis lyrata	36.14	4.00e-37	148.00
IUUC-Ath-007192	Arabidopsis thaliana	35.74	1.00e-36	146.00
IUUC-Ame-011678	Astyanax mexicanus	91.70	2.00e-141	494.00
IUUC-Bta-012750	Bos taurus	100.00	4.00e-154	536.00
IUUC-Bdi-014200	Brachypodium distachyon	36.51	2.00e-40	159.00
IUUC-Bol-015983	Brassica oleracea	35.74	4.00e-37	148.00
IUUC-Bra-017336	Brassica rapa	34.68	9.00e-38	150.00
IUUC-Cel-018320	Caenorhabditis elegans	69.32	2.00e-108	385.00
IUUC-Cja-019800	Callithrix jacchus	99.07	1.00e-154	538.00
IUUC-Cfa-020505	Canis familiaris	99.22	4.00e-154	536.00
IUUC-Cpo-021394	Cavia porcellus	98.84	1.00e-153	535.00
IUUC-Csa-023374	Chlorocebus sabaeus	99.07	1.00e-154	538.00
IUUC-Cho-024933	Choloepus hoffmanni	99.61	1.00e-154	538.00
IUUC-Cin-025674	Ciona intestinalis	84.00	4.00e-128	449.00
IUUC-Csv-026233	Ciona savignyi	83.20	9.00e-127	445.00
IUUC-Dre-027711	Danio rerio	91.30	5.00e-141	493.00
IUUC-Dno-029260	Dasypus novemcinctus	99.59	5.00e-148	516.00
IUUC-Dor-030489	Dipodomys ordii	95.68	2.00e-107	380.00
IUUC-Dme-031700	Drosophila melanogaster	81.85	3.00e-115	407.00
IUUC-Ete-032946	Echinops telfairi	90.43	4.00e-156	543.00
IUUC-Eca-033546	Equus caballus	99.22	9.00e-156	541.00
IUUC-Eeu-034861	Erinaceus europaeus	95.74	2.00e-148	518.00
IUUC-Fca-035362	Felis catus	84.52	2.00e-130	457.00
IUUC-Fal-037160	Ficedula albicollis	88.05	7.00e-133	465.00
IUUC-Gmo-039091	Gadus morhua	89.33	3.00e-139	487.00
IUUC-Gga-040252	Gallus gallus	97.67	4.00e-152	530.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.33	2.00e-139	488.00
IUUC-Gma-042926	Glycine max	34.52	4.00e-36	144.00
IUUC-Ggo-044618	Gorilla gorilla	99.07	1.00e-154	538.00
IUUC-Hsa-046179	Homo sapiens	99.07	1.00e-154	538.00
IUUC-Hvu-047574	Hordeum vulgare	36.51	3.00e-40	158.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	98.06	5.00e-154	535.00
IUUC-Lch-049496	Latimeria chalumnae	81.42	2.00e-150	524.00
IUUC-Lpe-050879	Leersia perrieri	37.86	8.00e-39	154.00
IUUC-Loc-052107	Lepisosteus oculatus	92.40	2.00e-141	494.00
IUUC-Laf-054257	Loxodonta africana	99.22	1.00e-153	535.00
IUUC-Mcc-055023	Macaca mulatta	99.07	1.00e-154	538.00
IUUC-Meu-055922	Macropus eugenii	96.86	2.00e-149	520.00
IUUC-Mtr-058747	Medicago truncatula	35.32	4.00e-38	151.00
IUUC-Mga-060070	Meleagris gallopavo	96.11	2.00e-148	517.00
IUUC-Mmr-061494	Microcebus murinus	99.38	1.00e-154	538.00
IUUC-Mdo-061971	Monodelphis domestica	98.43	3.00e-153	533.00
IUUC-Mmu-063206	Mus musculus	99.61	4.00e-153	533.00
IUUC-Mac-065014	Musa acuminata	36.84	3.00e-39	154.00
IUUC-Mpu-066597	Mustela putorius furo	99.07	1.00e-154	538.00
IUUC-Mlu-067199	Myotis lucifugus	99.22	5.00e-154	536.00
IUUC-Nle-069342	Nomascus leucogenys	99.07	1.00e-154	538.00
IUUC-Opr-070341	Ochotona princeps	56.86	2.00e-50	192.00
