iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000001329.3	ENSMMUT00000001882.3	ENSMMUP00000001777.3
ENSMMUG00000001329.3	ENSMMUT00000041358.2	ENSMMUP00000034386.2
ENSMMUG00000001329.3	ENSMMUT00000001885.3	ENSMMUP00000001780.3
ENSMMUG00000001329.3	ENSMMUT00000001879.3	ENSMMUP00000001774.3
ENSMMUG00000001329.3	ENSMMUT00000001883.3	ENSMMUP00000001778.2
ENSMMUG00000001329.3	ENSMMUT00000061842.1	ENSMMUP00000054316.1
ENSMMUG00000001329.3	ENSMMUT00000041356.2	ENSMMUP00000034384.2
ENSMMUG00000001329.3	ENSMMUT00000041355.2	ENSMMUP00000034383.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.60e-07	31.3	24	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n++++  +CPlC+
   Q: 24   CPICLELIKE-PVSTKCDHIFCRFCMLKL---LNQKKGPSQCPLCK 65
           ********99.**************9666...68899********7 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MDLSAVRVEE VQNVINAMQK ILECPICLEL IKEPVSTKCD HIFCRFCMLK LLNQKKGPSQ 60
CPLCKNDITK RSLQESTRFS QLVEELLKII HAFQLDTGLQ FANSYNFAKK ENHSPEHLKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCATTGGAA CAGAAAGAAA TGGATTTATC TGCTGTTCGC GTTGAAGAAG TACAAAATGT 60
CATTAATGCT ATGCAGAAAA TCTTAGAGTG TCCAATCTGG TAAGTCAGCA CAAGAGGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	73.93	0.00e+00	2651.00
IUUC-Apl-003252	Anas platyrhynchos	36.14	3.00e-130	460.00
IUUC-Aca-004526	Anolis carolinensis	54.55	1.00e-77	284.00
IUUC-Ame-011720	Astyanax mexicanus	47.29	2.00e-52	201.00
IUUC-Bgr-011969	Blumeria graminis	36.36	1.00e-08	54.30
IUUC-Bta-013433	Bos taurus	70.12	0.00e+00	2470.00
IUUC-Cel-018208	Caenorhabditis elegans	34.78	2.00e-11	64.30
IUUC-Cja-019149	Callithrix jacchus	86.74	0.00e+00	3148.00
IUUC-Cfa-020322	Canis familiaris	73.46	0.00e+00	2600.00
IUUC-Cpo-021583	Cavia porcellus	47.34	0.00e+00	1397.00
IUUC-Csa-024227	Chlorocebus sabaeus	93.03	0.00e+00	724.00
IUUC-Cho-024530	Choloepus hoffmanni	68.95	0.00e+00	1199.00
IUUC-Cin-025364	Ciona intestinalis	42.86	1.00e-14	73.90
IUUC-Csv-026245	Ciona savignyi	38.46	2.00e-13	69.30
IUUC-Dno-029247	Dasypus novemcinctus	70.95	0.00e+00	2081.00
IUUC-Dme-032032	Drosophila melanogaster	52.17	1.00e-10	57.40
IUUC-Ete-032472	Echinops telfairi	55.41	0.00e+00	1713.00
IUUC-Eca-033446	Equus caballus	75.87	0.00e+00	2767.00
IUUC-Eeu-034858	Erinaceus europaeus	60.74	0.00e+00	978.00
IUUC-Fca-035991	Felis catus	74.50	0.00e+00	2687.00
IUUC-Fal-036803	Ficedula albicollis	30.92	1.00e-106	382.00
IUUC-Gmo-038782	Gadus morhua	44.79	1.00e-45	178.00
IUUC-Ggr-039833	Gaeumannomyces graminis	36.73	1.00e-07	51.20
IUUC-Gga-040969	Gallus gallus	52.17	2.00e-81	298.00
