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Tag Content
iUUCD ID IUUC-Fal-036723
Ensembl Protein ID ENSFALP00000001509.1
UniProt Accession U3JFF5; U3JFF5_FICAL
Genbank Protein ID ENSFALP00000001509
Protein Name Tyrosine-protein kinase
Genbank Nucleotide ID AGTO01020941
Gene Name ABL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSFALG00000001447.1 ENSFALT00000001518.1 ENSFALP00000001509.1
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.20e-14 52.8 65 122
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
    +++ +lyd+ a+ d++L+++kG++++v+ ++++++W+++ ++++ +G +P+n+++ ++
   Q: 65 PHLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 122
    68899************************.***********..79999**********997 PP
   

Organism Ficedula albicollis
Protein Sequence
(Fasta)
MKMLEICLKL VGCKSKKGLS SSSSCYLEEA LQRPVVSDFE PQGLTEAARW NSKENLLSIP 60
SENDPHLFVA LYDFVASGDN TLSITKGEKL RVLGYNHNGE WCEAQTKNGQ GWVPSNYITP 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Fal-036723|UBD,SH3|Ficedula albicollis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC 60
CCCCCCCCCC CCCCCCGCCA GCACCCCGCC TGTATCCCGC CTGTACCCCG CCTGCACCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Fal-036723|UBD,SH3|Ficedula albicollis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031252--C:cell leading edge
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0090135--P:actin filament branching
GO:0050798--P:activated T cell proliferation
GO:1990051--P:activation of protein kinase C activity
GO:0046632--P:alpha-beta T cell differentiation
GO:0002322--P:B cell proliferation involved in immune response
GO:0050853--P:B cell receptor signaling pathway
GO:0001922--P:B-1 B cell homeostasis
GO:0060020--P:Bergmann glial cell differentiation
GO:0072358--P:cardiovascular system development
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071222--P:cellular response to lipopolysaccharide
GO:0021587--P:cerebellum morphogenesis
GO:0048668--P:collateral sprouting
GO:0006975--P:DNA damage induced protein phosphorylation
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0045184--P:establishment of protein localization
GO:0030035--P:microspike assembly
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0022408--P:negative regulation of cell-cell adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045930--P:negative regulation of mitotic cell cycle
GO:1900275--P:negative regulation of phospholipase C activity
GO:0071901--P:negative regulation of protein serine/threonine kinase activity
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0001843--P:neural tube closure
GO:0060563--P:neuroepithelial cell differentiation
GO:0050885--P:neuromuscular process controlling balance
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0006909--P:phagocytosis
GO:0035791--P:platelet-derived growth factor receptor-beta signaling pathway
GO:1904531--P:positive regulation of actin filament binding
GO:0043065--P:positive regulation of apoptotic process
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902715--P:positive regulation of interferon-gamma secretion
GO:1900042--P:positive regulation of interleukin-2 secretion
GO:1904528--P:positive regulation of microtubule binding
GO:0045931--P:positive regulation of mitotic cell cycle
GO:1901216--P:positive regulation of neuron death
GO:0033690--P:positive regulation of osteoblast proliferation
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:2000096--P:positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:0009791--P:post-embryonic development
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0030516--P:regulation of axon extension
GO:1903053--P:regulation of extracellular matrix organization
GO:0031113--P:regulation of microtubule polymerization
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0042770--P:signal transduction in response to DNA damage
GO:0048536--P:spleen development
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0048538--P:thymus development
GO:0002333--P:transitional one stage B cell differentiation