IUUC-Ont-071906	Oreochromis niloticus	89.72	2.00e-140	491.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	4.00e-50	191.00
IUUC-Ocu-073950	Oryctolagus cuniculus	100.00	4.00e-157	546.00
IUUC-Oba-075454	Oryza barthii	37.86	2.00e-38	152.00
IUUC-Obr-076037	Oryza brachyantha	35.32	7.00e-37	147.00
IUUC-Ogl-077712	Oryza glaberrima	37.86	2.00e-38	152.00
IUUC-Ogu-078910	Oryza glumaepatula	37.86	2.00e-38	152.00
IUUC-Oin-079749	Oryza indica	37.86	2.00e-38	152.00
IUUC-Olo-080244	Oryza longistaminata	35.32	1.00e-36	147.00
IUUC-Ome-081318	Oryza meridionalis	37.86	2.00e-38	152.00
IUUC-Oni-083109	Oryza nivara	37.86	2.00e-38	152.00
IUUC-Opu-084065	Oryza punctata	38.27	9.00e-39	153.00
IUUC-Oru-084785	Oryza rufipogon	37.86	2.00e-38	152.00
IUUC-Osa-085610	Oryza sativa	37.86	2.00e-38	152.00
IUUC-Ola-086814	Oryzias latipes	85.20	3.00e-130	457.00
IUUC-Oga-089154	Otolemur garnettii	99.07	1.00e-154	538.00
IUUC-Oar-089446	Ovis aries	99.23	2.00e-157	547.00
IUUC-Ptr-091088	Pan troglodytes	99.07	1.00e-154	538.00
IUUC-Pan-092012	Papio anubis	84.52	1.00e-130	458.00
IUUC-Psi-093079	Pelodiscus sinensis	98.86	5.00e-159	552.00
IUUC-Pma-094387	Petromyzon marinus	84.19	6.00e-129	452.00
IUUC-Ppa-095212	Physcomitrella patens	36.14	7.00e-38	150.00
IUUC-Pfo-097007	Poecilia formosa	84.98	6.00e-133	466.00
IUUC-Pab-098092	Pongo abelii	99.07	1.00e-154	538.00
IUUC-Pop-099970	Populus trichocarpa	34.52	6.00e-42	164.00
IUUC-Pca-100328	Procavia capensis	97.53	8.00e-150	522.00
IUUC-Ppe-101760	Prunus persica	36.95	9.00e-40	156.00
IUUC-Pva-102368	Pteropus vampyrus	99.11	5.00e-64	237.00
IUUC-Rno-105477	Rattus norvegicus	99.61	4.00e-153	533.00
IUUC-Sha-107630	Sarcophilus harrisii	98.48	1.00e-158	551.00
IUUC-Smo-109412	Selaginella moellendorffii	34.13	2.00e-35	142.00
IUUC-Sit-110595	Setaria italica	35.32	4.00e-38	151.00
IUUC-Sly-111259	Solanum lycopersicum	35.22	3.00e-37	148.00
IUUC-Stu-112571	Solanum tuberosum	35.63	1.00e-37	150.00
IUUC-Sbi-114090	Sorghum bicolor	35.32	1.00e-38	153.00
IUUC-Tgu-116579	Taeniopygia guttata	84.52	2.00e-130	457.00
IUUC-Tru-118004	Takifugu rubripes	86.96	1.00e-134	472.00
IUUC-Tsy-119548	Tarsius syrichta	88.72	3.00e-67	247.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.54	3.00e-137	480.00
IUUC-Tca-121228	Theobroma cacao	35.71	1.00e-37	149.00
IUUC-Tae-123647	Triticum aestivum	36.11	6.00e-40	157.00
IUUC-Tur-126049	Triticum urartu	34.52	1.00e-34	140.00
IUUC-Ttr-129166	Tursiops truncatus	83.47	2.00e-118	418.00
IUUC-Vpa-130799	Vicugna pacos	100.00	2.00e-104	370.00
IUUC-Vvi-131365	Vitis vinifera	36.82	2.00e-37	149.00
IUUC-Xtr-132113	Xenopus tropicalis	94.19	2.00e-148	518.00
IUUC-Xma-133670	Xiphophorus maculatus	85.20	3.00e-130	457.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence