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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063675
Ensembl Protein ID ENSMUSP00000022172.4
UniProt Accession Q9QUG2; Q7TPY7; POLK_MOUSE
Genbank Protein ID BAA86942.1; AAF02541.1; BAB59059.1; AAH52820.1
Protein Name DNA polymerase kappa; DINB protein
Genbank Nucleotide ID AB027563; AF163571; AB040765; BC052820
Gene Name Polk; Dinb1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000021668.14 ENSMUST00000022172.10 ENSMUSP00000022172.4
ENSMUSG00000021668.14 ENSMUST00000091387.3 ENSMUSP00000088950.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/UBZ UBZ 18162470
Classification
Family E-value Score Start End
UBD/ZnF/UBZ 1.60e-16 61.2 620 645
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/UBZ
   S: 2    lvCPvC...qkmvdqtdfeeHlDeCl 24
           + CPvC   q+ v++++f+eH+DeCl
   Q: 620  FICPVCfreQEGVSLEAFNEHVDECL 645
           68*****98888*************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).
 DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).
Protein Sequence
(Fasta)
MDNTKEKDNF KDDLLLRMGL NDNKAGMEGL DKEKINKIIM EATKGSRFYG NELKKEKQVN 60
QRIENMMQQK AQITSQQLRK AQLQVDKFAM ELERNRNLNN TIVHVDMDAF YAAVEMRDNP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063675|UBD,UBZ|Mus musculus
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Nucleotide Sequence
(Fasta)
GTGTCCTGGG CGCGCCTAAA GGCTGGTTGC CTAGGGGAAC CTTCTGAAGG CAAGTGGGCT 60
TCTTTTGAGA GTTGCGTGCC CCTTTCCGTC CAGCCTGGCT TCCGATTCTG CCTTGCGTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063675|UBD,UBZ|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0239--DNA-directed DNA polymerase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0515--Mutator protein
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0704--Schiff base
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR017061--DNA_pol_eta/kappa
IPR017961--DNA_pol_Y-fam_little_finger
IPR022880--DNApol_IV
IPR001126--UmuC
IPR006642--Znf_Rad18_put
PROSITE

PS50173--UMUC
Pfam

PF00817--IMS
PF11799--IMS_C
SMART

SM00734--ZnF_Rad18
Gene Ontology

GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003684--F:damaged DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication
GO:0006297--P:nucleotide-excision repair, DNA gap filling
KEGG mmu:27015
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001908 Ailuropoda melanoleuca 74.77 0.00e+00 1288.00
IUUC-Apl-003228 Anas platyrhynchos 53.93 0.00e+00 813.00
IUUC-Aca-005080 Anolis carolinensis 58.49 0.00e+00 870.00
IUUC-Afl-008688 Aspergillus flavus 31.49 2.00e-38 153.00
IUUC-Afu-008792 Aspergillus fumigatus 32.89 2.00e-51 196.00
IUUC-Aor-010225 Aspergillus oryzae 45.23 7.00e-44 172.00
IUUC-Ame-011889 Astyanax mexicanus 52.66 0.00e+00 740.00
IUUC-Bta-013127 Bos taurus 74.91 0.00e+00 1305.00
IUUC-Bra-017144 Brassica rapa 53.40 1.00e-58 221.00
IUUC-Cel-018629 Caenorhabditis elegans 41.62 2.00e-99 356.00
IUUC-Cja-019598 Callithrix jacchus 75.37 0.00e+00 1262.00
IUUC-Cfa-020661 Canis familiaris 73.68 0.00e+00 1267.00
IUUC-Cpo-022040 Cavia porcellus 70.23 0.00e+00 1156.00
IUUC-Csa-023669 Chlorocebus sabaeus 75.83 0.00e+00 1283.00
IUUC-Cho-024910 Choloepus hoffmanni 56.91 4.00e-169 588.00
IUUC-Csv-026293 Ciona savignyi 52.02 4.00e-138 484.00
IUUC-Dre-028317 Danio rerio 49.50 0.00e+00 741.00
IUUC-Dno-029973 Dasypus novemcinctus 73.88 0.00e+00 1255.00
IUUC-Dor-030667 Dipodomys ordii 76.07 0.00e+00 1315.00
IUUC-Dse-031339 Dothistroma septosporum 46.80 2.00e-49 190.00
IUUC-Ete-033030 Echinops telfairi 71.13 0.00e+00 1197.00
IUUC-Eca-033959 Equus caballus 76.12 0.00e+00 1303.00
IUUC-Fca-036160 Felis catus 72.18 0.00e+00 1239.00
IUUC-Fal-037116 Ficedula albicollis 56.71 0.00e+00 835.00
IUUC-Gmo-039003 Gadus morhua 51.81 0.00e+00 741.00
IUUC-Gga-040431 Gallus gallus 55.86 0.00e+00 849.00
IUUC-Gac-042455 Gasterosteus aculeatus 52.74 0.00e+00 750.00
IUUC-Gma-043303 Glycine max 53.26 3.00e-56 213.00
IUUC-Ggo-045024 Gorilla gorilla 74.94 0.00e+00 1296.00
IUUC-Hsa-046294 Homo sapiens 75.57 0.00e+00 1313.00
IUUC-Itr-048670 Ictidomys tridecemlineatus 74.79 0.00e+00 1243.00
IUUC-Lch-050251 Latimeria chalumnae 51.74 0.00e+00 804.00
IUUC-Loc-051939 Lepisosteus oculatus 52.14 0.00e+00 748.00
IUUC-Laf-054562 Loxodonta africana 69.94 0.00e+00 1168.00
IUUC-Mcc-055653 Macaca mulatta 75.57 0.00e+00 1318.00
IUUC-Meu-055994 Macropus eugenii 74.79 1.00e-143 503.00
IUUC-Mga-059228 Meleagris gallopavo 45.24 1.00e-179 623.00
IUUC-Mvi-060383 Microbotryum violaceum 36.63 8.00e-38 152.00
IUUC-Mmr-061202 Microcebus murinus 75.55 0.00e+00 1319.00
IUUC-Mdo-062829 Monodelphis domestica 62.57 0.00e+00 989.00
IUUC-Mpu-066825 Mustela putorius furo 74.60 0.00e+00 1272.00
IUUC-Mlu-067316 Myotis lucifugus 75.55 0.00e+00 1295.00
IUUC-Nle-069272 Nomascus leucogenys 75.89 0.00e+00 1312.00
IUUC-Opr-070616 Ochotona princeps 68.41 0.00e+00 1142.00
IUUC-Ont-072011 Oreochromis niloticus 55.01 0.00e+00 699.00
IUUC-Oan-073343 Ornithorhynchus anatinus 61.89 0.00e+00 998.00
IUUC-Ocu-073766 Oryctolagus cuniculus 67.13 0.00e+00 1029.00
IUUC-Ogl-077190 Oryza glaberrima 49.59 4.00e-50 192.00
IUUC-Ogu-078415 Oryza glumaepatula 41.07 1.00e-89 323.00
IUUC-Osa-085963 Oryza sativa 49.59 4.00e-50 192.00
IUUC-Ola-087034 Oryzias latipes 51.04 0.00e+00 716.00
IUUC-Oga-088157 Otolemur garnettii 72.67 0.00e+00 1265.00
IUUC-Oar-089218 Ovis aries 74.46 0.00e+00 1323.00
IUUC-Ptr-091552 Pan troglodytes 75.69 0.00e+00 1318.00
IUUC-Pan-092646 Papio anubis 74.94 0.00e+00 1300.00
IUUC-Psi-093608 Pelodiscus sinensis 57.45 0.00e+00 893.00
IUUC-Pma-094381 Petromyzon marinus 50.00 0.00e+00 714.00
IUUC-Pno-095081 Phaeosphaeria nodorum 39.47 5.00e-44 171.00
IUUC-Pfo-096545 Poecilia formosa 51.88 0.00e+00 771.00
IUUC-Pab-097613 Pongo abelii 71.01 0.00e+00 1248.00
IUUC-Pca-101071 Procavia capensis 58.94 2.00e-139 489.00
IUUC-Pva-102252 Pteropus vampyrus 75.20 0.00e+00 1291.00
IUUC-Pgr-103567 Puccinia graminis 31.93 4.00e-43 169.00
IUUC-Ptt-103934 Puccinia triticina 31.42 8.00e-27 115.00
IUUC-Rno-105793 Rattus norvegicus 88.29 0.00e+00 1489.00
IUUC-Sha-107230 Sarcophilus harrisii 64.97 0.00e+00 1070.00
IUUC-Spo-108028 Schizosaccharomyces pombe 43.81 8.00e-43 168.00
IUUC-Sly-111390 Solanum lycopersicum 54.74 6.00e-60 225.00
IUUC-Stu-112284 Solanum tuberosum 54.97 1.00e-60 228.00
IUUC-Sar-113594 Sorex araneus 65.94 0.00e+00 1082.00
IUUC-Sre-115078 Sporisorium reilianum 31.73 1.00e-42 167.00
IUUC-Ssc-116013 Sus scrofa 73.01 0.00e+00 1293.00
IUUC-Tgu-117442 Taeniopygia guttata 54.77 0.00e+00 829.00
IUUC-Tru-117935 Takifugu rubripes 56.47 0.00e+00 672.00
IUUC-Tsy-119489 Tarsius syrichta 59.41 5.00e-175 608.00
IUUC-Tni-120543 Tetraodon nigroviridis 56.62 0.00e+00 644.00
IUUC-Tbe-128112 Tupaia belangeri 77.07 0.00e+00 813.00
IUUC-Ttr-128371 Tursiops truncatus 68.89 0.00e+00 1170.00
IUUC-Uma-129377 Ustilago maydis 32.40 4.00e-46 179.00
IUUC-Vpa-130243 Vicugna pacos 75.46 0.00e+00 1318.00
IUUC-Xtr-132453 Xenopus tropicalis 54.07 0.00e+00 816.00
IUUC-Xma-133255 Xiphophorus maculatus 51.75 0.00e+00 763.00
Created Date 25-Jun-2017

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