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001550 Ailuropoda melanoleuca 82.91 0.00e+00 1610.00
IUUC-Atr-002778 Amborella trichopoda 32.99 5.00e-23 102.00
IUUC-Apl-003452 Anas platyrhynchos 96.01 0.00e+00 1919.00
IUUC-Aca-005312 Anolis carolinensis 84.93 0.00e+00 1340.00
IUUC-Ame-011903 Astyanax mexicanus 75.84 0.00e+00 1078.00
IUUC-Bta-012351 Bos taurus 81.12 0.00e+00 1607.00
IUUC-Cja-019491 Callithrix jacchus 82.81 0.00e+00 1670.00
IUUC-Cfa-021256 Canis familiaris 82.91 0.00e+00 1663.00
IUUC-Cpo-022046 Cavia porcellus 83.35 0.00e+00 1368.00
IUUC-Csa-023046 Chlorocebus sabaeus 83.38 0.00e+00 1726.00
IUUC-Dre-028190 Danio rerio 67.60 0.00e+00 1211.00
IUUC-Dno-029853 Dasypus novemcinctus 83.56 0.00e+00 1665.00
IUUC-Dor-030635 Dipodomys ordii 74.87 0.00e+00 1484.00
IUUC-Dme-032098 Drosophila melanogaster 74.89 0.00e+00 776.00
IUUC-Eca-033720 Equus caballus 82.01 0.00e+00 1667.00
IUUC-Eeu-035173 Erinaceus europaeus 80.85 0.00e+00 1296.00
IUUC-Fca-035967 Felis catus 82.55 0.00e+00 1634.00
IUUC-Gmo-039550 Gadus morhua 78.21 0.00e+00 1094.00
IUUC-Gga-040481 Gallus gallus 95.92 0.00e+00 1869.00
IUUC-Gac-041643 Gasterosteus aculeatus 67.91 0.00e+00 1261.00
IUUC-Ggo-045299 Gorilla gorilla 82.37 0.00e+00 1711.00
IUUC-Hsa-047033 Homo sapiens 93.33 2.00e-39 152.00
IUUC-Itr-047935 Ictidomys tridecemlineatus 81.10 0.00e+00 1580.00
IUUC-Lch-050530 Latimeria chalumnae 78.85 0.00e+00 1610.00
IUUC-Loc-052430 Lepisosteus oculatus 91.78 0.00e+00 973.00
IUUC-Laf-053609 Loxodonta africana 82.07 0.00e+00 1634.00
IUUC-Mcc-055654 Macaca mulatta 82.99 0.00e+00 1723.00
IUUC-Meu-056488 Macropus eugenii 76.31 0.00e+00 1510.00
IUUC-Mga-059270 Meleagris gallopavo 94.99 0.00e+00 1945.00
IUUC-Mmr-060593 Microcebus murinus 82.62 0.00e+00 1657.00
IUUC-Mdo-062227 Monodelphis domestica 91.35 0.00e+00 1269.00
IUUC-Mmu-064002 Mus musculus 79.71 0.00e+00 1614.00
IUUC-Mpu-066197 Mustela putorius furo 82.46 0.00e+00 1637.00
IUUC-Mlu-067255 Myotis lucifugus 82.78 0.00e+00 1642.00
IUUC-Nle-069977 Nomascus leucogenys 83.33 0.00e+00 1238.00
IUUC-Opr-070327 Ochotona princeps 75.75 0.00e+00 1450.00
IUUC-Ont-072307 Oreochromis niloticus 66.64 0.00e+00 1241.00
IUUC-Oan-073100 Ornithorhynchus anatinus 84.39 0.00e+00 1731.00
IUUC-Ocu-074892 Oryctolagus cuniculus 76.96 0.00e+00 1492.00
IUUC-Ola-087389 Oryzias latipes 68.29 0.00e+00 1065.00
IUUC-Oga-088145 Otolemur garnettii 83.39 0.00e+00 1671.00
IUUC-Oar-090432 Ovis aries 88.08 0.00e+00 1354.00
IUUC-Ptr-090800 Pan troglodytes 83.17 0.00e+00 1721.00
IUUC-Psi-093078 Pelodiscus sinensis 89.17 0.00e+00 1858.00
IUUC-Pma-094420 Petromyzon marinus 77.74 0.00e+00 900.00
IUUC-Pfo-096979 Poecilia formosa 70.88 0.00e+00 1031.00
IUUC-Pca-100874 Procavia capensis 97.31 0.00e+00 662.00
IUUC-Pva-102415 Pteropus vampyrus 81.92 0.00e+00 1621.00
IUUC-Rno-105370 Rattus norvegicus 80.63 0.00e+00 1641.00
IUUC-Sha-106711 Sarcophilus harrisii 84.12 0.00e+00 1721.00
IUUC-Ssc-115472 Sus scrofa 82.35 0.00e+00 1610.00
IUUC-Tgu-117037 Taeniopygia guttata 98.45 0.00e+00 1989.00
IUUC-Tru-118324 Takifugu rubripes 61.80 0.00e+00 1105.00
IUUC-Tsy-119216 Tarsius syrichta 94.49 0.00e+00 1056.00
IUUC-Tni-119950 Tetraodon nigroviridis 61.02 0.00e+00 1077.00
IUUC-Ttr-128209 Tursiops truncatus 83.00 0.00e+00 1689.00
IUUC-Xtr-132477 Xenopus tropicalis 74.10 0.00e+00 1115.00
Created Date 25-Jun-2017

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