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Tag Content
UUCD2 ID IUUC-Bta-012725
UUCD1 version UUC-BoT-01128
Ensembl Protein ID ENSBTAP00000038058.3
UniProt Accession F1N5V1; UBP37_BOVIN
Genbank Protein ID ENSBTAP00000038058
Protein Name Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37
Genbank Nucleotide ID AAFC03077731
Gene Name USP37
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000016572.4 ENSBTAT00000038243.3 ENSBTAP00000038058.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.60e-86 290.7 343 952
Active Site
Position(s) Description Evidence
352 Nucleophile {ECO:0000250|UniProtKB:Q86T82,
ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
908 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++l++ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 343  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLVKKDicNSETKKDLLKKVKNAISATAERFSGY 426
           69*****************************...*****9..679999999999999776567************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e+++k  nk+++ e    +++++d+   + ++ +++++ ++++++++++i+c+ c+++  ++e+f+dls+++
   Q: 427  MQNDAHEFLSQCLDQLKEDMEK-LNKTWKIEPVPGEENSPDI---SATRVYTCPVITNLEFEVQHSIICKVCGEIIPKREQFNDLSIDL 511
           ********************55.8888888877777888888...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP++LilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 512  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSH 595
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 596  CTEntkppfnlgwsaqmavsrplkasqmvnscitspstpsknftfksktslalsldsdsedelkrsvalshrlcemsgseqqqedlekd 684
           ***99999999999999999999999999999999999999999999999999999999999999999999999999988888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 685  skscriepdkselensgfdgmseeellaavleiskreaspslshedddkptsspdtgfaeddiqempenpdsvetekpktitepdpasf 773
           88888888888888888888888888888888877777777777777777777777777777777777777776666666666666666 PP
   S: 268  ...............peekqke................................................................... 274
                          p     e                                                                   
   Q: 774  teitkdcdenkenktP-----Egsqgevdwlqqydmerereeqelqqalaqslqeqeaweqkedddlkratelslqefnnsfvdslgsd 857
           6666666655555550.....05555555555555555555666666666666666777777777777777777888888888888888 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaY 331
                                         +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e++v++++++++Y
   Q: 858  edsgnedvldmeyteaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEASVQSDRDRSGY 946
           888888888888888888889999999999****************************99999************************** PP
   S: 332  vlfYkr 337
           ++fY++
   Q: 947  IFFYMH 952
           ****98 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
 Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
Protein Sequence
(Fasta)
MSPLKIHGPI RIRSMQTGIT KWKEGSFEVV EKENKVSLVV HYNTGGIPRI FQLSHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLNAA MKPSQGSGSF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012725|DUB,USP|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCTCCTC TGAAGATACA TGGCCCTATC AGAATTCGAA GTATGCAGAC TGGGATTACA 60
AAATGGAAAG AAGGATCCTT TGAAGTTGTG GAAAAAGAGA ATAAAGTCAG CCTAGTAGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012725|DUB,USP|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM
SMART

SM00726--UIM
Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0051301--P:cell division
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG bta:407168
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001400 Ailuropoda melanoleuca 95.92 0.00e+00 1762.00
IUUC-Apl-004033 Anas platyrhynchos 77.23 0.00e+00 1443.00
IUUC-Aca-005370 Anolis carolinensis 70.15 0.00e+00 1325.00
IUUC-Ame-011884 Astyanax mexicanus 58.84 0.00e+00 994.00
IUUC-Cja-019939 Callithrix jacchus 94.59 0.00e+00 1687.00
IUUC-Cfa-020835 Canis familiaris 96.12 0.00e+00 1814.00
IUUC-Cpo-022067 Cavia porcellus 92.41 0.00e+00 1555.00
IUUC-Cre-022867 Chlamydomonas reinhardtii 29.22 1.00e-23 105.00
IUUC-Csa-023085 Chlorocebus sabaeus 94.39 0.00e+00 1749.00
IUUC-Cho-024390 Choloepus hoffmanni 86.27 2.00e-166 579.00
IUUC-Cin-025496 Ciona intestinalis 37.25 6.00e-43 169.00
IUUC-Csv-025812 Ciona savignyi 36.61 1.00e-41 164.00
IUUC-Dre-028255 Danio rerio 57.57 0.00e+00 949.00
IUUC-Dno-028986 Dasypus novemcinctus 94.09 0.00e+00 1703.00
IUUC-Dor-031062 Dipodomys ordii 78.96 0.00e+00 876.00
IUUC-Ete-032359 Echinops telfairi 82.15 0.00e+00 820.00
IUUC-Eca-033964 Equus caballus 95.01 0.00e+00 1753.00
IUUC-Eeu-034492 Erinaceus europaeus 86.05 0.00e+00 832.00
IUUC-Fca-036359 Felis catus 95.20 0.00e+00 1748.00
IUUC-Fal-037640 Ficedula albicollis 77.53 0.00e+00 1414.00
IUUC-Gmo-039600 Gadus morhua 54.71 0.00e+00 935.00
IUUC-Gga-040126 Gallus gallus 77.13 0.00e+00 1373.00
IUUC-Gac-041557 Gasterosteus aculeatus 54.26 0.00e+00 916.00
IUUC-Ggo-045571 Gorilla gorilla 90.65 0.00e+00 1521.00
IUUC-Hsa-046043 Homo sapiens 94.69 0.00e+00 1705.00
IUUC-Itr-048207 Ictidomys tridecemlineatus 92.35 0.00e+00 1681.00
IUUC-Lch-050357 Latimeria chalumnae 64.37 0.00e+00 1044.00
IUUC-Loc-052849 Lepisosteus oculatus 61.12 0.00e+00 1005.00
IUUC-Laf-054570 Loxodonta africana 93.08 0.00e+00 1671.00
IUUC-Mcc-054989 Macaca mulatta 94.29 0.00e+00 1614.00
IUUC-Meu-056273 Macropus eugenii 64.33 6.00e-172 598.00
IUUC-Mga-059814 Meleagris gallopavo 75.51 0.00e+00 1374.00
IUUC-Mmr-061726 Microcebus murinus 93.58 0.00e+00 1731.00
IUUC-Mdo-062974 Monodelphis domestica 84.67 0.00e+00 1572.00
IUUC-Mmu-064069 Mus musculus 88.58 0.00e+00 1599.00
IUUC-Mpu-066008 Mustela putorius furo 95.31 0.00e+00 1719.00
IUUC-Nle-069259 Nomascus leucogenys 94.39 0.00e+00 1707.00
IUUC-Opr-070882 Ochotona princeps 77.51 5.00e-139 488.00
IUUC-Ont-072441 Oreochromis niloticus 55.27 0.00e+00 934.00
IUUC-Oan-073151 Ornithorhynchus anatinus 82.07 6.00e-119 420.00
IUUC-Ocu-074879 Oryctolagus cuniculus 92.86 0.00e+00 1699.00
IUUC-Ola-087007 Oryzias latipes 54.79 0.00e+00 897.00
IUUC-Oga-088385 Otolemur garnettii 92.29 0.00e+00 1709.00
IUUC-Oar-090305 Ovis aries 98.88 0.00e+00 1819.00
IUUC-Ptr-091299 Pan troglodytes 94.50 0.00e+00 1714.00
IUUC-Pan-091996 Papio anubis 94.54 0.00e+00 1695.00
IUUC-Psi-093176 Pelodiscus sinensis 78.59 0.00e+00 1451.00
IUUC-Pma-094331 Petromyzon marinus 48.22 0.00e+00 759.00
IUUC-Ppa-095732 Physcomitrella patens 30.38 3.00e-24 107.00
IUUC-Pfo-096503 Poecilia formosa 56.28 0.00e+00 932.00
IUUC-Pab-098543 Pongo abelii 93.83 0.00e+00 913.00
IUUC-Pca-101099 Procavia capensis 87.69 0.00e+00 1313.00
IUUC-Pva-103163 Pteropus vampyrus 88.79 0.00e+00 1630.00
IUUC-Rno-105766 Rattus norvegicus 89.70 0.00e+00 1615.00
IUUC-Sha-106610 Sarcophilus harrisii 81.01 0.00e+00 1478.00
IUUC-Sar-113256 Sorex araneus 90.09 1.00e-112 401.00
IUUC-Ssc-116353 Sus scrofa 96.03 0.00e+00 1729.00
IUUC-Tgu-116971 Taeniopygia guttata 77.33 0.00e+00 1380.00
IUUC-Tru-117932 Takifugu rubripes 46.82 2.00e-137 483.00
IUUC-Tsy-119185 Tarsius syrichta 87.99 0.00e+00 1108.00
IUUC-Tni-119842 Tetraodon nigroviridis 60.13 4.00e-110 392.00
IUUC-Tbe-127281 Tupaia belangeri 82.52 0.00e+00 654.00
IUUC-Ttr-128177 Tursiops truncatus 96.94 0.00e+00 1378.00
IUUC-Vpa-130031 Vicugna pacos 96.13 0.00e+00 1805.00
IUUC-Xtr-132949 Xenopus tropicalis 65.35 0.00e+00 1160.00
Created Date 25-Jun-2017

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