IUUC-Gac-042296	Gasterosteus aculeatus	45.45	1.00e-50	196.00
IUUC-Ggo-044740	Gorilla gorilla	88.61	0.00e+00	3128.00
IUUC-Hsa-046086	Homo sapiens	91.99	0.00e+00	3263.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	73.52	0.00e+00	2689.00
IUUC-Lch-049789	Latimeria chalumnae	35.73	3.00e-93	337.00
IUUC-Loc-051952	Lepisosteus oculatus	52.49	3.00e-68	254.00
IUUC-Laf-053648	Loxodonta africana	73.08	0.00e+00	2491.00
IUUC-Meu-056342	Macropus eugenii	38.19	4.00e-129	456.00
IUUC-Mpo-057316	Magnaporthe poae	39.13	9.00e-08	51.60
IUUC-Mga-060163	Meleagris gallopavo	31.20	3.00e-100	360.00
IUUC-Mmr-061402	Microcebus murinus	73.58	0.00e+00	867.00
IUUC-Mdo-062209	Monodelphis domestica	45.52	0.00e+00	1290.00
IUUC-Mmu-064003	Mus musculus	55.25	0.00e+00	1816.00
IUUC-Mpu-065825	Mustela putorius furo	74.66	0.00e+00	800.00
IUUC-Mlu-068176	Myotis lucifugus	71.04	0.00e+00	2364.00
IUUC-Nle-069178	Nomascus leucogenys	92.04	0.00e+00	3323.00
IUUC-Opr-070574	Ochotona princeps	60.70	0.00e+00	2002.00
IUUC-Ont-072380	Oreochromis niloticus	48.54	8.00e-57	216.00
IUUC-Oan-073243	Ornithorhynchus anatinus	75.00	1.00e-34	138.00
IUUC-Ocu-074424	Oryctolagus cuniculus	68.97	0.00e+00	2379.00
IUUC-Ola-086863	Oryzias latipes	48.29	8.00e-54	206.00
IUUC-Oar-089938	Ovis aries	70.46	0.00e+00	2528.00
IUUC-Ptr-090960	Pan troglodytes	92.47	0.00e+00	3315.00
IUUC-Pan-092609	Papio anubis	97.30	0.00e+00	3210.00
IUUC-Psi-093889	Pelodiscus sinensis	30.78	5.00e-54	206.00
IUUC-Pfo-096328	Poecilia formosa	51.17	4.00e-60	227.00
IUUC-Pab-097982	Pongo abelii	92.52	0.00e+00	3353.00
IUUC-Pca-100698	Procavia capensis	64.83	0.00e+00	672.00
IUUC-Pva-102631	Pteropus vampyrus	75.74	0.00e+00	1183.00
IUUC-Rno-105879	Rattus norvegicus	54.96	0.00e+00	1771.00
IUUC-Sha-106701	Sarcophilus harrisii	38.93	0.00e+00	672.00
IUUC-Spo-108335	Schizosaccharomyces pombe	32.58	2.00e-09	57.40
IUUC-Sar-113047	Sorex araneus	63.80	0.00e+00	1525.00
IUUC-Ssc-115846	Sus scrofa	72.78	0.00e+00	2619.00
IUUC-Tgu-116785	Taeniopygia guttata	30.84	2.00e-98	355.00
IUUC-Tru-117895	Takifugu rubripes	40.49	1.00e-54	209.00
IUUC-Tsy-118885	Tarsius syrichta	69.04	7.00e-178	619.00
IUUC-Tni-119654	Tetraodon nigroviridis	45.63	9.00e-50	192.00
IUUC-Tbe-127421	Tupaia belangeri	59.59	1.00e-158	554.00
IUUC-Ttr-128685	Tursiops truncatus	73.72	0.00e+00	2489.00
IUUC-Vpa-130216	Vicugna pacos	70.79	0.00e+00	860.00
IUUC-Xtr-132398	Xenopus tropicalis	36.16	1.00e-63	239.00
IUUC-Xma-133651	Xiphophorus maculatus	52.94	8.00e-46	179.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence